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Articles 1 - 30 of 1291
Full-Text Articles in Physics
Carrier Transport Engineering In Wide Bandgap Semiconductors For Photonic And Memory Device Applications, Ravi Teja Velpula
Carrier Transport Engineering In Wide Bandgap Semiconductors For Photonic And Memory Device Applications, Ravi Teja Velpula
Dissertations
Wide bandgap (WBG) semiconductors play a crucial role in the current solid-state lighting technology. The AlGaN compound semiconductor is widely used for ultraviolet (UV) light-emitting diodes (LEDs), however, the efficiency of these LEDs is largely in a single-digit percentage range due to several factors. Until recently, AlInN alloy has been relatively unexplored, though it holds potential for light-emitters operating in the visible and UV regions. In this dissertation, the first axial AlInN core-shell nanowire UV LEDs operating in the UV-A and UV-B regions with an internal quantum efficiency (IQE) of 52% are demonstrated. Moreover, the light extraction efficiency of this …
Photonic Monitoring Of Atmospheric Fauna, Adrien P. Genoud
Photonic Monitoring Of Atmospheric Fauna, Adrien P. Genoud
Dissertations
Insects play a quintessential role in the Earth’s ecosystems and their recent decline in abundance and diversity is alarming. Monitoring their population is paramount to understand the causes of their decline, as well as to guide and evaluate the efficiency of conservation policies. Monitoring populations of flying insects is generally done using physical traps, but this method requires long and expensive laboratory analysis where each insect must be identified by qualified personnel. Lack of reliable data on insect populations is now considered a significant issue in the field of entomology, often referred to as a “data crisis” in the field. …
Helioseismic Diagnostics Of Active Regions And Their Magnetic Fields, John T. Stefan
Helioseismic Diagnostics Of Active Regions And Their Magnetic Fields, John T. Stefan
Dissertations
While two and a half decades of nearly constant observation by the Solar and Heliospheric Observatory (SOHO) and the Solar Dynamics Observatory (SDO) spacecraft have yielded key insights into the structure and dynamics of active regions, it is still unclear if active regions can be identified before emerging on the solar surface and, once emerged, whether the subsurface structure of an active region’s magnetic field can be measured. Regarding the dynamical processes associated with active regions, the height and mechanism of sunquake excitation remains poorly understood. To answer these questions, a comprehensive survey of active region magnetic fields and their …
Hydrodynamic Investigation Of The Discharge Of Complex Fluids From Dispensing Bottles Using Experimental And Computational Approaches, Baran Teoman
Dissertations
The discharge of non-Newtonian, complex fluids through orifices of industrial tanks, pipes, dispensers, or packaging containers is a ubiquitous but often problematic process because of the complex rheology of such fluids and the geometry of the containers. This, in turn, reduces the discharge rate and results in residual fluid left in the container, often referred to as heel. Heel formation is undesired in general, since it causes loss of valuable material, container fouling, and cross-contamination between batches. Heel may be of significant concern not only in industrial vessels but also in consumer packaging. Despite its relevance, the research in this …
Interactions Of Amyloid Peptides With Lipid Membranes, Yanxing Yang
Interactions Of Amyloid Peptides With Lipid Membranes, Yanxing Yang
Dissertations
