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2005

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Articles 451 - 480 of 562

Full-Text Articles in Chemistry

Synthesis Of Pyrrolidines And Pyrrolizidines Using The Aza-Cope Rearrangement Mannich Cyclization Under Microwave Conditions, Amanda Schalk Jan 2005

Synthesis Of Pyrrolidines And Pyrrolizidines Using The Aza-Cope Rearrangement Mannich Cyclization Under Microwave Conditions, Amanda Schalk

Senior Honors Theses and Projects

No abstract provided.

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Development Of An Upper Level Undergraduate Research Based Laboratory: The Purification, Analysis, And Dinetic Study Of Cytochrome B5, Mary Mcphail Jan 2005

Development Of An Upper Level Undergraduate Research Based Laboratory: The Purification, Analysis, And Dinetic Study Of Cytochrome B5, Mary Mcphail

Senior Honors Theses and Projects

The purpose of this project was to develop an upper level undergraduate biochemistry laboratory (CHEM 453) based upon a novel research project, designed to replace an existing instructional laboratory that employs ‘cookbook’ exercises. Methods for the expression, purification, spectral analysis of structural integrity, and electron transfer capability of rabbit cyt b5 were adapted from published work done by Dr. Lucy Waskell of the University of Michigan and Dr. Mansuy of the University of Paris. In our hands, rabbit liver cyt b5 expressed in E. coli was purified to 45% specific content of the theoretical content. Additionally, 37 nmol …

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A Regularized And Renormalized Electrostatic Coupling Hamiltonian For Hybrid Quantum-Mechanical–Molecular-Mechanical Calculations, Pradip K. Biswas, Valentin Gogonea Jan 2005

A Regularized And Renormalized Electrostatic Coupling Hamiltonian For Hybrid Quantum-Mechanical–Molecular-Mechanical Calculations, Pradip K. Biswas, Valentin Gogonea

Chemistry Faculty Publications

We describe a regularized and renormalized electrostatic coupling Hamiltonian for hybrid quantum-mechanical (QM)–molecular-mechanical (MM) calculations. To remedy the nonphysical QM/MM Coulomb interaction at short distances arising from a point electrostatic potential (ESP) charge of the MM atom and also to accommodate the effect of polarized MM atom in the coupling Hamiltonian, we propose a partial-wave expansion of the ESP charge and describe the effect of a s-wave expansion, extended over the covalent radius rc, of the MM atom. The resulting potential describes that, at short distances, large scale cancellation of Coulomb interaction arises intrinsically from the localized expansion of the …

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Synthesis Of Alkylthiol-Containing Fluorene Derivatives For Gold Nanoparticle Functionalization, Sriram Mukundarajan Jan 2005

Synthesis Of Alkylthiol-Containing Fluorene Derivatives For Gold Nanoparticle Functionalization, Sriram Mukundarajan

Electronic Theses and Dissertations

A novel synthetic methodology has been developed for attaching fluorene derivatives, containing different types of electron donating and accepting groups at the 2 and 7 positions, to gold nanoparticles of different sizes by exploiting the affinity of the thiol functional group for gold. The distance between the dye and nanoparticles was varied by introducing two alkyl chains containing different number of carbon atoms at the 9 position on the fluorene ring system. The methodology that was developed gave enough scope for performing Radiative Decay Engineering (RDE) studies, in order to investigate the impact of gold nanoparticles on the singlet oxygen …

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Effect Of Humic Substance Photodegradation On Bacterial Growth And Respiration In Lake Water, Alexandre M. Anesio, William Granéli, George R. Aiken, David J. Kieber, Kenneth Mopper Jan 2005

Effect Of Humic Substance Photodegradation On Bacterial Growth And Respiration In Lake Water, Alexandre M. Anesio, William Granéli, George R. Aiken, David J. Kieber, Kenneth Mopper

Chemistry & Biochemistry Faculty Publications

This study addresses how humic substance (HS) chemical composition and photoreactivity affect bacterial growth, respiration, and growth efficiency (BGE) in lake water. Aqueous solutions of HSs from diverse aquatic environments representing different dissolved organic matter sources (autochthonous and allochthonous) were exposed to artificial solar UV radiation. These solutions were added to lake water passed through a 0.7-μm pore-size filter (containing grazer-free lake bacteria) followed by dark incubation for 5, 43, and 65 h. For the 5-h incubation, several irradiated HSs inhibited bacterial carbon production (BCP) and this inhibition was highly correlated with H2O2 photoproduction. The H2 …

