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Articles 241 - 270 of 325
Full-Text Articles in Chemistry
Forensic Analysis Of C-4 And Commercial Blasting Agents For Possible Discrimination, Katie Steele
Forensic Analysis Of C-4 And Commercial Blasting Agents For Possible Discrimination, Katie Steele
Electronic Theses and Dissertations
The criminal use of explosives has increased in recent years. Political instability and the wide spread access to the internet, filled with "homemade recipes," are two conjectures for the increase. C-4 is a plastic bonded explosive (PBX) comprised of 91% of the high explosive RDX, 1.6% processing oils, 5.3% plasticizer, and 2.1% polyisobutylene (PIB). C-4 is most commonly used for military purposes, but also has found use in commercial industry as well. Current methods for the forensic analysis of C-4 are limited to identification of the explosive; however, recent publications have suggested the plausibility of discrimination between C-4 samples based …
Analytical Evaluation Of The Fluorescence Characteristics Of Metabolites Of Polycyclic Aromatic Hydrocarbons At Room, Liquid Nitrogen And Liquid Helium Temperatures, Keerthika Vatsavai
Analytical Evaluation Of The Fluorescence Characteristics Of Metabolites Of Polycyclic Aromatic Hydrocarbons At Room, Liquid Nitrogen And Liquid Helium Temperatures, Keerthika Vatsavai
Electronic Theses and Dissertations
Although environmental monitoring of polycyclic aromatic hydrocarbons (PAH) is an essential step to prevent human exposure to contaminated sites, it provides little information on the actual human uptake and subsequent risks. To this end, urine analysis of short-term biomarkers such as PAH metabolites fill an important niche. The general approach follows the sequence of urine hydrolysis, sample clean-up and pre-concentration, chromatographic separation and determination. Whereas chromatographic methods are based on well established laboratory techniques, the development of easy-to-use, cost-effective and large sample throughput techniques is becoming increasingly relevant to investigate adverse PAH effects on large human populations. This thesis compares …
Remediation Of Heavy Metal Contamination In Sediments: Application Of In Situ Treatment Utilizing Emulsified Liquid Membrane An, Deborah Maxwell
Remediation Of Heavy Metal Contamination In Sediments: Application Of In Situ Treatment Utilizing Emulsified Liquid Membrane An, Deborah Maxwell
Electronic Theses and Dissertations
Heavy metal contamination of soils, sediments and groundwater presents an ongoing source of hazardous and persistent environmental pollution. How best to remediate these contaminants is the impetus of continuing research efforts. Methods include containment, ex situ and in situ techniques. A successful in situ method utilizing a combination of emulsified liquid membranes, ELM, and zero-valent metal, ZVM, and bimetals has demonstrated impressive heavy metal reduction in 100 ppm solutions of Cd, Cu, Ni, Pb, Cr and U. This promising in situ method has been employed by the Industrial Chemistry Laboratory at the University of Central Florida and it has demonstrated …
Singlet Oxygen Generation Using New Fluorene-Based Photosensitizers Under One- And Two-Photon Excitation, Stephen James Andrasik
Singlet Oxygen Generation Using New Fluorene-Based Photosensitizers Under One- And Two-Photon Excitation, Stephen James Andrasik
Electronic Theses and Dissertations
Molecular oxygen in its lowest electronically excited state plays an important roll in the field of chemistry. This excited state is often referred to as singlet oxygen and can be generated in a photosensitized process under one- or two-photon excitation of a photosensitizer. It is particularly useful in the field of photodynamic cancer therapy (PDT) where singlet oxygen formation can be used to destroy cancerous tumors. The use of two-photon activated photosensitizers possesses great potential in the field of PDT since near-IR light is used to activate the sensitizer, resulting in deeper penetration of light into biological tissue, less photobleaching …
Discrimination Of Forensic Trace Evidence Using Laser Induced Breakdown Spectroscopy, Candice Bridge
Discrimination Of Forensic Trace Evidence Using Laser Induced Breakdown Spectroscopy, Candice Bridge
Electronic Theses and Dissertations
