Statistics and Probability Commons^™

Large Scale Dynamical Model Of Macrophage/Hiv Interactions, Sean T. Bresnahan, Matthew M. Froid

UNO Student Research and Creative Activity Fair

Properties emerge from the dynamics of large-scale molecular networks that are not discernible at the individual gene or protein level. Mathematical models - such as probabilistic Boolean networks - of molecular systems offer a deeper insight into how these emergent properties arise. Here, we introduce a non-linear, deterministic Boolean model of protein, gene, and chemical interactions in human macrophage cells during HIV infection. Our model is composed of 713 nodes with 1583 interactions between nodes and is responsive to 38 different inputs including signaling molecules, bacteria, viruses, and HIV viral particles. Additionally, the model accurately simulates the dynamics of over …

Neural Shrubs: Using Neural Networks To Improve Decision Trees, Kyle Caudle, Randy Hoover, Aaron Alphonsus

SDSU Data Science Symposium

Decision trees are a method commonly used in machine learning to either predict a categorical response or a continuous response variable. Once the tree partitions the space, the response is either determined by the majority vote – classification trees, or by averaging the response values – regression trees. This research builds a standard regression tree and then instead of averaging the responses, we train a neural network to determine the response value. We have found that our approach typically increases the predicative capability of the decision tree. We have 2 demonstrations of this approach that we wish to present as …

Session: 4 Multilinear Subspace Learning And Its Applications To Machine Learning, Randy Hoover, Kyle Caudle Dr., Karen Braman Dr.

SDSU Data Science Symposium

Multi-dimensional data analysis has seen increased interest in recent years. With more and more data arriving as 2-dimensional arrays (images) as opposed to 1-dimensioanl arrays (signals), new methods for dimensionality reduction, data analysis, and machine learning have been pursued. Most notably have been the Canonical Decompositions/Parallel Factors (commonly referred to as CP) and Tucker decompositions (commonly regarded as a high order SVD: HOSVD). In the current research we present an alternate method for computing singular value and eigenvalue decompositions on multi-way data through an algebra of circulants and illustrate their application to two well-known machine learning methods: Multi-Linear Principal Component …

A Novel Pathway-Based Distance Score Enhances Assessment Of Disease Heterogeneity In Gene Expression, Yunqing Liu, Xiting Yan

Yale Day of Data

Distance-based unsupervised clustering of gene expression data is commonly used to identify heterogeneity in biologic samples. However, high noise levels in gene expression data and the relatively high correlation between genes are often encountered, so traditional distances such as Euclidean distance may not be effective at discriminating the biological differences between samples. In this study, we developed a novel computational method to assess the biological differences based on pathways by assuming that ontologically defined biological pathways in biologically similar samples have similar behavior. Application of this distance score results in more accurate, robust, and biologically meaningful clustering results in both …

Missing Data Augmentation For Bayesian Multiplex Ergms, Robert Krause, Alberto Caimo

Conference papers

In this paper we present an estimation algorithm for Bayesian multiplex exponential random graphs (BmERGMs) under missing net- work data. Social actors are often connected with more than one type of relation, thus forming a multiplex network. It is important to consider these multiplex structures simultaneously when analyzing a multiplex network. The importance of proper models of multiplex network structures is even more pronounced under the issue of missing network data. The proposed algorithm is able to estimate BmERGMs under missing data and can be used to obtain proper multiple imputations for multiplex network structures. It is an extension of …

Exploring The Variance Of The Sample Variance Through Estimation And Simulation, Christina Stradwick

Theses, Dissertations and Capstones

In this thesis, we examine properties of the variance of the sample variance, which we will denote V (S ² ). We derive a formula for this variance and show that it only depends on the sample size, variance, and kurtosis of the underlying distribution. We also derive the maximum likelihood estimators for this parameter, V^ˆ (S ² ), under the normal, exponential, Bernoulli, and Poisson distributions and end the thesis with simulations demonstrating the distributions of these estimators.

