Inorganic Chemistry Commons^™

Synthesis And Characterization Of Metal Complexes Of Oxindole-Based Β-Lactams, Kenya Rosas, Erick Morales Orrante, Carlos Sifuentes, Alexsei Nazarov

Posters - 2026

• β-lactams are essential structural components of many antibiotics and widely studied due to their biological importance and synthetic versatility.
• The Ugi reaction is a multicomponent reaction, involving a primary amine, carboxylic acid, isocyanide, and an aldehyde or a ketone, that rapidly generates α-acetamido carboxamide derivatives (Ugi adducts).
• The synthesis and characterization of four oxindole-based β-lactam derivatives:
  • 1-Benzyl-N-(tert-butyl)-2-oxo-3-(2-oxoazetidin-1-yl)indoline-3-carboxamide (4a).
  • N-(tert-butyl)-2-oxo-3-(2-oxoazetidin-1-yl)-1-phenylindol-3-carboxamide (4ab).
  • N-(tert-Butyl)-2-oxo-3-(2-oxoazetidin-1-yl)indoline-3-carboxamide (4d).
  • N-(tert-butyl)-1-methyl-2-oxo-3-(2-oxoazetidin-1-yl)indol-3-carboxamide (4e).
• The coordination of the four Ugi adducts with Cu (II) and Ni (II) at different pH points to enhance their stability and improve biological activity.

Synthesis And Characterization Of Water Soluble Thiosemicarbazone-Alkylthiocarbamate Ligands And Their Cu(Ii) Complexes, John J. Garvey Iv, Sanjit Karki, Haixun Guo, Levi J. Beverly, Craig A. Grapperhaus, Robert M. Buchanan

The Cardinal Edge

Thiosemicarbazone-alkylthiocarbamate N₂S₂ hybrid ligands are emerging as an important class of potential bioactive molecules that possess important pharmacokinetic properties. Resulting metal complexes have electronic properties that are composites of their homolog forms, bis-thiosemicarbazones and bis-alkylthiocarbamates, allowing for tuning redox potentials over a nearly 450 mV range. These versatile ligand frameworks possess remarkable antiproliferation activity against a broad range of solid tumors and low toxicity towards normal cells¹ indicating great promise for future drug development. Herein, we describe recent synthetic efforts to improve water solubility of thiosemicarbazone-alkylthiocarbamate hybrid ligand Cu(II) complexes. The parent 4-methyl-3-thiosemicarbazide half arm was …

Quaternary Diamond-Like Sulfides For Nonlinear Optical Applications: Investigation Into Composition-Structure-Property Relationships Of The I2-Ii-Iv-Vi4 And I4-Ii-Iv2-Vi7 Formulae, Jordan Kelly

Electronic Theses and Dissertations

The research work presented in this dissertation focuses on the synthesis, characterization, and property assessment of new and existing quaternary diamond-like semiconductor (DLS) materials for the potential application in infrared (IR) nonlinear optics (NLO). Chapter 2 discusses the previously discovered temperature-dependent polymorphs of Cu₂ZnGeS₄ (CZGS); however, the IR NLO properties, neutron powder diffraction data, and single crystal X-ray diffraction structures were previously undetermined. The high-temperature α-CZGS polymorph was superior to the low-temperature β-CZGS analog in both second harmonic generation (SHG) and laser-induced damage threshold (LIDT). Chapter 3 presents the discovery of Li₂MgGeS₄ and comparison …

3d-Printed Microfluidic Devices For Electrochemiluminescence Detection Of Mirna, Oscar Clement

Honors Scholar Theses

This thesis outlines the research conducted over the past two years on the production and application of microfluidic devices (MFDs) in electrochemiluminescent-based bioanalytical assays. The work is categorized into two main projects: designing and manufacturing MFDs and developing electrochemiluminescent (ECL) assays for detecting Alzheimer's disease (AD) associated microRNAs (miRNAs) using CRISPR technology. The process of learning to design MFDs involved acquiring proficiency in computer-aided design (CAD) software, stereolithography (SLA) 3D printing, and iterative design techniques. The development of the ECL-based assay for AD miRNA was a multidisciplinary endeavor, combining elements of inorganic and biological chemistry. Although the research on the …

