Other Applied Mathematics Commons^™

A Categorical Framework For Modeling Genetic Drift, Taylor G. Mendes

Rose-Hulman Undergraduate Mathematics Journal

Genetic drift describes changes in allele frequencies that arise from chance sampling in finite populations. This paper develops a categorical framework for organizing the structural features of drift. Population states are modeled as objects, evolutionary transitions as morphisms, reversible transitions as groupoid morphisms, and structure-preserving comparisons between models as functors. Group actions are used to describe deterministic evolutionary operators such as mutation and selection, while orbits and fixed points identify reachable allele-frequency states and stable absorbing outcomes. Universal properties are then used to describe drift as a coherence condition connecting stochastic transitions with deterministic evolutionary maps. The resulting framework complements …

What We Know About Accounting Ratios: Methodological Considerations, Wojciech Kuryłek, Oskar Kowalewski

Studia i Materiały Wydział Zarządzania Uniwersytet Warszawski

Purpose: This paper provides a comprehensive literature review of the methodological aspects of financial ratio analysis, consolidating dispersed knowledge on the computation, statistical properties, and appropriate usage of accounting ratios.

Design/Methodology/Approach: The study adopts a narrative literature review methodology, systematically surveying published research on financial ratio distributions, normality testing, data transformations, outlier handling, the proportionality assumption, dimensionality reduction techniques, compositional data analysis, and recommended ratio sets for corporate financial research.

Findings: Financial ratios predominantly deviate from normal distributions, exhibiting skewness, excess kurtosis, and sensitivity to outliers. Transformation techniques such as logarithmic, square root, and Box‑Cox methods yield mixed results in …

(R2140) Verifying The Proper Efficiency In Multi-Objective Problems, Javad Bavali, Hadi Basirzadeh

Applications and Applied Mathematics: An International Journal (AAM)

Over the past decade, numerous approaches have been put forward to address multi-objective optimization problems-focusing on approximating proper efficient solutions instead of the efficient solutions. These methods are important because, according to Geoffrion’s conjecture, proper non-dominated solutions constitute a dense subset of the non-dominated solution set. In the current study, first, using the definition of Kuhn-Tucker’s proper efficiency, we present a linear subproblem that investigates the proper efficiency of a randomly selected feasible point. Additionally, the relationship between the different types of solutions to this sub-problem and the proper efficient solutions of the main problem has been analyzed. Next, we …

Estimation Of Net Premium For Flight Delay Insurance Using The Aggregate Loss Model: A Case Study Of Indonesia Otas, Azka Nurul Husna, Yulial Hikmah, Ira Rosianal Hikmah

Jurnal Vokasi Indonesia

Air transportation, as one of the most chosen transportation modes, is frequently susceptible to delays. Flight Delay Insurance offers a vital solution to mitigate the financial losses associated with this risk. Premium pricing is a key factor influencing the decision to purchase this insurance, particularly on Online Travel Agent (OTA) platforms where product offerings are often highly comparable. The aggregate loss method is employed herein to ascertain the net premium (or pure premium) price. The loss severity component (X) is modeled using an empirical distribution, while the loss frequency component (N) is modeled using a Negative Binomial distribution with parameters …

A Probabilistic Modeling Analysis Of The Longitudinal Immune Response To Infection And Vaccination Across Demographic Groups And Pulmonary Symptoms, James O'Hanlon, Kaitlyn Sullivan, Lyndsey M. Muehling, Glenda Canderan, Jie Sun, Judith A. Woodfolk, Jeffrey M. Wilson, Rayanne A. Luke

Spora: A Journal of Biomathematics

Antibody and cytokine kinetics describe the dynamic response to immune events such as infection and vaccination. These dynamics are not fully understood, and mathematical characterization may help explain variability across demographic groups and pulmonary symptoms post-acute infection. We fit time-dependent probability models to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) data to obtain distributions of longitudinal antibody response and cytokine values. To assess differences between groups, an overlap metric is applied to the modeled response curves. Our antibody models suggest significant differences between male and female populations and demonstrate deficient antibody responses of less-healthy groups such as smokers. Our cytokine …

Optimal Intervention Strategies In Age-Structured Sirvd Model: Epidemiological And Economic Analysis Of Covid-19 In Korea, Joon Chun, Melisa Hendrata