Estimation Of Multivariate Asset Models With Jumps, Angela Loregian, Laura Ballotta, Gianluca Gianluca Fusai, Marcos Fabricio Perez

Business Faculty Publications

We propose a consistent and computationally efficient two-step methodology for the estimation of multidimensional non-Gaussian asset models built using Levy processes. The proposed framework allows for dependence between assets and different tail behaviors and jump structures for each asset. Our procedure can be applied to portfolios with a large number of assets as it is immune to estimation dimensionality problems. Simulations show good finite sample properties and significant efficiency gains. This method is especially relevant for risk management purposes such as, for example, the computation of portfolio Value at Risk and intra-horizon Value at Risk, as we show in detail …

A Comparison Of Bayesian Estimation Techniques In A Multidimensional Two-Parameter Partial Credit Item Response Model, Peiyan Liu

Electronic Theses and Dissertations

Bayesian estimation methods have shown better performance than the traditional Marginal Maximum Likelihood (MML) estimation method for parameter estimation in relatively simple item response models. However, extant literature is lacking on the investigation of Bayesian parameter estimation approaches for a multidimensional two parameter partial credit (M2PPC) model, therefore this simulation study investigated the performance of two Bayesian Markov Chain Monte Carlo (MCMC) algorithms: Gibbs Sampler and Hamiltonian Monte Carlo-No-U-Turn-Sampler (HMC-NUTS) for M2PPC models' parameter estimation. It compared the estimation accuracy and computing speed in different combinations of situations, including prior choices, test lengths, and the relationships between dimensions.

The datasets …

Controlling For Confounding Via Propensity Score Methods Can Result In Biased Estimation Of The Conditional Auc: A Simulation Study, Hadiza I. Galadima, Donna K. Mcclish

Community & Environmental Health Faculty Publications

In the medical literature, there has been an increased interest in evaluating association between exposure and outcomes using nonrandomized observational studies. However, because assignments to exposure are not random in observational studies, comparisons of outcomes between exposed and nonexposed subjects must account for the effect of confounders. Propensity score methods have been widely used to control for confounding, when estimating exposure effect. Previous studies have shown that conditioning on the propensity score results in biased estimation of conditional odds ratio and hazard ratio. However, research is lacking on the performance of propensity score methods for covariate adjustment when estimating the …

The Paradox Of Big Data, Gary N. Smith

Pomona Economics

Data-mining is often used to discover patterns in Big Data. It is tempting believe that because an unearthed pattern is unusual it must be meaningful, but patterns are inevitable in Big Data and usually meaningless. The paradox of Big Data is that data mining is most seductive when there are a large number of variables, but a large number of variables exacerbates the perils of data mining.

The Use Of 3-D Highway Differential Geometry In Crash Prediction Modeling, Kiriakos Amiridis

Theses and Dissertations--Civil Engineering

The objective of this research is to evaluate and introduce a new methodology regarding rural highway safety. Current practices rely on crash prediction models that utilize specific explanatory variables, whereas the depository of knowledge for past research is the Highway Safety Manual (HSM). Most of the prediction models in the HSM identify the effect of individual geometric elements on crash occurrence and consider their combination in a multiplicative manner, where each effect is multiplied with others to determine their combined influence. The concepts of 3-dimesnional (3-D) representation of the roadway surface have also been explored in the past aiming to …

Some New Generalized Distribution Via Lindley-Weibuli And Lindley-Log-Logistic Distributions With Applications, Soliu A. Raheem

College of Graduate Studies: Theses & Dissertations

In this thesis, new generalized distributions, namely Beta Lindley-Log-Logistic (BLLLoG) distribution, Marshall-Olkin Lindley-Weibull (MOLW) distribution, and Gamma LindleyWeibull (GLW) distribution as well as related sub-distributions are proposed. Series expansion of the densities are obtained. Statistical properties of these distributions, including hazard function, reverse hazard function, moments, reliability, quantile function, mean deviations, Bonferroni and Lorenz curves, entropy and Fisher information are derived. Method of maximum likelihood is used to estimate the parameters of the new distributions. Monte Carlo simulation is employed to examine the performance of the proposed distributions. Applications of the generalized distributions to real lifetime data are presented to …

