Chemistry Commons^™

Biosensors Derived From Copolymers Of Vinylferrocene With Various Para Substituted Phenylmaleimides, Nawrah Alghamdi, Ashlyn Conner, Charles J. Neef

Poster Presentations

Smart Parking Lot is a product that allows the user to know how many parking spots are avail- able and where that parking is located. The Smart Parking Lot provides convenience and flexibility to the student efficient parking. People may spend a long time looking for parking that may or may not be available. This project allows drivers to avoid this annoyance by displaying how many parking spots are available at the lot entrance. There will be an application for a cell phone that provides the availability of parking before checking arrival.

Effect Of Surfactant On Stuctural And Electrochemical Properties Of Nickel Oxide, Muidh Albalawi, Ram Krishna Gupta

Poster Presentations

The increasing demand for energy in the world led to focus on more efficient energy storage devices. Energy can be stored in various kind of devices such as batteries, capacitors and fuel cells. Among them, supercapacitors are very attractive due to their high power densities, fast charge-discharge behavior and long life cycles. They can be used in hybrid cars and devices where high-power delivery is required. The objective of this work is to study the effect of morphology of nickel oxide on their electrochemical properties. The morphology of nickel oxide was modified using various surfactants. Structural characterization performed using scanning …

The Morphology Of Atmospheric Aerosol And Some Implications, Claudio Mazzoleni, Swarup China, Barbara Scarnato, Noopur Sharma, Janarjan Bhandari, Lynn Mazzoleni, Paulo Fialho, Cristina Facchini, Stefano Decesari, Stefania Gilardoni, Nicola Zanca

Department of Chemistry Publications

The morphology of individual atmospheric particles, including their mixing state, shape and internal structure, can have important atmospheric implications. Understanding the mechanisms leading to specific morphologies, the role of morphology in different atmospheric processes, and accounting for these details in models present considerable challenges. Several approaches are currently underway to make progress toward the resolution of these difficulties; for example, development and deployment of improved single particle analytical and observational tools, use of accurate electromagnetic models to quantitatively predict the interactions of solar radiation with single complex particles, and particle resolved models. In this presentation we will present single particle …

Analysis Of Scientific Argumentation In Two Physical Chemistry Classrooms Using The Pogil Approach, Alena C. Moon

Open Access Dissertations

The benefits of facilitating argumentation in science education have been well reported (Jimenez-Aleixandre & Erduran, 2007). Engaging in argumentation has shown to model authentic scientific inquiry as well as promote development of content knowledge. However, less emphasis has been placed on facilitating argumentation in upper level undergraduate courses, though it is important for evaluating undergraduate curricula to characterize upper level students’ scientific reasoning. This work considers two implementations of the POGIL physical chemistry curriculum and evaluates the classroom argumentation. The researchers aimed to consider the content of the arguments and dialectical features characteristic of socially constructed arguments (Nielson, 2013). To …

The Coastal Monitor: Vol. 1, No. 2, John Tanacredi Ph.D.

The Coastal Monitor

At a recent event a colleague asked me, “So what do you do at CERCOM?” My immediate response was the “M” word fundamentally! After 45 years involved in environmental sciences, monitoring remains the most important and critical aspect of not only any field station in support of the academics conducted, but the seminal responsibility to be able, as a scientist, to reveal trends in the massive volume of data collected through routine monitoring exercises. It is extremely rare for a single data point, or even a single season of data, no matter how accurate the individual data point is, to …

Analysis Of Linoleic Acid Peroxidation Products By Gc/Ms, Joy Nyaanga

Celebration of Scholarship 2012-2017

This project utilized gas chromatography – mass spectrometry (GC-MS) to analyze the lipid peroxidation products of linoleic acid, an essential ω-6 fatty acid, and its reaction with oxygen. Optimum reaction conditions were identified by testing various combinations of variables: buffer, pH, oxidant, and time. With treatment of optimum conditions, several products were identified including, 2,4-decadienal, 4-hydroxy-2-nonenal (HNE), and 4-oxo-2-nonenal (ONE). The mechanisms behind the formation of these products have been proposed by several researchers. It was identified that varying oxidant concentration, pH, or time greatly impacted the obtained concentrations of final oxidation products. Additionally, beta-carotene and Vitamin E were tested …