Elemental analysis in forensic laboratories can be tedious and many trace evidence items are not analyzed to determine their elemental composition. Presently, scanning electron microscopy-energy dispersive x-ray spectroscopy (SEM-EDS) is the primary analytical tool for determining the elemental composition of trace evidence items. However, due to the time it takes to obtain the required vacuum and the limited number of samples that can be analyzed at any one time, SEM-EDS can be impractical for a high volume of evidence items. An alternative instrument that can be used for this type of analysis is laser ablation inductively coupled plasma mass spectrometry …
Two-Photon 3d Optical Data Storage Via Fluorescence Modulation Of Fluorene Dyes By Photochromic Diarylethenes, Claudia Corredor
Two-Photon 3d Optical Data Storage Via Fluorescence Modulation Of Fluorene Dyes By Photochromic Diarylethenes, Claudia Corredor
Electronic Theses and Dissertations
Three-dimensional (3D) optical data storage based on two-photon processes provides highly confined excitation in a recording medium and a mechanism for writing and reading data with less cross talk between multiple memory layers, due to the quadratic dependence of two photon absorption (2PA) on the incident light intensity. The capacity for highly confined excitation and intrinsic 3D resolution affords immense information storage capacity (up to 1012 bits/cm3). Recently, the use of photochromic materials for 3D memory has received intense interest because of several major advantages over current optical systems, including their erasable/rewritable capability, high resolution, and high sensitivity. This work …
Analytical Potential Of Polymerized Liposomes Bound To Lanthanide Ions For Qualitative And Quantitative Analysis Of Proteins, Marina Santos
Analytical Potential Of Polymerized Liposomes Bound To Lanthanide Ions For Qualitative And Quantitative Analysis Of Proteins, Marina Santos
Electronic Theses and Dissertations
One of the intriguing features of biological systems is the prevalence of highly selective and often very strong interactions among different cellular components. Such interactions play a variety of organizational, mechanical, and physiological roles at the cellular and organism levels. Antigen-antibody complexes are representative examples of highly selective and potent interactions involving proteins. The marked specificity of protein-antibody complexes have led to a wide range of applications in cellular and molecular biology related research. They have become an integral research tool in the present genomic and proteomic era. Unfortunately, the production of selective tools based on antigen-antibody interactions requires cumbersome …
Advances In Fire Debris Analysis, Mary Williams
Advances In Fire Debris Analysis, Mary Williams
Electronic Theses and Dissertations
Fire incidents are a major contributor to the number of deaths and property losses within the United States each year. Fire investigations determine the cause of the fire resulting in an assignment of responsibility. Current methods of fire debris analysis are reviewed including the preservation, extraction, detection and characterization of ignitable liquids from fire debris. Leak rates were calculated for the three most common types of fire debris evidence containers. The consequences of leaking containers on the recovery and characterization of ignitable liquids were demonstrated. The interactions of hydrocarbons with activated carbon during the extraction of ignitable liquids from the …
Simplified Low Copy Number Dna Analysis By Post Pcr Purification, Pamela Smith
Simplified Low Copy Number Dna Analysis By Post Pcr Purification, Pamela Smith
Electronic Theses and Dissertations
Frequently evidentiary items contain an insufficient quantity of DNA to obtain complete or even partial DNA profiles using standard forensic gentotyping techniques. Here, various methods of post PCR purification were evaluated for their effects on the sensitivity of fluophore-based allelic detection. A method of post PCR purification is described which increases the sensitivity of standard 28 cycle PCR such that low copy number DNA templates (<100 pg DNA) can be analyzed. Full profiles were consistently obtained with as little as 20 pg template DNA without increased cycle number. In mock case type samples with dermal ridge fingerprints, genetic profiles were obtained by amplification with 28 cycles followed by post-PCR purification whereas no profiles were obtained without purification of the PCR product. Allele drop-out, increased stutter, and contamination (allele drop-in) typical of LCN analysis were observed. A single incident of contamination was observed in a reagent blank (not duplicated upon re-amplification) however, no contamination was observed in negative amplification controls.
