Open Access. Powered by Scholars. Published by Universities.®
- Institution
-
- Old Dominion University (10)
- Prairie View A&M University (10)
- Claremont Colleges (4)
- Virginia Commonwealth University (3)
- University of Montana (2)
-
- California Polytechnic State University, San Luis Obispo (1)
- Calvin University (1)
- Chapman University (1)
- City University of New York (CUNY) (1)
- Coastal Carolina University (1)
- East Tennessee State University (1)
- Illinois State University (1)
- Kutztown University (1)
- Michigan Technological University (1)
- Nova Southeastern University (1)
- Seton Hall University (1)
- University of Central Florida (1)
- University of Nebraska - Lincoln (1)
- University of Nevada, Las Vegas (1)
- University of the Pacific (1)
- Keyword
-
- Electrodes (3)
- Electrophoresis (3)
- Hematocrit (3)
- Simulation (3)
- BioMEMS (2)
-
- Blood flow (2)
- CFD (2)
- Computational Fluid Dynamics (2)
- Computational fluid dynamics (2)
- Flow (2)
- Fluid flow (2)
- Impedance (2)
- Microelectrodes (2)
- Microfluidics (2)
- Particle size (2)
- Shear stress (2)
- Stenosis (2)
- Ventilation (2)
- AAV (1)
- ACEO (1)
- ACH (Air exchanges per hour) (1)
- ANSYS Fluent (1)
- Acoustics (1)
- Aggregation (1)
- Air-sea interaction (1)
- Alternating current (1)
- Arterial flow (1)
- Atrial fibrillation (1)
- Bacteria (1)
- Bacterial spores (1)
- Publication Year
- Publication
-
- Applications and Applied Mathematics: An International Journal (AAM) (10)
- Mechanical & Aerospace Engineering Faculty Publications (9)
- Biology and Medicine Through Mathematics Conference (2)
- Graduate Student Theses, Dissertations, & Professional Papers (2)
- KGI Theses and Dissertations (2)
-
- All HCAS Student Capstones, Theses, and Dissertations (1)
- Annual Symposium on Biomathematics and Ecology Education and Research (1)
- Biology, Chemistry, and Environmental Sciences Faculty Articles and Research (1)
- CMC Senior Theses (1)
- Computer Engineering (1)
- Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research (1)
- Dissertations, Master's Theses and Master's Reports (1)
- Electrical & Computer Engineering Faculty Publications (1)
- Electronic Theses and Dissertations (1)
- Euleriana (1)
- Honors Student Research (1)
- Indian River Lagoon Shorelines (1)
- Publications (WR) (1)
- Publications and Research (1)
- Scripps Senior Theses (1)
- Seton Hall University Dissertations and Theses (ETDs) (1)
- Summer Research (1)
- Theses and Dissertations (1)
- Undergraduate Honors Theses (1)
- Publication Type
- File Type
Articles 31 - 44 of 44
Full-Text Articles in Fluid Dynamics
Mathematical Modeling Of Two-Dimensional Unsteady Flow In Growing Tumor, N. Gracia, D. N. Riahi, R. Roy
Mathematical Modeling Of Two-Dimensional Unsteady Flow In Growing Tumor, N. Gracia, D. N. Riahi, R. Roy
Applications and Applied Mathematics: An International Journal (AAM)
We investigate the problem of unsteady fluid flow in growing solid tumors. We develop a mathematical model for a growing tumor whose boundary is taken as a sphere, and the unsteady fluid flow within the tumor is assumed to be two dimensional with respect to the radial distance and the latitudinal angle in spherical coordinates. The expressions for the time, radial and latitudinal variations of the flow velocity, pressure, and the two investigated drug concentrations within the tumor were determined analytically. We calculated these quantities in the tumor as well as in a corresponding normal tissue. We find, in particular, …
An Unexpected Particle Oscillation For Electrophoresis In Viscoelastic Fluids Through A Microchannel Constriction, Xinyu Lu, Saurin Patel, Meng Zhang, Sang Woo Joo, Shizhi Qian, Amod Ogale, Xiangchun Xuan
An Unexpected Particle Oscillation For Electrophoresis In Viscoelastic Fluids Through A Microchannel Constriction, Xinyu Lu, Saurin Patel, Meng Zhang, Sang Woo Joo, Shizhi Qian, Amod Ogale, Xiangchun Xuan
Mechanical & Aerospace Engineering Faculty Publications
