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Articles 271 - 300 of 449
Full-Text Articles in Chemistry
Kinetics And Mechanisms Of Release By Redox-Active Liposomes In Drug Delivery, Jerimiah Forsythe
Kinetics And Mechanisms Of Release By Redox-Active Liposomes In Drug Delivery, Jerimiah Forsythe
LSU Doctoral Dissertations
Liposomes have had a long and fruitful application of drug delivery devices in the treatment of select tumors and cancer types. Third-generation liposomes possess endogenous triggering methods that hold the ability for site-specific unloading of liposomal contents, thus providing necessary temporal and spatial control over contents release that can be tuned to match the drug efficacy for decreased side effects during treatment. Of these new endogenous triggers, redox-active liposomes that can be triggered to unload contents via two-electron reduction by enzymes or chemical means have demonstrated promise for the encapsulation and delivery of cargo. The research project undertaken involved the …
Dynamic Measurements With Scanning Probe Microscopy: Surface Studies Using Nanostructured Test Platforms Of Metalloporphyrins, Nanoparticles And Amyloid Fibrils, Wilson K. Serem
LSU Doctoral Dissertations
A hybrid imaging mode for characterization of magnetic nanomaterials has been developed, using atomic force microscopy (AFM) combined with electromagnetic sample actuation. Instead of using a coated AFM probe as a magnetic sensor; our strategy is to use a nonmagnetic probe with contact mode AFM to characterize the vibration of magnetic and superparamagnetic nanomaterials responding to the flux of an AC electromagnetic field. We refer to the hybrid imaging mode as magnetic sample modulation (MSM-AFM). An oscillating magnetic field is produced by applying an AC current to a wire coil solenoid placed under the sample stage for tuning selected parameters …
Fabrication Of Organosilane Nanostructures As Selective Sites For Surface Chemical Reactions, Kathie Lee Lusker
Fabrication Of Organosilane Nanostructures As Selective Sites For Surface Chemical Reactions, Kathie Lee Lusker
LSU Doctoral Dissertations
Naturally self-assembled mesospheres provide a practical route for controlling the arrangement of materials on surfaces at the nanoscale. Periodic arrays of well-defined nanostructures can be produced with different nanomaterials and interpattern spacings. Results presented in this dissertation demonstrate particle lithography methods developed for fabricating arrays of organosilane nanostructures. Surfaces were designed for the selective deposition of polymers and nanoparticles to produce multicomponent nanopatterns. The approaches for surface patterning provide new directions for studying surface chemistry at the molecular-level, and have practical application for emerging photovoltaic thin film technologies. Atomic force microscopy (AFM) provides unique capabilities for molecular visualization and ultrasensitive …
Structure-Function Relationships In Poly(3-Hexylthiophene)S Formed Via Manipulation Of Oxidative Coupling Routes, Warren James Solfiell
Structure-Function Relationships In Poly(3-Hexylthiophene)S Formed Via Manipulation Of Oxidative Coupling Routes, Warren James Solfiell
LSU Doctoral Dissertations
This investigation focused on the analytical characterization of poly(3-hexylthiophene), a heterocyclic conducting polymer system, with an overall objective of elucidating the effects that the experimental conditions during chemical oxidation using iron(III) chloride as an oxidant impart on the structure of the resulting polymers. Poly(3-alkylthiophene)s are extensively studied materials due to their high electrical conductivities and unique optical properties that make them extremely valuable for use in contemporary technological applications and devices. Specifically, the aim of this research was to determine the dependence of structural characteristics, such as endgroups, molecular weights, and regioregularities, on the solvent employed for the reaction and …
Analysis Of Amyloid Beta (A [Beta]) Peptides By Capillary Electrophoresis And Laser-Induced Fluorescence Anisotropy Detection, Ryan Andrew Picou
