Physical Sciences and Mathematics Commons^™

An Engineered Approach To Stem Cell Culture: Automating The Decision Process For Real-Time Adaptive Subculture Of Stem Cells, Dai Fei Elmer Ker, Lee E. Weiss, Silvina N. Junkers, Mei Chen, Zhaozheng Yin, Mike F. Sandbothe, Seungil Huh, Sungeun Eom, Ryoma Bise, Elvira Osuna-Highley, Takeo Kanade, Phil Gordon Campbell

Computer Science Faculty Research & Creative Works

Current cell culture practices are dependent upon human operators and remain laborious and highly subjective, resulting in large variations and inconsistent outcomes, especially when using visual assessments of cell confluency to determine the appropriate time to subculture cells. Although efforts to automate cell culture with robotic systems are underway, the majority of such systems still require human intervention to determine when to subculture. Thus, it is necessary to accurately and objectively determine the appropriate time for cell passaging. Optimal stem cell culturing that maintains cell pluripotency while maximizing cell yields will be especially important for efficient, cost-effective stem cell-based therapies. …

Holographic Recording In Corona Charged Acrylamide-Based Mfi-Zeolite Photopolymer, Temenujka Yovcheva, Izabela Naydenova, Simeon Sainov, Vincent Toal, Svetlana Mintova

Articles

The influence of corona charging on holographic recording in acrylamide-based photopolymer nanocomposite containing MFI zeolite nanoparticles has been studied. The holographic recording was carried out in two different geometries —transmission grating recording and total internal reflection grating recording. During the recording process, the layers were charged in a corona field. It was observed that independently of the corona polarity, in the case of transmission geometry of recording, the corona charging led to a decrease in the diffraction efficiency (DE) of the grating. In the case of the total internal reflection grating, the DE increased in the corona field presence.

Poincaré Sphere Representation Of The Fixed-Polarizer Rotating-Retarder Optical System, R. M.A. Azzam

Electrical Engineering Faculty Publications

The trajectory of the polarization state of a monochromatic light beam after it passes through a fixed linear polarizer and a rotating linear retarder of arbitrary retardance Δ is determined on the Poincaré sphere. The three-dimensional figure-8 contour is shown to be the line of intersection of a right-circular cylinder with the sphere. The cylinder is parallel to the polar (s₃) axis, touches the sphere at the equator (at the point that represents the linear polarization transmitted by the fixed polarizer), and has a radius r=sin²(Δ/2). Projections of the trajectory in the coordinate planes of the …

Magnetic Susceptibility As A Proxy For Investigating Microbially Mediated Iron Reduction, Farag M. Mewafy, Estella A. Atekwana, D. Dale Werkema, Lee D. Slater, Dimitrios Ntarlagiannis, Andre Revil, Magnus E. Skold, Geoffrey N. Delin

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

We investigated magnetic susceptibility (MS) variations in hydrocarbon contaminated sediments. Our objective was to determine if MS can be used as an intrinsic bioremediation indicator due to the activity of iron-reducing bacteria. A contaminated and an uncontaminated core were retrieved from a site contaminated with crude oil near Bemidji, Minnesota and subsampled for MS measurements. The contaminated core revealed enriched MS zones within the hydrocarbon smear zone, which is related to iron-reduction coupled to oxidation of hydrocarbon compounds and the vadose zone, which is coincident with a zone of methane depletion suggesting aerobic or anaerobic oxidation of methane is coupled …

On Elementary Loops Of Logic Programs, Martin Gerber, Joohyung Lee, Yuliya Lierler

Computer Science Faculty Publications

Using the notion of an elementary loop, Gebser and Schaub (2005. Proceedings of the Eighth International Conference on Logic Programming and Nonmonotonic Reasoning (LPNMR'05), 53–65) refined the theorem on loop formulas attributable to Lin and Zhao (2004) by considering loop formulas of elementary loops only. In this paper, we reformulate the definition of an elementary loop, extend it to disjunctive programs, and study several properties of elementary loops, including how maximal elementary loops are related to minimal unfounded sets. The results provide useful insights into the stable model semantics in terms of elementary loops. For a nondisjunctive program, …