Electrophoresis plays an important role in many applications, which, however, has so far been extensively studied in Newtonian fluids only. This work presents the first experimental investigation of particle electrophoresis in viscoelastic polyethylene oxide (PEO) solutions through a microchannel constriction under pure DC electric fields. An oscillatory particle motion is observed in the constriction region, which is distinctly different from the particle behavior in a polymer-free Newtonian fluid. This stream-wise particle oscillation continues until a sufficient number of particles form a chain to pass through the constriction completely. It is speculated that such an unexpected particle oscillating phenomenon is a …
Microfluidic Electrical Sorting Of Particles Based On Shape In A Spiral Microchannel, John Dubose, Xinyu Lu, Saurin Patel, Shizhi Qian, Sang Woo Joo
Microfluidic Electrical Sorting Of Particles Based On Shape In A Spiral Microchannel, John Dubose, Xinyu Lu, Saurin Patel, Shizhi Qian, Sang Woo Joo
Mechanical & Aerospace Engineering Faculty Publications
Shape is an intrinsic marker of cell cycle, an important factor for identifying a bioparticle, and also a useful indicator of cell state for disease diagnostics. Therefore, shape can be a specific marker in label-free particle and cell separation for various chemical and biological applications. We demonstrate in this work a continuous-flow electrical sorting of spherical and peanut-shaped particles of similar volumes in an asymmetric double-spiral microchannel. It exploits curvature-induced dielectrophoresis to focus particles to a tight stream in the first spiral without any sheath flow and subsequently displace them to shape-dependent flow paths in the second spiral without any …
The Two-Phase Arterial Blood Flow With Or Without A Catheter And In The Presence Of A Single Or Multi Stenosis, Ani E. Garcia, Daniel N. Riahi
The Two-Phase Arterial Blood Flow With Or Without A Catheter And In The Presence Of A Single Or Multi Stenosis, Ani E. Garcia, Daniel N. Riahi
Applications and Applied Mathematics: An International Journal (AAM)
We consider the problem of blood flow in an artery with or without a catheter and in the presence of single or multi stenosis whose shape is based on the available experimental data for the stenosis in a human’s artery. The presence of stenosis in the artery, which locally narrows portion of the artery, can be a result of fatty materials such as cholesterol in the blood. The use of catheter is important as a standard tool for diagnosis and treatment in patience whose blood flow passage in the artery is affected adversely by the presence of the stenosis within …
Near-Infrared Surface-Enhanced Fluorescence Using Silver Nanoparticles In Solution, Michael D. Furtaw
Near-Infrared Surface-Enhanced Fluorescence Using Silver Nanoparticles In Solution, Michael D. Furtaw
Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research
Fluorescence spectroscopy is a widely used detection technology in many research and clinical assays. Further improvement to assay sensitivity may enable earlier diagnosis of disease, novel biomarker discovery, and ultimately, improved outcomes of clinical care along with reduction in costs. Near-infrared, surface-enhanced fluorescence (NIR-SEF) is a promising approach to improve assay sensitivity via simultaneous increase in signal with a reduction in background. This dissertation describes research conducted with the overall goal to determine the extent to which fluorescence in solution may be enhanced by altering specific variables involved in the formation of plasmonactive nanostructures of dye-labeled protein and silver nanoparticles …
Microfluidic Impedance Spectroscopy As A Tool For Quantitative Biology And Biotechnology, Ahmet C. Sabuncu, Jie Zhuang, Juergen F. Kolb, Ali Beskok
Microfluidic Impedance Spectroscopy As A Tool For Quantitative Biology And Biotechnology, Ahmet C. Sabuncu, Jie Zhuang, Juergen F. Kolb, Ali Beskok
Mechanical & Aerospace Engineering Faculty Publications
A microfluidic device that is able to perform dielectric spectroscopy is developed. The device consists of a measurement chamber that is 250 μm thick and 750 μm radius. Around 1000 cells fit inside the chamber assuming average quantities for cell radius and volume fraction. This number is about 1000 folds lower than the capacity of conventional fixtures. A T-cell leukemia cell line Jurkat is tested using the microfluidic device. Measurements of deionized water and salt solutions are utilized to determine parasitic effects and geometric capacitance of the device. Physical models, including Maxwell-Wagner mixture and double shell models, are used to …
