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2024

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Articles 121 - 132 of 132

Full-Text Articles in Organic Chemistry

Stereocontrolled Synthesis Of Lactam-Fused Tetrahydropyrans As Potential Antidiabetic Agents, Ifeyinwa Stella Anosike Jan 2024

Stereocontrolled Synthesis Of Lactam-Fused Tetrahydropyrans As Potential Antidiabetic Agents, Ifeyinwa Stella Anosike

All Master's Theses

Functionalized tetrahydropyrans are structural motifs in diverse natural products, including polyether antibiotics, marine toxins, pheromones, and pharmaceuticals. They are frequently used as versatile building blocks for accessing stereochemically sophisticated biologically active compounds. Specifically, functionalized bicyclic tetrahydropyrans bearing contiguous stereocenters have garnered interest in the synthesis and medicinal chemistry communities. Thus far, some synthetic methods have been developed for their construction and functionalization. These methods include Prins' cyclization reactions, intramolecular oxa-Michael reactions, hetero-Diels-Alder cyclization, ring-closing metathesis, radical cyclization, and halocycloetherification. However, these methods have some drawbacks such as the need for expensive reagents and catalysts, substrate limitations, and environmentally unfriendly conditions. …

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Designing Fluorescent Moscs For Potential Applications In Illicit Drugs Detection, Robyn Nicole Cook Jan 2024

Designing Fluorescent Moscs For Potential Applications In Illicit Drugs Detection, Robyn Nicole Cook

Dissertations and Theses

Illicit and hazardous substances pose a serious effect on the human body which can create longer-term issues on the mental and physical health which potentially lead to fatalities. Current methods for detecting illicit substances include analytical techniques like mass spectrometry (MS) and gas/liquid chromatography (GC/LC) which are known for accuracy and sensitivity. However, these instruments are bulky, costly, time-consuming, and require highly trained personnel. An alternative approach to overcoming these limitations is to employ nanostructured molecule-based chemical sensing technologies that are user-friendly, portable, and cost-effective with the sensitivity for detecting illicit substances. One such candidate is metal-organic super-containers (MOSCs), which …

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Extraction Of Capsaicin Using The Polyol Induced Extraction (Pie) Method, Orlando Herrera Jan 2024

Extraction Of Capsaicin Using The Polyol Induced Extraction (Pie) Method, Orlando Herrera

All Student Theses and Dissertations

Polyol-induced extraction (PIE) is an extraction technique for separating organic solvents from water, using glycerol and polyol as separating agents. Glycerol binds water releasing the organic solvent as a separate liquid phase. this thesis, investigates how the PIE process may be used to separate caffeine and capsaicin. When acetonitrile and water are used as a 1:1 solvent mixture, two immiscible phases are created upon addition of the polyol, glycerol. Initially, for purposes of training on the PIE method, the studies primarly began with the extraction of pure caffeine. Using a 1:1 mixture of acetonitrile and water, 20 m/v % glycerol, …

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Unexpected Ring Opening Reactions, Solid-State Structures, And A Chemiluminescent Reaction, L Hiscock Jan 2024

Unexpected Ring Opening Reactions, Solid-State Structures, And A Chemiluminescent Reaction, L Hiscock

Theses and Dissertations (Comprehensive)

Functional π-materials involve the use of an aromatic π-system to carry out a function such as electron transport (organic electronics), absorbing and emitting photons (dyes, fluorescent materials), self-assembly (discotic liquid crystals), or sensors for various analytes. Our lab has recently published the syntheses of heteroaromatic derivatives of tetrafluoroterephthalonitrile (TFTP, 2.24) synthesised via nucleophilic aromatic substitution chemistry. The prepared derivatives have displayed fluorescent (e.g. 2.2)1 and liquid crystalline (1.0)2 properties, as well as displaying close π-π interactions in the solid state (2.8).3 As the materials we are synthesising all belong to the class of aromatic compounds, an introduction to aromaticity and …

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C–H Alkylation Of Diol Substrates Using Bifunctional Boronic Acid Catalysts, Matthew Ryan Ross Jan 2024

C–H Alkylation Of Diol Substrates Using Bifunctional Boronic Acid Catalysts, Matthew Ryan Ross

Graduate Theses, Dissertations, and Problem Reports (ETD)

Boronic acid catalysts in combination with a Lewis base have been used in previous work to perform site-selective C–H alkylation reactions targeting the α-hydroxy C–H bond of diols through a photoredox activated hydrogen atom transfer. This is done by accessing a tetracoordinate boronic acid – Lewis base complex which then mediates the hydrogen atom transfer. The research hypothesizes that combining the boronic acid and Lewis base into one molecule not only simplifies the reaction but also has the potential to unlock C–H alkylation sites previously inaccessible. This is plausible because the Lewis base portion of the synthesized bifunctional boronic acid …

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Use Of Interlaboratory Studies For The Development Of Consensus-Based Criteria For The Elemental Analysis Of Electrical Tapes, Lacey M. Leatherland Jan 2024

Use Of Interlaboratory Studies For The Development Of Consensus-Based Criteria For The Elemental Analysis Of Electrical Tapes, Lacey M. Leatherland

Graduate Theses, Dissertations, and Problem Reports (ETD)

Tape evidence is often used in criminal cases involving violent crimes, kidnappings, improvised explosive devices (IEDs), and drug trafficking. This evidence can reveal potential links between suspects, items, or scenes. The forensic examination of electrical tape can provide investigative leads or offer support to alternative hypotheses evaluated in the courtroom. A conventional analytical scheme includes microscopic examination, Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy Energy Dispersive Spectrometry (SEM-EDS), and Pyrolysis Gas Chromatography Mass Spectrometry (Py-GC/MS). Elemental analysis of electrical tapes is commonly achieved using SEM-EDS; however, recent scientific literature suggests that this analysis can evolve from using SEM-EDS to …

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Additive-Dependent Regioselective Boracarboxylation Of Alkenes Using Low Valent Copper And Co2, Carly H. Gordon Ph.D. Jan 2024

Additive-Dependent Regioselective Boracarboxylation Of Alkenes Using Low Valent Copper And Co2, Carly H. Gordon Ph.D.

