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Articles 1 - 13 of 13
Full-Text Articles in Fluid Dynamics
Using Computational Fluid Dynamics And Optical Sensor Technology To Scale Cell Culture Platforms, Mandar Makwana
Using Computational Fluid Dynamics And Optical Sensor Technology To Scale Cell Culture Platforms, Mandar Makwana
KGI Theses and Dissertations
Different cell culture vessels ranging from micro scale to laboratory scale to commercial scale play critical role in upstream process development for biologics manufacturing. Based on the mode of operation, cell culture vessels have different hydrodynamic environments, making it challenging to scale. Integrated approaches using computational tools supported by experimental studies can overcome these challenges. Computational Fluid Dynamics (CFD) is one such tool that can simulate hydrodynamics within the cell culture vessels and can provide insights at macro and micro-scale. Accuracy of a CFD model significantly depends on the fluid model and assumptions. Traditionally, simple two-equation fluid models were developed …
Modeling Self-Diffusiophoretic Janus Particles In Fluid, Kausik Das
Modeling Self-Diffusiophoretic Janus Particles In Fluid, Kausik Das
HMC Senior Theses
We explore spherical Janus particles in which a chemical reaction occurs on one face, depleting a substrate in the suspending fluid, while no reaction occurs on the other face. The steady state concentration field is governed by Laplace’s equation with mixed boundary conditions. We use the collocation method to obtain numerical solutions to the equation in spherical coordinates. The asymmetry of the reaction gives rise to a slip velocity that causes the particle to move spontaneously in the fluid through a process known as self-diffusiophoresis. Using the Lorentz reciprocal theorem, we obtain the swimming velocity of the particle. We extend …
Modeling Residence Time Distribution Of Chromatographic Perfusion Resin For Large Biopharmaceutical Molecules: A Computational Fluid Dynamic Study, Kevin Vehar
KGI Theses and Dissertations
The need for production processes of large biotherapeutic particles, such as virus-based particles and extracellular vesicles, has risen due to increased demand in the development of vaccinations, gene therapies, and cancer treatments. Liquid chromatography plays a significant role in the purification process and is routinely used with therapeutic protein production. However, performance with larger macromolecules is often inconsistent, and parameter estimation for process development can be extremely time- and resource-intensive. This thesis aimed to utilize advances in computational fluid dynamic (CFD) modeling to generate a first-principle model of the chromatographic process while minimizing model parameter estimation's physical resource demand. Specifically, …
Complex Ciliary Flows Around Stentor Polymorphus In Solutions Of 2% Buttermilk And Chlamydomonas Reinhardtii, Eliana B. Smithstein
Complex Ciliary Flows Around Stentor Polymorphus In Solutions Of 2% Buttermilk And Chlamydomonas Reinhardtii, Eliana B. Smithstein
Scripps Senior Theses
Stentor are large, unicellular ciliates of the Heterotricha order. They live in both freshwater and marine habitats and are mostly found in ponds. I studied Stentor polymorphus, which is a species of Stentor only recently discovered to be lab culturable. They range from 0.5-1.5mm in length and are unusual because they live with endosymbiotic algae and are much more likely than other, more widely studied, species of Stentor to form aggregates while they are eating. There are three main components to this thesis: First, I established protocols for keeping a viable S. polymorphus culture, since no protocols had been …
Giardia Lamblia Growth In Viscoelastic Fluids, Kelly Watanabe
Giardia Lamblia Growth In Viscoelastic Fluids, Kelly Watanabe
CMC Senior Theses
Giardia lamblia is a single-celled protozoan parasite that when ingested, causes diarrheal disease and infects 33% of people in developing countries. Previous studies observe Giardia in water-like fluids, but Giardia's infectious environment consists of viscoelastic mucus in the small intestine. Therefore, Giardia was cultured in viscoelastic fluids, and its population growth was observed in vitro. To create shear-thinning viscoelastic fluids, 0.2% and 0.4% long-chain polyacrylamide (LCPAM) was added to cell culture media. Giardia was cultured in control media, 0.2% LCPAM, and 0.4% LCPAM, and population growth was quantitatively determined over time. Increasing LCPAM concentration resulted in a solution with …
Turbulence, Climate And Supercomputers, Georgios Matheou
Turbulence, Climate And Supercomputers, Georgios Matheou
The Transdisciplinary STEAM+ Journal
Turbulence is often referred to as the last mystery of classical physics. Although turbulence is ubiquitous and prominent in our daily lives – from the mixing of milk in a cup of coffee to the perpetual motion of the atmosphere and the resulting weather variation – our understanding of this complex phenomenon is comparatively very limited (e.g., Davidson et al., 2011).