The aggregation of amyloid proteins into fibrils is a hallmark of several diseases including Alzheimer’s (AD), Parkinson’s, and Type II diabetes. This aggregation process involves the formation of small size oligomers preceding the formation of insoluble fibrils. Recent studies have shown that these oligomers are more likely to be responsible for cell toxicity than fibrils. A possible mechanism of toxicity involves the interaction of oligomers with the cell membrane compromising its integrity. In particular, oligomers may form pore-like structures in the cell membrane affecting its permeability or they may induce lipid loss via a detergent-like effect. This dissertation aims to …
Structural And Magneto Conductivity Studies Of Nio/Smba2cu3o7-Δ Superconducting Composite, Hadi Basma, Sajida Rmeid, Ramadan Awad, Mohammed Said
Structural And Magneto Conductivity Studies Of Nio/Smba2cu3o7-Δ Superconducting Composite, Hadi Basma, Sajida Rmeid, Ramadan Awad, Mohammed Said
BAU Journal - Science and Technology
In this work, we investigate the effect of NiO nanoparticles' addition on the structure, superconductivity, and magneto conductivity for the SmBa2Cu3O7-δ phase. Composite nano/superconductor of (NiO)x/SmBa2Cu3O7-δ (0.00≤x≤0.12 wt.%) were prepared by conventional solid-state reaction technique and characterized by X-ray powder diffraction (XRD) and scanning electron microscopy (SEM). The orthorhombic structure was maintained whereas the lattice parameters showed unsystematic variations with the NiO nanoparticles addition. The superconducting transition temperature Tc, determined from electrical resistivity measurements, showed an enhancement with x up to 0.04wt.% followed by a reduction …
Parton Distribution Functions For Pseudoscalar Mesons In The Confining Effective Chiral Quark Theory, Parada Tobel Paraduan Hutauruk, Seung-Il Nam
Parton Distribution Functions For Pseudoscalar Mesons In The Confining Effective Chiral Quark Theory, Parada Tobel Paraduan Hutauruk, Seung-Il Nam
Makara Journal of Science
This review paper presents the gluon, sea, and valence quark distributions of the pseudoscalar (PS) mesons. The calculations of the parton structure of PS mesons are performed using the Bethe-Salpeter equation—Nambu-Jona-Lasinio (BSE-NJL) model, which offers a clear description of the dynamical chiral symmetry breaking (D SB) of the low-energy non-perturbative quantum chromodynamics (QCD), with the help of the Schwinger proper-time regularization scheme that simulates the color QCD confinement. Our results for the dynamical quark mass—which emerged from the spontaneous chiral symmetry breaking (S SB)—are generated via the chiral condensate in the chiral limit and beyond. Results for the valence parton …
Perspectives On Determinism In Quantum Mechanics: Born, Bohm, And The “Quantal Newtonian” Laws, Viraht Sahni
Perspectives On Determinism In Quantum Mechanics: Born, Bohm, And The “Quantal Newtonian” Laws, Viraht Sahni
Publications and Research
Quantum mechanics has a deterministic Schrödinger equation for the wave function. The Göttingen–Copenhagen statistical interpretation is based on the Born Rule that interprets the wave function as a “probability amplitude.” A precept of this interpretation is the lack of determinism in quantum mechanics. The Bohm interpretation is that the wave function is a source of a field experienced by the electrons, thereby attributing determinism to quantum theory. In this paper, we present a new perspective on such determinism. The ideas are based on the equations of motion or “Quantal Newtonian” Laws obeyed by each electron. These Laws, derived from …
Atom-Specific Probing Of Electron Dynamics In An Atomic Adsorbate By Time-Resolved X-Ray Spectroscopy, Simon Schreck, Elias Diesen, Martina Dell'angela, Chang Liu, Matthew Weston, Flavio Capotondi, Hirohito Ogasawara, Jerry Larue, Roberto Costantini, Martin Beye, Piter S. Miedema, Joakim Halldin Stenlid, Jörgen Gladh, Boyang Liu, Hsin-Yi Wang, Fivos Perakis, Filippo Cavalca, Sergey Koroidov, Peter Amann, Emanuele Pedersoli, Denys Naumenko, Ivaylo Nikolov, Lorenzo Raimondi, Frank Abild-Pedersen, Tony F. Heinz, Johannes Voss, Alan C. Luntz, Anders Nilsson