Fabrication Of Nanofibers Of Metal Oxides For Energy Storage Applications, Sara Alkhalaf, Ram Krishna Gupta

Poster Presentations

Nanostructured materials have attracted considerable research interest for their applications as catalyst, energy storage, fuel cells, etc. The main objective of this work is to synthesize and characterize nanofibers of metal oxides using electrospun technique and use them for energy storage applications. Various metal oxides such as NiMn2O4, CoMn2O4 and ZnMn2O4 were prepared as 1 dimensional (1-D) architecture using processable polymers and metal salts. The synthesized nanofibers were structurally and electrochemically characterized. The supercapacitive performance of these nanofibers was examined using cyclic voltammetry (CV) and galvanostatic charge-discharge techniques. The CoMn2O4 nanofibers showed a promising value of ~ 120 F/g in …

Proposed Mechanism Of Alzheimer’S Disease: The Role Of Oxidative Stress A Review Of Scientific Literature, Alicia Monahan

Senior Honors Projects

Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder that has become the sixth leading cause of death in the United States. The most notable neuropathological hallmarks of AD are the accelerated accumulation of β-amyloid deposits around neurons and the accumulation of neurofibrillary tangles (NFT) within neurons. These abnormalities block proteasome function, inhibit mitochondrial function, alter biometal levels, stimulate inflammatory processes, disrupt synaptic communication, and ultimately result in cell death. Mitochondrial dysfunction has been cited as an underlying cause of AD pathologies, specifically by enhancing the production and accumulation of β-amyloid. Once the β-amyloid oligomers form, they disrupt the Ca^{2+ …}

Undergraduate Students' Goals For Chemistry Laboratory Coursework, Brittland K. Dekorver

Open Access Dissertations

Chemistry laboratory coursework has the potential to offer many benefits to students, yet few of these learning goals are realized in practice. Therefore, this study seeks to characterize undergraduate students’ learning goals for their chemistry laboratory coursework. Data were collected by recording video of students completing laboratory experiments and conducting interviews with the students about their experiences that were analyzed utilizing the frameworks of Human Constructivism and Self-Regulated Learning. A cross-sectional sampling of students allowed comparisons to be made among students with varying levels of chemistry experience and interest in chemistry. The student goals identified by this study were compared …

Advances In Solid Phase Microextraction For The Analysis Of Volatile Compounds In Explosives, Tire Treatments, And Entomological Specimens, William D. Kranz

Open Access Dissertations

Solid phase microextraction is a powerful and versatile technique, well-suited to the analysis of numerous samples of forensic interest. The exceptional sensitivity of the SPME platform, combined with its adaptability to traditional GC-MS systems and its ability to extract samples with minimal work-up, make it appropriate to applications in forensic laboratories.

In a series of research projects, solid phase microextraction was employed for the analysis of explosives, commercial tire treatments, and entomological specimens. In the first project, the volatile organic compounds emanating from two brands of pseudo-explosive training aids for use in detector dog imprinting were determined by SPME-GC-MS, and …

Development Of A Kinetic Model For The Transesterification Of Glycerol Fatty Acid Triesters Using 1H (1d And 2d) Nmr, Leonard W. Sprague

Honors Program Theses and Projects

Fossil fuels dating back to the first coal mine dug from the Earth have been vital to society’s advances, but have come at a significant cost. Rise in pollutants such as CO2 and particulate matter due to combustion byproducts of these fuels (coal, oil, gasoline, diesel) continue to negatively impact the environment, harming various ecosystems by disrupting precarious balances. Attempts have been made to “clean” fossil fuels, but only to temporary degrees of success. Alternative energy sources such as solar, wind, or hydroelectric are increasing in viability, but are often a difficult transition for fossil fuel reliant individuals. Biodiesel (Fatty …