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Messenger Rna Profiling: A Prototype Method For Body Fluidand Tissue Identification, Jane Juusola Jan 2005

Messenger Rna Profiling: A Prototype Method For Body Fluidand Tissue Identification, Jane Juusola

Electronic Theses and Dissertations

Conventional methods of body fluid identification use labor-intensive, technologically diverse techniques that are performed in a series, not parallel, manner and are costly in terms of time and sample. Furthermore, for some frequently encountered body fluids, such as saliva or vaginal secretions, no confirmatory technique exists. Terminally differentiated cells, such as blood lymphocytes or epithelial cells lining the oral cavity, have a unique pattern of gene expression, which is evinced by the presence and relative abundance of specific mRNA species. If the type and abundance of mRNAs can be determined in a stain or tissue sample recovered at the crime …

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Synthesis, Characterizations, And Evaluation Of New Reactive Two-Photon Absorbing Dyes For Two-Photon Excited Fluorescence Imaging Applications, Katherine J. Hales Jan 2005

Synthesis, Characterizations, And Evaluation Of New Reactive Two-Photon Absorbing Dyes For Two-Photon Excited Fluorescence Imaging Applications, Katherine J. Hales

Electronic Theses and Dissertations

Recent, cooperative advances in chemistry, biology, computing, photophysics, optics, and microelectronics have resulted in extraordinary developments in the biological sciences, resulting in the emergence of a novel area termed 'biophotonics'. The integrative and interdisciplinary nature of biophotonics cuts across virtually all disciplines, extending the frontiers of basic cellular, molecular, and biology research through the clinical and pharmaceutical industries. This holds true for the development and application of the novel imaging modality utilizing multiphoton absorption and its extraordinary contribution to recent advances in bioimaging. Intimately involved in the revolution of nonlinear bioimaging has been the development of optical probes for probing …

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Punishment And Rehabilitation Views Of Social Work Majors And Non-Social Work Students: An Exploratory Study, Eric G. Lambert, Sudershan Pasupuleti, Reva I. Allen Jan 2005

Punishment And Rehabilitation Views Of Social Work Majors And Non-Social Work Students: An Exploratory Study, Eric G. Lambert, Sudershan Pasupuleti, Reva I. Allen

Journal of the South Carolina Academy of Science

No abstract provided.

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Molecular Dynamics Simulations Of Amphiphilic Molecules, Roger L. Mcmullen Jr. Jan 2005

Molecular Dynamics Simulations Of Amphiphilic Molecules, Roger L. Mcmullen Jr.

Seton Hall University Dissertations and Theses (ETDs)

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Dielectric Properties And Maxwell-Wagner Relaxation Of Compounds Acu3ti4o12 (A=Ca,Bi2/3,Y2/3,La2/3), Jianjun Liu, Chun-Gang Duan, Wai-Ning Mei, Robert W. Smith, John R. Hardy Jan 2005

Dielectric Properties And Maxwell-Wagner Relaxation Of Compounds Acu3ti4o12 (A=Ca,Bi2/3,Y2/3,La2/3), Jianjun Liu, Chun-Gang Duan, Wai-Ning Mei, Robert W. Smith, John R. Hardy

Physics Faculty Publications

We have studied the frequency and temperature dependences of permittivity and impedance of the compounds ACu3Ti4O12 A=Ca, Bi2/3, Y2/3, La2/3 in the ranges of 10−1–106 Hz and −150–200 °C. All compounds investigated display similar dielectric properties. Specifically, they all have a Debye-like relaxation and their dielectric constants are independent of frequency and temperature over a wide range. They all have two electrical responses in impedance formalism, indicating that there are two distinct contributions. We attribute them to grains and grain boundaries in the ceramic samples and explain the dielectric behaviors by Maxwell-Wagner relaxation arising at the interfaces between grains and …

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Phase Transition In Single Crystal Cs2nb4o11, Jianjun Liu, E. P. Kharitonova, Chun-Gang Duan, Wai-Ning Mei, Robert W. Smith, John R. Hardy Jan 2005

Phase Transition In Single Crystal Cs2nb4o11, Jianjun Liu, E. P. Kharitonova, Chun-Gang Duan, Wai-Ning Mei, Robert W. Smith, John R. Hardy

