Chemistry Commons^™

Synthetic Pathways For Potential Platinum 1,10-Phenanthroline Compounds, Jacob Young

Mahurin Honors College Capstone Experience/Thesis Projects

There are extremely important uses for platinum when it comes to the treatment of cancers and dementias. One potential therapeutic combines platinum with a structure known as phenanthroline. This platinum phenanthroline structure is normally extremely water-insoluble, rendering it difficult to study and use in biological systems. The Williams’ Biochemistry Laboratory endeavored to find a simpler synthetic pathway for a water-soluble phenanthroline product. While unsuccessful in identifying a product as of yet, many synthetic pathways have been ruled out, and more hypothetical pathways are being formulated for testing.

Among the strategies analyzed are varying solvent, reagents, apparatus, methodology, and temperature in …

Influence Of The Nature Of The Medium On The Conformational States Of Macromolecules Of Anionic Polyelectrolytes And Their Flocculating Effect, Mapruza Dzhumamuratova, Amanbay Pirniyazov, Oleg Dormeshkin, Akhmed Reymov, Tleumuratov Kuanish, Saparbay Kalbaev

Karakalpak Scientific Journal

The properties of surfactants of anionic polyelectrolytes are investigated depending on the nature of the medium, conformational states neutralized by organic bases, differing in the length of the hydrocarbon radical. The concept of the role of the state of macromolecules in solution in the indicated processes has been developed. The anionic carboxyl-containing polyelectrolytes synthesized on the basis of methacrylic acid differed not only in the length of the hydrocarbon radical of the organic base - counterion, but also in their branching. The relationship between the state of polyelectrolyte macromolecules in solution and their ability to regulate the properties of natural …

Synthesis And Performance Of Novel Supramolecular Tools For Single-Particle Cryogenic Electron Microscopy And Drug And Gene Delivery, Kyle J. Wright

Open Access Dissertations

High-resolution biomacromolecular structure elucidation is fundamentally important to structure-based drug design and basic research into complex biochemical processes. Cryo-EM is an emerging alternative to XRD and NMR that is complementary in many ways relative to XRD and NMR. Materials approaches to cryo-EM are anticipated to greatly facilitate the cryo-EM process, allowing progress toward a more high-throughput application of cryo-EM to address challenges in structural biology. ^ Various affinity-based approaches inspired by approaches previously introduced for 2D crystallization were developed for facilitation of cryo-EM. A library of affinity lipopolymer constructs were synthesized consisting of lipopolymers of various PEG molecular weights conjugated …