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2013

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Articles 931 - 960 of 1354

Full-Text Articles in Chemistry

Ruthenium(Ii) Polypyridyl Complexes As Potential Anticancer Drugs: Synthesis, Characterization, Cell Permeability And Localization, Yanling Chen Jan 2013

Ruthenium(Ii) Polypyridyl Complexes As Potential Anticancer Drugs: Synthesis, Characterization, Cell Permeability And Localization, Yanling Chen

Chemistry & Biochemistry Theses - Archive

Research on biological activities of ruthenium polypyridyl complexes (RPCs) continues to attract interest as these complexes have shown promising anticancer activity both in vitro and in vivo.¹⁻³ The mononuclear RPC, [(phen)₂Ru(tatpp)]²⁺ (MP) and related dinuclear complex [(phen)₂Ru(tatpp)Ru(phen)₂]⁴⁺ (P) have been shown to both intercalate with DNA and shown potentiated DNA cleavage under anaerobic and reducing conditions⁴⁻⁵, as well as shown good selectivity and cytotoxicity towards malignant cell lines in vitro and tumors in vivo.⁵ Both complexes contain the redox-active tatpp ligand which is thought to be an essential component for the observed biological activities. This thesis is focused on developing …

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Development Of New Stationary Phases And Their Applications In High Performance Liquid Chromatography, Haixiao Qiu Jan 2013

Development Of New Stationary Phases And Their Applications In High Performance Liquid Chromatography, Haixiao Qiu

Chemistry & Biochemistry Dissertations - Archive

High performance liquid chromatography (HPLC) has proven to be the most widely applicable and versatile technique in separation science. Hydrophilic interaction liquid chromatography (HILIC) has attracted considerable interest and has become a viable option for the separation of polar compounds. Chirality is another major concern in the modern pharmaceutical industry for two reasons: 1). the majority of bio-organic molecules are chiral; 2). enantiomers of a racemic drug may often exhibit different biological activities, pharmacokinetics, and toxicities. The field of enantiomeric separations has reached a clear level of maturity after approximately 30 years of development. However, with the continued emphasis on …

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Examining Ruthenium Chromophores For The Photochemical Reduction Of Co₂To Methanol, David J. Boston Jan 2013

Examining Ruthenium Chromophores For The Photochemical Reduction Of Co₂To Methanol, David J. Boston

Chemistry & Biochemistry Dissertations - Archive

Our consumption of energy for transportation and electricity has been growing as quickly as our population. As this demand for energy increases we increase our production of carbon dioxide by the burning of fossil fuels to try and meet this increasing demand. A sustainable method to convert carbon dioxide (CO₂) to a viable liquid fuel is one potential way in which both the increasing energy demand and increasing CO₂ concentration issues can both be helped. Currently such methods being investigated include thermal, electrochemical, and photochemical processes. Because thermal conversion is not an ideal situation because of the requirement of strong …

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The Use Of Supercritical Fluid Chromatography (Sfc) And Liquid Chromatography (Lc) For The Separation Of Pharmaceutical Products, Natural Products And Chiral Phosphoric And Sulfonic Acids, Jonathan Paul Smuts Jan 2013

The Use Of Supercritical Fluid Chromatography (Sfc) And Liquid Chromatography (Lc) For The Separation Of Pharmaceutical Products, Natural Products And Chiral Phosphoric And Sulfonic Acids, Jonathan Paul Smuts

Chemistry & Biochemistry Dissertations - Archive

This dissertation focuses on two chromatographic techniques, supercritical fluid chromatography (SFC) and high performance liquid chromatography (HPLC). The goal of the SFC work is to describe the synthesis of new stationary phases based upon ionic liquids and to discuss their application to the separation of pharmaceutical compounds. The tunable nature of immobilized ionic liquids will be demonstrated by the variation of the cation-anion combination.The goal of the remaining chapters is to demonstrate HPLC applications for analyzing natural products and for performing enantiomeric separations. The usefulness of HPLC in separating antioxidants in rosemary and in conducting a degradation study of the …

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Diffusion Of Vitamin B12 Across A Mesoporous Metal Organic Framework, Veronica Valencia Jan 2013

Diffusion Of Vitamin B12 Across A Mesoporous Metal Organic Framework, Veronica Valencia