Analysis Of Amyloid Beta (A [Beta]) Peptides By Capillary Electrophoresis And Laser-Induced Fluorescence Anisotropy Detection, Ryan Andrew Picou
LSU Doctoral Dissertations
The goal of the research presented in this dissertation is to develop laser-induced fluorescence anisotropy (LIFA) detection for detecting and characterizing amyloid beta (Aβ) peptide aggregates separated by capillary electrophoresis (CE). Senile plaques composed primarily of aggregated Aβ (1-40) and Aβ (1-42) peptides have been found in the brains of Alzheimer’s disease patients. These peptides are thought to be responsible for the disease pathology. A CE method using UV absorbance detection was developed for the quantification of Aβ (1-40) monomer and testing of Aβ monomer preparations for undesired aggregates (Chapter 2). Analyses of both Aβ (1-40) and Aβ (1-42) monomer …
Formation And Stabilization Of Combustion-Generated Environmentally Persistent Free Radicals On Transition Metal Oxides Supported On Silica, Eric Warren Pimentel Vejerano
Formation And Stabilization Of Combustion-Generated Environmentally Persistent Free Radicals On Transition Metal Oxides Supported On Silica, Eric Warren Pimentel Vejerano
LSU Doctoral Dissertations
The formation of environmentally persistent free radicals in combustion system was investigated from chemisorptions of chlorine- and hydroxy-substituted benzenes on transition metal oxide surface under post-combustion conditions. This manuscript reports the formation of EPFRs on silica particles containing 5% Fe(III)2O3, Ni(II)O, and Zn(II)O. The EPFRs are formed by the chemisorption of substituted aromatic molecular adsorbates on the metal cation center followed by electron transfer from the adsorbate to the metal ion at temperatures from 150 to 400 oC. Depending on the nature of the adsorbate and the temperature, two organic EPFRs were formed: a phenoxyl-type radical, which has a lower …
Application Of Scanning Probe Microscopy For New Physical Measurements And Studies Of Surface Chemical Reactions Of Materials At The Molecular Level, Stephanie Loletha Daniels
Application Of Scanning Probe Microscopy For New Physical Measurements And Studies Of Surface Chemical Reactions Of Materials At The Molecular Level, Stephanie Loletha Daniels
LSU Doctoral Dissertations
Scanning probe microscopy (SPM) provides unique capabilities for surface visualization and measurements that reach atomic and molecular dimensions. My research focus is directed toward applying and developing new measurements for analytical and surface chemistry with SPM. Two distinct goals based on studies with atomic force microscopy (AFM) will be described within this dissertation. The primary goal was to develop and apply a new AFM imaging mode for ultrasensitive measurements of the superparamagnetic properties of proteins. Magnetic sample modulation (MSM)-AFM, has capabilities to investigate and map the magnetic response of nanomaterials with unprecedented spatial resolution. The second goal was to apply …
Exotic Ground States: A Study In The Structural Effects On Frustration And Dimensionality, Melissa C. Menard
Exotic Ground States: A Study In The Structural Effects On Frustration And Dimensionality, Melissa C. Menard
LSU Doctoral Dissertations
Structural disorder and dimensionality play central roles in the characterization of structure and properties of crystalline materials. Although structural disorder is commonly considered an undesirable quality, structural disorder may be desirable when searching for new materials with exotic properties. Disorder can be used as a tunable parameter when considering atomic sizes, coordination preferences, and electronegativity differences can be varied by substituting elements into a given structure. Dimensionality can be viewed as another adjustable parameter when searching for new materials presenting unique challenges when characterizing new materials. One way to tune dimensionality is by chemical doping to affect coupling between layers/chains. …
Proteomic Analysis Of The Blood Of Alligator Mississippiensis, Lancia Nadinia Fallen Darville-Bowleg
Proteomic Analysis Of The Blood Of Alligator Mississippiensis, Lancia Nadinia Fallen Darville-Bowleg
LSU Doctoral Dissertations