Coordination Chemistry Of N,N’- Azodoxides, Lakshmi Balaraman

ETD Archive

The coordination chemistry of nitric oxide (NO) with transition metals has been extensively investigated, but that of organic NO derivatives as ligands less so. Some nitrosoalkanes RNO and nitrosoarenes ArNO are in equilibrium with dimeric species known as N,N'–azodioxides, R(O)NN(O)R or Ar(O)NN(O)Ar. The cis diastereomers of azodioxides have been proposed to act as bidentate chelating ligands for both main-group and transition metals, but only three azodioxide complexes, a dicationic iron (II) complex, a neutral scandium (III) complex, and a dicationic calcium (II) complex, have thus far been structurally characterized before our work in this area. The delocalized π system of …

Reactivity Of Molybdenum And Tungsten Sulfido Complexes With First-Series Transition Metals, Khalil Mudarmah

ETD Archive

Ammonium tetrathiomolybdate (ATTM) is an important compound in bioinorganic chemistry, with medicinal applications. Metal complexes of sulfur-containing ligands have been widely used as building block in biology and inorganic chemistry. This project aims to increase the number of Mo-S and W-S complexes that may contribute to fields such as bioinorganic and medicinal chemistry, by the preparation of heterometallic complexes containing both Mo or S and a metal of the first transition series. The homobimetallic complex anion salts (Et4N)2[Mo2(S)2(μ-S)2(edt)2] (1) and (Et4N)2[W2(S)2(μ-S)2(edt)2] (2) have been prepared from ATTM and ammonium tetrathiotungstate (ATTW) in order to start our work. The overnight treatment …

Synthesis And Characterization Of A Novel Platinum Ligand Complex ((Κ-N,C,N- 2,6-Bis(Diethylaminomethyl)Phenyl)(4- Tert-Butylphenyl) Platinum(Ii)), Carly Roleder

CMC Senior Theses

A novel platinum ligand complex (NCN)PtAr, ((κ-N,C,N- 2,6-bis (diethylaminomethyl)phenyl)(4- tert-butylphenyl) platinum(II)), was synthesized. A reaction of 1-Bromo-4-tert-butylbenzene Grignard with (NCN)PtCl, (where NCN = 2,6-bis(diethylaminomethyl)phenyl) yielded the (NCN)PtAr (where Ar = 4-tert­-butylphenyl). The product was then characterized with NMR spectra through ¹H NMR, ¹³C NMR, COSY, HSQC, and HMBC to verify it structure.

Exploratory Synthesis Of New Open-Framework Iron (Ii,Iii)-Containing Polyanion Systems Targeted For Lithium-Ion Battery Applications, Gregory Becht

All Dissertations

The chemistry demonstrated in this dissertation is concerned with the synthesis, structure, properties and applications of inorganic solids containing iron(II,II) redox centers. The endeavor in exploratory synthesis is due largely to the employment of molten salt fluxes such as alkali metal chloride. These halide-fluxes act in two parts; 1) as a solvent to lower the reaction temperature and 2) as an in situ source of unavailable alkali oxides through metathesis reactions. Using these halide fluxes has allowed for the discovery of several new transition metal-containing phosphates, arsenates, and vanadates for a structure/property correlation study. From this study the selected compounds …

An On-Line Acid-Base Titration Applet In The Generic Tutorial System For The Sciences Project, Thomas Lee Gummo

Theses Digitization Project

The purpose of this Master's Project was to develop an Acid-Base Titration Simulator. It was also to be a part of the California State University - San Bernardino's GTSS, Generic Tutorial System for the Sciences, project. The main benefit is that students will be able to conduct titration experiments over the Internet without being in the laboratory and without costly equipment or dangerous chemicals. Instructors at the high school and college level can demonstrate the key principles of titration.