Undergraduate Journal of Mathematical Modeling: One + Two

We measure the rate of uptake and the rate of release of a Vitamin B12 solution (dissolved in water) at 2 different temperatures (room temperature and 37°C) by the mesoporous metal organic framework TbMOF-100 at 1-hour intervals using a spectrophotometer. Using the Beer-Lambert law, we calculate the concentration of the stock solution based on the absorbance values obtained with the spectrophotometer. These values allow for the quantification of the initial rate of uptake and the rate of uptake at a random incubation time of the Vitamin B12 by the TbMOF-100. We also calculate the value of the coefficient of diffusion …

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Study Of Dieldrin In Coralville Reservoir, Jeremy Smith Jan 2013

Study Of Dieldrin In Coralville Reservoir, Jeremy Smith

Undergraduate Journal of Mathematical Modeling: One + Two

Using existing experimental data taken over a period of roughly 12 years that documents the concentrations of dieldrin levels in the environment and fatty tissue of the fish, we construct a model of the total dieldrin concentration decline. Comparisons between the experimental data and speculative data can be made using calculus and elements of statistics in order to better understand the movement of dieldrin in the reservoir. Because of the potentially harmful exposure effects of dieldrin to humans as well as the environment, it is important to be able to predict when stability has been restored to the ecosystem.

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The Use Of Molecular Dynamics To Predict The Stability Of Squaraine Rotaxanes, Ruth Nelson, Jeffrey Baumes, Richard D. Connell, Ivan Murgu, Allen Oliver, Bradley Smith, Andrew Johnson Jan 2013

The Use Of Molecular Dynamics To Predict The Stability Of Squaraine Rotaxanes, Ruth Nelson, Jeffrey Baumes, Richard D. Connell, Ivan Murgu, Allen Oliver, Bradley Smith, Andrew Johnson

CUP Undergraduate Research

Squaraine rotaxanes are fluorescent molecules comprised of two parts—a dumbbell-shaped squaraine dye threaded through a ring-shaped macrocycle—that are held together by hydrogen bonding, hydrophobic effects, and the size of the opening in the macrocycle1. Since the squaraine is an extremely electrophilic species3, nucleophilic attack by water is possible when it slips out of the macrocycle. This results in a loss of fluorescence. These near-IR dyes have many applications, including effective labeling of bacterial cells4. Previous studies have shown that the unprotected squaraine dye is unstable, and the adamantyl rotaxane degrades over time while the isophthalamidyl and pyridinyl rotaxanes remain stable2(Fig. …

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2013 Ii Cu Suri (Common Poster), Vanessa Selimovic, Loriann Reese, Ruthie Nelson, Emma Sleeman, Hibery Ho, Maria Polozova Jan 2013

2013 Ii Cu Suri (Common Poster), Vanessa Selimovic, Loriann Reese, Ruthie Nelson, Emma Sleeman, Hibery Ho, Maria Polozova

CUP Undergraduate Research

A common poster providing information for several research projects: aerosol particles, deoxycytidine kinase, squaraine rotaxanes, glycol nucleic acied, and Kombucha.

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Uv And Visible Light Activated Tio2 Photocatalysis Of 6-Hydroxymethyluracil, A Model Compound For The Potent Cyanotoxin Cylindrospermopsin, Cen Zhao, Miquel Pelaez, Dionysios Dionysiou, Suresh Pillai, John Byrne, Kevin O'Shea Jan 2013

Uv And Visible Light Activated Tio2 Photocatalysis Of 6-Hydroxymethyluracil, A Model Compound For The Potent Cyanotoxin Cylindrospermopsin, Cen Zhao, Miquel Pelaez, Dionysios Dionysiou, Suresh Pillai, John Byrne, Kevin O'Shea

Articles

TiO2 photocatalyses of 6-hydroxymethyl uracil (6-HOMU) a model compound for the potent cyanotoxin, cylindrospermopsin (CYN), were carried out employing visible and UV irradiation using different non-metal doped TiO2 materials, nitrogen and fluorine-TiO2 (NF-TiO2), phosphorus and fluorine-TiO2 (PF-TiO2) and sulfur-TiO2 (S-TiO2). The model compound was readily degraded under UV TiO2 photocatalysis with pseudo-first-order rate constants (k) of 2.1, 1.0, and 0.44 h−1 for NF-TiO2, PF-TiO2 and S-TiO2, respectively. Under visible light activated (VLA), NF-TiO2 was the most active photocatalyst, PF-TiO …

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Lithium-Ion Batteries, Aaron Reed Jan 2013

Lithium-Ion Batteries, Aaron Reed

Natural Sciences Student Research Presentations

Summarizes the history of lithium-ion batteries, and their uses. This is a project for the Natural Sciences Poster Session at Parkland College.

