Chemistry Commons^™

Topology Driven And Soft Phonon Mode Enabled Na-Ion Diffusion In Quaternary Chalcogenides, Na3zngax4 (X = S, And Se), Sajan Kumar, Mayanak K. Gupta, Ranjan Mittal, Santhoshkumar Sundaramoorthy, Amitava Choudhury, Naresh C. Osti, Alexander I. Kolesnikov, Matthew B. Stone, Yongqiang Cheng, Samrath L. Chaplot

Chemistry Faculty Research & Creative Works

The compounds Na3ZnGaX4 (X = S, Se) are potential solid electrolyte materials in sodium-based batteries, which have certain advantages over oxide materials and have shown significant ionic conductivity at ambient temperature. In this paper, we bring out atomic-level features of the diffusion process in these new materials using the microscopic techniques of inelastic neutron scattering (INS), Quasi elastic neutron scattering (QENS), and ab initio molecular dynamics (AIMD) simulations. The insights obtained from these techniques are unique and not available from other macroscopic experiments. Neutron scattering experiments have been performed at temperatures from 100 to 700 K. The simulations have been …

Nmr Study Of Co2 Capture By Butylamine And Oligopeptide Kdde In Aqueous Solution: Capture Efficiency And Gibbs Free Energy Of The Capture Reaction As A Function Of Ph**, Kaidi Yang, Joseph Schell, Fabio Gallazzi, Wei Wycoff, Rainer Glaser

Chemistry Faculty Research & Creative Works

We Have Been Interested in the Development of Rubisco-Based Biomimetic Systems for Reversible CO₂ Capture from Air. Our Design of the Chemical CO₂ Capture and Release (CCR) System is Informed by the Understanding of the Binding of the Activator CO₂ (^ACO₂) in Rubisco (Ribulose-1,5-Bisphosphate Carboxylase/oxygenase). the Active Site Consists of the Tetrapeptide Sequence Lys-Asp-Asp-Glu (Or KDDE) and the Lys Sidechain Amine is Responsible for the CO₂ Capture Reaction. We Are Studying the Structural Chemistry and the Thermodynamics of CO₂ Capture based on the Tetrapeptide CH₃CO−KDDE−NH₂ ("KDDE") in Aqueous …

Effect Of Calcium Carbonate Particle Size And Content On The Thermal Properties Of Pvc Foamed Layer Used For Coated Textiles, Mouna Stambouli, Walid Chaouch, Sondes Gargoubi, Riadh Zouari, Slah Msahli

Turkish Journal of Chemistry

The goal of this research is to see how the amount and particle size of calcium carbonate (CaCO$_{3}$) used in the foamed layer in use for PVC-coated textiles affects the thermal properties of the material. Two different particle sizes were used at various concentrations. The impact of different CaCO$_{3}$ loadings and particle sizes on the PVC foamed layer's thermal properties were examined. Thermogravimetry (TGA and DTG) and differential scanning calorimetry (DSC) measurements were utilized to investigate the thermal properties of the PVC foamed layer and the samples have been also characterized by FTIR spectroscopy. According to the findings, the thermal …

Structural Engineering Of Thermostable Fluorescent Proteins Tgp-E And Ytp-E And Crystal Structure Of Tgp-E, Matthew Ryan Anderson

Graduate Theses/Dissertations

Thermostable fluorescent proteins, such as thermal green protein (TGP) and yellow thermal protein (YTP), could be used as biosensors to monitor cellular activity and as a fusion tag to monitor a protein of interest. The use of fluorescent proteins can sometimes be limited in certain organelles with low pH and in thermophilic organisms. This research aims to improve the thermal stability of TGP and YTP. TGP was created from a synthetically derived eCGP123 protein to improve solubility by substituting residues on the positively charged b- barrel surface with negatively charged glutamate (E) at Los Alamos National Lab. YTP was developed …

Impact Of Sample Conditions On Dna Phosphodiester Backbone Bi/Bii Conformational Equilibrium Dynamics, Autumn C. Pilarski

Graduate Theses/Dissertations

DNA damage, such as single base lesions and mismatches, is highly prevalent within cells. If these DNA damage events are not repaired, they could lead to mutations and thus disease and cancer. Intricate repair mechanisms are in place to fix these damage events, one such being Base Excision Repair (BER) and associated enzyme: Thymine DNA Glycosylase (TDG). The first step of this repair process, recognition of the lesion by TDG, is not well understood. The following thesis presents results to better understand the fundamental biophysical question of how a DNA lesion within a mismatch context is recognized in a million …