Physics Faculty Publications

We studied temperature dependence of complex capacitance, impedance, and polarized Raman spectra of single crystal Cs2Nb4O11. First, we observed a sharp λ-shaped peak at 165 °C in the complex capacitance, then found drastic changes in the Raman spectra in the same temperature range. Utilizing the pseudosymmetry search of structure space group, we attributed the observed anomalies to a structural change from the room temperature orthorhombic Pnn2 to another orthorhombic Imm2. We also measured room temperature polarized Raman spectra in different symmetries of normal vibrations and assigned high wavenumber Raman bands to the …

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Determination Of Trifluoroacetate By Ion Chromatography For Snow And Ice Analysis, Jon Hanson Jan 2005

Determination Of Trifluoroacetate By Ion Chromatography For Snow And Ice Analysis, Jon Hanson

The Journal of Undergraduate Research

Trifluoroacetic acid (TEA) is a product of the atmospheric degradation of hydrochlorofluorocarbons (HCFCs) and hydrofluorocarbons (HFCs). HCFCs and HFCs are widely used substitutes for chlorofluorocarbons (CFCs) that have been found to contribute to the loss of stratospheric ozone. Deposits of TEA with precipitation (rain and snow) can lead to its presence and accumulation in the aquatic and cryosphere environments, with unknown long-term environmental consequences. Investigation on TEA impact and its fate in the environment requires sensitive, accurate, and fast analytical methods. The determination of trace concentrations of TEA using the technique of ion chromatography (IC) is investigated in this study, …

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In Situ Remediation Of Heavy Metal Contaminated Sediments Using Emulsified Zero-Valent Metal Particles, Kristen Marie Milum Jan 2005

In Situ Remediation Of Heavy Metal Contaminated Sediments Using Emulsified Zero-Valent Metal Particles, Kristen Marie Milum

Electronic Theses and Dissertations

Sediments can act as both a sink for pollutants and a source for aquatic contaminants. Natural and human disturbances of the sediments can release the contaminants to the overlying water where bottom dwelling, or benthic, organisms may be exposed through direct contact, ingestion of sediment particles, or uptake of dissolved contaminants present in the water. Dredging, the most common remediation technology for heavy metals, exacerbates this process. The in situ use of emulsified metal has been studied for its ability to pull heavy metals from aqueous solution and from saturated soils. It has proven successful in the laboratory with removal …

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Reaction Rates For The Dehalogenation Of Trichloroethylene Using Various Types Of Zero-Valent Iron, Neil Stewart Jan 2005

Reaction Rates For The Dehalogenation Of Trichloroethylene Using Various Types Of Zero-Valent Iron, Neil Stewart

Electronic Theses and Dissertations

Remediation of trichloroethylene (TCE) and other chlorinated solvents is of great concern due to their toxicity and their persistence in the environment. Iron has been used extensively in the past decade as a subsurface reactive agent for the remediation of dense, nonaqueous-phase liquids (DNAPLs). Permeable reactive barrier walls (PRBW) have been installed at many sites around the country to treat contaminated plumes resulting from the presence of DNAPL pools. The use of zero-valent metals, such as iron, to effectively reductively dechlorinate DNAPLs has been employed as the reactive material in these PRBWs (Gillham et al., 1993). However, limited work has …

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Part I : Isolation Of Dipentyl 2-(4-(Pentan-3-Yl) Phenyl) Malonate From Sanguisorba Officinalis Labill Part Ii: Synthesis Of A Novel Family Of Ethers Of Podocarpic Acid, Manjeera Yalavarty Jan 2005

Part I : Isolation Of Dipentyl 2-(4-(Pentan-3-Yl) Phenyl) Malonate From Sanguisorba Officinalis Labill Part Ii: Synthesis Of A Novel Family Of Ethers Of Podocarpic Acid, Manjeera Yalavarty

Electronic Theses and Dissertations

The goal of part I of this thesis was to isolate pure anti cancer compounds from the Russian plant Sanguisorba officinalis. This plant was selected for investigation because it showed 100% activity against leukemia (L1210 mouse leukemia cells) during the preliminary screening of approximately 100 Russian plant extracts. This work has resulted in the isolation of novel compound 11 using traditional chromatography techniques. Compound 11 was characterized with spectroscopic techniques such as IR, 1H NMR, 13C NMR, DEPT, DQCOSY and MS. Compound 11 was assigned the structure dipentyl 2-(4-(pentan-3-yl) phenyl) malonate. The goal of part II of this thesis was …

