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Medicinal-Pharmaceutical Chemistry Commons™
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Full-Text Articles in Medicinal-Pharmaceutical Chemistry
Removal Of Pharmaceuticals From Aqueous Solutions Using A1-Mg/Rgo Composite, Spencer Jones
Removal Of Pharmaceuticals From Aqueous Solutions Using A1-Mg/Rgo Composite, Spencer Jones
Summer Community of Scholars Posters (RCEU and HCR Combined Programs)
No abstract provided.
Improving Binding Affinity Through Cyclization, Kaylee M. Newcomb, Nicolas Abrigo
Improving Binding Affinity Through Cyclization, Kaylee M. Newcomb, Nicolas Abrigo
Undergraduate Research Posters
Cancer chemotherapy results in systematic damage as the drugs used are also toxic to benign tissue. Sensitizing a cancer cell to therapy by interfering with the DNA repair mechanisms would decrease overall toxicity, as the necessary dosage of chemotherapy drugs would be lowered. The Hartman lab developed a peptide (8.6) that binds with a KD of 1 μM to the C-terminal domain of breast cancer associated protein (BRCA1), blocking homologous recombination. The crystal structure of the peptide shows the tyrosine and threonine residues are close together, suggesting that by cyclizing these positions, the peptide may already be constrained into its …