An Analysis Of The Effect Of Stress Diffusion On The Dynamics Of Creeping Viscoelastic Flow, Becca Thomases

Mathematics Sciences: Faculty Publications

The effect of stress diffusivity is examined in both the Oldroyd-B and FENE-P models of a viscoelastic fluid in the low Reynolds (Stokes) limit for a 2D periodic time-dependent flow. A local analytic solution can be obtained when assuming a flow of the form u=Wi-1(x,-y), where Wi is the Weissenberg number. In this case the width of the birefringent strand of the polymer stress scales with the added viscosity as ν1/2, and is independent of the Weissenberg number. Also, the " expected" maximum extension of the polymer coils remains finite with any stress diffusion and scales as Wi·ν-1/2. These predictions …

The Role Of Colour Duplex Ultrasound In The Surveillance Of Patients Undergoing Endovascular Aneurysm Repair, C. Gray

Doctoral

No abstract provided.

Removal Of 2,4-Dichlorophenoxyacetic Acid By Calcined Zn–Al–Zr Layered Double Hydroxide, Allen Chaparadza, Jeanne Hossenlopp

Chemistry Faculty Research and Publications

The adsorption equilibrium, kinetics, and thermodynamics of removal of 2,4-dichlorophenoxy-acetic acid (2,4-D) from aqueous solutions by a calcined Zn–Al layered double hydroxide incorporated with Zr⁴⁺ were studied with respect to time, temperature, pH, and initial 2,4-D concentration. Zr⁴⁺ incorporation into the LDH was used to enhance 2,4-D uptake by creating higher positive charges and surface/layer modification of the adsorbent. The LDH was capable of removing up to 98% of 2,4-D from 5 to 400 ppm aqueous at adsorbent dosages of 500 and 5000 mg L⁻¹. The adsorption was described by a Langmuir-type isotherm. The percentage 2,4-D …

Analysis Of Binding Site Hot Spots On The Surface Of Ras Gtpase, Greg Buhrman, Casey O'Connor, Brandon Zerbe, Bradley M. Kearney, Raeanne Napoleon, Elizaveta A. Kovrigina, Sandor Vajda, Dima Kozakov, Evgenii L. Kovrigin, Carla Mattos

Chemistry Faculty Research and Publications

We have recently discovered an allosteric switch in Ras, bringing an additional level of complexity to this GTPase whose mutants are involved in nearly 30% of cancers. Upon activation of the allosteric switch, there is a shift in helix 3/loop 7 associated with a disorder to order transition in the active site. Here, we use a combination of multiple solvent crystal structures and computational solvent mapping (FTMap) to determine binding site hot spots in the “off” and “on” allosteric states of the GTP-bound form of H-Ras. Thirteen sites are revealed, expanding possible target sites for ligand binding well beyond the …

Reactivity Of Acyclic (Pentadienyl)Iron(1+) Cations: Synthetic Studies Directed Toward The Frondosins, Do W. Lee, Rajesh K. Pandey, Sergey V. Lindeman, William A. Donaldson

Chemistry Faculty Research and Publications

A short, 4-step route to the scaffold of frondosin A and B is reported. The [1-methoxycarbonyl-5-(2′,5′-dimethoxyphenyl)pentadienyl]Fe(CO)₃⁺ cation was prepared in two steps from (methyl 6-oxo-2,4-hexadienoate)Fe(CO)₃. Reaction of this cation with isopropenyl Grignard or cyclohexenyllithium reagents affords (2-alkenyl-5-aryl-1-methoxycarbonyl-3-pentene-1,5-diyl)Fe(CO)₃ along with other addition products. Oxidative decomplexation of these (pentenediyl)iron complexes, utilizing CuCl₂, affords 6-aryl-3-methoxycarbonyl-1,4-cycloheptadienes via the presumed intermediacy of a cis-divinylcyclopropane.

The Good, The Bad, And The Actively Verified, John Williamson

Dartmouth College Master’s Theses

We believe that we can use active probing for compromise recovery. Our intent is to exploit the differences in behavior between compromised and uncompromised systems and use that information to identify those which are not behaving as expected. Those differences may indicate a deviation in either con figuration or implementation from what we expect on the network, either of which suggests that the misbehaving entity might not be trustworthy. In this work, we propose and build a case for a method for using altered behavior directly resulting from or introduced as a side-effect of the compromise of a network service …

Book Review: The Cambridge Atlas Of Herschel Objects, T. D. Oswalt

Publications

This document is Dr. Oswalt’s review of The Cambridge Atlas of Herschel Objects by James Mullaney and Wil Tirion Cambridge, 2011 183p, 0521138175 $35.00, 9780521138178 $35.00.