Renewable Fuels: Molecular Dynamics Investigations Into Pyrolysis Of Methyl Linoleate, Elson Osakpolor Eguaosa

Graduate Theses/Dissertations

With the rapid depletion of the world’s supply of fossil fuels, especially petroleum products, petroleum prices have risen by approximately 800% between the 1970s and now and are projected to continue rising. It is also expected that the world’s consumption of energy will increase commensurate with its growing population. Although biodiesel is a good renewable alternative, it has its limitations including high production costs and poor low-temperature performance. We seek to improve conventional biodiesel with pyrolysis to produce low molecular-weight compounds with high energy densities. Understanding the pyrolysis path on the atomic scale is key as it will allow us …

Exploration And Synthesis Of Half-Heusler And Disordered Ternary Intermetallic Single Crystals, Md Fahel Bin Noor

Graduate Theses/Dissertations

Due to their distinct physical and chemical characteristics, half-Heusler compounds are intermetallic materials that have undergone substantial research. The general formula for these compounds is XYZ, where X and Y are transition metals and Z is a p-block element. Thermoelectricity is among the half-Heusler compounds' most exciting potential uses, but additional possible applications include spintronics, magnetic refrigeration, and superconductivity, among others. Recently, half-Heuslers (and Heuslers) have emerged as candidates for catalysts for hydrogenation. The CoNbSn half-Heusler compound, as well as another unique intermetallic ternary compound, the disordered Mn_4-xCr_xAl₁₁, were successfully grown as single crystals …

Identification And Quantification Of Novel Antimicrobials, Hazera Khatun Koly

Electronic Theses and Dissertations

No abstract provided.

Ongoing Fragmentation Of The Subducting Cocos Slab, Central America, Tu Xue, Diandian Peng, Kelly H. Liu, Jonathan Obrist-Farner, Marek Locmelis, Stephen S. Gao, Lijun Liu

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Fundamental to plate tectonics is the subduction of cold and mechanically strong oceanic plates. While the subducted plates are conventionally regarded to be impermeable to mantle flow and separate the mantle wedge and the sub slab region, isolated openings have been proposed. by combining new shear wave splitting measurements with results from geodynamic modeling and recent seismic tomography and geochemical observations, we show that the upper ~200 km of the Cocos slab in northern Central America is intensively fractured. the slab there is strong enough to produce typical arc volcanoes and Benioff Zone earthquakes but allows mantle flow to traverse …

Triplet Sensitization Enables Bidirectional Isomerization Of Diazocine With 130 Nm Redshift In Excitation Wavelengths, Jussi Isokuortti, Thomas Griebenow, Jan-Simon Von Glasenapp, Tim Raeker, Timo Laaksonen, Rainer Herges, Nikita A. Durandin

Articles

Diazocines are bridged azobenzenes with phenyl rings connected by a CH2–CH2 group. Despite this rather small structural difference, diazocine exhibits improved properties over azobenzene as a photoswitch and most importantly, its Z configuration is more stable than the E isomer. Herein, we reveal yet another unique feature of this emerging class of photoswitches. In striking contrast to azobenzenes and other photochromes, diazocine can be selectively switched in E / Z direction and most intriguingly from its thermodynamically stable Z to metastable E isomer upon successive excitation of two different triplet sensitizers present in solution at the same time. This approach …

The Biological Responses Of Vitamin K2: A Comprehensive Review, Quanxiang Yan, Tao Zhang, Christine O'Connor, James W. Barlow, John Walsh, Gaia Scalabrino, Feng Xu, Helan Sheridan

Articles

Vitamin K1 (VitK1) and Vitamin K2 (VitK2), two important naturally occurring micronutrients in the VitK family, found, respectively, in green leafy plants and algae (VitK1) and animal and fermented foods (VitK2). The present review explores the multiple biological functions of VitK2 from recently published in vitro and in vivo studies, including promotion of osteogenesis, prevention of calcification, relief of menopausal symptoms, enhancement of mitochondrial energy release, hepato-and neuro-protective effects, and possible use in treatment of coronavirus disease. The mechanisms of action associated with these biological effects are also explored. Overall, the findings presented here suggest that VitK, especially VitK2, is …