My research focus was to investigate alligator blood using mass spectrometry-based proteomics methods to understand their innate immune systems. The first goal was to sequence peptides and proteins from the blood serum and leukocytes using tandem mass spectrometry and de novo sequencing. The second goal was to determine the function of these biological molecules and their relationship to the immune system. One- and two-dimensional gel electrophoresis was used to separate proteins from alligator leukocytes, which were enzymatically digested. The peptides were measured using reversed phase nano-high performance liquid chromatography coupled with tandem mass spectrometry (nano-HPLC-MS/MS) followed with de novo sequencing. …
Characterization Of Triggerable Quinones For The Development Of Enzyme-Responsive Liposomes, Maria Fabiana Mendoza
Characterization Of Triggerable Quinones For The Development Of Enzyme-Responsive Liposomes, Maria Fabiana Mendoza
LSU Doctoral Dissertations
For decades, there has been a lot of focus on the development of new carriers for drug delivery applications. From all of the carriers, stimuli-responsive liposomes have been studied extensively, but only a handful have been enzyme-responsive liposomes. Therefore, the field of endogenous proteins as activators of liposomes is a fertile field worthy of exploration. The research described in this dissertation involves how structural changes on the quinone moiety altered their electronic properties, as well as their behavior toward the human enzyme NAD(P)H:quinone oxidoreductase type-1 (hNQO1, over expressed in certain tumor tissues), thus yielding a series of triggerable quinones to …
Fully Integrated Microsystem For Bacterial Genotyping, Hui-Wen Chen
Fully Integrated Microsystem For Bacterial Genotyping, Hui-Wen Chen
LSU Doctoral Dissertations
Methods for bacterial detection and identification has garnered renewed interest in recent years due to the infections they may cause and the antimicrobial resistances they can develop, the potential for bioterrorism threats and possible contamination of food/water supplies. Therefore, the rapid, specific and accurate detection of pathogens is crucial for the prevention of pathogen-related disease outbreaks and facilitating disease management as well as the containment of suspected contaminated food and/or water supplies. In this dissertation an integrated modular-based microfluidic system composed of a fluidic cartridge and a control instrument has been developed for bacterial pathogen detection. The integrated system can …
Crystal Growth Of Complex Intermetallics In Search For Heavy Electron Systems, Brenton L. Drake
Crystal Growth Of Complex Intermetallics In Search For Heavy Electron Systems, Brenton L. Drake
LSU Doctoral Dissertations
The structural solution and physical property characterization of several Ln-T-Al/Ga and Ln-T-Al-Si contain phases, which include Ln(Cu,Al)12 (Ln = Y, Ce, Pr, Sm, and Yb), Ln(Ag,Al,Si)2 (Ln = Ce and Gd), LnCu2(Al,Si)5 (Ln = La and Ce), Ln(Cu,Al,Ga)13-x (Ln = La, Ce, Pr, and Eu), α and β LnNiGa4 (α Ln = Y and Gd – Yb; β Ln = (Tb – Er)), and Ln4FeGa12 (Ln = Tb – Er) will be presented in this work with an emphasis on crystal growth. The systems cover a large breadth of phase space and serve to illustrate the new and rich chemistry …
Integrated Modular Microfluidic System For Forensic Alu Dna Typing, Samuel Kimani Njoroge
Integrated Modular Microfluidic System For Forensic Alu Dna Typing, Samuel Kimani Njoroge
LSU Doctoral Dissertations
Driven by the numerous applications of genome-related research, fully integrated microfluidic systems have been developed that have advanced the capabilities of molecular and, in particular, genetic analyses. A brief overview on integrated microfluidic systems for DNA analysis is given in Chapter 1 followed by a report on micro-capillary electrophoresis (µCE) of Alu elements with laser-induced fluorescence (LIF) detection, in which the monomorphic Alu insertions on the X and Y chromosomes were utilized to detect male DNA in large female DNA background (Y: X = 1:19) without cell sorting prior to the determination. The polymorphic Alu loci with known restricted geographical …
Microfluidic Devices Interfaced To Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry For Proteomics, Jeonghoon Lee