Spora: A Journal of Biomathematics

This study employed an age-structured Susceptible-Infected-Recovered-Vaccinated-Deceased (SIRVD) model to design optimal COVID‑19 intervention strategies by integrating epidemiological dynamics with economic costs. Using empirical data from South Korea, we estimated transmission parameters and analyzed quarantine-based non-pharmaceutical interventions (NPIs) alongside targeted vaccination scenarios. Our results indicated that a stronger form of mild NPI (upper range of Level I), when combined with targeted vaccination that prioritized seniors, achieved substantial reductions in infection peaks and overall economic burden. These findings underscore the effectiveness of age-specific strategies in epidemic management and offer critical insights for policymakers seeking balanced, resource-efficient approaches.

Inhomogeneous Branching Random Walks: Incorporating Genealogy And Density Effects, Lauren Ajax, Beatrice Durham, Pratima Hebbar, Cade Johnston, Jiayi Zhang

Spora: A Journal of Biomathematics

We introduce a novel framework using inhomogeneous branching random walks (BRWs) to model biological processes, specifically by introducing genealogy-dependence in branching rates and displacement distributions to model bacterial colony growth. Current stochastic models often either assume independent and identical behavior of individual agents or incorporate only spatiotemporal inhomogeneity, ignoring the effect of genealogy-based inhomogeneity on the long-time behavior of these processes. Such asymptotics are of independent mathematical interest and are crucial in understanding the emergence of patterns. We propose several inhomogeneous BRW models in 2D space where displacement distributions and branching rates vary with time, space, and genealogy. A combined …

Investigating The Market Dynamics Of Aeroponically Cultivated Products With Delay, Pulak Kundu, Uzzwal Kumar Mallick

Mathematical Modelling and Numerical Simulation with Applications

Aeroponically grown potatoes offer higher yields and year-round production but often face delayed market entry due to high setup costs, technical barriers, and logistical challenges. A delay-based mathematical model has been newly proposed in this study to analyze the dynamics of demand, supply, and pricing for aeroponically grown products. The model’s existence, stability, and sensitivity have been investigated analytically, and numerical simulations have been carried out using the Runge-Kutta 4th order method with the dde23 solver. Findings reveal that market stability is maintained when delays are below seven years, but delays beyond this threshold lead to persistent fluctuations in price, …

Investigating Potential Alzheimer's Disease Therapies Through An Agent-Based Model Of Impaired Microglia Metabolismmodeling Impaired Microglia Metabolism, Cheyenne Ty, Abigail Penland, John Gerving, Martin Mendoza-Ceja, Megan Pratt, Kamila Larripa

Spora: A Journal of Biomathematics

Alzheimer’s disease is the leading cause of dementia globally and is marked by amyloid-β plaque accumulation, decreased brain pH, disrupted metabolism, and increased permeability of the blood-brain barrier. Microglia, the resident immune cells of the central nervous system, are essential for maintaining brain homeostasis and are critically involved in the progression of AD. While microglia can initiate protective immune responses to injury and disease, dysregulated microglial metabolism may contribute to the exacerbation of Alzheimer's pathology. To investigate potential therapeutic strategies, we developed an agent-based model simulating the effects of exercise and metabolic enhancement on dysfunctional microglia. Our findings suggest that …

Modifications To The Spiral Array: A Computational Approach To Music Analysis, Rose Bittle

DePaul Discoveries

The Spiral Array is a geometric model of musical tonality and exists as a tool in computer-aided music analysis. The model was first published in 2000 by Elaine Chew, PhD, in her thesis, Towards a Mathematical Model of Tonality. This project aimed to restructure the Spiral Array, limiting user ambiguity and optimizing the application of musical key finding. The existing model defines pitch, chord, and key location to form a series of spirals dependent on a set of flexible weights. In our research we were able to identify potential issues with the pitch definitions themselves and experiment with methods …

Using A Pharmacokinetic Model To Design And Evaluate An Early Ctdna Biomarker For Response To Targeted Therapy, Aaron Li

Spora: A Journal of Biomathematics

Early prediction of response to therapy or lack thereof can help physicians plan treatment more efficiently. Biomarkers based on circulating tumor DNA (ctDNA) are promising. However, biomarkers beyond direct comparison to baseline have not been thoroughly explored. We develop a model for ctDNA shedding under targeted therapy that incorporates pharmacokinetics. Using a simulated cohort of virtual patients with varied parameters, we define and analyze a biomarker based on ctDNA samples at baseline, 12 hours, and 24 hours after initiation of treatment. The biomarker identified patients who would achieve partial or complete response with high sensitivity and specificity and was able …