Synthesis And Characterization Of Organic-Inorganic Hybrid Materials For Thermoelectric Devices, Paige M. Huzyak

Masters Theses & Specialist Projects

The development of organic-inorganic hybrid materials is of great interest in thermoelectrics for its potential to combine the desirable characteristics of both classes of materials. Thermoelectric materials must combine low thermal conductivity with high electrical conductivity, but in most materials, thermal and electrical conductivity are closely related and positively correlated. By combining the low thermal conductivity, flexibility, facile processing, and low cost of organic components with the high electrical conductivity and stability of inorganic components, materials with beneficial thermoelectric properties may be realized.

Here, we describe the synthesis and characterization of anthracene-containing organic-inorganic hybrid materials for thermoelectric purposes. Specifically, POSS-ANT …

Colloidal Self-Assembly Of Multi-Fluorescent Silsesquioxane Microparticles, Niharika Neerudu Sreeramulu

Masters Theses & Specialist Projects

Self-assembly of colloidal microparticles is one of the strategies for making characteristic patterns. These versatile self-assemblies provide a route to elevate the efficiency of an electronic device. Silsesquioxane particles with various functionalities were synthesized by a modified Stöber condensation method. This thesis describes the synthesis of benzylchloride silsesquioxanes, benzylchloride-amine silsesquioxanes and amine-functionalized silsesquioxane particles with multi-fluorescent tags. The size and morphology of the particles were controlled by varying the concentration of base and anhydrous ethanol (solvent). The size distribution of particles was controlled by adjusting the molar ratios of organotrialkoxy silane, base, and ethanol concentrations. Through selective post-functionalization with fused …

Visible-Light-Responsible Co-Catalysts Enhanced By Graphene For Solar Energy Harvesting, Chen Ying

Masters Theses & Specialist Projects

This study focuses on the visible light response of hetero-structures of TiO2-graphene- MoS2 for solar energy harvestings. The commercial P25 TiO2 nano-particles, and selfprepared layered reduced graphene oxides (RG) and MoS2 were assembled for the targeted hetero-structure materials as visible-light responsible solar harvesting cocatalysts. The hydrothermal method was applied for nano-material synthesis, the reduction of graphene oxides, and bonding formation. Multiple characterization methods (SEM-TEM, XRD, XPS, UV-VIS, PL, FT-IR, TGA) have been applied to understand the electron-hole pair separation and recombination, and performance tuning in their visible-light photo-catalysis rhodamine B (Rh.B) degradations process

Compared to TiO2, an obvious red shift …

Synthetic And Mechanistic Studies Of Ruthenium Catalyzed C-C And C-O Bond Activation Reactions, Junghwa Kim

Dissertations (1934 -)

Etherification of alcohols is one of the most fundamental transformations in organic synthesis. Williamson ether synthesis is the most well-known synthetic method of unsymmetrical ether synthesis which is still being used in both industrial and academic laboratories. We have developed a novel catalytic etherification reaction using two different alcohols by using a well-defined cationic ruthenium catalyst. The reaction scope as well as the mechanistic study of the reaction are described.Hydroacylation is considered to be a powerful synthetic transformation for producing functionalized ketones from relatively simple olefin substrates. Despite remarkable progress in intra and intermolecular hydroacylations, the substrate scope of the …

Binding Of Oxaliplatin And Its Analogs With Dna Nucleotides At Variable Ph And Concentration Levels, Rippa Sehgal

Masters Theses & Specialist Projects

Oxaliplatin is one of the three FDA-approved platinum anticancer drugs and considered a third generation drug, discovered after the first generation drug cisplatin and second generation drug carboplatin. It is known to react with proteins and DNA nucleotides in the body. Reaction with DNA occurs primarily at guanosine residues and secondarily at adenine residues for oxaliplatin and other platinum drugs. We have previously studied oxaliplatin and an analog with additional steric hindrance in the amine ligand and found that the analog had different reactivity with methionine. Now, we have prepared oxaliplatin and its three analogs Pt(Me2dach)(ox), Pt(en)(ox) and Pt(Me4en)(ox) and …

