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Articles 91 - 93 of 93
Full-Text Articles in Organic Chemistry
Development Of Novel Ahr Antagonists, Hyosung Lee
Development Of Novel Ahr Antagonists, Hyosung Lee
University of Kentucky Doctoral Dissertations
Aryl hydrocarbon receptor (AHR) is a sensor protein, activated by aromatic chemical species for transcriptionally regulating xenobiotic metabolizing enzymes. AHR is also known to be involved in a variety of pathogenesis such as cancer, diabetes mellitus, cirrhosis, asthma, etc. The AHR signaling induced by xenobiotics has been intensively studied whereas its physiological role in the absence of xenobiotics is poorly understood. Despite a number of ligands of AHR have been reported thus far, further applications are still hampered by the lack of specificity and/or the partially agonistic activity. Thus, a pure AHR antagonist is needed for deciphering the AHR cryptic …
Inversion Symmetry And Local Vs. Dispersive Interactions In The Nucleation Of Hydrogen Bonded Cyclic N-Mer And Tape Of Imidazolecarboxamidines, Sihui Long, Venkatraj Muthusamy, Peter G. Willis, Sean Parkin, Arthur Cammers
Inversion Symmetry And Local Vs. Dispersive Interactions In The Nucleation Of Hydrogen Bonded Cyclic N-Mer And Tape Of Imidazolecarboxamidines, Sihui Long, Venkatraj Muthusamy, Peter G. Willis, Sean Parkin, Arthur Cammers
Chemistry Faculty Publications
Substitutional changes to imidazolecarboxamidine that preserved intermolecular hydrogen bonding in the solid state were used to study the relationship between packing and the hydrogen bond motif. Various motifs competed, but the most common imidazolecarboxamidine crystalline phase was a Ci symmetric dimer that established inversion centers by associating enantiomeric tautomers. Counter to intuition, the calculated gas-phase energies per molecule of the solid state atomic coordinates of the Ci dimer motifs were higher than those of the C1 dimer, trimer, tetramer and tape motifs, while the packing densities of Ci dimers were found to be higher. This result …
The Chemical And Physical Examination Of The Oils From The Seeds Of The Aster, Bachelor's Button, Larkspur, Muskmelon, Okra, Pansy, Snapdragon, Henry Neal Marsh
The Chemical And Physical Examination Of The Oils From The Seeds Of The Aster, Bachelor's Button, Larkspur, Muskmelon, Okra, Pansy, Snapdragon, Henry Neal Marsh
Archived Theses and Dissertations
No abstract provided.