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Articles 661 - 690 of 954
Full-Text Articles in Chemistry
04. Botany, University Of Central Oklahoma
04. Botany, University Of Central Oklahoma
Oklahoma Research Day Abstracts
No abstract provided.
09. Environmental Science, University Of Central Oklahoma
09. Environmental Science, University Of Central Oklahoma
Oklahoma Research Day Abstracts
No abstract provided.
12. Kinesiology, University Of Central Oklahoma
12. Kinesiology, University Of Central Oklahoma
Oklahoma Research Day Abstracts
No abstract provided.
08. Engineering, University Of Central Oklahoma
08. Engineering, University Of Central Oklahoma
Oklahoma Research Day Abstracts
No abstract provided.
10. Forensic Science, University Of Central Oklahoma
10. Forensic Science, University Of Central Oklahoma
Oklahoma Research Day Abstracts
No abstract provided.
05. Chemistry, University Of Central Oklahoma
05. Chemistry, University Of Central Oklahoma
Oklahoma Research Day Abstracts
No abstract provided.
14. Optometry, University Of Central Oklahoma
14. Optometry, University Of Central Oklahoma
Oklahoma Research Day Abstracts
No abstract provided.
15. Pharmacy, University Of Central Oklahoma
15. Pharmacy, University Of Central Oklahoma
Oklahoma Research Day Abstracts
No abstract provided.
17. Psychology, University Of Central Oklahoma
17. Psychology, University Of Central Oklahoma
Oklahoma Research Day Abstracts
No abstract provided.
19. Zoology, University Of Central Oklahoma
19. Zoology, University Of Central Oklahoma
Oklahoma Research Day Abstracts
No abstract provided.
03. Biology, University Of Central Oklahoma
03. Biology, University Of Central Oklahoma
Oklahoma Research Day Abstracts
No abstract provided.
13. Mathematics, University Of Central Oklahoma
13. Mathematics, University Of Central Oklahoma
Oklahoma Research Day Abstracts
No abstract provided.
16. Physics, University Of Central Oklahoma
16. Physics, University Of Central Oklahoma
Oklahoma Research Day Abstracts
No abstract provided.
02. Animal Science, University Of Central Oklahoma
02. Animal Science, University Of Central Oklahoma
Oklahoma Research Day Abstracts
No abstract provided.
07. Criminal Justice, University Of Central Oklahoma
07. Criminal Justice, University Of Central Oklahoma
Oklahoma Research Day Abstracts
No abstract provided.
11. Genetics, University Of Central Oklahoma
11. Genetics, University Of Central Oklahoma
Oklahoma Research Day Abstracts
No abstract provided.
18. Statistics, University Of Central Oklahoma
18. Statistics, University Of Central Oklahoma
Oklahoma Research Day Abstracts
No abstract provided.
Design, Synthesis And Applications Of Fluorescent And Electrochemical Probes, Giri K. Vegesna
Design, Synthesis And Applications Of Fluorescent And Electrochemical Probes, Giri K. Vegesna
Dissertations, Master's Theses and Master's Reports - Open
“Seeing is believing” the proverb well suits for fluorescent imaging probes. Since we can selectively and sensitively visualize small biomolecules, organelles such as lysosomes, neutral molecules, metal ions, anions through cellular imaging, fluorescent probes can help shed light on the physiological and pathophysiological path ways. Since these biomolecules are produced in low concentrations in the biochemical pathways, general analytical techniques either fail to detect or are not sensitive enough to differentiate the relative concentrations. During my Ph.D. study, I exploited synthetic organic techniques to design and synthesize fluorescent probes with desirable properties such as high water solubility, high sensitivity and …
Upregulation Of Functional Kv11.1 Isoform Expression By Inhibition Of Intronic Polyadenylation With Antisense Morpholino Oligonucleotides, Qiuming Gong, Matthew R. Stump, Zhengfeng Zhou
Upregulation Of Functional Kv11.1 Isoform Expression By Inhibition Of Intronic Polyadenylation With Antisense Morpholino Oligonucleotides, Qiuming Gong, Matthew R. Stump, Zhengfeng Zhou
Faculty Publications - Department of Biological & Molecular Science