Microfluidic Devices Interfaced To Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry For Proteomics, Jeonghoon Lee
LSU Doctoral Dissertations
Microfluidic interfaces were developed for off-line matrix-assisted laser desorption/ionization mass spectrometry (MALDI). Microfluidic interfaces allow samples to be manipulated on-chip and deposited onto a MALDI target plate for analysis. For this research, microfluidic culturing devices and automated digestion and deposition microfluidic chip platforms were developed for the identification of proteins. The microfluidic chip components were fabricated on a poly(methyl methacrylate), PMMA, wafer using the hot embossing method and a molding tool with structures prepared via micromilling. One of the most important components of the chip system was a trypsin microreactor. An open channel microreactor was constructed in a 100 µm …
Synthesis And Characterization Of Rare Earth-Nickel-Gallium Ternary Intermetallics, Kandace R. Thomas
Synthesis And Characterization Of Rare Earth-Nickel-Gallium Ternary Intermetallics, Kandace R. Thomas
LSU Doctoral Dissertations
The structural and physical characterization of several early and latter rare earth Ln-Ni-Ga systems, which include Ln2NiGa12 (Ln = Pr, Nd, Sm), alpha-LnNiGa4 (Ln = Y, Gd – Yb) and beta-LnNiGa4 (Ln = Tb – Ho) will be presented in this work. These systems are thermodynamically located within a copious, robust phase space and provide a rich understanding of how slight modifications to synthetic preparations can yield the adoption of different structure types in a Ga-rich regime. Each of these phases is made up of well-studied substructures which lend an additional angle of apperception as to how their structure and …
Design And Development Of Chiral And Achiral Molecularly Imprinted Stationary Phases, Jason Paul Lejeune
Design And Development Of Chiral And Achiral Molecularly Imprinted Stationary Phases, Jason Paul Lejeune
LSU Doctoral Dissertations
Although the cross-linker can comprise over 80% of the polymer composition, improving the nature of the cross-linker in molecularly imprinted polymers has not been studied extensively. The goal of this research is to develop novel cross-linking monomers to either use in the One MoNomer Molecularly Imprinted Polymer system (OMNiMIP) or use in conjunction with other commercially available cross-linkers and functional monomers. Chapter 2 contains research into the understanding of the performance of a new cross-linking monomer (N, O - bismethacryloyl ethanolamine, NOBE) discovered in the Spivak Research Group. The ability of this monomer to outperform traditional two monomer systems in …
Fabrication Of Receptor-Modified Microfluidic Surfaces For Applications In Glycoprotein Screening, Jennifer Macalindong De Guzman
Fabrication Of Receptor-Modified Microfluidic Surfaces For Applications In Glycoprotein Screening, Jennifer Macalindong De Guzman
LSU Doctoral Dissertations
Glycoproteins have long been identified to have a profound association with human pathological processes, and they are much sought after as potential biomarkers to aid in the early diagnosis and clinical prognosis of cancers and diseases. There is currently high demand for high-throughput and low–limit–of–detection techniques that can afford profiling of the glycoproteome. Micro-total analysis systems (µTAS) based on microfluidics have the potential to fulfill these requirements, but in order to reduce the complexity of the protein pool, the µTAS devices must contain a pre-isolation and enrichment component. The research project undertaken here involved derivatization of microfluidic …
Investigations Of Structure / Property Interrelationships Of Organic Thin Films Using Scanning Probe Microscopy And Nanolithography, Zorabel Mallorca Lejeune
Investigations Of Structure / Property Interrelationships Of Organic Thin Films Using Scanning Probe Microscopy And Nanolithography, Zorabel Mallorca Lejeune
LSU Doctoral Dissertations