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Drug Delivery Via Nanoparticles, Laura Ward Jan 2013

Drug Delivery Via Nanoparticles, Laura Ward

Natural Sciences Student Research Presentations

Much research is being conducted to investigate the potential use of nanoparticles as an efficient drug delivery system. Important characteristics of nanoparticles that affect how they interact with biological systems include size, composition ,surface characteristics and shape. One of the many potential medical uses of nanoparticles is targeted drug delivery; nanoparticles have the potential to deliver concentrated amounts of medication to select areas of the body, reducing toxic effects in healthy areas of the body.

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Lyrica, Shannon Hayward Jan 2013

Lyrica, Shannon Hayward

Natural Sciences Student Research Presentations

Illustrates the chemical components of Lyrica, a pain management medication.

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Chlomid, Niki Smith Jan 2013

Chlomid, Niki Smith

Natural Sciences Student Research Presentations

This poster details the use of Clomid and provides a chemical analysis.

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Polymers And Cement?, Randee Newsom Jan 2013

Polymers And Cement?, Randee Newsom

Natural Sciences Student Research Presentations

Identifies the improvements made to modern cement by adding polymers. This is a project for the Natural Sciences Poster Session at Parkland College.

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Cymbalta, Ryann S. Elder Jan 2013

Cymbalta, Ryann S. Elder

Natural Sciences Student Research Presentations

Poster outlines the chemical make-up and uses of Cymbalta (Duloxetine Hydrochloride) which is used to treat major depression, generalized anxiety, fibromyalgia, and diabetic neuropathy. This is a project for the Natural Sciences Poster Session at Parkland College.

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Xenical, Megan Brown Jan 2013

Xenical, Megan Brown

Natural Sciences Student Research Presentations

Poster outlines the chemical make-up and uses of the weight loss drug, Xenical. This is a project for the Natural Sciences Poster Session at Parkland College.

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Multi-Dimentional Use Of Mri For Optimizing Reactions In Industries, Vyanti Sagram Jan 2013

Multi-Dimentional Use Of Mri For Optimizing Reactions In Industries, Vyanti Sagram

Natural Sciences Student Research Presentations

MRI Imaging has been used for many years and in a wide variety of industries. Recently. another application of MRI has been discovered by chemists. This research in MRI, a major step toward bridging the gap between laboratory studies and industrial catalysts, could help improve the design and environmental impact of catalytic reactors. This is a project for the Natural Sciences Poster Session at Parkland College.

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Effects Of Iodine On Radioactive Treatment, Jun Ho Park Jan 2013

Effects Of Iodine On Radioactive Treatment, Jun Ho Park

Natural Sciences Student Research Presentations

This poster investigates the causes and treatments of radioactive exposure and the diseases that follow and outlines how Iodine plays an effective treatment. Focuses on a specific isotope of Iodine, I-131, investigating its effects and uses in radioactive activity and treatment. This is a project for the Natural Sciences Poster Session at Parkland College.

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Testosterone Use And Effects, Brandon Mills Jan 2013

Testosterone Use And Effects, Brandon Mills

Natural Sciences Student Research Presentations

Summarizes the chemical make-up, medical applications and side effects for the steroidal hormone Testosterone. This is a project for the Natural Sciences Poster Session at Parkland College.

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Levothyroxine, Vanessa Powell Jan 2013

Levothyroxine, Vanessa Powell

Natural Sciences Student Research Presentations

Poster outlines the chemical make-up and uses of the thyroid medication, Levothyroxine. This is a project for the Natural Sciences Poster Session at Parkland College.

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Hideki Shirakawa: Synthesized Counductive Polymers, Erika Rosenberger Jan 2013

Hideki Shirakawa: Synthesized Counductive Polymers, Erika Rosenberger

Natural Sciences Student Research Presentations

Hideki Shirakawa discovered how to create polyacteylene thin films by accidentally adding extra Zieglar-Natta catalyst. this led him to discovering conductive polymers by using a technique called chemical doping, which oxydizes polyacetylene. This is a project for the Natural Sciences Poster Session at Parkland College.