The KCNH2 gene encodes the Kv11.1 potassium channel that conducts the rapidly activating delayed rectifier current in the heart. KCNH2 pre-mRNA undergoes alternative processing; intron 9 splicing leads to the formation of a functional, full-length Kv11.1a isoform, while polyadenylationwithin intron 9 generates a non-functional, Cterminally truncated Kv11.1a-USO isoform. The relative expression of Kv11.1 isoforms plays an important role in the regulation of Kv11.1 channel function and the pathogenesis of long QT syndrome. In this study,we identified cis-acting elements that are required for KCNH2 intron 9 poly(A) signal activity. Mutation of these elements decreased Kv11.1a-USO expression and increased the expression of …
Synthesis And Characterization Of Brain Penetrant Prodrug Of Neuroprotective D264: Potential Disease Modifying Treatment Agent For Parkinson's Disease, Fahd Shamoon Dholkawala
Synthesis And Characterization Of Brain Penetrant Prodrug Of Neuroprotective D264: Potential Disease Modifying Treatment Agent For Parkinson's Disease, Fahd Shamoon Dholkawala
Wayne State University Theses
Parkinson's disease (PD) is a complex neurodegenerative disorder with progressive loss of dopamanergic neurons in the substantia nigra region of the brain and accumulation of intracytoplasmic inclusions called `Lewy bodies'. PD is characterized by tremors, rigidity, slowness of movement, bradykinesia and postural imbalances. Although the etiology of PD is not well understood, it is well established that oxidative stress, mitochondrial dysfunction, alpha-synuclein aggregation play a central role in the pathogenesis of PD. Current treatment methods are based on symptomatic relief without addressing the underlying pathophysiological factors responsible for the disease. It is important to develop therapies which can address these …
Art Or Science?, Allison Marsh
Art Or Science?, Allison Marsh
Section 3: Imaging the Fast Moving
No abstract provided.
Position Of Premature Termination Codons Determines Susceptibility Of Herg Mutations To Nonsense-Mediated Mrna Decay In Long Qt Syndrome, Qiuming Gong, Matthew R. Stump, Zhengfeng Zhou
Position Of Premature Termination Codons Determines Susceptibility Of Herg Mutations To Nonsense-Mediated Mrna Decay In Long Qt Syndrome, Qiuming Gong, Matthew R. Stump, Zhengfeng Zhou
Faculty Publications - Department of Biological & Molecular Science
The degradation of human ether-a-go-go-related gene (hERG, KCNH2) transcripts containing premature termination codon (PTC)mutations by nonsense-mediatedmRNA decay (NMD) is an importantmechanismof long QT syndrome type 2 (LQT2). The mechanisms governing the recognition of PTC-containing hERG transcripts asNMD substrates have not been established. We used a minigene system to study two frameshift mutations, R1032Gfs*25 and D1037Rfs*82. R1032Gfs*25 introduces a PTC in exon 14, whereas D1037Rfs*82 causes a PTC in the last exon (exon 15). We showed that R1032Gfs*25, but not D1037Rfs*82, reduced the level of mutant mRNA compared to thewild-type minigene in an NMD-dependent manner. The deletion of intron 14 prevented …
Dj-1 And Atp13a2: Two Proteins Involved In Parkinson’S Disease, Josephat M Asiago
Dj-1 And Atp13a2: Two Proteins Involved In Parkinson’S Disease, Josephat M Asiago
Open Access Dissertations
Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, affecting approximately 0.3% of the total U.S. population, and its prevalence increases with age. Two neuropathological hallmarks of PD are the loss of dopaminergic neurons in the substantia nigra pars compacta, a region in the midbrain involved in initiating and sustaining movement, and the presence of cytosolic inclusions called Lewy bodies (LBs) in various brain regions. LBs are enriched with fibrillar forms of the presynaptic protein &agr;-synuclein (aSyn). Two autosomal recessive genes implicated in familial PD are PARK9, encoding the P-type ATPase ATP13A2, a lysosomal ATPase; and …
Table Of Contents, Michele Harmon
Table Of Contents, Michele Harmon
Journal of the South Carolina Academy of Science
No abstract provided.