Studies of the surface assembly and molecular organization of organic thin films were studied using scanning probe microscopy (SPM) and scanning probe lithography (SPL). Systems of organic thin films such as n-alkanethiols and pyridyl functionalized porphyrins were characterized at the molecular level, and measurements of the conductive properties of polythiophenes containing in-chain cobaltabisdicarbollides were accomplished. Understanding the self-organization and mechanisms of self-assembly of organic molecules provides fundamental insight for structure/property interrelationships. Investigations of the surface assembly of 5,10-diphenyl-15,20-di-pyridin-4-yl-porphyrin (DPP) on Au(111) were done using SPL methods of nanoshaving and nanografting. Automated computer designs were developed for nanofabrication to provide local …
Studies Of Nanoparticles From A Group Of Uniform Materials Based On Organic Salts (Gumbos), Aaron Tesfai
Studies Of Nanoparticles From A Group Of Uniform Materials Based On Organic Salts (Gumbos), Aaron Tesfai
LSU Doctoral Dissertations
Tesfai, Aaron, B.S., B.A., University of Missouri, Columbia, 2003 Doctor of Philosophy, Spring Commencement 2010 Major: Chemistry Studies of Nanoparticles from a Group of Uniform Materials Based on Organic Salts (GUMBOS) Dissertation directed by Professor Isiah M. Warner Pages in dissertation, 101. Words in abstract, 271. Ionic liquids (ILs) are defined as organic salts composed of ions with melting points at or below 100 °C. ILs have gained considerable attention because of their desirable properties such as low volatility, high thermal stability, and tunability. GUMBOS are an emergent class of organic salts, many of which are ionic liquids (ILs). However, …
Particle Analysis In Infrared Laser Desorption And Ablation, Xing Fan
Particle Analysis In Infrared Laser Desorption And Ablation, Xing Fan
LSU Doctoral Dissertations
The fundamental physical processes of mid infrared laser ablation in the context of laser desorption mass spectrometry were investigated. Understanding the mechanisms of infrared laser desorption and ablation can lead to improvements in these techniques and expand their applications. Particles were generated from glycerol irradiated at atmospheric pressure using a tunable infrared laser at wavelengths between 2.6 and 3.8 µm. The wavelength dependence of size distributions of ablated particles was measured. The particle concentration roughly tracked the infrared absorption spectrum of glycerol and the mean particle size tracked the inverse of the IR absorption. A novel approach, post ablation particle …
Part I: Syntheses, Characterizations, And Investigations Of Molecular Micelles And Imidazolium-Based Ionic Liquids For Protein Separations In Electrophoresis Part Ii: Investigating The Mentoring Canon Through Exploration Of Thirty Years Of Mentoring By An Exemplar, Monica R. Sylvain
LSU Doctoral Dissertations
The research reported in this dissertation is presented in two parts. The first part is the Syntheses, Characterizations, and Investigations of Molecular Micelles and Imidazolium-Based Ionic Liquids for Protein Separations in Electrophoresis, and the second part is a case study entitled Investigating the Mentoring Canon through Exploration of Thirty Years of Mentoring by an Exemplar. Protein separations in the gel electrophoretic format are ubiquitous analyses used on a daily basis throughout biochemistry, analytical chemistry, and biotechnology. The goal of the research reported in the first part of this dissertation is to synthesize and characterize molecular micelles and ether-functionalized imidazolium-based ionic …
Iron (Iii) Oxide And Copper (Ii) Oxide Mediated Formation Of Pcdd/Fs From Thermal Degradation Of 2-Mcp And 1,2-Dcbz, Shadrack Kirwa Nganai
Iron (Iii) Oxide And Copper (Ii) Oxide Mediated Formation Of Pcdd/Fs From Thermal Degradation Of 2-Mcp And 1,2-Dcbz, Shadrack Kirwa Nganai
LSU Doctoral Dissertations
Formation of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) which occurs inexorably from most thermal and combustion processes constitutes a major toxic component of environmental pollutants. Generally, it is well established that transition metal-mediated reactions account for the majority of PCDD/F emissions from combustion sources. Specifically, both copper and iron ions, which occur abundantly in combustion generated particulate matter, are considered probably the most active in promoting PCDD/F formation typically in the low temperature post-combustion zone and flue gas pollution control devices. It has also been demonstrated that chlorinated phenols are key intermediates in essentially all pathways of PCDD/F formation. Chlorinated benzenes …