Microfluidic Separation Of Live And Dead Yeast Cells Using Reservoir-Based Dielectrophoresis, Saurin Patel, Daniel Showers, Pallavi Vedantam, Tzuen-Rong Tzeng, Shizhi Qian, Xiangchun Xuan
Microfluidic Separation Of Live And Dead Yeast Cells Using Reservoir-Based Dielectrophoresis, Saurin Patel, Daniel Showers, Pallavi Vedantam, Tzuen-Rong Tzeng, Shizhi Qian, Xiangchun Xuan
Mechanical & Aerospace Engineering Faculty Publications
Separating live and dead cells is critical to the diagnosis of early stage diseases and to the efficacy test of drug screening, etc. This work demonstrates a novel microfluidic approach to dielectrophoretic separation of yeast cells by viability. It exploits the cell dielectrophoresis that is induced by the inherent electric field gradient at the reservoir-microchannel junction to selectively trap dead yeast cells and continuously separate them from live ones right inside the reservoir. This approach is therefore termed reservoir-based dielectrophoresis (rDEP). It has unique advantages as compared to existing dielectrophoretic approaches such as the occupation of zero channel space and …
Mathematical Modeling Of Peristaltic Flow Of Chyme In Small Intestine, Daniel N. Riahi, Ranadhir Roy
Mathematical Modeling Of Peristaltic Flow Of Chyme In Small Intestine, Daniel N. Riahi, Ranadhir Roy
Applications and Applied Mathematics: An International Journal (AAM)
Mathematical models based on axisymmetric Newtonian incompressible fluid flow are studied for the peristaltic flow of chyme in the small intestines, which is an axisymmetric cylindrical tube. The flow is modeled more realistically modeled by assuming that the peristaltic rush wave is a non-periodic mode composed of two sinusoidal waves of different wavelengths, which propagate at the same speed along the outer boundary of the tube. Both cases of flow in a tube and in an annulus that are modeled and investigated in the present paper correspond respectively to the cases of flow of chyme in the small intestine in …
A Cell Electrofusion Microfluidic Device Integrated With 3d Thin-Film Microelectrode Arrays, Ning Hu, Jun Yang, Shizhi Qian, Sang W. Joo, Xiaolin Zheng
A Cell Electrofusion Microfluidic Device Integrated With 3d Thin-Film Microelectrode Arrays, Ning Hu, Jun Yang, Shizhi Qian, Sang W. Joo, Xiaolin Zheng
Mechanical & Aerospace Engineering Faculty Publications
A microfluidic device integrated with 3D thin film microelectrode arrays wrapped around serpentine-shaped microchannel walls has been designed, fabricated and tested for cell electrofusion. Each microelectrode array has 1015 discrete microelectrodes patterned on each side wall, and the adjacent microelectrodes are separated by coplanar dielectric channel wall. The device was tested to electrofuse K562 cells under a relatively low voltage. Under an AC electric field applied between the pair of the microelectrode arrays, cells are paired at the edge of each discrete microelectrode due to the induced positive dielectrophoresis. Subsequently, electric pulse signals are sequentially applied between the microelectrode arrays …
Negative Dielectrophoretic Capture Of Bacterial Spores In Food Matrices, Mehti Koklu, Seungkyung Park, Suresh D. Pillai, Ali Beskok
Negative Dielectrophoretic Capture Of Bacterial Spores In Food Matrices, Mehti Koklu, Seungkyung Park, Suresh D. Pillai, Ali Beskok
Mechanical & Aerospace Engineering Faculty Publications
A microfluidic device with planar square electrodes is developed for capturing particles from high conductivity media using negative dielectrophoresis (n-DEP). Specifically, Bacillus subtilis and Clostridium sporogenes spores, and polystyrene particles are tested in NaCl solution (0.05 and 0.225 S/m), apple juice (0.225 S/m), and milk (0.525 S/m). Depending on the conductivity of the medium, the Joule heating produces electrothermal flow (ETF), which continuously circulates and transports the particles to the DEP capture sites. Combination of the ETF and n-DEP results in different particle capture efficiencies as a function of the conductivity. Utilizing 20 μm height DEP chambers, “almost complete” and …