Assessing The Impact Of Non-Differential Genotyping Errors On Rare Variant Tests Of Association, Scott Powers, Shyam Gopalakrishnan, Nathan L. Tintle

Faculty Work Comprehensive List

Background/Aims: We aim to quantify the effect of non-differential genotyping errors on the power of rare variant tests and identify those situations when genotyping errors are most harmful. Methods: We simulated genotype and phenotype data for a range of sample sizes, minor allele frequencies, disease relative risks and numbers of rare variants. Genotype errors were then simulated using five different error models covering a wide range of error rates. Results: Even at very low error rates, misclassifying a common homozygote as a heterozygote translates into a substantial loss of power, a result that is exacerbated even further as the minor …

Compositions, Partitions, And Fibonacci Numbers, Andrew Sills

Mathematical Sciences: Faculty Publications

A bijective proof is given for the following theorem: the number of compositions of n into odd parts equals the number of compositions of n+ 1 into parts greater than one. Some commentary about the history of partitions and compositions is provided.

A Bayesian Model For Gene Family Evolution, Liang Liu, Lili Yu, Venugopal Kalavacharla, Zhanji Liu

Biostatistics: Faculty Publications

Background

A birth and death process is frequently used for modeling the size of a gene family that may vary along the branches of a phylogenetic tree. Under the birth and death model, maximum likelihood methods have been developed to estimate the birth and death rate and the sizes of ancient gene families (numbers of gene copies at the internodes of the phylogenetic tree). This paper aims to provide a Bayesian approach for estimating parameters in the birth and death model.

Results

We develop a Bayesian approach for estimating the birth and death rate and other parameters in the birth …

C(Naphthyl)-H Bond Activation By Rhodium: Isolation, Characterization And Td-Dft Study Of The Cyclometallates, Achintesh Narayan Biswas, Purak K. Das, Sandip K. Sengupta, Amitava Choudhury, Pinaki K. Bandyopadhyay

Chemistry Faculty Research & Creative Works

The C1(naphthyl)-H, C2(naphthyl)-H, C3(naphthyl)-H and C8(naphthyl)-H bonds of the naphthyl group present in a group of naphthylazo-2'-hydroxyarenes (H ₂L) have been activated by [Rh(PPh ₃) ₃Cl] in a toluene medium. Here the cyclometallation is accompanied by metal centered oxidation [Rh(i)?Rh(iii)]. All the resulting cyclometallates [Rh(PPh ₃) ₂(L)Cl] (2-5) have been isolated in a pure form. The characterization of the cyclometallates [Rh(PPh ₃) ₂(L)Cl] have been done on the basis of spectral (IR, UV-vis, and FAB mass) data. The structures of the representative cyclometallates 2a, 3a, 4a, 4b and 5b have been determined by …

Infinite-Randomness Criticality In A Randomly Layered Heisenberg Magnet, Fawaz Hrahsheh, Hatem Barghathi, Thomas Vojta

Physics Faculty Research & Creative Works

We study the ferromagnetic phase transition in a randomly layered Heisenberg magnet using large-scale Monte Carlo simulations. Our results provide numerical evidence for the infinite-randomness scenario recently predicted within a strong-disorder renormalization-group approach. Specifically, we investigate the finite-size scaling behavior of the magnetic susceptibility, which is characterized by a nonuniversal power-law divergence in the Griffiths phase. We also study the perpendicular and parallel spin-wave stiffnesses in the Griffiths phase. In agreement with the theoretical predictions, the parallel stiffness is nonzero for all temperatures T < T_c. In contrast, the perpendicular stiffness remains zero in part of the ordered phase, giving …

Quantum Phase Transition Of The Sub-Ohmic Rotor Model, Manal Al-Ali, Thomas Vojta