Enhancing The Photovoltaic Efficiency Of A Bulk Heterojunction Organic Solar Cell, Swapnil Ashok Sahare

Masters Theses & Specialist Projects

Active layer morphology of polymer-based solar cells plays an important role in improving power conversion efficiency (PCE). In this thesis, the focus is to improve the device efficiency of polymer-based solar cells. In the first objective, active layer morphology of polymer-solar cells was optimized though a novel solvent annealing technique. The second objective was to explore the possibility of replacing the highly sensitive aluminum cathode layer with a low-cost and stable alternative, copper metal. Large scale manufacturing of these solar cells is also explored using roll-to-roll printing techniques.

Poly (3-hexylthiophene) (P3HT) and phenyl-C61-butyric acid methyl (PCBM) were used as the …

Polyglutamine Aggregates Impair Lipid Membrane Integrity And Enhance Lipid Membrane Rigidity, Chian Sing Ho, Nawal K. Khadka, Fengyu She, Jianfeng Cai, Jianjun Pan

Physics Faculty Publications

Lipid membranes are suggested as the primary target of amyloid aggregates. We study aggregates formed by a polyglutamine (polyQ) peptide, and their disruptive effect on lipid membranes. Using solution atomic force microscopy (AFM), we observe polyQ oligomers coexisting with short fibrils, which have a twisted morphology that likely corresponds to two intertwined oligomer strings. Fourier transform infrared spectroscopy reveals that the content of β-sheet enriched aggregates increases with incubation time. Using fluorescence microscopy, we find that exposure to polyQ aggregates results in deflated morphology of giant unilamellar vesicles. PolyQ aggregates induced membrane disruption is further substantiated by time-dependent calcein leakage …

Investigation Of The Interactions Between Pt(Ii) And Pd(Ii) Derivatives Of 5,10,15,20-Tetrakis (N-Methyl-4-Pyridyl) Porphyrin And G-Quadruplex Dna, Navin C. Sabharwal , '14, O. Mendoza, John Michael Nicoludis , '12, Thomas Ruan , '16, J.-L. Mergny, Liliya A. Yatsunyk

Chemistry & Biochemistry Faculty Works

G-quadruplexes are non-canonical DNA structures formed by guanine-rich DNA sequences that are implicated in cancer and aging. Understanding how small molecule ligands interact with quadruplexes is essential both to the development of novel anticancer therapeutics and to the design of new quadruplex-selective probes needed for elucidation of quadruplex biological functions. In this work, UV–visible, fluorescence, and circular dichroism spectroscopies, fluorescence resonance energy transfer (FRET) melting assays, and resonance light scattering were used to investigate how the Pt(II) and Pd(II) derivatives of the well-studied 5,10,15,20-tetrakis(N-methyl-4-pyridyl)porphyrin (TMPyP4) interact with quadruplexes formed by the human telomeric DNA, Tel22, and by the G-rich sequences …

Mutlifunctional Platforms For Gene And Drug Delivery For Cancer Therapy, Jeffery J. Ambrose Jr.

Doctoral Dissertations

The National Cancer Institute and the American Cancer Society estimate that 1.6 million new cancer incidences and over half a million cancer related deaths occur annually [1][2]. Cancer the second most common cause of death in the United States [1], [2]. Although the causes of cancer can vary depending on cell type, all or almost all instances of cancer arise from a mutation or from an abnormal activation of the cellular genes that control cell growth and mitosis [3].