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Predicted Properties Of Microhollow Cathode Discharges In Xenon, J. P. Boeuf, L. C. Pitchford, K. H. Schoenbach Jan 2005

Predicted Properties Of Microhollow Cathode Discharges In Xenon, J. P. Boeuf, L. C. Pitchford, K. H. Schoenbach

Bioelectrics Publications

A fluid model has been developed and used to help clarify the physical mechanisms occurring in microhollow cathode discharges (MHCD). Calculated current-voltage (I-V) characteristics and gas temperatures in xenon at 100 Torr are presented. Consistent with previous experimental results in similar conditions, we find a voltage maximum in the I-V characteristic. We show that this structure reflects a transition between a low-current, abnormal discharge localized inside the cylindrical hollow cathode to a higher-current, normal glow discharge sustained by electron emission from the outer surface of the cathode. This transition, due to the geometry of …

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Synthesis And Characterization Of Rhodium And Iridium Complexes With The Bis(Dimethylsilylcyclopentadienyl) Ligand, Gordon J. Hunter Jan 2005

Synthesis And Characterization Of Rhodium And Iridium Complexes With The Bis(Dimethylsilylcyclopentadienyl) Ligand, Gordon J. Hunter

Dissertations and Theses @ UNI

The synthesis of transition-metal complexes ( n5 -C5H3SiMe2)2[Rh(CO)2]2 and ( n5- -C5H3SiMe2)2[Rh(CO)2]2, both featuring the bis( dimethylsilylcyclopentadienyl) ligand, is reported. Preparation of the rhodium complex yielded a cis:trans ratio of 1 :2, while the iridium analogue generated a 2: 1 ratio. Thermal reaction of cis-( n5- - C5H3SiMe2)2[Rh(CO)2]2 yields cis-( n5 -C5H3SiMe2)2Rh2(CO)3, which features an asymmetrically bridging carbonyl ligand. Reaction of I2with cis-( n5- - C5H3SiMe2)2[Ir(CO)2]2 yields cis-( n5 -C5H3SiMe2)2[Ir(CO)I2]2 Synthesis of ( n5- - C5H3SiMe2)2[Ir(cyclooctadiene)h in a cis:trans ratio of 1 :2.5 is also reported.

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The Determination Of Environmentally Important Metals In Marine Sediments, Linda Tyrrell Jan 2005

The Determination Of Environmentally Important Metals In Marine Sediments, Linda Tyrrell

Masters

Surface sediment samples were collected at sites within the Rockall Through at water depth ranges from 700 – 2774 metres. The study area was predefined by the availability of samples. Samples were collected by the British Geological Survey during their gravity core survey undertaken in 1998. Methods were optimised and validated for lead, cadmium, chromium, copper, nickel, zinc, lithium and aluminium using atomic absorption spectroscopy following total digestion, and for mercury, using cold vapour atomic fluorescence spectroscopy following partial digestion. The measured metal concentration were normalised to Li to compensate for the influence of natural variability in the concentration of …

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Melting And Solidification Study Of Indium And Bismuth Nanocrystals Using Reflection High-Energy Electron Diffraction, Mohamed K. Zayed Jan 2005

Melting And Solidification Study Of Indium And Bismuth Nanocrystals Using Reflection High-Energy Electron Diffraction, Mohamed K. Zayed

Electrical & Computer Engineering Theses & Dissertations

As technology begins to utilize nanocrystals for many chemical, biological, medical, electrical, and optoelectrical applications, there is a growing need for an understanding of their fundamental properties. The study of melting and solidification of nanocrystals is of interest to fundamental understanding of the effect of reduced size and crystal shape on the solid-liquid phase transition. Melting and solidification of as-deposited and recrystallized indium and bismuth nanocrystals were studied using reflection high-energy electron diffraction (RHEED). The nanocrystals were thermally deposited on highly oriented 002-graphite substrate at different deposition temperatures. The growth dynamics of the nanocrystals was studied using in situ RHEED …

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Novel Cyanine-Amp Conjugates For Efficient 5' Rna Fluorescent Labeling By One-Step Transcription And Replacement Of [γ-32P] Atp In Rna Structural Investigation, Na Li, Changjun Yu, Faqing Huang Jan 2005