Atom-Specific Probing Of Electron Dynamics In An Atomic Adsorbate By Time-Resolved X-Ray Spectroscopy, Simon Schreck, Elias Diesen, Martina Dell'angela, Chang Liu, Matthew Weston, Flavio Capotondi, Hirohito Ogasawara, Jerry Larue, Roberto Costantini, Martin Beye, Piter S. Miedema, Joakim Halldin Stenlid, Jörgen Gladh, Boyang Liu, Hsin-Yi Wang, Fivos Perakis, Filippo Cavalca, Sergey Koroidov, Peter Amann, Emanuele Pedersoli, Denys Naumenko, Ivaylo Nikolov, Lorenzo Raimondi, Frank Abild-Pedersen, Tony F. Heinz, Johannes Voss, Alan C. Luntz, Anders Nilsson
Biology, Chemistry, and Environmental Sciences Faculty Articles and Research
The electronic excitation occurring on adsorbates at ultrafast timescales from optical lasers that initiate surface chemical reactions is still an open question. Here, we report the ultrafast temporal evolution of x-ray absorption spectroscopy (XAS) and x-ray emission spectroscopy (XES) of a simple well-known adsorbate prototype system, namely carbon (C) atoms adsorbed on a nickel [Ni(100)] surface, following intense laser optical pumping at 400 nm. We observe ultrafast (∼100 fs) changes in both XAS and XES showing clear signatures of the formation of a hot electron-hole pair distribution on the adsorbate. This is followed by slower changes on a few picoseconds …
Fill And Dump Measurement Of The Neutron Lifetime Using An Asymmetric Magneto-Gravitational Trap, Alexander Komives, Et Al.
Fill And Dump Measurement Of The Neutron Lifetime Using An Asymmetric Magneto-Gravitational Trap, Alexander Komives, Et Al.
Physics & Astronomy Faculty publications
The past two decades have yielded several new measurements and reanalysis of older measurements of the neutron lifetime. These have led to a 4.4 standard deviation discrepancy between the most precise measurements of the neutron decay rate producing protons in cold neutron beams and the most precise lifetime measured in neutron storage experiments. Measurements using different techniques are important for investigating whether there are unidentified systematic effects in any of the measurements. In this paper we report a new measurement using the Los Alamos asymmetric magneto-gravitational trap where the surviving neutrons are counted external to the trap using the fill …
Highly Efficient Photocatalysts For Methylene Blue Degradation Based On A Platform Of Deposited Go-Zno Nanoparticles On Polyurethane Foam, Mohamed Morsy
Nanotechnology Research Centre
No abstract provided.
Effect Of Graphene Oxide On Spectral-Luminescenct Properties Of Xanthene Dye, E. V. Seliverstova, E. Zh. Alikhaidarova, N. Kh. Ibrayev
Effect Of Graphene Oxide On Spectral-Luminescenct Properties Of Xanthene Dye, E. V. Seliverstova, E. Zh. Alikhaidarova, N. Kh. Ibrayev
Eurasian Journal of Physics and Functional Materials
The effect of graphene oxide on the spectral and luminescent properties of xanthene dyes was studied. During the interaction of graphene oxide (GO) with a cationic dye, aggregation of Rhodamine 6G occurs, which is expressed as an increase in the optical density of the short-wavelength shoulder in the absorption spectrum of the dye. GO sheets can act as adsorption centers for dye molecules due to the influence of the Coulomb and intermolecular forces between GO and Rhodamine 6G. This effect is practically not pronounced for anionic dyes. The quenching of the dye fluorescence intensity in the presence of GO was …
Neutron-Tomographic Study Of The Structural Features Of A Bronze Mirror Found In The Akterek Burial Complex, N. Torezhanova, O. Myakisheva, B. Mukhametuly, M. Kenessarin, R. Baitugulov, A. K. Bekbayev, K. M. Nazarov