(Si14-06) Influence Of Hall Effects On Rotating Mhd Casson Fluid Flow Over A Vertical Plate, Zankhana Mali, Akhil Mittal, Harshad Patel

Applications and Applied Mathematics: An International Journal (AAM)

Studies of Hall effects regarding motion of fluid due to some external forces in MHD transport of reacting Casson fluid with heat generation over an impulsively emerging vertical plate are considered in this work. This theory proposes that because of a sudden rise in temperature and an accompanying surface concentration profile, which shows an elevation with time, the boundary plate has endured rapid expansion. In a rotational environment, this characteristic occurs homogeneously inside a porous uniform material. It applies the Laplace transform method for determining the fundamental equations subject to imposed starting and side conditions. Under isothermal conditions, accurate formulae …

An Agent-Based Model Of Microglia And Neuron Interaction: Implications In Neurodegenerative Disease, Cheyenne Ty, Amanda Case, Emmanuel Mezzulo, Abigail Penland, Kamila Larripa

Spora: A Journal of Biomathematics

Whether immune cells protect or harm the brain is an open question depending on context, and their role is implicated in multiple diseases such as Alzheimer's disease, dementia, and other neurological disorders. Microglia, a specific type of immune cell in the central nervous system, play a key role in homeostasis, and genes associated with an elevated risk of Alzheimer's disease correspond with deficiencies in their behavior. We created an agent-based model that incorporates inflammatory signaling, chemotaxis, and phagocytosis of damaged neurons and allows the exploration of crucial pathways in the maintenance of brain health. We specifically investigated pathways related to …

The Faithfulness Of An Extension Of Lawrence-Krammer-Bigelow Representation On The Group Of Conjugating Automorphisms $C_N$ In The Cases $N=3$ And $N=4$, Mohamad Nasser

BAU Journal - Science and Technology

Let $C_n$ be the group of conjugating automorphisms. V. Bardakov defined a representation $\rho$ of $C_n$, which is an extension of Lawrence-Krammer-Bigelow representation of the braid group $B_n$. Bardakov proved that the representation $\rho$ is unfaithful for $n \geq 5$. The cases $n=3,4$ remain open. M. N. Nasser and M. N. Abdulrahim made attempts towards the faithfulness of $\rho$ in the case $n=3$. In this work, we prove that $\rho$ is unfaithful in the both cases $n=3$ and $n=4$.

Asymptotic Expansion Of A Maier-Saupe Type Potential Near The Nematic-Isotropic Transition Point In Liquid Crystals, Ryan P. Oneill, Giangvuthanh Nguyen, Xiang Xu

OUR Journal: ODU Undergraduate Research Journal

In this paper we study a Maier-Saupe type bulk potential (Maier & Saupe, 1959) in the Landau-de Gennes free energy in the Q-tensor theory modeling nematic liquid crystal configurations. This potential was originally introduced in Katriel et al. (1986), which is considered as a natural enforcement of a physical constraint on the eigenvalues of symmetric, traceless Q-tensors. More specifically, we present a rigorous derivation of the asymptotic expansion of this singular potential near the nematic-isotropic transition point up to the 4-th order.

(Si13-04) System Of Variational Inclusions Involving Cayley Operator And Yosida Approximation Operator With Xor Operations, Mohd Iqbal, Tirth Ram

Applications and Applied Mathematics: An International Journal (AAM)

In this paper, we consider and study a new class of system of variational inclusions called a system of variational inclusions involving Cayley operator and Yosida approximation operator with XOR operation. We have shown that our problem is equivalent to a fixed point equation. Based on fixed point formulation, an iterative algorithm is designed to obtain existence and convergence result for our problem.