Novel Cyanine-Amp Conjugates For Efficient 5' Rna Fluorescent Labeling By One-Step Transcription And Replacement Of [γ-32P] Atp In Rna Structural Investigation, Na Li, Changjun Yu, Faqing Huang

Faculty Publications

Two novel fluorescent cyanine-AMP conjugates, F550/570 and F650/670, have been synthesized to serve as transcription initiators under the T7 φ2.5 promoter. Efficient fluorophore labeling of 5′ RNA is achieved in a single transcription step by including F550/570 and F650/670 in the transcription solution. The current work makes fluorescently labeled RNA readily available for broad applications in biochemistry, molecular biology, structural biology and biomedicine. In particular, site-specifically fluorophore-labeled large RNAs prepared by the current method may be used to investigate RNA structure, folding and mechanism by various fluorescence techniques. In addition, F550/570 and F650/670 may replace [γ-32P]ATP to prepare …

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Near-Edge X-Ray Absorption Fine Structure Study Of Ion-Beam-Induced Phase Transformation In Gd2(Ti1-Yzry)2o7, Ponnusamy Nachimuthu, S. Thevuthasan, V. Shutthanandan, E. M. Adams, W. J. Weber, B. D. Begg, D. K. Shuh, Dennis W. Lindle, Eric M. Gullikson, Rupert C. Perera Jan 2005

Near-Edge X-Ray Absorption Fine Structure Study Of Ion-Beam-Induced Phase Transformation In Gd2(Ti1-Yzry)2o7, Ponnusamy Nachimuthu, S. Thevuthasan, V. Shutthanandan, E. M. Adams, W. J. Weber, B. D. Begg, D. K. Shuh, Dennis W. Lindle, Eric M. Gullikson, Rupert C. Perera

Chemistry and Biochemistry Faculty Research

The structural and electronic properties of Gd2(Ti1−yZry)2O7 (y=0–1) pyrochlores following a 2.0-MeV Au2+ ion-beam irradiation (~5.0 X 1014 Au2+/cm2) have been investigated by Ti 2p and O 1s near-edge x-ray absorption fine structure (NEXAFS). The irradiation of Gd2(Ti1−yZry)2O7 leads to the phase transformation from the ordered pyrochlore structure (Fd3m) to the defect fluorite structure (Fm3m) regardless of Zr concentration. Irradiated Gd2(Ti1−y …

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Fragmentation Dynamics Of H2s Following S 2p Photoexcitation, Renaud Guillemin, S-W Yu, Wayne C. Stolte, Dennis W. Lindle Jan 2005

Fragmentation Dynamics Of H2s Following S 2p Photoexcitation, Renaud Guillemin, S-W Yu, Wayne C. Stolte, Dennis W. Lindle

Chemistry and Biochemistry Faculty Research

The fragmentation dynamics of core-excited H2S has been studied by means of partial anion and cation yield measurements around the S L2,3-subshell ionization thresholds. All detectable ionic fragments are reported, and significant differences between partial ion yields are observed. Possible dissociation pathways are discussed by comparison to previous studies of electron spectra.

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Synthesis Of Gold Nanoparticles Attached To Polypyrrole Nanofibers, Sunil K. Pillalamarri, Frank D. Blum, Massimo F. Bertino Jan 2005

Synthesis Of Gold Nanoparticles Attached To Polypyrrole Nanofibers, Sunil K. Pillalamarri, Frank D. Blum, Massimo F. Bertino

Chemistry Faculty Research & Creative Works

Polypyrrole is a frequently studied conducting polymer due to its application in sensing and catalysis.1 Polypyrrole is considered among the most promising conductive polymers due to its stability and ease of conversion between conducting and insulating forms.2 Different chemical and electrochemical methods are generally used in the synthesis of polypyrrole.2 Despite many interesting applications, the use of polypyrrole is limited because of difficulty in processing it. Several approaches have been explored to improve the ability to process polypyrrole, including the use of emulsion, inverse emulsion, steric stabilizer, and microemulsion methods.1 Several reports have also been published on the synthesis of …

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Copolymers And Blends Of Methyl Acrylate And Acrylic Isobutyl Poss Nanomaterials, Manikantan B. Nair, Frank D. Blum Jan 2005

Copolymers And Blends Of Methyl Acrylate And Acrylic Isobutyl Poss Nanomaterials, Manikantan B. Nair, Frank D. Blum