Cross-Talk-Free Dual-Color Fluorescence Cross-Correlation Spectroscopy For High-Throughtput Screening, Wonbae Lee
Cross-Talk-Free Dual-Color Fluorescence Cross-Correlation Spectroscopy For High-Throughtput Screening, Wonbae Lee
LSU Doctoral Dissertations
High throughput processing of chemical/biochemical information is critical in many areas, such as genome sequencing, drug discovery and clinical diagnostics. Integral to collecting information at high rates with the necessary throughput is the development of systems that can not only monitor the results with high precision and accuracy, but also prepare and process samples prior to the analytical measurement. To achieve the required throughput, we have conducted work directed toward developing a system that provides detection sensitivity at the single-molecule detection (SMD) level. The research was first focused on the development of a sensitive strategy for the detection of proteins …
Dissolution Of Chitosan In Ionic Liquids For Acylation Chemistry And Formation Of Cellulose-Chitosan Blends, Cristina Stefanescu
Dissolution Of Chitosan In Ionic Liquids For Acylation Chemistry And Formation Of Cellulose-Chitosan Blends, Cristina Stefanescu
LSU Doctoral Dissertations
Dissolution of chitosan in ionic liquids was accomplished. It has been shown that 1-butyl-3-methylimidazolium acetate (BMIMAc) is a better solvent than 1-butyl-3-methylimidazolium chloride (BMIMCl). Dissolution of chitosan in BMIMCl required a prior regeneration of chitosan from 1% acetic acid solution. In the case of BMIMAc, both dried chitosan and regenerated chitosan from acetic acid solution have been dissolved in a relatively short amount of time. While concentrations up to 2 wt% of chitosan in BMIMCl could be obtained, concentrations of 10 wt % of chitosan in BMIMAc were realized. Homogeneous phthalation and benzoylation of chitosan were achieved in these ionic …
Chemistry Of Rhenium(I) Tricarbonyl Complexes Of Biomedical Relevance, Theshini Perera
Chemistry Of Rhenium(I) Tricarbonyl Complexes Of Biomedical Relevance, Theshini Perera
LSU Doctoral Dissertations
fac-[ReI(CO)3L]n complexes serve as models for short-lived fac-[99mTcI(CO)3L] imaging tracers. Dangling groups on L, needed to achieve desirable biodistribution, complicate the NMR spectra, which are not readily understood. In fac-[ReI(CO)3L]+ with less complicated L, NH groups (exo-NH) projecting toward the L face sometimes showed an upfield shift attributable to steric shielding of the exo-NH group from the solvent by the chelate rings. To investigate whether exo-NH groups in six-membered rings exhibit the same effect and whether the …
Computer Simulation Of Ion-Induced Nucleation In The Presence Of Single Ions And Ion Pairs, Samuel Keasler
Computer Simulation Of Ion-Induced Nucleation In The Presence Of Single Ions And Ion Pairs, Samuel Keasler
LSU Doctoral Dissertations
Atmospheric aerosol particles play an important role in climate and human health. Despite their importance, the mechanisms of their formation are still poorly understood. Ion-induced nucleation may play a role in the process, but details are lacking about how the nucleation rate depends on the size, charge, and number of ions in the cluster. In order to better understand the role that ions might play in new particle formation, we have performed a series of AVUS-HR simulations of the water nucleation in the presence of both single ions and ion pairs. These simulations have shown that the location of the …
Highly Efficient Selection, Enumeration, Enrichment, And Molecular Profiling Of Low-Abundance Biological Cells, Udara R. Dharmasiri Rasika Dharmasiri
Highly Efficient Selection, Enumeration, Enrichment, And Molecular Profiling Of Low-Abundance Biological Cells, Udara R. Dharmasiri Rasika Dharmasiri
LSU Doctoral Dissertations