Neutron-Tomographic Study Of The Structural Features Of A Bronze Mirror Found In The Akterek Burial Complex, N. Torezhanova, O. Myakisheva, B. Mukhametuly, M. Kenessarin, R. Baitugulov, A. K. Bekbayev, K. M. Nazarov
Eurasian Journal of Physics and Functional Materials
This work presents a study on the structure of a bronze mirror found in the Akterek burial complex by using neutron radiography and tomography. The manufacturing features and the physical state of this mirror was analyzed by three-dimensional model. It turned out that the rim on the edge was made of a different alloy, and the border between the rim and the base of the mirror is also visually visible. The morphological features and spatial distribution of pores and voids formed during secondary casting with the application of various patterns and ornaments have been studied in detail. The neutron tomography …
Analysis Procedures In Deriving Of The Differential Cross Section Of The Reaction Pp ! {Pp}Sp0 At Energies 1.6–2.4 Gev, B. S. Baimurzinova, D. A. Tsirkov
Analysis Procedures In Deriving Of The Differential Cross Section Of The Reaction Pp ! {Pp}Sp0 At Energies 1.6–2.4 Gev, B. S. Baimurzinova, D. A. Tsirkov
Eurasian Journal of Physics and Functional Materials
The reaction pp → {pp}sp0 , where {pp}s denotes a diproton, i.e. an unbound interacting proton pair in the 1S0 , state, was investigated in order to obtain a differential cross section ds/dW at small angles
in the energy range 1.6–2.4 GeV. This work is intended for the presentation of the main procedures in the processing of experimental data.
Formation Of High Strength And Corrosion Resistance Composition Cover On The Surface Of Casting, R. J. Bashirov, F. R. Rasulov
Formation Of High Strength And Corrosion Resistance Composition Cover On The Surface Of Casting, R. J. Bashirov, F. R. Rasulov
Eurasian Journal of Physics and Functional Materials
The article is devoted in the casting process of alloying the surface of castings by impregnating the powder composition with liquid iron when pouring the last casting mold. It is established that the impregnability of powder with liquid iron depends on the temperature of the metal, the thickness of the coatings and the particle size composition of the powders.
Non-Destructive Structural Studies Of Coins From The Uzundara Fortress Using X-Ray Diffraction And Neutron Tomography, Yu. M. Tashmetov, B. S. Yuldashev, S. M. Adizov, N. B. Ismatov, Sh. R. Pidaev, S. E. Kichanov, B. A. Abdurakhimov, D. P. Kozlenko, N. D. Dvurechenskaya, I. A. Saprykina
Non-Destructive Structural Studies Of Coins From The Uzundara Fortress Using X-Ray Diffraction And Neutron Tomography, Yu. M. Tashmetov, B. S. Yuldashev, S. M. Adizov, N. B. Ismatov, Sh. R. Pidaev, S. E. Kichanov, B. A. Abdurakhimov, D. P. Kozlenko, N. D. Dvurechenskaya, I. A. Saprykina
Eurasian Journal of Physics and Functional Materials
The copper Heliocles coin and two silver Demetrius coins dated to the II century BC from the archaeological works of the Uzundara fortress of the Greco-Bactrian Kingdom were studied using non-destructive structural diagnostics methods. The phase analysis of the coins was performed using the X-ray diffraction method. Also, the spatial distribution of the internal components of the coins was investigated by neutron imaging methods. It has been established that the dominant phase of the Heliocles coin is copper, however, a small volume of patina was found. It is mainly represented by tenorite CuO phase. The neutron tomography method indicates a …
Model-Based Cross-Correlation Search For Gravitational Waves From The Low-Mass X-Ray Binary Scorpius X-1 In Ligo O3 Data, R. Abbott, H. Abe, Fausto Acernese, Teviet Creighton, Mario C. Diaz, Francisco Llamas, Soma Mukherjee, Gaukhar Nurbek, Volker Quetschke, Wenhui Wang
