Organic Chemistry Commons^™

Cu(Ii) Potentiation Of Alzheimer A Neurotoxicity, Xudong Huang, Math P. Cuajungco, Craig S. Atwood, Mariana A. Hartshorn, Joel D. A. Tyndall, Graeme R. Hanson, Karen C. Stokes, Michael C. Leopold, Et Al.

Chemistry Faculty Publications

Oxidative stress markers as well as high concentrations of copper are found in the vicinity of Aβ amyloid deposits in Alzheimer's disease. The neurotoxicity of Aβ in cell culture has been linked to H2O2generation by an unknown mechanism. We now report that Cu(II) markedly potentiates the neurotoxicity exhibited by Aβ in cell culture. The potentiation of toxicity is greatest for Aβ1–42 > Aβ1–40 ≫ mouse/rat Aβ1–40, corresponding to their relative capacities to reduce Cu(II) to Cu(I), form H2O2 in cell-free assays and to exhibit amyloid pathology. The copper complex of Aβ1–42 has a highly positive formal reduction potential (≈+500–550 mV versus …

Is Hyperconjugation Responsible For The "Gauche Effect" In 1-Fluoropropane And Other 2-Substituted-1-Fluoroethanes?, Paul R. Rablen, R. W. Hoffman, D. A. Hrovat, W. T. Borden

Chemistry & Biochemistry Faculty Works

The energies and geometries of a series of 2-substituted-1-fluoroethanes were computed at the MP2/6-311++G**(6D)//MP2/6-31+G* level of theory for both the maxima and minima of the rotation about the C-C bond. The results did not support the predictions of a hyperconjugative model, that both 1,2-difluoroethane and 1-chloro-2-fluoroethane would strongly prefer a gauche conformation, and that 1-fluoro-2-silylethane would strongly prefer an anti conformation. The existence of competing electrostatic interactions between the fluorine and the substituents at C-2 was indicated by the detailed geometries of the gauche conformers and by the calculated sensitivity of the gauche-anti energy differences to the presence of a …

The Discovery-Oriented Approach To Organic Chemistry. 2. Selectivity In Alcohol Oxidation. An Exercise In 1H Nmr Spectroscopy For Sophomore Organic Laboratories, Ram Mohan, Steven Shadwick

Scholarship

We have developed a simple oxidation experiment that presents the student with a puzzle and is a good exercise in ¹H NMR spectroscopy. The experiment, which illustrates the important concept of selectivity in organic synthesis, involves selective oxidation of a mixture of 1-heptanol and 2-heptanol using commercial swimming pool chlorine. ¹H NMR analysis of the product mixture allows the student to determine the selectivity exhibited by the reagent.

Media Coverage Of Epa's Draft Dioxin Reassessment Report, Sharon M. Friedman, Megan A. Fitzpatrick, Brenda P. Egolf

RISK: Health, Safety & Environment (1990-2002)

Using content analysis, the authors examine the utility of news media in democratic decision making.

The Discovery-Oriented Approach To Organic Chemistry 1. Nitration Of Unknown Organic Compounds. An Exercise In 1H Nmr And 13C Nmr Spectroscopy For Sophomore Organic Laboratories, Ram Mohan, Sonia Mcelveen, Kostas Gavardinas, Jean Stamberger

Scholarship

Nitration is one of the most fundamental reactions in organic chemistry. However, the majority of the nitration experiments found in the standard lab textbooks are of the "cookbook" variety and convey none of the excitement associated with discovery in experimental chemistry. We have developed two simple nitration experiments that present the student with a puzzle and are a good exercise in ¹H NMR and ¹³C NMR spectroscopy. ¹³ C NMR spectroscopy is a powerful structure elucidation tool and yet not many examples of the use of ¹³C NMR spectroscopy in organic lab experiments can be found. The …

Bulletin 4357 - Fertilisers For Pastures On Sandy Soils Of The Swan Coastal Plain, K. W. Angell

Bulletins 4000 -

When newly cleared for agriculture, the sandy soils of the Swan Coastal Plain were acutely deficient in phosphorus (P), nitrogen (N), and the trace elements copper ( Cu) and zinc (Zn) and sometimes molybdenum (Mo). Phosphorus deficiency was overcome by applying single superphosphate. Trace element deficiencies were overcome by adding Cu, Zn and Mo to superphosphate during manufacture, allowing P, Cu, Zn and Mo to be applied to the pasture in the one operation.