Discrimination Of Automobile Carpet Fibers Using Multiple Analytical Techniques And The Subsequent Creation Of A Searchable Data, Derek Dorrien
Discrimination Of Automobile Carpet Fibers Using Multiple Analytical Techniques And The Subsequent Creation Of A Searchable Data, Derek Dorrien
Electronic Theses and Dissertations
Forensic fiber examination is an important part of trace evidence analysis. Fibers may be recovered from a crime scene that could link a particular suspect to the scene. Clothing fibers are most frequently encountered but automobile carpeting fibers may also be recovered. An understanding of the frequency of occurrence and the discrimination power of different analytical techniques is needed in order to better establish the evidentiary value of automobile carpet fiber evidence. Seventy-five automobile carpet fiber samples were analyzed using a series of techniques ranging from nondestructive to destructive. These techniques included polarized light microscopy, fluorescence microscopy, microspectrophotometry, Fourier-transform infrared …
Performance Efficacy Using A Comparison Of Commerical And In-House Y-Str Multiplex Systems For Operational Use, Kathleen Mayntz-Press
Performance Efficacy Using A Comparison Of Commerical And In-House Y-Str Multiplex Systems For Operational Use, Kathleen Mayntz-Press
Electronic Theses and Dissertations
It is routine for the forensic scientist to obtain a genetic profile of an individual from DNA recovered from a biological stain deposited at a crime scene. In contrast, only a limited number of laboratories in the United States have the capability of performing Y-STR analysis in casework. In order to aid in facilitating the transfer of Y-STR technology to the crime laboratory community for operational use, a comparison between commercial products from three main vendors (Applied Biosystems AmpFLSTR Yfiler PCR Amplification Kit, Promega PowerPlex - Y System, Reliagene Y-PLEX 12) and two in-house Y-STR multiplexes (MPI and MPB) commenced. …
New Developments On High-Resolution Luminescence Spectroscopy And Their Application To The Direct Analysis Of Organic Pollutants, Shenjiang Yu
Electronic Theses and Dissertations
Polycyclic aromatic compounds (PACs), which comprise a complex class of condensed multi-ring benzenoid compounds, are important environmental pollutants originating from a wide variety of natural and anthropogenic sources. PACs are generally formed during incomplete combustion of pyrolisis of organic matter containing carbon and hydrogen. Because combustion of organic materials is involved in countless natural processes or human activities, PACs are omnipresent and abundant pollutants in air, soil, and water. Chemical analysis of PACs is of great environmental and toxicological importance. Many of them are highly suspect as etiological agents in human cancer. Because PACs carcinogenic properties strongly depend on molecular …
Truly Non Invasive Glucose Optical Sensor Based On Metal Nanoparticles Generation, Marisol Garcia
Truly Non Invasive Glucose Optical Sensor Based On Metal Nanoparticles Generation, Marisol Garcia
Electronic Theses and Dissertations
Diabetes is a disease that causes many complications in human normal function. This disease represents the sixth-leading cause of death in USA. Prevention of diabetes-related complications can be accomplished through tight control of glucose levels in blood. In the last decades many different glucose sensors have been developed, however, none of them are really non invasive. Herein, we present the study of the application of gold and silver nanoparticles with different shapes and aspect ratios to detect glucose traces in human fluids such as tears and sweat. This is to our knowledge the first truly non invasive glucose optical sensor, …
Analytical Potential Of Polymerized Liposomes Bound To Lanthanide Ions For Qualitative And Quantitative Analysis Of Proteins, Marina Santos
Analytical Potential Of Polymerized Liposomes Bound To Lanthanide Ions For Qualitative And Quantitative Analysis Of Proteins, Marina Santos
Electronic Theses and Dissertations
One of the intriguing features of biological systems is the prevalence of highly selective and often very strong interactions among different cellular components. Such interactions play a variety of organizational, mechanical, and physiological roles at the cellular and organism levels. Antigen-antibody complexes are representative examples of highly selective and potent interactions involving proteins. The marked specificity of protein-antibody complexes have led to a wide range of applications in cellular and molecular biology related research. They have become an integral research tool in the present genomic and proteomic era. Unfortunately, the production of selective tools based on antigen-antibody interactions requires cumbersome …
Recovery Of Hydrogen And Helium From Their Mixtures Using Metal Hydrides, Muzaffer Tonguc Oztek
Recovery Of Hydrogen And Helium From Their Mixtures Using Metal Hydrides, Muzaffer Tonguc Oztek
Electronic Theses and Dissertations