Molecular Elucidation Of Reaction Mechanisms In Aluminum & Lithium Metal Batteries By Solid-State Nmr Spectroscopy And Electrochemical Methods, Leo W. Gordon

Dissertations and Theses

As society wrestles with the ever-growing climate consequences of burning fossil fuels, the increased demand for electric vehicles and renewable power generation mandates safe, sustainable, earth-abundant, low cost, and energy dense batteries. Different use cases will necessitate different types of batteries; for example, stationary storage systems prioritize minimal expense, whereas mobile applications like electric vehicles emphasize high energy densities. Aluminum and lithium metal batteries hold great promise for next-generation energy storage due to their large specific capacities (2980 mA h g^-1, and 3860 mA h g^-1, respectively). In particular, aluminum metal is low cost, has high …

Investigating The Effect Of Poly (Ε-Caprolactone) Nanofibers Scaffolds With Random, Unidirectionally, And Radially Aligned Morphologies On The Fibroblast Cell?S Attachment And Growth Behavior, Saeed Nezari, Mohammadamin Sarli, Ahmad Hivechi, Hajir Bahrami, Peiman B. Milan, Noorahmad Latifi, Fatemeh Latifi, Tayyeb Ghadimi, S. Mohammad Amin Haramshahi, Soheila Naderi Gharahgheshlagh

Turkish Journal of Chemistry

In the last decade, significant progress in tissue engineering, repairing, and replacing organs has been achieved. The design and production of scaffolds for tissue engineering are one of the main areas which have attracted the researcher's interest. In this regard, electrospinning is one of the most popular methods of nanoscale scaffold similar to extracellular matrix production. This paper reports the fabrication of scaffolds consisting of radially aligned PCL nanofibers by utilizing a collector composed of a central point electrode and a peripheral ring electrode. The chemical and physical properties were compared using SEM, FTIR, XRD, and DSC experiments, as well …

Synthesis, Molecular Simulation Studies, In Vitro Biological Assessment Of 2-Substituted Benzoxazole Derivatives As Promising Antimicrobial Agents, Gajanan S. Shanbhan, Amit Bhargava, Giridhar Pal Singh, Shrinivas D. Joshi, Narendra Chundawat

Turkish Journal of Chemistry

The 2-substituted benzoxazole derivatives are known to exhibit a wide spectrum of biological potential. Two series of novel benzoxazole derivatives containing 2-phenyl and 2-N-phenyl groups were synthesized, by following the green chemistry approach. All the newly synthesized derivatives were screened against gram-positive bacteria (Streptococcus pyogenes, Staphylococcus aureus), gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli) and the fungus (Aspergillus clavatus and Candida albicans). Most of these compounds have demonstrated potent antibacterial activities, especially against E. coli at 25 μg/mL, along with moderate antifungal activity. Among these, two compounds, 21 and 18, showed interesting antibacterial profile. Molecular …

Zinc-Mediated Efficient And Selective Reductive Aza-Claisen Rearrangement Of N-Allyland N-Propargylaminoanthraquinones In Ionic Liquid, Fereshteh Albooyeh, Ghasem Aghapour

Turkish Journal of Chemistry

An efficient method is described for the first time for reductive aza-Claisen rearrangement of 1-(N-allylamino) anthraquinones to 1-amino-2-(prop-2?-enyl)anthraquinones using zinc powder in 1-methylimidazolium tetrafluoroborate ([Hmim] BF4) as an ionic liquid in good to excellent yields. Extending of this method on 1-(N-propargylamino)anthraquinones causes the production of 1,2,3,4-tetrahydronaphtho[2,3-h]quinoline-7,12-diones containing a newly synthesized six membered heterocyclic ring on anthraquinone core via performing this reductive [3,3] sigmatropic reaction followed by cyclization in a tandem manner. These rearrangements can be executed even in the presence of some other functional groups with excellent chemoselectivity.

