Other Applied Mathematics Commons^™

Large Deviation Theory In Stochastic Processes: Applications To Biological Modeling, Moshe C. Silverstein

Dissertations

This dissertation delves into developing and applying stochastic models to analyze complex biological systems. It leverages Large Deviation Theory (LDT) to gain insights into these systems, focusing on two key examples: neural networks and calcium signaling dynamics. Traditional deterministic methods frequently fail to capture biological processes' randomness and inherent variability. Meanwhile, many stochastic approaches struggle to be mathematically tractable or provide accessible insights. The approach introduced in this study provides rigorous mathematical frameworks to enhance understanding of these stochastic behaviors while remaining tractable and insightful.

A stochastic model for a random biological neural network is constructed that addresses the dependencies …

Agent-Based Modeling Of Locust Foraging And Social Behavior, Hannah Larson

HMC Senior Theses

Locust swarms contain millions of individuals and are a threat to agriculture on four continents. At low densities, locusts are solitary foragers; however, when crowded, they undergo an epigenetic phase change to a gregarious state in which they are attracted to other locusts. It is believed that this is an evolutionary adaptation that optimizes the seeking of resources. We have developed an agent-based model based on the solitary-gregarious transition and foraging behaviors due to hunger levels. A novel feature of our model is that it treats food resources as a dynamic variable in the environment. We discuss how social interaction …

Determination Of Optimal Parameter Estimates For Medical Interventions In Human Metabolism And Inflammation, Marcella Torres

Theses and Dissertations

In this work we have developed three ordinary differential equation models of biological systems: body mass change in response to exercise, immune system response to a general inflammatory stimulus, and the immune system response in atherosclerosis. The purpose of developing such computational tools is to test hypotheses about the underlying biological processes that drive system outcomes as well as possible real medical interventions. Therefore, we focus our analysis on understanding key interactions between model parameters and outcomes to deepen our understanding of these complex processes as a means to developing effective treatments in obesity, sarcopenia, and inflammatory diseases.

We develop …

Quantifying The Structure Of Misfolded Proteins Using Graph Theory, Walter G. Witt

Electronic Theses and Dissertations

The structure of a protein molecule is highly correlated to its function. Some diseases such as cystic fibrosis are the result of a change in the structure of a protein so that this change interferes or inhibits its function. Often these changes in structure are caused by a misfolding of the protein molecule. To assist computational biologists, there is a database of proteins together with their misfolded versions, called decoys, that can be used to test the accuracy of protein structure prediction algorithms. In our work we use a nested graph model to quantify a selected set of proteins that …

Mathematical Models For Infectious Disease Transmission With Stochastic Simulation Of Measles Outbreaks, Valerie Welty

Honors College Theses

As they are the leading cause of death among children and adolescents worldwide, it is of extreme importance to control the spread of infectious diseases. Information gained from mathematical modeling of these events often proves quite useful in establishing policy decisions to accomplish this goal. Human behavior, however, is quite difficult to recreate when using equations with pre-determined results, such as deterministic differential equations often used with epidemic models. Because of this, the focus of the research was to create a simulation of an outbreak, specifically of measles, by using an imaginary population experiencing simulated stochastic events on a discrete …