Simulations Of Surfactant Driven Thin Film Flow, Shreyas Kumar
Simulations Of Surfactant Driven Thin Film Flow, Shreyas Kumar
HMC Senior Theses
This thesis is intended to fulfill the requirements of the Math and Physics departments at Harvey Mudd College. We begin with a brief introduction to the study of surfactant dynamics followed by some background on the experimental framework our work is related to. We then go through a derivation of the model we use, and explore in depth the nature of the Equation of State (EoS), the relationship between the surface tension on a fluid and the surfactant concentration. We consider the effect of using an empirical equation of state on the results of the simulations and compare the new …
Simulations Of Surfactant Spreading, Jeffrey Wong
Simulations Of Surfactant Spreading, Jeffrey Wong
HMC Senior Theses
Thin liquid films driven by surface tension gradients are studied in diverse applications, including the spreading of a droplet and fluid flow in the lung. The nonlinear partial differential equations that govern thin films are difficult to solve analytically, and must be approached through numerical simulations. We describe the development of a numerical solver designed to solve a variety of thin film problems in two dimensions. Validation of the solver includes grid refinement studies and comparison to previous results for thin film problems. In addition, we apply the solver to a model of surfactant spreading and make comparisons with theoretical …
Generation Of Mie Size Microdroplet Aerosols With Applications In Laser-Driven Fusion Experiments, Andrew P. Higginbotham '09, O. Semonin '06, S. Bruce '08, C. Chan '08, M. Maindi '07, Thomas D. Donnelly, M. Maurer, W. Bang, I. Churina, J. Osterholz, I. Kim, A. C. Bernstein, T. Ditmire
Generation Of Mie Size Microdroplet Aerosols With Applications In Laser-Driven Fusion Experiments, Andrew P. Higginbotham '09, O. Semonin '06, S. Bruce '08, C. Chan '08, M. Maindi '07, Thomas D. Donnelly, M. Maurer, W. Bang, I. Churina, J. Osterholz, I. Kim, A. C. Bernstein, T. Ditmire
All HMC Faculty Publications and Research
We have developed a tunable source of Mie scale microdroplet aerosols that can be used for the generation of energetic ions. To demonstrate this potential, a terawatt Ti:Al2O3 laser focused to 2×1019 W/cm2 was used to irradiate heavy water (D2O) aerosols composed of micron-scale droplets. Energetic deuterium ions, which were generated in the laser-droplet interaction, produced deuterium-deuterium fusion with approximately 2×103 fusion neutrons measured per joule of incident laser energy.
Stability Of Traveling Waves In Thin Liquid Films Driven By Gravity And Surfactant, Ellen Peterson, Michael Shearer, Thomas P. Witelski, Rachel Levy
Stability Of Traveling Waves In Thin Liquid Films Driven By Gravity And Surfactant, Ellen Peterson, Michael Shearer, Thomas P. Witelski, Rachel Levy
All HMC Faculty Publications and Research
A thin layer of fluid flowing down a solid planar surface has a free surface height described by a nonlinear PDE derived via the lubrication approximation from the Navier Stokes equations. For thin films, surface tension plays an important role both in providing a significant driving force and in smoothing the free surface. Surfactant molecules on the free surface tend to reduce surface tension, setting up gradients that modify the shape of the free surface. In earlier work [12, 13J a traveling wave was found in which the free surface undergoes three sharp transitions, or internal layers, and the surfactant …
Gravity-Driven Thin Liquid Films With Insoluble Surfactant: Smooth Traveling Waves, Rachel Levy, Michael Shearer, Thomas P. Witelski
Gravity-Driven Thin Liquid Films With Insoluble Surfactant: Smooth Traveling Waves, Rachel Levy, Michael Shearer, Thomas P. Witelski
All HMC Faculty Publications and Research
The flow of a thin layer of fluid down an inclined plane is modified by the presence of insoluble surfactant. For any finite surfactant mass, traveling waves are constructed for a system of lubrication equations describing the evolution of the free-surface fluid height and the surfactant concentration. The one-parameter family of solutions is investigated using perturbation theory with three small parameters: the coefficient of surface tension, the surfactant diffusivity, and the coefficient of the gravity-driven diffusive spreading of the fluid. When all three parameters are zero, the nonlinear PDE system is hyperbolic/degenerateparabolic, and admits traveling wave solutions in which the …
The Motion Of A Thin Liquid Film Driven By Surfactant And Gravity, Michael Shearer, Rachel Levy
The Motion Of A Thin Liquid Film Driven By Surfactant And Gravity, Michael Shearer, Rachel Levy
All HMC Faculty Publications and Research
We investigate wave solutions of a lubrication model for surfactant-driven flow of a thin liquid film down an inclined plane. We model the flow in one space dimension with a system of nonlinear PDEs of mixed hyperbolic-parabolic type in which the effects of capillarity and surface diffusion are neglected. Numerical solutions reveal distinct patterns of waves that are described analytically by combinations of traveling waves, some with jumps in height and surfactant concentration gradient. The various waves and combinations are strikingly different from what is observed in the case of flow on a horizontal plane. Jump conditions admit new shock …
Tabletop X-Ray Lasers, D. C. Eder, P. Amendt, L. B. Dasilva, R. A. London, B. J. Macgowan, D. L. Matthews, B. M. Penetrante, M. D. Rosen, S. C. Silks, Thomas D. Donnelly, R. W. Falcone, G. L. Strobel
Tabletop X-Ray Lasers, D. C. Eder, P. Amendt, L. B. Dasilva, R. A. London, B. J. Macgowan, D. L. Matthews, B. M. Penetrante, M. D. Rosen, S. C. Silks, Thomas D. Donnelly, R. W. Falcone, G. L. Strobel
All HMC Faculty Publications and Research
Details of schemes for two tabletop size x‐ray lasers that require a high‐intensity short‐pulse driving laser are discussed. The first is based on rapid recombination following optical‐field ionization. Analytical and numerical calculations of the output properties are presented. Propagation in the confocal geometry is discussed and a solution for x‐ray lasing in Li‐like N at 247 Å is described. Since the calculated gain coefficient depends strongly on the electron temperature, the methods of calculating electron heating following field ionization are discussed. Recent experiments aimed at demonstrating lasing in H‐like Li at 135 Å are discussed along with modeling results. The …