Model-Based Cross-Correlation Search For Gravitational Waves From The Low-Mass X-Ray Binary Scorpius X-1 In Ligo O3 Data, R. Abbott, H. Abe, Fausto Acernese, Teviet Creighton, Mario C. Diaz, Francisco Llamas, Soma Mukherjee, Gaukhar Nurbek, Volker Quetschke, Wenhui Wang
Physics and Astronomy Faculty Publications and Presentations
We present the results of a model-based search for continuous gravitational waves from the low-mass X-ray binary Scorpius X-1 using LIGO detector data from the third observing run of Advanced LIGO and Advanced Virgo. This is a semicoherent search that uses details of the signal model to coherently combine data separated by less than a specified coherence time, which can be adjusted to balance sensitivity with computing cost. The search covered a range of gravitational-wave frequencies from 25 to 1600 Hz, as well as ranges in orbital speed, frequency, and phase determined from observational constraints. No significant detection candidates were …
Classical Mechanics, Mark D. Shattuck
Classical Mechanics, Mark D. Shattuck
Open Educational Resources
Syllabus for Classical Mechanics
Temperature Influence On The Optical Properties, Attenuation Coefficient, And Total Molecular Cross Section Of Dhunge Dhara Drinking Water, Saddam Husain Dhobi, Bibek Koirala, Kishori Yadav, Jeevan Jyoti Nakarmi, Suresh Prasad Gupta, Santosh Kumar Das, Arun Kumar Shah, Kuldip Paudel, Kushal Dahal, Ram Lal Sah
Temperature Influence On The Optical Properties, Attenuation Coefficient, And Total Molecular Cross Section Of Dhunge Dhara Drinking Water, Saddam Husain Dhobi, Bibek Koirala, Kishori Yadav, Jeevan Jyoti Nakarmi, Suresh Prasad Gupta, Santosh Kumar Das, Arun Kumar Shah, Kuldip Paudel, Kushal Dahal, Ram Lal Sah
Makara Journal of Science
This work aims to measure the different parameters of Dhunge Dhara water (DDW) such as absorbance, transmittance, mass attenuation coefficient (MAC), and molecular cross section (MCS) and experimentally compare the obtained values with those of pure water (PW) at various temperatures (5 °C to 90 °C) using a theremino spectrometer. Observation shows that the parameters vary with temperature and wavelength. The transmittance of DDW ranges from 18% to 85% and absorbance of the same ranges from 0.09 Au to 0.7 Au. Meanwhile, the transmittance of PW ranges from 40% to 98% and the absorbance of the same ranges from 0.09 …
Density Functional Theory (Dft) Study Of A Binary Mixture Of Mbba And Paa Liquid Crystal For Thz Application, Mirtunjai Mishra, Narinder Kumar, Pawan Singh, B. S. Rawat, Reena Dhyani, Devendra Singh, Devesh Kumar
Density Functional Theory (Dft) Study Of A Binary Mixture Of Mbba And Paa Liquid Crystal For Thz Application, Mirtunjai Mishra, Narinder Kumar, Pawan Singh, B. S. Rawat, Reena Dhyani, Devendra Singh, Devesh Kumar
Makara Journal of Science
The present scenario expresses the electro-optical effect of abinary mixture of MBBA and PAA liquid crystal studied under the impact of the electric field in THz frequency. The binary mixture has a negative order parameter, negative birefringence, and a nematic phase stability under such an electric field. The refractive index remains constant at high THz frequency. The director angle is sensitive to THz frequency, contributing to the maximum fluctuation. The atomic contribution of a binary mixture is approximately equal to the molecular contribution. The binary mixture has a remarkably high bandgap. The C-H, O-C, C-N atom stretching, and wagging of …
Golay Codes And Quantum Contextuality, Mordecai Waegell, P. K. Aravind
Golay Codes And Quantum Contextuality, Mordecai Waegell, P. K. Aravind
Mathematics, Physics, and Computer Science Faculty Articles and Research
It is shown that the codewords of the binary and ternary Golay codes can be converted into rays in RP23 and RP11 that provide proofs of the Kochen-Specker theorem in real state spaces of dimensions 24 and 12, respectively. Some implications of these results are discussed.