Investigating Visinin-Like Protein 1 And Ubiquitinated Visinin-Like Protein 1 As Mild Traumatic Brain Injury Biomarkers, Yueming Wu

Theses and Dissertations--Chemistry

Traumatic brain injury (TBI) continues to be a significant cause of morbidity and mortality worldwide. Despite significant progress in understanding the complex pathophysiology of TBI, the underlying mechanisms remain poorly understood. The primary brain damage is acute and irreversible. However, secondary brain injuries often develop gradually over months to years, creating an opportunity for critical therapeutic interventions. In the past decade, research on TBI biomarkers has seen significant progress. This progress has been driven by the diverse nature of TBI pathologies and the challenges they present for evaluation, management, and prognosis. TBI biomarker proteins resulting from axonal, neuronal, or glial …

College Of Natural Sciences 2022 Year-End Publication, College Of Natural Sciences

College of Natural Sciences Newsletters and Reports

This is the 2022 issue of the annual College of Natural Sciences year-end publication.

Contents:
[Page] 2 Dean's message
[Page] 3 Department highlights
[Page] 4 Overview of Bold & Blue Campaign
[Page] 5 Dr. Edward Hogan recognition & endowment
[Page] 6 Career milestones
[Page] 7 Student travel and research
[Page] 8 $11 million COBRE grant
[Page] 9 Professional Science Masters & Research highlights
[Page]10 Outreach highlights throughout the state
[Page] 11 2022 events recap – join us in 2023!
[Page] 12 Updates on our VR initiative
[Page] 14 Overview of awards and recognitions from 2022

One-Pot Enol Silane Formation-Allylation Of Ketones Promoted By Trimethylsilyl Trifluoromethanesulfonate, Elizabeth D. Heafner, Xuechun Lin, Alexa Connors, Hanyu Zhong, R. J. Coyle, Yiqi Liu, C. Wade Downey

Chemistry Faculty Publications

Ketones and related substrate classes undergo enol silane formation in the presence of trimethylsilyl trifluoromethanesulfonate (TMSOTf) and triethylamine, reaction conditions that also promote the in situ ionization of allyl propionates. When these two processes are performed in one pot, allylation of the ketone is observed in high yields. Aldehydes, esters, and thioesters also serve as enol silane precursors under these conditions. When unsymmetrical allyl cations are employed, regioselectivity depends upon the electronic and steric properties of the substituents.

Organic Chemistry Ii, Layne Morsch, Steven Farmer, Krista Cunningham, Zachery Sharrett, Kevin M. Shea

Open Educational Resources: Textbooks

This text has many contributors. It was adapted for use in CHM 223 at Smith College by Kevin Shea with the assistance of a Smith College Library OER Incentive Grant.

Deposited Cigarette Smoke As A Driver Of Oxidation And Partitioning Processes On Indoor Surfaces, April Hurlock

Honors Theses

Despite the large amount of time that individuals spend indoors during their lives, very little attention was paid to the chemistry that occurs on indoor surfaces until recently. Although not visible to the naked eye, physical and chemical processes, such as partitioning and oxidation, are occurring on virtually every indoor surface in a typical household. Indoor pollutants, ranging from skin oils to environmental cigarette smoke, drive a lot of these processes. The transformation of indoor surfaces by indoor pollutants can increase chemical exposure risks as new irritants or carcinogens can be introduced to the surfaces. In this thesis, I describe …

Evaluation Of Photochemically Cross-Linked Collagen/Gold Nanoparticle Composites As Potential Skin Tissue Scaffolds, Evri̇m Meri̇ç Yelkuvan, Özge Erdemli̇, Bengi̇ Yilmaz, Ömer Aktürk

Turkish Journal of Chemistry

Collagen type I is the main structural unit in skin tissue and is therefore used preferentially in skin tissue scaffolds. However, collagen-based 3D scaffolds have weak aqueous stability and degradation profiles in their uncross-linked states and chemical cross-linking reagents arise toxicity concerns, which generally restrict the spectrum of their biomedical applicability. Here, the research goal is to photochemically cross-link collagen type I with rose bengal (RB) when subjected to green laser light and to investigate the effect of silk sericin-capped gold nanoparticles (S-AuNP) when incorporated into scaffolds on the cross-linking process and thus on the scaffold properties. All the collagen …

Polymeric Nanoparticle-Based Electrochemical Sensor For The Detection Of Ca 125, Ceren Türkcan, Si̇nan Akgöl