Treatment of a given cancer type depends on the subtype, stage and progression of the cancer. Varieties of cancer therapy include …

Folate-Peg-Histidine For Use In Detection, Capture, And Analysis Of Fr+ Cells, Sean Dwyer

All Capstone Projects

Folate receptor alpha is a membrane-bound protein displaying high affinity for folic acid. This receptor serves as a receptor-mediated transport system of folic acid into cancer and cells associated with inflammation (e.g., macrophages). Folate is a basic component of cell metabolism in both the synthesis of DNA and proteins, which is hypothesized to be necessary for maintaining adequate processes during increased metabolic demand. Interestingly, most normal cells in the body have little or no high affinity folate receptor alpha. Based on these attributes, folate based drug delivery, imaging systems, and diagnostic systems are in several stages of development worldwide. To …

Feasibility Study Of Waste Isolation And Characterization By Instrumental Methods, Janith A. Wiehe-Wazio

All Capstone Projects

The original focus of this project was to develop an in house procedure for the recovery of commonly used science laboratory solvents consisting of Acetone, Ethyl (Ethanol) Alcohol, Hexane, Methanol and Hydrochloric Acid from everyday laboratory waste. However, the projects scope shifted a little further back to basics when it was discovered that Laboratory Waste Safety and Accounting practices were insufficient. It was assumed that identification of waste products was being recorded accurately. It became apparent with the very first waste bottle analysis that chemicals recorded on the standardized waste log sheets were not always what was in the waste …

Binary Metal Oxides Based On Fe (Iii) And Ti (Iv) As Efficient Catalysts For Total Oxidation Of Volatile Organic Compound Pollutants, Said Abdullah Sulaiman Almamari

Theses

Fe (III)-modified Titania and Fe (III)-Ti (IV) binary oxides have received much less attention as possible catalysts compared to their parent single-metal oxides, Fe₂O₃ and TiO₂. This could be due to the difficulty of obtaining pure desired monophases. In addition, the effect of different preparative conditions on the textural properties of sol-gel-prepared Ti-Fe mixed oxides was rarely studied. Furthermore, the effect of the composition on the reducibility and the catalytic activity of these composites was never studied. In the present work, Ti-Fe mixed oxides were prepared using a modified sol-gel method and their textural properties …

A 1-D Coordination Polymer Route To Catalytically Active Co@C Nanoparticles, Anand Pariyar, Siddharth Gopalakrishnan, Joseph Stansbery, Rajankumar L. Patel, Xinhua Liang, Nikolay Nikolaevich Gerasimchuk, Amitava Choudhury

Chemistry Faculty Research & Creative Works

Pyrolysis of a 1-D polymeric cobalt(ii) coordination complex ([Co(BDC)(Mim)₂]_n, H₂BDC = benzenedicarboxylic acid; Mim = N-methylimidazole) results in the formation of carbon embedded fcc cobalt nanoparticle composites, Co@C. The as-prepared Co@C shows an agglomerated secondary structure with a highly embedded carbon shell comprising of cobalt nanoparticles of 20-100 nm. These Co@C particles show excellent catalytic activity in the reduction of nitrophenol to aminophenol, studied as a model reaction, and evolves as a promising candidate for the gas phase reduction process.

Mechanistic Binding Insights For 1-Deoxy-D-Xylulose-5-Phosphatesynthase, The Enzyme Catalyzing The First Reaction Of Isoprenoid Biosynthesis In The Malaria-Causing Protists, Plasmodium Falciparum And Plasmodium Vivax, Matthew R. Battistini, Christopher Shoji, Sumit Handa, Leonid Breydo, David J. Merkler

Chemistry Faculty Publications

We have successfully truncated and recombinantly-expressed 1-deoxy-D-xylulose-5-phosphate synthase (DXS) from both Plasmodium vivax and Plasmodium falciparum. We elucidated the order of substrate binding for both of these ThDP-dependent enzymes using steady-state kinetic analyses, dead-end inhibition, and intrinsic tryptophan fluorescence titrations. Both enzymes adhere to a random sequential mechanism with respect to binding of both substrates: pyruvate and D-glyceraldehyde-3-phosphate. These findings are in contrast to other ThDP-dependent enzymes, which exhibit classical ordered and/or ping-pong kinetic mechanisms. A better understanding of the kinetic mechanism for these two Plasmodial enzymes could aid in the development of novel DXS-specific inhibitors that might prove useful …