Variable Selection In Accelerated Failure Time (Aft) Frailty Models: An Application Of Penalized Quasi-Likelihood, Sarbesh R. Pandeya

College of Graduate Studies: Theses & Dissertations

Variable selection is one of the standard ways of selecting models in large scale datasets. It has applications in many fields of research study, especially in large multi-center clinical trials. One of the prominent methods in variable selection is the penalized likelihood, which is both consistent and efficient. However, the penalized selection is significantly challenging under the influence of random (frailty) covariates. It is even more complicated when there is involvement of censoring as it may not have a closed-form solution for the marginal log-likelihood. Therefore, we applied the penalized quasi-likelihood (PQL) approach that approximates the solution for such a …

Estimation And Variable Selection In High-Dimensional Settings With Mismeasured Observations, Michael Byrd

Statistical Science Theses and Dissertations

Understanding high-dimensional data has become essential for practitioners across many disciplines. The general increase in ability to collect large amounts of data has prompted statistical methods to adapt for the rising number of possible relationships to be uncovered. The key to this adaptation has been the notion of sparse models, or, rather, models where most relationships between variables are assumed to be negligible at best. Driving these sparse models have been constraints on the solution set, yielding regularization penalties imposed on the optimization procedure. While these penalties have found great success, they are typically formulated with strong assumptions on the …

Modeling Stochastically Intransitive Relationships In Paired Comparison Data, Ryan Patrick Alexander Mcshane

Statistical Science Theses and Dissertations

If the Warriors beat the Rockets and the Rockets beat the Spurs, does that mean that the Warriors are better than the Spurs? Sophisticated fans would argue that the Warriors are better by the transitive property, but could Spurs fans make a legitimate argument that their team is better despite this chain of evidence?

We first explore the nature of intransitive (rock-scissors-paper) relationships with a graph theoretic approach to the method of paired comparisons framework popularized by Kendall and Smith (1940). Then, we focus on the setting where all pairs of items, teams, players, or objects have been compared to …

Canadian Hockey Leagues Game-To-Game Performance, Nick R. Riccardi

Sport Management - All Scholarship

This study examines game-to-game performance of players across the three Canadian Hockey Leagues (Western Hockey League, Ontario Hockey League, and Quebec Major Junior Hockey League) for the 2017-2018 season. It tests the importance of factors such as rest, travel, weather conditions, and more. Data for this study were collected from each of the three CHL websites and from www.weatherunderground.com. The null hypotheses of different factors affecting performance were tested through regression models using Ordinary Least Squares. The dependent variables, used across different specifications, were on-ice performance variables such as points, goals, and penalty minutes on a per-game basis.

Transforms In Sufficient Dimension Reduction And Their Applications In High Dimensional Data, Jiaying Weng

Theses and Dissertations--Statistics

The big data era poses great challenges as well as opportunities for researchers to develop efficient statistical approaches to analyze massive data. Sufficient dimension reduction is such an important tool in modern data analysis and has received extensive attention in both academia and industry.

In this dissertation, we introduce inverse regression estimators using Fourier transforms, which is superior to the existing SDR methods in two folds, (1) it avoids the slicing of the response variable, (2) it can be readily extended to solve the high dimensional data problem. For the ultra-high dimensional problem, we investigate both eigenvalue decomposition and minimum …

Unsupervised Learning In Phylogenomic Analysis Over The Space Of Phylogenetic Trees, Qiwen Kang

Theses and Dissertations--Statistics

A phylogenetic tree is a tree to represent an evolutionary history between species or other entities. Phylogenomics is a new field intersecting phylogenetics and genomics and it is well-known that we need statistical learning methods to handle and analyze a large amount of data which can be generated relatively cheaply with new technologies. Based on the existing Markov models, we introduce a new method, CURatio, to identify outliers in a given gene data set. This method, intrinsically an unsupervised method, can find outliers from thousands or even more genes. This ability to analyze large amounts of genes (even with missing …