Dose Dependent Effects Of Caffeine On Cognitive Performance And Neuronal Activation, Stephan Albrecht, Helen Morris, Michelle Vieyra
Dose Dependent Effects Of Caffeine On Cognitive Performance And Neuronal Activation, Stephan Albrecht, Helen Morris, Michelle Vieyra
Journal of the South Carolina Academy of Science
Many students assume that the more caffeine you drink, the better your cognitive performance. Over-consumption of caffeine has many negative effects, so if there are no dose related cognitive benefits to large amounts of caffeine, then college students should limit their intake. This study looked at whether ingesting a medium dose (200 mg) versus a lower dose (100 mg) of caffeine improved short term memory as measured by Flanker and n-back tests, compared to a control group. In addition, we looked at whether larger doses of caffeine produced a difference in neuronal activation during these tests as measured by functional …
Fourier Analysis Of Phase Resetting Curves Of Neural Oscillators, Robert A. Raidt, Sorinel A. Oprisan
Fourier Analysis Of Phase Resetting Curves Of Neural Oscillators, Robert A. Raidt, Sorinel A. Oprisan
Journal of the South Carolina Academy of Science
We investigated the impact of changes in biologically relevant control parameters, such as the shape of an external perturbation or the conductance values of an individual model neuron, on the shape of the phase resetting curve (PRC) of that neuron. For that purpose, PRCs were generated for groups of Morris-Lecar (ML) model neurons with different conductance values but similar firing periods (within 0.005ms) using external rectangular, triangular, or trapezoidal perturbations of varying areas. These PRCs were numerically described and analyzed as a series of coefficient values using a Fourier Discrete Sine Transform (DST). We found that changes in the shape …
Identification Of Disulfide Bond Formation Between Mitoneet And Glutamate Dehydrogenase 1, Morgan E. Roberts, Jacquelyn P. Crail, Megan M. Laffoon, William G. Fernandez, Michael A. Menze, Mary E. Konkle
Identification Of Disulfide Bond Formation Between Mitoneet And Glutamate Dehydrogenase 1, Morgan E. Roberts, Jacquelyn P. Crail, Megan M. Laffoon, William G. Fernandez, Michael A. Menze, Mary E. Konkle
Faculty Research & Creative Activity
MitoNEET is a protein that was identified as a drug target for diabetes, but its cellular function as well as its role in diabetes remains elusive. Protein pull-down experiments identified glutamate dehydrogenase 1 (GDH1) as a potential binding partner. GDH1 is a key metabolic enzyme with emerging roles in insulin regulation. MitoNEET forms a covalent complex with GDH1 through disulfide bond formation and acts as an activator. Proteomic analysis identified the specific cysteine residues that participate in the disulfide bond. This is the first report that effectively links mitoNEET to activation of the insulin regulator GDH1.
Ua66 Ogden College Of Science & Engineering Newsletter, Cheryl Stevens, Dean
Ua66 Ogden College Of Science & Engineering Newsletter, Cheryl Stevens, Dean
Ogden College of Science & Engineering Publications
No abstract provided.
Identification Of Disufide Bond Formation Between Mitoneet And Glutamate Dehydrogenase 1, Morgan E. Roberts, Jacquelyn P. Crail, Megan M. Laffoon, William G. Fernandez, Michael A. Menze, Mary E. Konkle
Identification Of Disufide Bond Formation Between Mitoneet And Glutamate Dehydrogenase 1, Morgan E. Roberts, Jacquelyn P. Crail, Megan M. Laffoon, William G. Fernandez, Michael A. Menze, Mary E. Konkle
Faculty Research & Creative Activity
MitoNEET is a protein that was identified as a drug target for diabetes, but its cellular function as well as its role in diabetes remains elusive. Protein pull-down experiments identified glutamate dehydrogenase 1 (GDH1) as a potential binding partner. GDH1 is a key metabolic enzyme with emerging roles in insulin regulation. MitoNEET forms a covalent complex with GDH1 through disulfide bond formation and acts as an activator. Proteomic analysis identified the specific cysteine residues that participate in the disulfide bond. This is the first report that effectively links mitoNEET to activation of the insulin regulator GDH1.
Identification Of Disufide Bond Formation Between Mitoneet And Glutamate Dehydrogenase 1., Morgan Roberts, Jacquelyn Crail, Megan Laffoon, William Fernandez, Michael Menze, Mary Konkle
Identification Of Disufide Bond Formation Between Mitoneet And Glutamate Dehydrogenase 1., Morgan Roberts, Jacquelyn Crail, Megan Laffoon, William Fernandez, Michael Menze, Mary Konkle
Faculty and Staff Scholarship
MitoNEET is a protein that was identified as a drug target for diabetes, but its cellular function as well as its role in diabetes remains elusive. Protein pull-down experiments identified glutamate dehydrogenase 1 (GDH1) as a potential binding partner. GDH1 is a key metabolic enzyme with emerging roles in insulin regulation. MitoNEET forms a covalent complex with GDH1 through disulfide bond formation and acts as an activator. Proteomic analysis identified the specific cysteine residues that participate in the disulfide bond. This is the first report that effectively links mitoNEET to activation of the insulin regulator GDH1.