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Synthesis And Evaluation Of Some 17-Acetamidoandrostane And N,N-Dimethyl-7-Deoxycholic Amide Derivatives As Cytotoxic Agents: Structure/Activity Studies, Yanmin Huang, Jianguo Cui, Linyi Jia, Chunfang Gan, Huacan Song, Chun Zeng, Aimin Zhou Jan 2013

Synthesis And Evaluation Of Some 17-Acetamidoandrostane And N,N-Dimethyl-7-Deoxycholic Amide Derivatives As Cytotoxic Agents: Structure/Activity Studies, Yanmin Huang, Jianguo Cui, Linyi Jia, Chunfang Gan, Huacan Song, Chun Zeng, Aimin Zhou

Chemistry Faculty Publications

Using pregnenolone and 7-deoxycholic acid as starting materials, some 17-acetamidoandrostane and N,N-dimethyl-7-deoxycholic amide derivatives were synthesized. The cytotoxicity of the synthesized compounds was tested in vitro against two tumor cell lines: SGC 7901 (human gastric carcinoma) and Bel 7404 (human liver carcinoma). The result showed that the blockage of the interaction of the amide group with outside groups might cause a decrease of the cytotoxicity, and an O-benzyloximino group at the 3-position of N,N-dimethyl-7-deoxycholic amide could enhance the cytotoxic activity of the compound. The information obtained from the studies provides the structure-activity relationship for these compounds and may be useful …

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Chem 109: General Chemistry I—A Peer Review Of Teaching Project Benchmark Portfolio, Eric D. Dodds Jan 2013

Chem 109: General Chemistry I—A Peer Review Of Teaching Project Benchmark Portfolio, Eric D. Dodds

UNL Faculty Course Portfolios

This portfolio has been developed for CHEM 109: General Chemistry I. The course is the first of a freshman level two semester sequence in General Chemistry taken by students with majors in a wide variety of technical and scientific disciplines. CHEM 109 is a high enrollment class, with class sizes for individual sections nearing 200 students. The development of this portfolio was conducted with the following objectives: 1. Clearly identify, justify, and codify the major learning objectives for this course, 2. Describe and rationalize the course structure and learning assessment methods, 3. Analyze and reflect on student achievement in the …

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Light-Matter Interactions Of Plasmonic Nanostructures, Jennifer Reed Jan 2013

Light-Matter Interactions Of Plasmonic Nanostructures, Jennifer Reed

Electronic Theses and Dissertations

Light interaction with matter has long been an area of interest throughout history, spanning many fields of study. In recent decades, the investigation of light-matter interactions with nanostructures has become an intense area of research in the field of photonics. Metallic nanostructures, in particular, are of interest due to the interesting properties that arise when interacting with light. The properties are a result of the excitation of surface plasmons which are the collective oscillation of the conduction electrons in the metal. Since the conduction electrons can be thought of as harmonic oscillators, they are quantized in a similar fashion. Just …

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Genetically Modified Myoglobin As A Mimic For Heme Enzymes, Subhash Chand Jan 2013

Genetically Modified Myoglobin As A Mimic For Heme Enzymes, Subhash Chand

Chemistry & Biochemistry Dissertations - Archive

This study addresses the mechanistic relationships between formation of reactive oxygen species (ROS) and their catalytic oxidation functions in oxygenation and peroxygenation reactions in heme enzymes. Even though both cytochrome P450s (CYP P450s) and peroxidases have different catalytic activities, the involvement of common ROS (Compound 0 and Compound I) have been proposed. Therefore, to understand the generation and activation of peroxide to form ROS, genetically-engineered myoglobin (Mb) mutants were created by incorporating redox-sensitive 3-amino-L-tyrosine (NH2Tyr) or L-3, 4-dihydroxyphenylalanine (DOPA) into its active site. Distal His 64 replaced with redox amino acids mutant Mb showed excellent turnover rates for thioanisole and …

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Investigation Of Drinking Water/Beverage Contaminants Within The Beverage Industry, Elizabeth Hobbs Jan 2013

Investigation Of Drinking Water/Beverage Contaminants Within The Beverage Industry, Elizabeth Hobbs

Theses

The impact of water resource quality has influenced the community worldwide. It is an on-going target for water suppliers to produce suitable drinking water and the beverage industry to provide suitable water for the production of beverages. This diligence will ensure the consumer is provided with a product safe for consumption. The research and analytical techniques explored in this thesis may be of benefit to the beverage industry for the monitoring of inorganic contaminants present in water and carbonated soft drinks. The occurrence of certain contaminants in drinking water has become a major issue in the water industry in recent …