Composite Nonparametric Tests In High Dimension, Alejandro G. Villasante Tezanos

Theses and Dissertations--Statistics

This dissertation focuses on the problem of making high-dimensional inference for two or more groups. High-dimensional means both the sample size (n) and dimension (p) tend to infinity, possibly at different rates. Classical approaches for group comparisons fail in the high-dimensional situation, in the sense that they have incorrect sizes and low powers. Much has been done in recent years to overcome these problems. However, these recent works make restrictive assumptions in terms of the number of treatments to be compared and/or the distribution of the data. This research aims to (1) propose and investigate refined …

Bayesian Analysis For The Intraclass Model And For The Quantile Semiparametric Mixed-Effects Double Regression Models, Duo Zhang

Dissertations, Master's Theses and Master's Reports

This dissertation consists of three distinct but related research projects. The first two projects focus on objective Bayesian hypothesis testing and estimation for the intraclass correlation coefficient in linear models. The third project deals with Bayesian quantile inference for the semiparametric mixed-effects double regression models. In the first project, we derive the Bayes factors based on the divergence-based priors for testing the intraclass correlation coefficient (ICC). The hypothesis testing of the ICC is used to test the uncorrelatedness in multilevel modeling, and it has not well been studied from an objective Bayesian perspective. Simulation results show that the two sorts …

Hydroclimate Drivers And Atmospheric Dynamics Of Floods, Nasser Najibi

Dissertations and Theses

Our preliminary survey showed that most of the recent flood-related studies did not formally explain the physical mechanisms of long-duration and large-peak flood events that can evoke substantial damages to properties and infrastructure systems. These studies also fell short of fully assessing the interactions of coupled ocean-atmosphere and land dynamics which are capable of forcing substantial changes to the flood attributes by governing the exceeding surface flow regimes and moisture source-sink relationships at the spatiotemporal scales important for risk management. This dissertation advances the understanding of the variability in flood duration, peak, volume, and timing at the regional to the …

Quantifying Human Biological Age: A Machine Learning Approach, Syed Ashiqur Rahman

Graduate Theses, Dissertations, and Problem Reports (ETD)

Quantifying human biological age is an important and difficult challenge. Different biomarkers and numerous approaches have been studied for biological age prediction, each with its advantages and limitations. In this work, we first introduce a new anthropometric measure (called Surface-based Body Shape Index, SBSI) that accounts for both body shape and body size, and evaluate its performance as a predictor of all-cause mortality. We analyzed data from the National Health and Human Nutrition Examination Survey (NHANES). Based on the analysis, we introduce a new body shape index constructed from four important anthropometric determinants of body shape and body size: body …

Design Of Experiment And Analysis Techniques For Fuel Consumption Data Using Heavy-Duty Diesel Vehicles And On-Road Testing, Sarah Ann Mills

Graduate Theses, Dissertations, and Problem Reports (ETD)

Chassis dynamometer and on-road testing are usually employed to test vehicle operation. Testing on a chassis dynamometer reduces data variability compared to on-road testing due to the controlled environment but it does not account for other important variables that affects real-world vehicle operation. This study used on-road testing to investigate the differences between two test fuels under real-world conditions. Three heavy-duty diesel vehicles were driven on different routes for a period of three months. Each vehicle was instrumented with flow meters to gather fuel consumption data, which was then compared to the fuel rate broadcasted by the engine control unit …

Latent Growth Model Approach To Characterize Maternal Prenatal Dna Methylation Trajectories, Dana Lapato

Theses and Dissertations

Background. DNA methylation (DNAm) is a removable chemical modification to the DNA sequence intimately associated with genomic stability, cellular identity, and gene expression. DNAm patterning reflects joint contributions from genetic, environmental, and behavioral factors. As such, differences in DNAm patterns may explain interindividual variability in risk liability for complex traits like major depression (MD). Hundreds of significant DNAm loci have been identified using cross-sectional association studies. This dissertation builds on that foundational work to explore novel statistical approaches for longitudinal DNAm analyses. Methods. Repeated measures of genome-wide DNAm and social and environmental determinants of health were collected up to six …