Chemistry Faculty Research & Creative Works

Ultra-thin polymer films attached to solid substrates (supported films) have attracted significant interest in recent years. Supported films are used in the design of advanced materials like photoresists, lubricants and other electronic devices. Glass transition temperatures (Tgs) of supported polymer films have also been of significant interest. The Tg has been shown to depend on the thickness of the polymer film on the surface and the inherent nature of the surface. The effect of end-grafting of a polymer chain to a surface, on the Tg of the polymer has been studied previously.1 Reports on the study of glass transition behaviors …

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Fourier Transform Infrared Analysis Of Hydroxyl Content Of Hydrothermally Processed Heteroepitaxial Barium Titanate Films, Sandeep K. Patil, Nipun Shah, Frank D. Blum, M. N. Rahaman Jan 2005

Fourier Transform Infrared Analysis Of Hydroxyl Content Of Hydrothermally Processed Heteroepitaxial Barium Titanate Films, Sandeep K. Patil, Nipun Shah, Frank D. Blum, M. N. Rahaman

Chemistry Faculty Research & Creative Works

The concentration of hydroxyl (-OH) groups in epitaxial barium titanate (BaTiO3) films (thickness ≈ 200 nm), deposited on single-crystal strontium titanate (SrTiO3) at 150 °C by a hydrothermal technique, was investigated using x-ray photoelectron spectroscopy and Fourier transform infrared (FTIR) spectroscopy. After hydrothermal treatment, a broad FTIR resonance for the hydroxyl groups indicated a significant concentration of surface -OH groups in the films. The as-deposited films were subsequently treated hydrothermally with D2O, and the kinetics of the exchange reaction between -OH incorporated into the film and -OD from the D2O were studied using FTIR. For reactions carried out intermittently, the …

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Studies Of Zeolite Entrapped Ruthenium Polypyridine Complexes, Anwar A. Bhuiyan Jan 2005

Studies Of Zeolite Entrapped Ruthenium Polypyridine Complexes, Anwar A. Bhuiyan

Journal of the Arkansas Academy of Science

There is an intense interest in designing molecular systems which will absorb visible sunlight, initiate an electron transfer process, and ultimately convert the solar energy to useful chemical energy of fuels such as hydrogen produced from water. The zeolite-entrapped polypyridine complexes of divalent ruthenium hold promise as efficient photocatalysts for net charge separation and such efficiencies are further enhanced by organized incorporation of donor and acceptor components. This paper deals with the synthesis and spectroscopic investigation of zeolite-entrapped ruthenium polypyridine complexes which may be useful in the development of solar energy conversion schemes. The sensitizer molecules, such as Ru(bpy)3 2+ …

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The Subsystems Approach To Genome Annotation And Its Use In The Project To Annotate 1000 Genomes, Ross Overbeek, Tadhg Begley, Ralph M. Butler, Jomuna V. Choudhuri, Han-Yu Chuang, Matthew Cohoon, Valérie De Crécy-Lagard, Naryttza Diaz, Terry Disz, Robert Edwards, Michael Fonstein, Ed D. Frank, Svetlana Gerdes, Elizabeth M. Glass, Alexander Goesmann, Andrew Hanson, Dirk Iwata-Reuyl, Roy Jensen, Neema Jamshidi, Lutz Krause, Michael Kubal, Niels Larsen, Burkhard Linke, Alice C. Mchardy, Folker Meyer, Heiko Neuweger, Gary Olsen, Robert Olson, Andrei Osterman, Vasiliy Portnoy, Gordon D. Pusch, Dmitry A. Rodionov, Christian Rückert, Jason Steiner, Rick Stevens, Ines Thiele, Olga Vassieva, Yuzhen Ye, Olga Zagnitko, Veronika Vonstein Jan 2005

The Subsystems Approach To Genome Annotation And Its Use In The Project To Annotate 1000 Genomes, Ross Overbeek, Tadhg Begley, Ralph M. Butler, Jomuna V. Choudhuri, Han-Yu Chuang, Matthew Cohoon, Valérie De Crécy-Lagard, Naryttza Diaz, Terry Disz, Robert Edwards, Michael Fonstein, Ed D. Frank, Svetlana Gerdes, Elizabeth M. Glass, Alexander Goesmann, Andrew Hanson, Dirk Iwata-Reuyl, Roy Jensen, Neema Jamshidi, Lutz Krause, Michael Kubal, Niels Larsen, Burkhard Linke, Alice C. Mchardy, Folker Meyer, Heiko Neuweger, Gary Olsen, Robert Olson, Andrei Osterman, Vasiliy Portnoy, Gordon D. Pusch, Dmitry A. Rodionov, Christian Rückert, Jason Steiner, Rick Stevens, Ines Thiele, Olga Vassieva, Yuzhen Ye, Olga Zagnitko, Veronika Vonstein