Coordination Chemistry Of Uranyl Ions With Surface-Immobilized Peptides: An Xps Study, Esha Mishra, Cody M. Schultz, Rebecca Lai, Peter A. Dowben
Coordination Chemistry Of Uranyl Ions With Surface-Immobilized Peptides: An Xps Study, Esha Mishra, Cody M. Schultz, Rebecca Lai, Peter A. Dowben
Department of Physics and Astronomy: Faculty Publications
The coordination chemistry of uranyl ions with surface immobilized peptides was studied using X-ray photoemission spectroscopy (XPS). All the peptides in the study were modified using a six-carbon alkanethiol as a linker on a gold substrate with methylene blue as the redox label. The X-ray photoemission spectra reveal that each modified peptide interacts differently with the uranyl ion. For all the modified peptides, the XPS spectra were taken in both the absence and presence of the uranium, and their comparison reveals that the interaction depends on the chemical group present in the peptides. The XPS results show that, among all …
Fourier Acceleration In The Linear Sigma Model, Cameron Cianci
Fourier Acceleration In The Linear Sigma Model, Cameron Cianci
Honors Scholar Theses
The linear sigma model is a low energy effective model of Quantum Chromodynamics. This model mimics the breaking of chiral symmetry both spontaneously and explicitly through the quark condensate and pion mass matrix respectively. Fourier acceleration is a method that can be implemented in the Hybrid Monte-Carlo algorithm which decreases autocorrelations due to critical slowing down through tuning the mass parameters in the HMC algorithm. Fourier acceleration is applied to the linear sigma model with a novel mass estimation procedure, by assuming the modes behave approximately like simple harmonic oscillators. The masses are chosen by sampling the expectation values of …
Pyseg: A Python Package For 2d Material Flake Localization, Segmentation, And Thickness Prediction, Diana B. Horangic
Pyseg: A Python Package For 2d Material Flake Localization, Segmentation, And Thickness Prediction, Diana B. Horangic
Student Research Projects
Thin materials are of interest for their extraordinary physical, mechanical, thermal, electrical, and optical properties. Monolayers and bilayers of 2D materials can be manufactured through a variety of exfoliation methods. To determine layer thickness, Raman spectroscopy or other methods like Rayleigh scattering are used. These methods are, however, slow, and they require equipment beyond an optical microscope. A Python package that automates flake identification processes was built, with access solely to RGB data from an optical microscope assumed. My package, pyseg, localizes flakes on a substrate and then makes a rough estimate of their thickness from first principles. It can …
Effects Of Exposure To Atmospheric Humidity On Breakdown Field Strength Measurements Of Polymers, Megan Loveland Dewaal
Effects Of Exposure To Atmospheric Humidity On Breakdown Field Strength Measurements Of Polymers, Megan Loveland Dewaal
Physics Capstone Projects
This study investigates the effects of absorbed water introduced via exposure to atmospheric humidity on electrostatic breakdown field strength measurements of polymers. Conducting breakdown tests under sample conditions appropriate for different applications is essential. If the breakdown field strength is overestimated for an application, an insulator may be used inappropriately in high electric fields where they are more likely to break down. Comparisons are made between: sets of pristine samples, samples that underwent a thorough vacuum bake out to remove absorbed water, and samples subject to subsequent incremental prolonged atmospheric exposure. These investigated the effects of absorbed water and determined …
Observation Of Novel Phases Of Quantum Matter Beyond Topological Insulator, Sabin Regmi
Observation Of Novel Phases Of Quantum Matter Beyond Topological Insulator, Sabin Regmi
Electronic Theses and Dissertations, 2020-