Statistical Designs For Network A/B Testing, Victoria V. Pokhilko

Theses and Dissertations

A/B testing refers to the statistical procedure of experimental design and analysis to compare two treatments, A and B, applied to different testing subjects. It is widely used by technology companies such as Facebook, LinkedIn, and Netflix, to compare different algorithms, web-designs, and other online products and services. The subjects participating in these online A/B testing experiments are users who are connected in different scales of social networks. Two connected subjects are similar in terms of their social behaviors, education and financial background, and other demographic aspects. Hence, it is only natural to assume that their reactions to online products …

Statistical Methods For Joint Analysis Of Multiple Phenotypes And Their Applications For Phewas, Xueling Li

Dissertations, Master's Theses and Master's Reports

Genome-wide association studies (GWAS) have successfully detected tens of thousands of robust SNP-trait associations. Earlier researches have primarily focused on association studies of genetic variants and some well-defined functions or phenotypic traits. Emerging evidence suggests that pleiotropy, the phenomenon of one genetic variant affects multiple phenotypes, is widespread, especially in complex human diseases. Therefore, individual phenotype analyses may lose statistical power to identify the underlying genetic mechanism. Contrasting with single phenotype analyses, joint analysis of multiple phenotypes exploits the correlations between phenotypes and aggregates multiple weak marginal effects and is therefore likely to provide new insights into the functional consequences …

A Multilayer Exponential Random Graph Modelling Approach For Weighted Networks, Alberto Caimo, Isabella Gollini

Articles

A new modelling approach for the analysis of weighted networks with ordinal/polytomous dyadic values is introduced. Specifically, it is proposed to model the weighted network connectivity structure using a hierarchical multilayer exponential random graph model (ERGM) generative process where each network layer represents a different ordinal dyadic category. The network layers are assumed to be generated by an ERGM process conditional on their closest lower network layers. A crucial advantage of the proposed method is the possibility of adopting the binary network statistics specification to describe both the between-layer and across-layer network processes and thus facilitating the interpretation of the …

Statistical Modeling Of Influenza-Like-Illness In Montana Using Spatial And Temporal Methods, Benjamin A. Stark

Graduate Student Theses, Dissertations, & Professional Papers

Studying air pollution and public health has been a historically important question in science. It has long been hypothesized that severe air pollution conditions lead to negative implications in basic human health. Primarily, areas thats are prone to severe degrees of human pollution are the focus of such studies. Such research relating to less populated areas are scarce, and this scarcity raises the question of how such pollution dynamics (human-made and natural) influence human health in more rural areas.

The aim of this study is to explore this hole in research; in particular we explore possible links between air pollution …

Application Of Bradford’S Law Of Scattering On Research Publication In Astronomy & Astrophysics Of India, Satish Kumar, Senthilkumar R.

Library Philosophy and Practice (e-journal)

The present study is focused on examining the application of Bradford’s law of scattering on research articles published in the field of Astronomy & Astrophysics by Indian scientist during 1988-2017. The bibliographic data was retrieved from Web of Science (WoS) bibliographic data base for different period of time. Total 18,877 journal’s article have been published by Indian scientist in the field of Astronomy & Astrophysics during 1988-2017 which was further retrieved and analyzed separately for different blocks of 10 years as well as for 30 years consolidated too. The core journal of the field was identified. The Bradford law of …

Analysis Of Covariance (Ancova) In Randomized Trials: More Precision, Less Conditional Bias, And Valid Confidence Intervals, Without Model Assumptions, Bingkai Wang, Elizabeth Ogburn, Michael Rosenblum

Johns Hopkins University, Dept. of Biostatistics Working Papers

Covariate adjustment" in the randomized trial context refers to an estimator of the average treatment effect that adjusts for chance imbalances between study arms in baseline variables (called “covariates"). The baseline variables could include, e.g., age, sex, disease severity, and biomarkers. According to two surveys of clinical trial reports, there is confusion about the statistical properties of covariate adjustment. We focus on the ANCOVA estimator, which involves fitting a linear model for the outcome given the treatment arm and baseline variables, and trials with equal probability of assignment to treatment and control. We prove the following new (to the best …