Enhancing Decision In Information System Through Weighted Preliminary Pretopology Analysis, Mustafa Elsayed, Rifet Agassi

Journal of Engineering Research

It is clear from adequate study of the past decades that there has been rapid growth in the information system, which relies mainly on programming systems. This has led to the necessity of dealing with high efficiency with the information system necessary for decision support. Information systems are a mixture of software and hardware to store and process all the data required and are presented in a useful form to extract information by applying topological concepts. In this paper a pretopological space from an information system is to be constructed. The computation of decision accuracy stands as a pivotal stage …

Impact Of Covid-19 On Disaggregate Consumption And Online Retail Sales: Evidence From The Usa, Gulzar Ahmed, Olcay Akman

Spora: A Journal of Biomathematics

This study applies the difference-in-difference technique to analyze the consumption pattern during COVID-19 against pre-COVID-19 years. We analyze the online retail sales before and after COVID-19 using time series and linear regression models. Time series intervention analysis results suggest that COVID-19 has caused a statistically significant change in the mean level of online retail sales share in e-commerce. Using a difference-in-difference approach, we find a 4% decrease in aggregate consumption from March to December 2020 compared to the benchmark period although statistically insignificant. Further, using a fixed effects model with time dummies, we find a nearly 8% significant decrease in …

Model Selection Through Cross-Validation For Supervised Learning Tasks With Manifold Data, Derek Brown

The Journal of Purdue Undergraduate Research

No abstract provided.

Compartmental Modeling For The Neophyte: An Application Of Berkeley Madonna, Olcay Akman, Siddharth Bhumpelli, Cody Cline, Christopher Hay-Jahans

Spora: A Journal of Biomathematics

Compartmental modeling serves as a necessary framework in many fields, especially biomathematics and ecology. This article introduces readers to a user-friendly approach to constructing compartmental models and solving the resulting systems of differential equations to simulate real-world applications. The platform used is Berkeley Madonna, a software package that has an intuitive graphical interface which empowers users—even those with limited mathematical and programming backgrounds—to focus on modeling concepts rather than mathematical or programming intricacies. This makes Berkeley Madonna an ideal platform for students, educators, and researchers.

A Novel Scheme Based On Bessel Operational Matrices For Solving A Class Of Nonlinear Systems Of Differential Equations, Atallah El-Shenawy, Mohamed El-Gamel, Muhammad E. Anany

Mansoura Engineering Journal

The system of ordinary differential equations arises in many natural phenomena, especially in the field of disease spread. In this paper, a perfect spectral technique is introduced to solve systems of nonlinear differential equations. The technique enhanced the Bessel collocation technique by converting the series notation of unknown variables and their derivatives to matrix relations. The Newton algorithm is developed to solve the resulting nonlinear system of algebraic equations. The effectiveness of the scheme is proved by the convergence analysis and error bound as demonstrated in Theorem 1. The scheme of solution is tested to clarify the efficiency and the …

Reducing Food Scarcity: The Benefits Of Urban Farming, S.A. Claudell, Emilio Mejia

Journal of Nonprofit Innovation

Urban farming can enhance the lives of communities and help reduce food scarcity. This paper presents a conceptual prototype of an efficient urban farming community that can be scaled for a single apartment building or an entire community across all global geoeconomics regions, including densely populated cities and rural, developing towns and communities. When deployed in coordination with smart crop choices, local farm support, and efficient transportation then the result isn’t just sustainability, but also increasing fresh produce accessibility, optimizing nutritional value, eliminating the use of ‘forever chemicals’, reducing transportation costs, and fostering global environmental benefits.

Imagine Doris, who is …

Efficient And Secure Digital Signature Algorithm (Dsa), Nissa Mehibel, M'Hamed Hamadouche

Emirates Journal for Engineering Research

The digital signature is used to ensure the integrity of messages as well as the authentication and non-repudiation of users. Today it has a very important role in information security. Digital signature is used in various fields such as e-commerce and e-voting, health, internet of things (IOT). Many digital signature schemes have been proposed, depending on the computational cost and security level. In this paper, we analyzed a recently proposed digital signature scheme based on the discrete logarithm problem (DLP). Our analysis shows that the scheme is not secure against the repeated random number attack to determine the secret keys …

An Adaptive Algorithm For `The Secretary Problem': Alternate Proof Of The Divergence Of A Maximizer Sequence, Andrew Benfante, Xiang Xu