Low-Temperature Artificial Maturation Studies Of Type Ii And Type Iii Kerogens: Implications For Biogenic Gas Production, Albert Willy Nguena Kamga

Chemistry & Biochemistry Theses & Dissertations

Ancient organic matter (OM) in shales and coals, known mainly as Type II and Type III OM are known to produce both biogenic, thermogenic gas and oil. In this dissertation, mild artificial maturation, via closed system pyrolysis, is employed to determine the thermal reactivity of Type II and Type III OM beyond diagenesis. We select three Type II kerogens: i) Type II kerogen isolated from recent cores (3.3 Ma, Ro = 0.28) recovered from an upwelling basin in Namibia, Africa referred to as ODP Sediment, ii) Type II-S isolated from sediments (150 Ma, Ro = 0.38) recovered from an outcrop …

Ferrocene Incorporated Into Polyurethanes For Improved Flame-Retardant Properties, Michael Giffin

Electronic Theses & Dissertations

Flame retardant polyurethanes are needed for various commercial and industrial applications; toward that end ferrocene derivatives with multiple hydroxyl groups were synthesized for incorporation into polyurethane thin films for testing. The derivatives synthesized were 2,3-dihydroxypropyl ferrocene carboxylate and di-(2,3-dihydroxypropyl) ferrocene 1-1’-dicarboxylate, which are a diol and a diol, respectively. These compounds were characterized using FT-IR spectroscopy, 1H-NMR and 13C-NMR spectroscopy. These derivatives were incorporated into a commercially available polyol mixture at various weight percentages, mixed with methylene diphenyl diisocyanate, and cast as thin films on glass plates. Each film was tested for flame retardance using a standard burn test chamber …

Principles Of Chemistry I (University Of North Georgia), Jim Konzelman, Greta Giles

Chemistry Grants Collections

This Grants Collection for Principles of Chemistry I was created under a Round Two ALG Textbook Transformation Grant. It contains materials used within the implementation of OpenStax Chemistry and uses the Open Course Principles of Chemistry I from the University of North Georgia.

Affordable Learning Georgia Grants Collections are intended to provide faculty with the frameworks to quickly implement or revise the same materials as a Textbook Transformation Grants team, along with the aims and lessons learned from project teams during the implementation process.

Documents are in .pdf format, with a separate .docx (Word) version available for download. Each …

Survey Of Chemistry Ii, Jonathan Cannon, Estelle Nuckels, Renat Khatmullin, Andrew Lauer

Chemistry Grants Collections

This Grants Collection uses the grant-supported open wiki textbook Survey of Chemistry II from Middle Georgia State University:

http://oer.galileo.usg.edu/chemistry-textbooks/1/

This Grants Collection for Survey of Chemistry II was created under a Round Two ALG Textbook Transformation Grant.

Affordable Learning Georgia Grants Collections are intended to provide faculty with the frameworks to quickly implement or revise the same materials as a Textbook Transformation Grants team, along with the aims and lessons learned from project teams during the implementation process.

Documents are in .pdf format, with a separate .docx (Word) version available for download. Each collection contains the following materials:

• Linked …

Survey Of Chemistry I, Jonathan Cannon, Estelle Nuckels, Renat Khatmullin, Andrew Lauer

Chemistry Grants Collections

This Grants Collection for Survey of Chemistry I was created under a Round Two ALG Textbook Transformation Grant.

Affordable Learning Georgia Grants Collections are intended to provide faculty with the frameworks to quickly implement or revise the same materials as a Textbook Transformation Grants team, along with the aims and lessons learned from project teams during the implementation process.

Documents are in .pdf format, with a separate .docx (Word) version available for download. Each collection contains the following materials:

• Linked Syllabus
• Initial Proposal
• Final Report