Physics Faculty Research & Creative Works

We investigate the behavior of an N-component quantum rotor coupled to a bosonic dissipative bath having a sub-Ohmic spectral density J (ω) ∝ ω^s with s < 1.With increasing dissipation strength, this system undergoes a quantum phase transition from a delocalized phase to a localized phase.We determine the exact critical behavior of this transition in the large-N limit. For 1 > s > 1/2, we find nontrivial critical behavior corresponding to an interacting renormalization group fixed point, while we find mean-field behavior for s < 1/2. The results agree with those of the corresponding long-range …

Influence Of Gas Pressure On High-Order-Harmonic Generation Of Ar And Ne, Guoli Wang, Cheng Jin, Anh-Thu Le, C. D. Lin

Physics Faculty Research & Creative Works

We study the effect of gas pressure on the generation of high-order harmonics where harmonics due to individual atoms are calculated using the recently developed quantitative rescattering theory, and the propagation of the laser and harmonics in the medium is calculated by solving the Maxwell's wave equation. We illustrate that the simulated spectra are very sensitive to the laser focusing conditions at high laser intensity and high pressure since the fundamental laser field is severely reshaped during the propagation. By comparing the simulated results with several experiments we show that the pressure dependence can be qualitatively explained. The lack of …

Stress Modulation On The San Andreas Fault By Interseismic Fault System Interactions, John P. Loveless, Brendan J. Meade

Geosciences: Faculty Publications

During the interseismic phase of the earthquake cycle, between large earthquakes, stress on faults evolves in response to elastic strain accumulation driven by tectonic plate motions. Because earthquake cycle processes induce non-local stress changes, the interseismic stress accumulation rate on one fault is influenced by the behavior of all nearby faults. Using a geodetically constrained block model, we show that the total interseismic elastic strain field generated by fault interactions within Southern California may increase stressing rates on the Mojave and San Bernardino sections of the San Andreas fault within the Big Bend region by as much as 38% relative …

Support Varieties And Representation Type Of Self-Injective Algebras, Jorg Feldvoss, Sarah Witherspoon

University Faculty and Staff Publications

We use the theory of varieties for modules arising from Hochschild cohomology to give an alternative version of the wildness criterion of Bergh and Solberg [7]: If a finite dimensional self-injective algebra has a module of complexity at least 3 and satisfies some finiteness assumptions on Hochschild cohomology, then the algebra is wild. We show directly how this is related to the analogous theory for Hopf algebras that we developed in [23]. We give applications to many different types of algebras: Hecke algebras, reduced universal enveloping algebras, small half- quantum groups, and Nichols (quantum symmetric) algebras.

Thermodynamics Of Magnetic Multilayers, Tathagata Mukherjee

Department of Physics and Astronomy: Dissertations, Theses, and Student Research

Our interest in thermodynamics of magnetic thin film heterostructure began by exploring the possibility to use magnetic nanostructures in the search for optimized magnetocaloric materials for potential room temperature refrigeration. In the present thesis magnetic thin film heterostructures are experimentally realized by Molecular Beam Epitaxy (MBE) and Pulsed Laser Deposition (PLD). Co/Cr and Fe/Cr superlattices were fabricated using mean-field theoretical concepts as guiding principles. The potential of artificial antiferromagnets for near room-temperature refrigeration is explored. Magnetocaloric properties are deduced from measurements of the temperature and field dependence of the magnetization of our samples. The effects of intra-plane and inter-plane exchange …

A Mild One-Pot Conversion Of Alkenes Into Amines Through Tandem Ozonolysis And Reductive Amination, Shivakumar Kyasa, Thomas J. Fisher, Patrick Dussault

Patrick Dussault Publications

The selective reduction of hydroperoxyacetals to aldehydes by sodium triacetoxyborohydride provides the basis for a mild one-pot synthesis of amines from alkenes.

Includes Supplementary Materials.

Maximum Lifetime Coverage Preserving Scheduling Algorithms In Sensor Networks, Maggie X. Cheng, Xuan Gong

Computer Science Faculty Research & Creative Works

In wireless sensor networks, when each target is covered by multiple sensors, sensors can take turns to monitor the targets in order to extend the lifetime of the network. in this paper, we address how to improve network lifetime through optimal scheduling of sensor nodes. We present two algorithms to achieve the maximum lifetime while maintaining the required coverage: A linear programming-Based exponential-time exact solution, and an approximation algorithm. Numerical simulation results from the approximation algorithm are compared to the exact solution and show a high degree of accuracy and efficiency. © 2010 Springer Science Business Media, LLC.