It was subsequently found that low sulphur (S) and potassium (K) were limiting production and persistence of subterranean clover-based pastures on the sandy soils of the …

[2,3:5,6]Dibenzo[2.2.2]Octa-2,5,7-Triene (C2/C) And [2,3:5,6]Dibenzo[2.2.2]Octa-2,5-Diene, Lary Burrows, John M. Masnovi, Ronald J. Baker

Chemistry Faculty Publications

Two barrelene homologs are reported. Strain in the bicyclic framework of [2,3:5,6]dibenzo[2.2.2]octa-2,5,7- triene, (I) (C16H12), which is manifest in the deviations from ideality of the bond angles in the central bicyclic ringoSyStem and compression of the double bond [1.312 (3)A], is reduced in the more saturated derivative, [2,3:5,6]dibenzo[2.2.2]octa-2,5-diene, (II) (CI6H14), with the corresponding single bond being 1.5380 (19)A. The formation of isomorphs of (I) in both chiral (C2) and achiral (C2/c) space groups has implications for asymmetric syntheses involving solid (I) which rely on a non-centrosymmetric space group.

The Hofmann Rearrangement Using Household Bleach: Synthesis Of 3-Nitroaniline, Ram Mohan, Keith Monk

Scholarship

No abstract provided.

Oxidation Of Benzoins To Benzils Using Bismuth(Iii) Nitrate-Copper(Ii) Acetate, Ram Mohan, Steven Tymonko, Bryce Nattier

Scholarship

Benzoins are oxidized to benzils in excellent yields by 0.4 equivalents of Bi(NO₃)3.5H₂0 and 4 mol% of Cu(OAc)₂₃)₃.5H₂0 is a stable, inexpensive, commercially available solid. The relatively low cost and low toxicity of bismuth(Ill) nitrate makes this procedure a particularly attractive method for oxidation of benzoins.

Cyclopropane Fatty Acid Expression In Plants, Katherine M. Schmid

Scholarship and Professional Work - LAS

Pants [sic] are transformed with a bacterial cyclopropane fatty acid synthase gene to produce lipids containing cyclopropane fatty acids. Using this technology dihydrosterculate is produced in oilseed crops such as rape.

Aneuploidy Frequencies In Semen Fractions From Ten Oligoasthenoteratozoospermic Patients Donating Sperm For Intracytoplasmic Sperm Injection, Jerome Pfeffer, Myung-Geol Pang, Stanton F. Hoegerman, Christopher J. Osgood, M. W. Stacey, Jacob Mayer, Sergio Oehninger, William G. Kearns

Biological Sciences Faculty Publications

Objective: To determine aneuploidy frequencies in pellet and swim-up semen fractions from 10 infertile men with severe oligoasthenoteratozoospermia (OAT) who were donating sperm for intracytoplasmic sperm injection and to determine whether the swim-up isolation method would successfully separate aneuploid from haploid sperm.

Design: Prospective study.

Setting: Infertility clinic and molecular genetics laboratory.

Patient(s): Ten patients with severe OAT.

Intervention(s): Cytogenetic analyses by fluorescence in situ hybridization to determine aneuploidy frequencies for chromosomes 1, 13, 18, 21, X, and Y in sperm from swim-up and pellet fractions.

Main Outcome Measure(s): Gametic aneuploidy was scored in sperm fractions separated by the swim-up …

The Cytotoxicity And Mode Of Action Of 2,3,4-Trisubstituted Pyrroles And Related Derivatives In Human Tmolt4 Leukemia Cells, John T. Gupton, B. S. Burham, B. D. Byrd, K. E. Krumpe, C. Stokes, J. Shuford, S. Winkle, T. Webb, A. E. Warren, C. R. Barnes, J. Henry, I. H. Hall

Chemistry Faculty Publications

4-Carbechoxy-l-methyl-2-phenacyl-3-phenylpyrrole (9), 4-carbethoxy-2-(4-methoxybcnzoyl)-3-(4-methoxyphcnyl)pyrrole (10) and 2-(4-methoxybenzoyl)-3,4-bis-(4-methoxyphenyl)pyrrole (11) proved to be potent cytotoxic agents against the growth of murine and human leukemias and lymphomas. Selective toxicity was demonstrated against the growth of solid tumors, e.g. human adenocarcinoma of the colon SW480 and ileum HCT-8, glioma U-87-MG, and rat UMR-106 osteosarcoma. A mode of action study in Tmolt₄ leukemia cells demonstrated that the agents inhibited de novo purine synthesis at the regulatory sites PRPP-amido transferase, IMP dehydrogenase as well as dihydrofolate reductase resulting in significant inhibition of DNA synthesis in 60 min. Other biochemical sites …