Organic Chemistry Commons^™

Towards The Synthesis Of An Α-L-Rhamnose And Α-D-Galactose Containing Trisaccharide Epitope Related To Trypanosoma Cruzi, Merieme Khamsi ^, Katja Michael *

COURI Symposium Abstracts, Spring 2012

No abstract provided.

Synthesis, Structure, And Spectroscopic Properties Of Diphenyl Pyridine Amine Platinum (Ii) Complexes, Jacqueline Gamboa Varela^, Alejandro J. Metta-Magaña, Jose E. Núñez*

COURI Symposium Abstracts, Spring 2012

No abstract provided.

Synthesis And Theoretical Studies Of Pyridyl Fullerene Derivatives For Supramolecular Applications In Photovoltaic Systems, Robert Vina-Marrufo ^, Danisha M. Rivera-Nazario, Agustin Molina-Ontoria, Luis Echegoyen *

COURI Symposium Abstracts, Spring 2012

No abstract provided.

Zirconium Mediated One-Pot Synthesis Of Γ-Amino Acids From Carbon Dioxide, Diego A. Pedroza ^, Shizue Mito *

COURI Symposium Abstracts, Summer 2011

No abstract provided.

Fullerene-Based Organized Self-Assembled Photoactive Layer, Marcelo A. Yates ^, Danisha M. Rivera, Luis Echegoyen *

COURI Symposium Abstracts, Summer 2011

No abstract provided.

Endohedral Derivatives For Bulk Heterojunction Organic Photovoltaic Devices, Gustavo Hernandez^, Michael D. Irwin*

COURI Symposium Abstracts, Summer 2011

No abstract provided.

Octaethyl-Nickel-Porphyrin Functionalized Silica For Fullerene Separation, Adriana Rodríguez^, Danisha M. Rivera, Luis Echegoyen*

COURI Symposium Abstracts, Summer 2011

No abstract provided.

Synthesis Of The Precursors For A New Covalent Organic Framework With Triangular Shaped Pores, Fernando J. Correa ^, Venkata P. Neti, Luis A. Echegoyen *

COURI Symposium Abstracts, Summer 2011

No abstract provided.

Trypanosoma Cruzi - Derived Sugar Epitopes - Synthesis And Immunology, Erika Y. Monroy^, Roger A. Ashmus, Jamal Khamsi, Andrew Pardo, Nathaniel S. Schocker, Rosa A. Maldonado, Kayla Vasquez, Alexandre F. Marques, Igor C. Almeida, Katja Michael*

COURI Symposium Abstracts, Spring 2011

The protozoan parasite Trypanosoma cruzi is the causative agent of Chagas disease. As of today no effective vaccine has been developed for it. Certain developmental stages of T.cruzi express cell surface oligosaccharides with terminal alpha-galactosyl and rhamnosyl residues, which are believed to be highly immunogenic in humans. The exact structures and sizes of these epitopes are still unknown. Our quest is to shine light on the chemical structures of immunogenic alpha-Gal and alpha-Rha containing mono-, di-, and trisaccharides that are conjugated to a keyhole limpet hemocyanin (KLH) carrier protein through a combination of chemical synthesis and immunological studies. The compounds …

Synthesis Of Pyridine-Based Ligands As Potential Magnetic Liquid Crystals, Jacqueline Gamboa Varela^, Jose E. Nunez*

COURI Symposium Abstracts, Spring 2011

Ligands for the development of metallomesogens (metal-containing-liquid-crystals) have attracted attention due to potential applications in materials science such as optical devices, magnetic switches, and conductors. The attempts to synthesize bis(3-alkoxy) pyridine amines are presented. These structures are designed to exhibit liquid crystalline properties as metal complexes. Reaction conditions using potassium carbonate and potassium tert-butoxide as bases under Ullmann-type conditions in various solvents (aromatic and non-aromatic), between -78 ⁰C to 160 ⁰C, have been unsuccessful. It is imperative to understand the electronic effects of the meta-substituted pyridine precursors to further develop the copper-catalyzed conditions of these types of molecules.

Bis( N, N-Dipheny-3-Pyridineamine) Tungsten Complex As Molecular Gyroscope, Verenice Ramirez^, Jose E. Nunez*

COURI Symposium Abstracts, Spring 2011

In recent years, the interest in molecular machines has increased based on inspiration from macroscopic machines, such as gyroscopes applied in racecar engines and arrays of gyroscopes in automatic pilot functions. The same concept has been taken down to the nanoscopic level as molecular machines in solution like bevel gears and turnstiles, but for application use they must be in the solid state. Gyroscope molecules can exhibit fast rotation and the aim is to design free rotation in the crystal lattice that maintains volume conserving motion. Bis(N,N-diphenyl-3-pyridinamine) tungsten complex was prepared by irradiation of tungsten hexacarbonyl in the presence of …

A New Photochemical Method For The Preparation Of Amino Acid-α-Phenylthioesters And Peptide-α-Phenylthioesters, Tyrone Hogenauer