Waste streams of hydrogen and helium mixtures are produced at the Kennedy Space Center during purging of the hydrogen systems and supply lines. This process is done prior to and after hydrogen servicing. The purged waste gases are lost to the atmosphere, resulting in an annual loss of 2 million and 0.1 million standard cubic meters of helium and hydrogen, respectively. Recovery of these gases will have an economic benefit. Metals, alloys, and intermetallics are known to react with hydrogen in favorable conditions; therefore, they have the possibility of serving as separating and recovery agents. In this study, Mg2Ni, VTiNi …
Messenger Rna Profiling: A Prototype Method For Body Fluidand Tissue Identification, Jane Juusola
Messenger Rna Profiling: A Prototype Method For Body Fluidand Tissue Identification, Jane Juusola
Electronic Theses and Dissertations
Conventional methods of body fluid identification use labor-intensive, technologically diverse techniques that are performed in a series, not parallel, manner and are costly in terms of time and sample. Furthermore, for some frequently encountered body fluids, such as saliva or vaginal secretions, no confirmatory technique exists. Terminally differentiated cells, such as blood lymphocytes or epithelial cells lining the oral cavity, have a unique pattern of gene expression, which is evinced by the presence and relative abundance of specific mRNA species. If the type and abundance of mRNAs can be determined in a stain or tissue sample recovered at the crime …
Synthesis, Characterizations, And Evaluation Of New Reactive Two-Photon Absorbing Dyes For Two-Photon Excited Fluorescence Imaging Applications, Katherine J. Hales
Synthesis, Characterizations, And Evaluation Of New Reactive Two-Photon Absorbing Dyes For Two-Photon Excited Fluorescence Imaging Applications, Katherine J. Hales
Electronic Theses and Dissertations
Recent, cooperative advances in chemistry, biology, computing, photophysics, optics, and microelectronics have resulted in extraordinary developments in the biological sciences, resulting in the emergence of a novel area termed 'biophotonics'. The integrative and interdisciplinary nature of biophotonics cuts across virtually all disciplines, extending the frontiers of basic cellular, molecular, and biology research through the clinical and pharmaceutical industries. This holds true for the development and application of the novel imaging modality utilizing multiphoton absorption and its extraordinary contribution to recent advances in bioimaging. Intimately involved in the revolution of nonlinear bioimaging has been the development of optical probes for probing …
In Situ Remediation Of Heavy Metal Contaminated Sediments Using Emulsified Zero-Valent Metal Particles, Kristen Marie Milum
In Situ Remediation Of Heavy Metal Contaminated Sediments Using Emulsified Zero-Valent Metal Particles, Kristen Marie Milum
Electronic Theses and Dissertations
Sediments can act as both a sink for pollutants and a source for aquatic contaminants. Natural and human disturbances of the sediments can release the contaminants to the overlying water where bottom dwelling, or benthic, organisms may be exposed through direct contact, ingestion of sediment particles, or uptake of dissolved contaminants present in the water. Dredging, the most common remediation technology for heavy metals, exacerbates this process. The in situ use of emulsified metal has been studied for its ability to pull heavy metals from aqueous solution and from saturated soils. It has proven successful in the laboratory with removal …
Reaction Rates For The Dehalogenation Of Trichloroethylene Using Various Types Of Zero-Valent Iron, Neil Stewart
Reaction Rates For The Dehalogenation Of Trichloroethylene Using Various Types Of Zero-Valent Iron, Neil Stewart
Electronic Theses and Dissertations
Remediation of trichloroethylene (TCE) and other chlorinated solvents is of great concern due to their toxicity and their persistence in the environment. Iron has been used extensively in the past decade as a subsurface reactive agent for the remediation of dense, nonaqueous-phase liquids (DNAPLs). Permeable reactive barrier walls (PRBW) have been installed at many sites around the country to treat contaminated plumes resulting from the presence of DNAPL pools. The use of zero-valent metals, such as iron, to effectively reductively dechlorinate DNAPLs has been employed as the reactive material in these PRBWs (Gillham et al., 1993). However, limited work has …
Part I : Isolation Of Dipentyl 2-(4-(Pentan-3-Yl) Phenyl) Malonate From Sanguisorba Officinalis Labill Part Ii: Synthesis Of A Novel Family Of Ethers Of Podocarpic Acid, Manjeera Yalavarty
Part I : Isolation Of Dipentyl 2-(4-(Pentan-3-Yl) Phenyl) Malonate From Sanguisorba Officinalis Labill Part Ii: Synthesis Of A Novel Family Of Ethers Of Podocarpic Acid, Manjeera Yalavarty
Electronic Theses and Dissertations