Because of the unique electronic properties, intriguing novel phenomena, and potentiality in quantum device applications, the quantum materials with non-trivial band structures have enticed a bulk of research works over the last two decades. The experimental discovery of the three-dimensional topological insulators (TIs) - bulk insulators with surface conduction via spin-polarized electrons - kicked off the flurry of research interests towards such materials, which resulted in the experimental discovery of new topological phases of matter beyond TIs. The topological semimetallic phase in Dirac, Weyl, and nodal-line semimetals is an example, where the classification depends on the dimensionality, degeneracy, and symmetry …
Investigation Of The Effect Of Corundum Layer On The Heat Transfer Of Sic Slab, Sri Elsa Fatmi, Donanta Dhaneswara, Muhammad Anis, Ahmad Ashari
Investigation Of The Effect Of Corundum Layer On The Heat Transfer Of Sic Slab, Sri Elsa Fatmi, Donanta Dhaneswara, Muhammad Anis, Ahmad Ashari
Journal of Materials Exploration and Findings
Aluminum is the most widely used metal in industry. Aluminum smelting is one of the important steps that needs to be carried out to produce products made of aluminum metal with good quality. In the process of smelting aluminum there are several problems that occur, one of which is the growth of corundum in Si C refractories which affects the quality of aluminum melt and the durability of Si C refractories. This research was conducted to see the heat transfer in Si C and the effect of the presence of Corundum on heat transfer. This research was carried out by …
Dynamic Rbi With Central Difference Method Approach In Calculation Of Uniform Corrosion Rate: A Casestudy On Gas Pipelines, M.Riefqi Dwi Alviansyah, Fernanda Hartoyo, Zahra Nadia Nurullia, Ari Kurniawan
Dynamic Rbi With Central Difference Method Approach In Calculation Of Uniform Corrosion Rate: A Casestudy On Gas Pipelines, M.Riefqi Dwi Alviansyah, Fernanda Hartoyo, Zahra Nadia Nurullia, Ari Kurniawan
Journal of Materials Exploration and Findings
The oil and gas industry generally uses a piping system to drain fluids. Even though the pipes used have been well designed, the use of pipes as a means of fluid transportation still provides the possibility of failure that can occur at any time, one of which is due to uniform corrosion. The use of standard Risk Based Inspection (RBI) according to the API RBI 581 document has been widely used to anticipate potential failures to pipe components. The use of standard RBI can reduce the risk of failure significantly. Because the standard RBI considers the component risk value to …
Systems Level Analysis Of Organelle Biogenesis In Saccharomyces Cerevisiae, Kiandokht Panjtan Amiri
Systems Level Analysis Of Organelle Biogenesis In Saccharomyces Cerevisiae, Kiandokht Panjtan Amiri
Arts & Sciences Electronic Theses and Dissertations
Eukaryotic cells contain hundreds of subcellular structures that serve different functions to maintain cellular homeostasis. A hallmark of Eukaryotic cells is its compartmentalization into membrane-bound organelles. One of the grand challenges in quantitative cell biology is understanding the precision with which cells assemble and maintain subcellular organelles. Despite identification of numerous molecular factors that regulate organelle sizes we lack insight into the quantitative principles underlying organelle size control. We examine organelle sizes from Saccharomyces cerevisiae and human iPS cells with mathematical theory to show that cells can robustly control average fluctuations in organelle size. By demonstrating that organelle sizes obey …
The Physics Of Associative Polymers And Applications To Biomolecular Condensates, Furqan Dar
The Physics Of Associative Polymers And Applications To Biomolecular Condensates, Furqan Dar
Arts & Sciences Electronic Theses and Dissertations
Biomolecular condensates represent a new and ubiquitous class of membraneless organelles (MLOs) that are essential for healthy cellular functioning. The constituent molecules of such condensates span a vast bio-macromolecular gamut from intrinsically disordered regions and proteins (IDPs/IDRs), to RNA and RNA-binding proteins (RNPs), to polymerases and DNA etc. Apart from being part of the regular healthy cell cycle, these condensates are also implicated in many diseases, most notably progressive neurodegenerative diseases like Amyotropic Lateral Sclerosis (ALS) and Huntingtin's Disease (HD). Since the constituent molecules of these condensates span a broad range of length scales and modes of interaction, uncovering a …