Graduate Theses, Dissertations, and Problem Reports (ETD)

As a major greenhouse gas, carbon dioxide (CO2) is an abundant and renewable C1 feedstock, and developing methods for fixing CO2 into high-value products is a major interest for the movement of greener chemistry. The boracarboxylation of alkenes provides access to difunctionalized products containing pharmaceutically relevant motifs, including carboxylic acids and boron-containing moieties. Significant work has been done to improve the versatility and efficiency of this methodology, with the recent expansion into a wide variety of terminal alkenes. The use of different phosphine and alkene additives have demonstrated positive effects on reaction rates and productivity, indicating …

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Α-Hydroxy C–H Functionalization Of Alcohols Via Boronic Acid, Hat, Photoredox Triad Catalytic System, Seth Christopher Cowan Jan 2024

Α-Hydroxy C–H Functionalization Of Alcohols Via Boronic Acid, Hat, Photoredox Triad Catalytic System, Seth Christopher Cowan

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation explores the research that I have conducted in my time at West Virginia University. Most of my work has focused on the development of methods and studies to further understand the α-OH C–H functionalization of alcohols. This work involves a system of catalysts including photocatalysts, HAT catalysts, and boronic acid catalysts. Chapter 1 highlights a background for each of these areas. Photoredox catalysis has been an increasing area of chemistry over the past two decades as this technique can be used to design conditions to form new bonds in a selective manner through the utilization of light energy. …

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Photoinduced Alpha-Hydroxy C–H Alkylation Of Mono-Alcohols Via Hydrogen Atom Transfer (Hat) Of An Activated Boron-Containing Complex, Courtney Deanna Glenn Jan 2024

Photoinduced Alpha-Hydroxy C–H Alkylation Of Mono-Alcohols Via Hydrogen Atom Transfer (Hat) Of An Activated Boron-Containing Complex, Courtney Deanna Glenn

Graduate Theses, Dissertations, and Problem Reports (ETD)

Hydroxy (-OH) groups are one of the most abundant functional groups found in natural products and pharmaceuticals with many of these compounds containing multiple alcohol classes. The ability to selectively functionalize a specific α-OH C–H bond in the presence of other competitive sites would provide straightforward access to new, potentially bioactive compounds. In recent literature, photoredox catalysis has been implemented to perform site and stereoselective α-OH C–H functionalization of cis-diol containing substrates. Incorporating an organoboron cocatalyst into these systems have proven to be crucial in decreasing the bond dissociation energy (BDE) and increasing hydricity of the α-OH C–H bond …

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Chemical Synthesis Of Sensitive Dna, Komal Chillar Jan 2024

Chemical Synthesis Of Sensitive Dna, Komal Chillar

Dissertations, Master's Theses and Master's Reports

Over the past decades, researchers have tried various chemical methods to synthesize modified oligodeoxynucleotides (ODNs, i.e. short segments of DNAs). Traditional ODN synthesis methods require strong basic, and nucleophilic conditions for the deprotection and cleavage of the ODN from the solid support. However, the sensitive ODNs containing labile functionalities are vulnerable to such harsh conditions. Sensitive ODNs have a wide range of applications in research and pharmaceuticals. To synthesize sensitive ODNs, researchers devised different strategies but no practical methods have been developed. To overcome these challenges, we developed alkyl Dim alkyl Dmoc technology. This innovative technology uses weakly basic and …

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Establishing A Two-Color Fluorescence Probe Assay For The Simultaneous Screening Of Glut5 And Glut2 Fructose Transporters In Live Cells, Oluwanifesimi Mary Afolabi Jan 2024

Establishing A Two-Color Fluorescence Probe Assay For The Simultaneous Screening Of Glut5 And Glut2 Fructose Transporters In Live Cells, Oluwanifesimi Mary Afolabi

Dissertations, Master's Theses and Master's Reports

The mammalian facilitative glucose transporter (GLUT) family comprises 14 members that mediate the transport of hexoses across cell membranes. GLUT5 is the only member specific to fructose, and together with GLUT2, which transports fructose in addition to glucose, they make up the primary fructose transporters in humans. This study introduces a novel two-color fluorescence assay designed to simultaneously monitor the activity of GLUT5 and GLUT2 in live cells. 2,5-anhydro-D-mannitol (2,5-AM) a GLUT5 targeting compound has facilitated the development of various fructose-mimicking probes with a wide range of properties, such as radioactive imaging, fluorescent, photoactive, and drug delivery capabilities. Effective and …

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Synthesis Of Long Oligodeoxynucleotides, Yipeng Yin Jan 2024

Synthesis Of Long Oligodeoxynucleotides, Yipeng Yin

Dissertations, Master's Theses and Master's Reports

Synthetic long oligodeoxynucleotides (ODNs) have found wide applications in diverse fields such as chemical biology, synthetic biology, and genes and genomes synthesis. Those applications leading to a significant demand for their production. However, traditional methods for purifying synthetic ODNs present notable drawbacks, particularly their inability to purify long ODNs, rendering long ODN synthesis challenging. To address these issues, chemical synthesis techniques for long ODNs coupled with non-chromatographic purification methods have been developed. This technology makes the purification of long synthetic ODNs feasible and offers a viable pathway for producing genes and genomes with extensive repeats or stable secondary structures, which …

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