OUR Journal: ODU Undergraduate Research Journal

This paper presents an alternate proof of the divergence of the unique maximizer sequence {𝑥∗ 𝑛} of a function sequence {𝐹𝑛(𝑥)} that is derived from an adaptive algorithm based on the now classic optimal stopping problem, known by many names but here ‘the secretary problem’. The alternate proof uses a result established by Nguyen, Xu, and Zhao (n.d.) regarding the uniqueness of maximizer points of a generalized function sequence {𝑆𝜇,𝜎 𝑛 } and relies on the strict monotonicity of 𝐹𝑛(𝑥) as 𝑛 increases in order to show divergence of {𝑥∗ 𝑛}. Towards this, limits of the exponentiated Gaussian CDF are …

Quantum Computing And Its Applications In Healthcare, Vu Giang

OUR Journal: ODU Undergraduate Research Journal

This paper serves as a review of the state of quantum computing and its application in healthcare. The various avenues for how quantum computing can be applied to healthcare is discussed here along with the conversation about the limitations of the technology. With more and more efforts put into the development of these computers, its future is promising with the endeavors of furthering healthcare and various other industries.

Swarm Intelligence For Solving Some Nonlinear Differential Equations, Ahmed Elzaghal, Mohammed Mohammed Elgamal, Ahmed H. Eltanboly

Mansoura Engineering Journal

The Euler method is a well-known numerical technique employed for solving initial value problems of ordinary differential equations. The solution obtained through Euler's method is subject to significant inaccuracies, which tend to amplify with each successive iteration. The Particle Swarm Optimization (PSO) algorithm is a highly effective method for finding optimal solutions to both linear and nonlinear optimization problems. In this particular investigation, the PSO technique was utilized to solve initial value problems associated with ordinary differential equations. The Euler method, on the other hand, employs equidistant grid points to approximate solutions, which can result in significant errors and a …

Computational Models To Detect Radiation In Urban Environments: An Application Of Signal Processing Techniques And Neural Networks To Radiation Data Analysis, Jose Nicolas Gachancipa

Beyond: Undergraduate Research Journal

Radioactive sources, such as uranium-235, are nuclides that emit ionizing radiation, and which can be used to build nuclear weapons. In public areas, the presence of a radioactive nuclide can present a risk to the population, and therefore, it is imperative that threats are identified by radiological search and response teams in a timely and effective manner. In urban environments, such as densely populated cities, radioactive sources may be more difficult to detect, since background radiation produced by surrounding objects and structures (e.g., buildings, cars) can hinder the effective detection of unnatural radioactive material. This article presents a computational model …

On Efficacy And Effectiveness Of Vaccines: A Mathematical Approach Based On Conditional Probability With Applications To The Covid-19 Context, Flavius Guias

Spora: A Journal of Biomathematics

This paper presents a mathematically formalized approach which points out the relation between efficacy and effectiveness of vaccines. The first term denotes the relative degree of protection in clinical trials or under ideal conditions, while the latter is based on observed real-life data. We define the efficacy by a similar formula to the effectiveness, but the probabilities involved in the relative risk are conditional with respect to the exposure to the virus. If exposure and vaccination status are independent, the two quantities are equal. Otherwise, the observed value of the effectiveness is a biased one, as it could be seen …

An Axiomatic And Contextual Review Of The Armitage And Doll Model Of Carcinogenesis, W. Zane Billings, Justin Clifton, Josh Hiller, Tommy Meek, Andrew Penland, Wesley Rogers, Gabriella Smokovich, Andrew Velasquez-Berroteran, Eleni Zamagias

Spora: A Journal of Biomathematics

In 1954, Armitage and Doll published one of the most influential papers in the history of mathematical epidemiology. However, when one examines the literature one finds that there are in fact at least three distinct mathematical models attributed to the 1954 paper. In this study, we examine this important paper and the mathematical derivation of their model. We find, very surprisingly, that no stochastic process can account for all the assumptions of the model and that many of the models in the literature use a consistent subset of the assumptions used in Armitage and Doll's paper.

Using Adaptive Research Design To Define The Proper Methodology To Use A Data Peek For Power: Step By Step Process, Tom Wasser

Advances in Clinical Medical Research and Healthcare Delivery

When planning or conducting research in the hospital setting, often termed Real-World Environment (RWE), therapeutic assumptions and outcomes are often different than in the Randomized Clinical Trial (RCT) where medications, devices and therapies are tested and developed. This is because RWE research has a lack of experimental control, additional confounding due to patient complications and comorbid conditions, lack of pure patient selection and compliance with therapy in the patients being treated and many other factors as well. However, when RWE experiments are conducted, sample size determination using data from the RCT is common because that is the only data that …