Paim: Peer-Based Automobile Identity Management In Vehicular Ad-Hoc Network, Anna Squicciarini, Dan Lin, Alessandro Mancarella

Computer Science Faculty Research & Creative Works

The emerging Vehicular Ad-hoc Network (VANET) technology will enable many exciting applications such as vehicular safety assistance and mobile entertainment. One of the key challenges toward successful roll-out of VANET applications is to provide security and privacy preserving mechanisms for users. Existing efforts on this topic rely heavily on infrastructure like road-side units which however are not available everywhere. to minimize the dependence on infrastructure, we propose a novel Peer-Based Automobile Identity Management (PAIM) Framework which is mainly based on vehicle-to-vehicle communication. PAIM supports dynamic event-Based moving zones formed by vehicles sharing common interest. PAIM achieves the level of privacy …

Performance Improvement For Collection Operations Using Join Query Optimization, Venkata Krishna Suhas Nerella, Sanjay Kumar Madria, Thomas Weigert

Computer Science Faculty Research & Creative Works

Programming languages with explicit support for queries over collections allow programmers to express operations on collections more abstractly than relying on their realization in loops or through provided libraries. Join optimization techniques from the field of database technology support efficient realizations of such language constructs. We describe an algorithm that performs run-time query optimization and is effective for single runs of a program. the proposed approach relies on histograms built from the data at run time to estimate the selectivity of joins and predicates in order to construct query plans. Information from earlier executions of the same query during run …

Investigating Combinatorial Approaches In Virtual Screening On Human Inducible 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase (Pfkfb3): A Case Study For Small Molecule Kinases, Robert B. Crochet, Michael C. Cavalier, Minsuh Seo, Jeong Do Kim, Young Sun Yim, Seung Jong Park, Yong Hwan Lee

Computer Science Faculty Research & Creative Works

Efforts toward improving the predictiveness in tier-based approaches to virtual screening (VS) have mainly focused on protein kinases. Despite their significance as drug targets, small molecule kinases have been rarely tested with these approaches. In this paper, we investigate the efficacy of a pharmacophore screening-combined structure-based docking approach on the human inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, an emerging target for cancer chemotherapy. Six out of a total 1364 compounds from NCI's Diversity Set II were selected as true actives via throughput screening. Using a database constructed from these compounds, five programs were tested for structure-based docking (SBD) performance, the MOE of which showed …

Lsuhsc Facilities Biweekly Update: November 2011, Lsuhsc Property And Facilities Management

LSUHSC Facilities Biweekly Updates: 2011

LSUHSC Facilities Biweekly Updates from November 4 and 18, 2011.

These updates describe damage and a timeline of repairs at the LSU Health Sciences Center - New Orleans campus due to Hurricane Katrina which made landfall August 29, 2005.

Lsuhsc Facilities Daily Updates: November 2011, Lsuhsc Property And Facilities Management

LSUHSC Facilities Daily Updates: 2011

LSUHSC Facilities Daily Updates from November 2011.

On the original documents, the daily update for Tuesday, November 8, 2011 was misdated as Tuesday, November 9, 2011.

These updates describe damage and a timeline of repairs at the LSU Health Sciences Center - New Orleans campus due to Hurricane Katrina which made landfall August 29, 2005.

A Recognition-Based Motion Capture Baseline On The Humaneva Ii Test Data, Nicholas Howe

Computer Science: Faculty Publications

The advent of the HumanEva standardized motion capture data sets has enabled quantitative evaluation of motion capture algorithms on comparable terms. This paper measures the performance of an existing monocular recognition-based pose recovery algorithm on select HumanEva data, including all the HumanEva II clips. The method uses a physically-motivated Markov process to connect adajacent frames and achieve a 3D relative mean error of 8.9 cm per joint. It further investigates factors contributing to the error, and finds that research into better pose retrieval methods offers promise for improvement of this technique and those related to it. Finally, it investigates the …