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In Vivo Ultrasonic Detection Of Polyurea Crosslinked Silica Aerogel Implants, Firouzeh Sabri, Merry E. Sebelik, Ryan K. Meacham, John Dudley Boughter, Mitchell J. Challis, Nicholas Leventis Jan 2013

In Vivo Ultrasonic Detection Of Polyurea Crosslinked Silica Aerogel Implants, Firouzeh Sabri, Merry E. Sebelik, Ryan K. Meacham, John Dudley Boughter, Mitchell J. Challis, Nicholas Leventis

Chemistry Faculty Research & Creative Works

Background:Polyurea crosslinked silica aerogels are highly porous, lightweight, and mechanically strong materials with great potential for in vivo applications. Recent in vivo and in vitro studies have demonstrated the biocompatibility of this type of aerogel. the highly porous nature of aerogels allows for exceptional thermal, electric, and acoustic insulating capabilities that can be taken advantage of for non-invasive external imaging techniques. Sound-based detection of implants is a low cost, non-invasive, portable, and rapid technique that is routinely used and readily available in major clinics and hospitals.Methodology:In this study the first in vivo ultrasound response of polyurea crosslinked silica aerogel implants …

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Charge-Pairing Interactions Control The Conformational Setpoint And Motions Of The Fmn Domain In Neuronal Nitric Oxide Synthase, Mohammad Mahfuzul Haque, Mekki Bayachou, Mohammed A. Fadlalla, Deborah Durra, Dennis J. Stuehr Jan 2013

Charge-Pairing Interactions Control The Conformational Setpoint And Motions Of The Fmn Domain In Neuronal Nitric Oxide Synthase, Mohammad Mahfuzul Haque, Mekki Bayachou, Mohammed A. Fadlalla, Deborah Durra, Dennis J. Stuehr

Chemistry Faculty Publications

The NOS (nitric oxide synthase; EC 1.14.13.39) enzymes contain a C-terminal flavoprotein domain [NOSred (reductase domain of NOS)] that binds FAD and FMN, and an N-terminal oxygenase domain that binds haem. Evidence suggests that the FMN-binding domain undergoes large conformational motions to shuttle electrons between the NADPH/FAD-binding domain [FNR (ferredoxin NADP-reductase)] and the oxygenase domain. Previously we have shown that three residues on the FMN domain (Glu(762), Glu(816) and Glu(819)) that make charge-pairing interactions with the FNR help to slow electron flux through nNOSred (neuronal NOSred). In the present study, we show that charge neutralization or reversal at each of …

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Super-Aptamer Bio-Imprinted Hydrogels : An Investigation Into The Optimization And Characterization Of Cross-Linked Polymeric Materials Displaying Macromolecular Amplified Responses, Nicholas Alexander Gariano Jan 2013

Super-Aptamer Bio-Imprinted Hydrogels : An Investigation Into The Optimization And Characterization Of Cross-Linked Polymeric Materials Displaying Macromolecular Amplified Responses, Nicholas Alexander Gariano

LSU Doctoral Dissertations

It is becoming more important to detect ultra-low concentrations of analytes for biomedical, environmental, and national security applications. Equally important is that new methods should be easy to use, inexpensive, portable, and if possible allow detection using the naked eye. Detection of low concentrations of analytes generally cannot be achieved directly, but requires signal amplification by catalysts, macromolecules, metal surfaces or supramolecular aggregates. The rapidly progressing field of macromolecular signal amplification has been advanced using conjugated polymers, chirality in polymers, solvating polymers and polymerization/depolymerization strategies. The use of molecularly imprinted polymers is ideal for creation of novel sensors to meet …

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Molecular-Level Investigations Combining Nanoscale Lithography And Atomic Force Microscopy, Chamarra Karmelia Saner Jan 2013

Molecular-Level Investigations Combining Nanoscale Lithography And Atomic Force Microscopy, Chamarra Karmelia Saner

LSU Doctoral Dissertations

In this dissertation, nanostructures of octadecyltrichlorosilane (OTS) and were prepared using particle lithography and evaluated using characterizations with atomic force microscopy (AFM). The nanostructures of OTS were used as a resist for patterning fibronectin, an extracellular matrix protein. Particle lithography provides a practical and reproducible approach to generate billions of nanostructures comprised of organic thin films or nanomaterials. A film of mesospheres can be applied as a surface mask to define the periodicity and size of nanopatterns using processes of self-assembly. A close-packed arrangement of mesospheres is produced spontaneously when monodisperse solutions of latex or silica are dried on a …

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