Dielectrophoretic Choking Phenomenon In A Converging-Diverging Microchannel, Ye Ai, Shizhi Qian, Sheng Liu, Sang W. Joo
Dielectrophoretic Choking Phenomenon In A Converging-Diverging Microchannel, Ye Ai, Shizhi Qian, Sheng Liu, Sang W. Joo
Mechanical & Aerospace Engineering Faculty Publications
Experiments show that particles smaller than the throat size of converging-diverging microchannels can sometimes be trapped near the throat. This critical phenomenon is associated with the negative dc dielectrophoresis arising from nonuniform electric fields in the microchannels. A finite-element model, accounting for the particle-fluid-electric field interactions, is employed to investigate the conditions for this dielectrophoretic (DEP) choking in a converging-diverging microchannel for the first time. It is shown quantitatively that the DEP choking occurs for high nonuniformity of electric fields, high ratio of particle size to throat size, and high ratio of particle's zeta potential to that of microchannel. © …
Pressure-Driven Transport Of Particles Through A Converging-Diverging Microchannel, Ye Ai, Sang W. Joo, Xiangchun Xuan, Shizhi Qian
Pressure-Driven Transport Of Particles Through A Converging-Diverging Microchannel, Ye Ai, Sang W. Joo, Xiangchun Xuan, Shizhi Qian
Mechanical & Aerospace Engineering Faculty Publications
Pressure-driven transport of particles through a symmetric converging-diverging microchannel is studied by solving a coupled nonlinear system, which is composed of the Navier-Stokes and continuity equations using the arbitrary Lagrangian-Eulerian finite-element technique. The predicted particle translation is in good agreement with existing experimental observations. The effects of pressure gradient, particle size, channel geometry, and a particle's initial location on the particle transport are investigated. The pressure gradient has no effect on the ratio of the translational velocity of particles through a converging-diverging channel to that in the upstream straight channel. Particles are generally accelerated in the converging region and then …
A Theoretical Model For Blood Flow In Small Vessels, V. P. Srivastava
A Theoretical Model For Blood Flow In Small Vessels, V. P. Srivastava
Applications and Applied Mathematics: An International Journal (AAM)
A two-fluid model consisting of a core region of suspension of all the erythrocytes (particles) in plasma (fluid) assumed to be a particle-fluid mixture and a peripheral layer of cell-free plasma (Newtonian fluid), has been proposed to represent blood flow in small diameter tubes. The analytical results obtained in the proposed model for effective viscosity, velocity profiles and flow rate have been evaluated numerically for various values of the parameters available from published works. Quantitative comparison has shown that present model suitability represents blood flow at hematocrit (less than or equal to 40%) and in vessels up to 70 micrometers …
Influence Of Las Vegas Wash Density Current On Nutrient Availability And Phytoplankton Growth In Lake Mead, John R. Baker, Larry J. Paulson
Influence Of Las Vegas Wash Density Current On Nutrient Availability And Phytoplankton Growth In Lake Mead, John R. Baker, Larry J. Paulson
Publications (WR)
Density currents are commonly formed in reservoirs because of temperature or salinity induced density differences between inflowing and receiving waters. Anderson and Pritchard (1951) were among the first to demonstrate this in their investigations of density currents in Lake Mead. They found that the Colorado River formed an underflow in Lake Mead during the winter, an overflow in the spring and an interflow in the summer and fall. Wunderlich and Elder (1973) have since described the hydromechanics of these types of flow patterns, and density currents have been reported for several other large reservoirs (Carmack et al. 1979, Johnson and …