The goal of part I of this thesis was to isolate pure anti cancer compounds from the Russian plant Sanguisorba officinalis. This plant was selected for investigation because it showed 100% activity against leukemia (L1210 mouse leukemia cells) during the preliminary screening of approximately 100 Russian plant extracts. This work has resulted in the isolation of novel compound 11 using traditional chromatography techniques. Compound 11 was characterized with spectroscopic techniques such as IR, 1H NMR, 13C NMR, DEPT, DQCOSY and MS. Compound 11 was assigned the structure dipentyl 2-(4-(pentan-3-yl) phenyl) malonate. The goal of part II of this thesis was …
Synthesis Of Alkylthiol-Containing Fluorene Derivatives For Gold Nanoparticle Functionalization, Sriram Mukundarajan
Synthesis Of Alkylthiol-Containing Fluorene Derivatives For Gold Nanoparticle Functionalization, Sriram Mukundarajan
Electronic Theses and Dissertations
A novel synthetic methodology has been developed for attaching fluorene derivatives, containing different types of electron donating and accepting groups at the 2 and 7 positions, to gold nanoparticles of different sizes by exploiting the affinity of the thiol functional group for gold. The distance between the dye and nanoparticles was varied by introducing two alkyl chains containing different number of carbon atoms at the 9 position on the fluorene ring system. The methodology that was developed gave enough scope for performing Radiative Decay Engineering (RDE) studies, in order to investigate the impact of gold nanoparticles on the singlet oxygen …
Assessment And In Vitro Repair Of Damaged Dna Templates From Forensic Stains, Ashley Hall
Assessment And In Vitro Repair Of Damaged Dna Templates From Forensic Stains, Ashley Hall
Electronic Theses and Dissertations
DNA extracted from biological stains is often intractable to analysis. This may due to a number of factors including a low copy number (LCN) of starting molecules, the presence of soluble inhibitors or damaged DNA templates. Remedies may be available to the forensic scientist to deal with LCN templates and soluble inhibitors but none presently exist for damaged DNA. In fact, only recently has the biochemical nature, the extent of DNA damage in physiological stains and the point at which the damage inflicted upon a particular sample precludes the ability to obtain a genetic profile for purposes of identification been …
Structural Study Of Disease Related Proteins, Ayse Sinem Ozyurt
Structural Study Of Disease Related Proteins, Ayse Sinem Ozyurt
Electronic Theses and Dissertations
The availability of complete sequences for the genomes of many organisms changes the researcher's attention from genome sequencing to finding the function of gene products, the proteins. The three dimensional (3D) structure of a protein is helpful to understand its function, because tertiary structure is more conserved in evolution than sequence. The 3D structures can be found quickly by using high-throughput (HT) methods for protein expression, purification, characterization and structure determination. This process is very challenging in every step. Therefore we selected nearly 200 cancer related proteins as targets to see the difficulties in trying to determine the web predicted …
The Use And Development Of Laser Microdissection To Separate Spermatozoa From Epithelial Cells For Str Analysis, Christine Sanders
The Use And Development Of Laser Microdissection To Separate Spermatozoa From Epithelial Cells For Str Analysis, Christine Sanders
Electronic Theses and Dissertations
Short Tandem Repeat (STR) analysis has become a valuable tool in identifying the source of biological stains, particularly from the investigation of sexual assault crimes. Difficulties in analysis arise primarily in the interpretation of mixed genotypes when cell separation of the sexual assailant's sperm from the victim's cells is incomplete. The forensic community continues to seek improvements in cell separation methods from mixtures for DNA typing. This report describes the use of laser microdissection (LMD) for the separation of pure populations of spermatozoa from two-donor cell mixtures. In this study, cell separation was demonstrated by microscopic identification of histologically stained …
New Organic/Inorganic Hybrid Sol-Gel Nanocomposite Materials For Raman Gain In Fiber Optics, Stephen James Andrasik
New Organic/Inorganic Hybrid Sol-Gel Nanocomposite Materials For Raman Gain In Fiber Optics, Stephen James Andrasik
Electronic Theses and Dissertations
The recent increased availability of additional wavelengths in the telecommunications window of about 1300-1600 nm has generated an interest in new optical materials and devices that can operate outside the normally used regions of 840 nm, 1310 nm, and 1550 nm. Specifically, methods to amplify fiber optical data transmission in the regions where there is limited or no existing methods to achieve amplification is of interest in the chemistry and photonic communities. Raman gain is one method that has been proposed to passively amplify optical data transmission through a distributed process. Amplification is obtained through a nonlinear light scattering process …