Open Access Theses & Dissertations

We describe the development of a novel resin with a photoreactive N-acylnitroindoline linker that allows for the synthesis of amino acid- (in solution) or peptide-α-thioesters using standard Fmoc/t-Bu standard solid phase peptide synthesis (SPPS). Recent advances have shown that the yields of this thioesterification reaction have dramatically increased due to a simple change in the order of addition of reagents. Upon illumination with UV-light, in the presence of N-hydroxybenzotriazole (HOBt), the amino acid- or peptide-α-OBt ester is generated by direct photo-release from the nitroindoline linker with minimal epimerization, followed by reaction with thiophenol in the dark to produce amino acid-α-phenylthioesters …

Titanium Niobium Nano Porous Materials: New Photocatalysts For Water Decontamination, Maryam Zarei Chaleshtori

Open Access Theses & Dissertations

Water pollution is major environmental problem worldwide. Many common industrial organic compounds that make their way into water systems can be carcinogenic at trace levels and are difficult and costly to remove completely with conventional technologies. Because of this, authorities and researchers are trying to improve current water cleanup techniques.

Heterogeneous photocatalysts that accelerate the photocatalytic destruction of organic contaminants in water are a potentially inexpensive and highly effective way to remove both trace-level and saturated harmful compounds from industrial waste streams and drinking water. Titanium dioxide has the potential to completely mineralize organic compounds in water under ultraviolet light. …

Oxidation Of Dibenzothiophene To Dibenzothiophene Using Metal Nanoparticles Supported On Silica, Karina Castillo

Open Access Theses & Dissertations

Silica and nanoparticles of Pt, Au, and Ag supported on silica were tested for the ability to oxidize dibenzothiophene (DBT) to sulfone. High performance liquid chromatography was used to study the removal of DBT from solution. In addition, X- ray diffraction, infrared spectroscopy and Raman Spectroscopy were used to characterize the product of the oxidation reaction. Further studies involved the use X-ray absorption spectroscopy to characterize the nanoparticle catalysts before and after the oxidation reaction.

To better understand the reaction, silica was synthesized at different pHs using three different acids. The acids used to synthesize the silica were HCl, HNO3, …

Conversion Of Racemic Ibuprofen To (S)-Ibuprofen, David Chavez-Flores

Open Access Theses & Dissertations

Ibuprofen is a common Non-Steroidal Anti-Inflammatory Drug (NSAID) sold as a racemic or equal mixture of (R) and (S) mirror-image enantiomers. Without patent protection, ibuprofen is an orphan drug even though one enantiomer, (S)-ibuprofen, provides relief three times faster than its racemic mixture with fewer side effects. The goal of this research was to develop a facile, environmentally benign (no waste of ibuprofen or catalysts), and inexpensive process to convert a commercially available racemic mixture of ibuprofen to the therapeutically active (S)-ibuprofen.

After many attempts, the most successful conversion of racemic ibuprofen to (S)-ibuprofen was the in situ racemization and …

Microwave Assisted Solid-Supported Organic Synthesis: A Novel Methodology To Obtain 2,3-Disubstituted-1,4-Naphthoquinones, Israel Garcia-Martinez

Open Access Theses & Dissertations

This research focuses on the combinatorial solid phase organic synthesis (SPOS) of different bioactive compounds utilizing transition metal mediated reactions via microwave assisted organic synthesis (MAOS).

A microwave-assisted solid-supported Dötz benzannulation of chromium Fischer carbene complexes with various alkynes has been reported. The oxidative cleavage of the resulting resin-bound 1,4-naphthols affords 2,3-disubstituted-1,4-naphthoquinone derivatives in good to moderate yields with high purities. We demonstrated that solid phase organic synthesis of naphthoquinones via conventional heating is limited due to their long reaction times and high temperatures. The products decompose leading to low yields and purities.2 Microwave assisted synthesis of these naphthoquinones will …

Optical And Vibrational Spectroscopic Studies Of Synthetic Maya Pigments As A Function Of, Swati Kumar

Open Access Theses & Dissertations

Pigments developed by the Mayan civilization around 8th century, represent some of the most versatile pigments known to date. Several derivatives of these pigments are popular subjects of current research interest. This is due to the characteristic stability which is provided by a bonding mechanism between the dye and the clay. One such pigment "Maya Blue", a mixture of Indigo and Palygorskite, provides a dramatic background for murals and ceramics throughout Mesoamerica. Several research groups have devoted time and interest in unlocking its particular features.1-3

The work embodied in this Thesis is focused on the synThesis and characterization of three …

A Study Of The Interaction Of Thioindigo Dye, With Several Inorganic Host Materials, Alejandra Ramirez

Open Access Theses & Dissertations

Maya Blue has been the focus of numerous studies and is believed to be a mixture of palygorskite clay and indigo dye.^1,2 Several derivatives of this pigment have been developed with intriguing properties. For instance, the dye thioindigo reacts with the palygorskite clay to exhibit a broad range of colors from red to blue under UV-Vis excitation. Based on FT-Raman and computer simulation, previous work performed in our group could relate indigo and thioindigo interaction to the aluminum sites in the framework. super>3,4

The work performed with other inorganic host materials such as, layer structures and zeolites have …