Chemistry Faculty Publications and Presentations

The release of the 1000th complete microbial genome will occur in the next two to three years. In anticipation of this milestone, the Fellowship for Interpretation of Genomes (FIG) launched the Project to Annotate 1000 Genomes. The project is built around the principle that the key to improved accuracy in high through put annotation technology is to have experts annotate single subsystems over the complete collection of genomes, rather than having an annotation expert attempt to annotate all of the genes in a single genome. Using the subsystems approach, all of the genes implementing the subsystem are analyzed by …

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The Importance Of Size And Shape In Imprinted Polymers, Jason Campbell Jan 2005

The Importance Of Size And Shape In Imprinted Polymers, Jason Campbell

LSU Master's Theses

The existence of shape selectivity in non-covalent molecularly imprinted polymers has been proven using molecular probes. A series of amines varying with different structural motifs and secondary amines with different sized side chains were imprinted, and binding evaluated by HPLC for each amine on polymers imprinted with similar amines. Trends in the binding relationships revealed two major contributions of cavity structure on selectivity afforded by molecularly imprinted polymers (MIPs). First, sterics play a dominant role in cases where a molecules structure is too big too fit into an imprinted site formed from a smaller template molecule. Second, molecular structures that …

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Synthetic Studies In Phytochrome Chemistry, Peter A. Jacobi, Imad Odeh, Subhas Buddhu, Guolin Cai, Sundaramoorthi Rajeswari, Douglas Fry, Wanjun Zheng, Robert W. Desimone, Jiasheng Guo, Lisa D. Coutts, Sheila I. Hauck, Sam H. Leung, Indranath Ghosh, Douglas Pippin Jan 2005

Synthetic Studies In Phytochrome Chemistry, Peter A. Jacobi, Imad Odeh, Subhas Buddhu, Guolin Cai, Sundaramoorthi Rajeswari, Douglas Fry, Wanjun Zheng, Robert W. Desimone, Jiasheng Guo, Lisa D. Coutts, Sheila I. Hauck, Sam H. Leung, Indranath Ghosh, Douglas Pippin

Dartmouth Scholarship

An account is given of the author’s several approaches to the synthesis of the parent chromophore of phytochrome (1), a protein-bound linear tetrapyrrole derivative that controls photomorphogenesis in higher plants. These studies culminated in enantioselective syntheses of both (2R)- and (2S)-phytochromobilin (4), as well as several 13C-labeled derivatives designed to probe the site of Z,E-isomerization during photoexcitation. When reacted in vitro, synthetic 2R-4 and recombinant-derived phytochrome apoprotein N-C produced a protein-bound chromophore with identical difference spectra to naturally occurring 1.

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Crystal Structure Of The Gtpase Domain Of Rat Dynamin 1, Thomas F. Reubold, Susanne Eschenburg, Andreas Becker, Marilyn Leonard, Sandra L. Schmid, Richard B. Vallee, F. Jon Kull, Dietmar J. Manstein Jan 2005

Crystal Structure Of The Gtpase Domain Of Rat Dynamin 1, Thomas F. Reubold, Susanne Eschenburg, Andreas Becker, Marilyn Leonard, Sandra L. Schmid, Richard B. Vallee, F. Jon Kull, Dietmar J. Manstein

Dartmouth Scholarship

Here, we present the 1.9-A crystal structure of the nucleotide-free GTPase domain of dynamin 1 from Rattus norvegicus. The structure corresponds to an extended form of the canonical GTPase fold observed in Ras proteins. Both nucleotide-binding switch motifs are well resolved, adopting conformations that closely resemble a GTP-bound state not previously observed for nucleotide-free GTPases. Two highly conserved arginines, Arg-66 and Arg-67, greatly restrict the mobility of switch I and are ideally positioned to relay information about the nucleotide state to other parts of the protein. Our results support a model in which switch I residue Arg-59 gates GTP binding …

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