Turkish Journal of Chemistry

In this paper, Cys-graft-p(HEMA) nanomaterials and a new electrochemical method were developed for determination of CA 125. Cys-graft-p(HEMA) nanomaterials were synthesized with emulsion polymerization method and modified with grafting procedure. It was determined that Cys-graft-p(HEMA) nanomaterials had 50 nm dimension and spherical morphology, and per gram polymeric material contained 0.011 mmol L-cysteine. Electrode surface was prepared step by step for electrochemical analysis with optimization process. Linear determination range was determined as 5-400 U/mL (R= 0.9935). Detection limit (LOD) was calculated as 1.87 U/mL, and quantification limit (LOQ) was determined as 5.62 U/mL. The fabricated sensor system showed good repeatability, accuracy, …

Carbon Quantum Dots And Chitosan-Based Heterogeneous Silver Catalyst For Reduction Of Nitroaromatic Compounds, Farah Sami̇r Sali̇m, İdri̇s Sargin, Gülşi̇n Arslan

Turkish Journal of Chemistry

Chitosan plays a crucial role in catalysis, environmental remediation, and sustainable chemistry as a renewable and cationic polysaccharide. Chitosan-based metal catalysts are used in a broad range of chemical transformations. In the study, carbon quantum dots (CQDs) were derived from Momordica charantia fruits by microwave irradiation following a green chemistry approach. Three catalysts were designed: Ag(0)-chitosan, Ag(0)-chitosan-M. charantia fruit powder, and Ag(0)-chitosan-CQDs. The catalyst supports were prepared by stabilizing CQDs or M. charantia powder within the polymeric matrix of chitosan beads. Metallic silver particles were anchored onto glutaraldehyde cross-linked chitosan beads from the aqueous solution of silver nitrate. The …

Synthesis And Kinetic Analysis Of Poly(N-Acryloylmorpholine) Brushes Via Surface Initiated Raft Polymerization, Esma Mutlutürk, Tuncer Çaykara

Turkish Journal of Chemistry

Polymer brushes are promising many applications as smart materials and biocompatible surfaces. Surface-initiated reversible addition-fragmentation chain transfer (RAFT) polymerization is one of the most effective techniques for synthesis of well-defined polymer brushes. Herein, a biocompatible, uniform and stable poly(N-acryloylmorpholine)-silicon hybrid system was achieved using surface-initiated RAFT polymerization. Evidence of a well-controlled surface-initiated RAFT polymerization was confirmed by a linear increase of number average molecular weight (M$_{n}$) with overall monomer conversions. Water contact angle, ellipsometry, X-ray photoelectron spectroscopy and atomic force microscopy verified the presence of poly(N-acryloylmorpholine) (poly(NAM)) on silicon wafers. The grafting density (σ) and the average distance between grafting …

Synthesis And Characterization Of Nicr$_{2}$O$_{3}$- Ceo$_{2nrs}$ Anode Electrocatalyst For Ethanol Electrooxidation Reaction In Alkaline Media, Emi̇ne Sena Kazan, Mahmut Rahi̇m Bayramoğlu

Turkish Journal of Chemistry

In this paper, ceria (CeO$_{2}$) nanorod (NR) supported Ni-Cr$_{2}$O$_{3}$ anode electrocatalysts were synthesized as nonnoble metalbased anode electrocatalysts for ethanol electrooxidation reaction (EOR) in alkaline media. Physicochemical characterization of the electrocatalysts was investigated by XRD, SEM, and TEM techniques. Electrochemical performances of the catalysts were investigated via cyclic voltammetry (CV), linear sweep voltammetry (LSV), and chronoamperometry (CA) techniques. The data from linear LSV were used for the diffusion coefficient of the electrocatalysts. The CA experiments' results showed the tolerance for catalytic poisoning and durability of the synthesized electrocatalysts.