Part I: Evaluation Of Russian Synthetic Compounds As A Potential Source Of New Drug Leads Agains Breast And Colon Cancer Part Ii: Isolation Of Beta-Amyrin Formate From Eucalyptus Viminalis Labill And Investigation Of Its Colon Cancer Activity, Mihaela Cohanoschi
Electronic Theses and Dissertations
Although modern medicine made great steps toward curing most diseases considered deadliest, yet cancer remains one of the major public health problems. The first part of this thesis investigates a new source of selective compounds that are potential candidates against cancer. Fifteen Russian compounds were tested in order to establish their efficiency against two types of cancer: human breast SK-Br-3 and colorectal carcinoma HT-29. The bioassay results show that seven of the new synthetic Russian compounds can be considered new drug leads, based upon their low toxicity and efficacy in slowing the growth of human breast cancer and colon cancer …
The Use Of Pyrosequencing For The Analysis Of Y Chromosome Single Nucleotide Polymorphisms, Jeremy Charles Fletcher
The Use Of Pyrosequencing For The Analysis Of Y Chromosome Single Nucleotide Polymorphisms, Jeremy Charles Fletcher
Electronic Theses and Dissertations
The potential value of the Y chromosome for forensic applications has been recognized for some time with the current work dedicated to Short Tandem Repeat analysis and Single Nucleotide Polymorphism (SNP) discovery. This study examined the ability of two different SNP analysis methods to determine if they could be utilized in forensic applications and ultimately be developed into an established system for Y chromosome SNP analysis. This study examined two principle SNP analysis systems: single base extension and Pyrosequencing. Pyrosequencing was determined to be superior to single base extension, due to the wealth of information provided with sequencing and the …
Method For Determination Of Singlet Oxygen Quantum Yields For New Fluorene-Based Photosensitizers In Aqueous Media For The Advancement Of Photodynamic Therapy, Wade William Grabow
Method For Determination Of Singlet Oxygen Quantum Yields For New Fluorene-Based Photosensitizers In Aqueous Media For The Advancement Of Photodynamic Therapy, Wade William Grabow
Electronic Theses and Dissertations
Photodynamic therapy (PDT) has been investigated over the past three decades and is currently an approved therapeutic modality for skin cancer, the treatment of superficial bladder, early lung and advanced esophageal cancers, and age-related macular degeneration in a number of countries. In PDT, the absorption of light by a chromophore generates cytotoxic species such as reactive singlet oxygen, leading to irreversible destruction of the treated tissue. The measurement of the singlet oxygen quantum yield is an important determinant used to evaluate the efficiency of new photodynamic therapy agents developed in the laboratory, to screen potential photosensitizers in aqueous media.The singlet …
Synthesis And Polymerization Of Bifunctional Five-Membered Cyclic Dithiocarbonates And Their Use As Stabilizers For Magnetic Nan, Mohammed Daoudi
Synthesis And Polymerization Of Bifunctional Five-Membered Cyclic Dithiocarbonates And Their Use As Stabilizers For Magnetic Nan, Mohammed Daoudi
Electronic Theses and Dissertations
Novel bifunctional five-membered cyclic dithiocarbonates (1,3-oxathiolane-2-thione)s were synthesized by the reactions of the corresponding bifunctional oxiranes (epoxides) with carbon disulfide at room temperature with lithium bromide as catalyst. Full characterization of these monomers was performed including elemental analysis, proton and carbon nuclear magnetic resonance (NMR) spectroscopy, gas chromatography-mass spectroscopy, and Fourier transmission infrared (FTIR) spectroscopy. The polyaddition polymerization of 1,3-oxathiolane-2-thione with 1,4-diaminobutane at room temperature resulted in a poly(thiourethane) material. The latter undergoes crosslinking due probably to the autooxidation of the product and formation of disulfide linkages. The five-membered cyclic dithiocarbonate, 5-decyl-1,3-oxathiolane-2-thione, was used a model to demonstrate the usefulness …
Synthesis Of A Novel Family Of Amide Derivatives Of Podocarpic Acid, Dao Nguyen
Synthesis Of A Novel Family Of Amide Derivatives Of Podocarpic Acid, Dao Nguyen
Electronic Theses and Dissertations
As a class, amides are of great interest in biological studies and pharmaceutical application. In this work, podocarpic acid, a natural tricyclic diterpene, derived from Podocarpus species, has been employed to form a novel family of amide derivatives which will later be studied for their potential as new drug leads. Novel amide derivatives of podocarpic acid were synthesized from podocarpic acid in three steps. The first step involved methylation with dimethylsulfate to form methyl-O-methylpodocarpate. This step was followed by iodination with iodine to give iodomethyl-O-methylpodocarpate. Finally amidation with various aliphatic amides using a copper catalyst yielded four amide derivatives of …