After brief overviews of low-abundance cell selection techniques in chapter 1 and circulating tumor cells in chapter 2, this dissertation initially focuses on the development of aptamer incorporated high-throughput microfluidic techniques to select rare circulation prostate cancer cells (LNCaP) directly from whole blood with subsequent quantification of these rare cells using a non-labeling approach. Then, I extended the technology to environmental samples in an effort around time, sensitivity, and portability of traditional groundwater assessment. As a model bio- pathogen, E. coli O157:H7 was chosen due to its toxicity and its adverse impact on recreational waters. Low-abundance (<100 cells mL-1) E. coli O157:H7 cells were isolated and enriched from environmental water samples using a microfluidic chip that its capture beds were covalently decorated with E.coli O157:H7 specific polyclonal antibodies. The selected cells were enumerated using RT-qPCR technique. Finally, I have integrated HTMSU with electrokinetic enrichment microfluidic unit for performance of single recombinant low-abundance CTC cell-based assay. A series of analytical processes were carried out, including immunoaffinity selection of rare CTCs, quantification of selected cells via conductivity impedance and electrophoretic enrichment of selected cells for PCR/LDR/CE interrogation for detection of low-abundance point mutations in genomic DNA.
A Study Of The Interactions Of Lipid Bilayers And Dendrimers Using Small Angle X-Ray Scattering And Freeze Fracture Transmission Electron Microscopy, Derek R. Dorman
A Study Of The Interactions Of Lipid Bilayers And Dendrimers Using Small Angle X-Ray Scattering And Freeze Fracture Transmission Electron Microscopy, Derek R. Dorman
LSU Doctoral Dissertations
Lipids are fundamental to all life forms, a key component of cell walls, and essential to proper respiratory function. They are amphiphilic molecules and readily form bilayers. Dendrimers are designer molecules that can be tailored to provide a variety of endgroup moieties, sizes, and charges. The interaction of liposomes and dendrimers can provide information on how medicine interacts with cells and an array of unique structures can be imagined from their assembly into superstructures. Polypropylenimine tetraamine (DAB-Am) and 1-directional arborol dendrimers have been studied in different molar concentrations with 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) bilayers. One-directional arborols are amphiphilic dendrimers with a hydrophilic …
Platforms And Protocols For The Multidimensional Microchip Electrophoretic Analysis Of Complex Proteomes, John K. Osiri
Platforms And Protocols For The Multidimensional Microchip Electrophoretic Analysis Of Complex Proteomes, John K. Osiri
LSU Doctoral Dissertations
The need for rapid, portable and high-throughput systems in proteomics is now prevalent because of demands for generating new protein-based disease biomarkers. However, 2-D protein profile patterns are lending themselves as potential diagnostic tools for biomarker discovery. It is difficult to identify protein biomarkers which are low abundant in the presence of highly abundant proteins, especially in complex biological samples like serum. Protein profiles from 2-D separation of the protein content of cells or body fluids, which are unique to certain physiological or pathological states, are currently available on internet databases. In this work, we demonstrate the ability to separate …
Studies Of Homogeneous Dirhodium Catalyst System, Catherine L. Thomas Alexander
Studies Of Homogeneous Dirhodium Catalyst System, Catherine L. Thomas Alexander
LSU Doctoral Dissertations
Hydroformylation studies were conducted to investigate the effects of various H&sub2;/CO ratios on rac-[Rh&sub2;H&sub2;(μ-CO)&sub2;(et,ph-P4)]²+;, a dirhodium tetraphosphine catalyst system. Similar experiments were also conducted with monometallic catalysts based on BISBI, NAPHOS, and Xantphos, some of the best bisphosphine ligands for hydroformylation catalysis. This was due to the lack of information in literature on the effects of variable ratios and pressures on activities and selectivities of catalysts that contain bisphosphine ligands, and these studies were also used as a basis of comparison for the dirhodium system. Results indicate that the dirhodium system is more efficient with higher H&sub2;/CO ratios (2:1, 90 …