Inclusion Complexes Of Squalene With Beta-Cyclodextrin And Methyl-Beta-Cyclodextrin: Preparation And Characterization, Anh Van Nguyen, Victor Ivanovic Deineka, Anh Thi Ngoc Vu, Tuan Dinh Le, Hieu Tran Trung, Tien Anh Nguyen

Turkish Journal of Chemistry

The present work aimed to investigate inclusion complexes of squalene with various cyclodextrins (native ß-cyclodextrin and methyl-ß-cyclodextrin). The production of squalene-ß-cyclodextrin inclusion complex was obtained using Response Surface Methodology and obtained inclusion complexes were studied with FTIR spectroscopy, X-ray diffractometry, thermal analysis, and 1H-NMR spectrometry. At the same time, squalene content was determined by reversed-phase high-performance liquid chromatography. All results confirmed that squalene was successfully involved in the cyclodextrin cavities. Optimizing the condition in preparation for the squalen-ß-cyclodextrin inclusion complex yielded 54.3% with squalene content of 9.01%. The essential difference for the inclusion complex of squalene with methylated beta-cyclodextrin was …

Additive-Free Synthesis Of Poly(N-Vinyl Pyrrolidone) And Poly(N-Isopropylacrylamide) Nanogels With Controlled Sizes, Semi̇ha Duygu Süteki̇n, Feyza Kiraç, Olgun Güven

Turkish Journal of Chemistry

An easy method is proposed to prepare poly(vinyl pyrrolidone) (PVP) and poly(N-isopropylacrylamide) (PNiPAAm) nanogels with sizes less than 100 nm. The underlying principle is to prepare dilute polymer solutions in acetone/water mixtures where acetone acts to break tridimensional structure of water hence disrupting the H-bonds bridging polymer coils causing separation and shrinkage in their sizes. Irradiation of these solutions by gamma-rays directly leads to the formation of intramolecular crosslinks within the coils resulting with nanogels with sizes smaller than precursor coils. While the average size of nanogels of PVP irradiated in water only is 236 nm, they were reduced to …

Synthesis Optimization Of Zro2 Nanostructures For Photocatalytic Applications, Fi̇li̇z Boran, Merve Okutan

Turkish Journal of Chemistry

This study aims to optimize the synthesis of semiconductor zirconia (ZrO2) nanoparticles for future photocatalytic applications in degradation of pollutants in wastewater under ultraviolet (UV) light. The synthesis procedure of ZrO2 nanoparticles was optimized by examining the effects of synthesis methods (ultrasound-assisted, hydrothermal method in an autoclave and conventional precipitation), reaction time (2, 6, 10, and 18 h), ambient pH (3, 7, 10, 13), and surfactant type (anionic, cationic, and non-ionic), on the particle size and crystal phase of the nanomaterial. The characterization of the synthesized samples was performed by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), energy-dispersive X-ray …

In Vitro Tyrosinase Inhibitory, Dna Interaction Studies, And Lc?Hrms Analysis Of Ficus Carica Leaves, Güli̇n Renda, Burak Barut, Rümeysa Ceren, Enes Aydin

Turkish Journal of Chemistry

Turkey is the world?s leading producer of figs, a typical Mediterranean fruit. The fig, Ficus carica L. (Moraceae), has been widely cultivated since ancient times due to the nutritional value of its fruits. It was aimed to investigate the phytochemical characterization and biological properties of F. carica leaf extracts in order to determine their potential for use in the treatment of various diseases. F. carica leaves were extracted in 70% methanol at 40 °C under reflux. To obtain extracts of different polarities, the crude extract was fractionated with n-hexane, dichloromethane, and n-butanol. Phenolic content was determined using liquid chromatography?high resolution …

New Pyrimidine-N-Ss-D-Glucosides: Synthesis, Biological Evaluation, And Molecular Docking Investigations, Nuran Kahri̇man, Kivanç Peker, Vi̇ldan Serdaroğlu, Ali̇ Aydin, Burçi̇n Türkmenoğlu, Asu Usta, Nuretti̇n Yayli

Turkish Journal of Chemistry

In this study, syntheses of new pyrimidine-coupled N-ß-glucosides and tetra-O-acetyl derivatives were carried out. All glycoconjugates were investigated in comparison with known chemotherapeutic agents in terms of their antimicrobial and anticancer functions and DNA/protein binding affinities. Spectral data showed that all glycoside derivatives were obtained by diastereoselectivity as ß-anomers. Both tested groups exhibited strong antiproliferative activity (2.29?66.84 ?g/mL), but some of them had sufficiently ideal % cytotoxicity values (10.01%?16.78%). And also all synthetic compounds exhibited remarkable antibacterial activity against human pathogenic bacteria. Binding of these compounds to CT-DNA resulted in significant changes in spectral properties, consistent with groove binding. Molecular …