Physical Sciences and Mathematics Commons^™

Dual Inhibition Of Sodium-Mediated Proton And Calcium Efflux Triggers Non-Apoptotic Cell Death In Malignant Gliomas, William Harley, Candace Floyd, Tamara Dunn, Xiao-Dong Zhang, Tsung-Yu Chen, Manu Hegde, Hasan Palandoken, Michael H. Nantz, Leonardo Leon, K.L. Carraway Iii, Bruce Lyeth, Fredric A. Gorin

Chemistry and Biochemistry

Malignant glioma cells maintain an elevated intracellular pH (pH_i) within hypoxic–ischemic tumormicroenvironments through persistent activation of sodium–proton transport (McLean et al., 2000). Amiloride has been reported to selectively kill human malignant glioma cell lines but not primary astrocytes (Hegde et al., 2004). While amiloride reduces pH_i of malignant gliomas by inhibiting isoform 1 of sodium–proton exchange (NHE1), direct acidification was shown to be cytostatic rather than cytotoxic. At cytotoxic concentrations, amiloride has multiple drug targets including inhibition of NHE1 and sodium–calciumexchange. Amiloride's glioma cytotoxicity can be explained, at least in part, by dual inhibition of NHE1 and …

Reconstructability Analysis Of Epistasis, Martin Zwick

Complex Systems Faculty Publications and Presentations

The literature on epistasis describes various methods to detect epistatic interactions and to classify different types of epistasis. Reconstructability analysis (RA) has recently been used to detect epistasis in genomic data. This paper shows that RA offers a classification of types of epistasis at three levels of resolution (variable-based models without loops, variable-based models with loops, state-based models). These types can be defined by the simplest RA structures that model the data without information loss; a more detailed classification can be defined by the information content of multiple candidate structures. The RA classification can be augmented with structures from related …

Some Results For Integral Inclusions Of Volterra Type In Banach Spaces, Ravi P. Agarwal, Mouffak Benchohra, Juan Jose Nieto, Abdelghani Ouahab

Mathematics and System Engineering Faculty Publications

We first present several existence results and compactness of solutions set for the following Volterra type integral inclusions of the form: y(t) ∈ ∫0 t a(t-s)[Ay(s)+F(s,y(s)) ]ds,a.e.t ∈ J, where J=[ 0,b ], A is the infinitesimal generator of an integral resolvent family on a separable Banach space E, and F is a set-valued map. Then the Filippov's theorem and a Filippov-Waewski result are proved.

African Water: An Experience With Project Management In Bulima, Tanzania, Robert Sharp

Honors Theses

Details the author's experiences researching, designing, and implementing a water system for a boarding school in Africa.

Radiative Forcing Over The Conterminous United States Due To Contemporary Land Cover Use Change And Sensitivity To Snow And Interannual Albedo Variability, Christoper A. Barnes, David P. Roy

GSCE Faculty Publications

Satellite‐derived land cover land use (LCLU), snow and albedo data, and incoming surface solar radiation reanalysis data were used to study the impact of LCLU change from 1973 to 2000 on surface albedo and radiative forcing for 58 ecoregions covering 69% of the conterminous United States. A net positive surface radiative forcing (i.e., warming) of 0.029 Wm−2 due to LCLU albedo change from 1973 to 2000 was estimated. The forcings for individual ecoregions were similar in magnitude to current global forcing estimates, with the most negative forcing (as low as −0.367 Wm−2) due to the transition to forest and the …

Watershed Survey And Pilot Lcc Project, Norman Turgeon, Three Ponds Protective Association

PREP Reports & Publications

This describes two projects accomplished in 2010 by the Three Ponds Protective Association (TPPA) and several partners to identify and reduce soil erosion due to storm water runoff into the Milton Three Ponds

When Curiosity Kills More Than The Cat: The Perils Of Unchecked Scientific Inquiry, Jamie Shannon

Pomona Senior Theses

This work analyzes the ecological, physical, emotional and health impacts of the US nuclear testing done in the Marshall Islands in the mid-20th century.

Spatial Semantics For Better Interoperability And Analysis: Challenges And Experiences In Building Semantically Rich Applications In Web 3.0, Amit P. Sheth

Kno.e.sis Publications

No abstract provided.

Measurements Of Gas‐Phase Inorganic And Organic Acids From Biomass Fires By Negative‐Ion Proton‐Transfer Chemical‐Ionization Mass Spectrometry, P. Veres, James M. Roberts, I. R. Burling, C. Warneke, Joost De Gouw, Robert J. Yokelson

Chemistry and Biochemistry Faculty Publications

[1] Emissions from 34 laboratory biomass fires were investigated at the combustion facility of the U.S. Department of Agriculture Fire Sciences Laboratory in Missoula, Montana. Gas-phase organic and inorganic acids were quantified using negative-ion proton-transfer chemical-ionization mass spectrometry (NI-PT-CIMS), open-path Fourier transform infrared spectroscopy (OP-FTIR), and proton-transfer-reaction mass spectrometry (PTR-MS). NI-PT-CIMS is a novel technique that measures the mass-to-charge ratio (m/z) of ions generated from reactions of acetate (CH₃C(O)O⁻) ions with inorganic and organic acids. The emission ratios for various important reactive acids with respect to CO were determined. Emission ratios for isocyanic acid (HNCO), 1,2 …

Network Science: Using Information Technology To Enable Collaboration, Arden L. Bement Jr.

PPRI Digital Library

No abstract provided.

Quantitative Stability And Optimality Conditions In Convex Semi-Infinite And Infinite Programming, M J. Cánovas, M A. Lopez, Boris S. Mordukhovich, J Parra

Mathematics Research Reports

This paper concerns parameterized convex infinite (or semi-infinite) inequality systems whose decision variables run over general infinite-dimensional Banach (resp. finite-dimensional) spaces and that are indexed by an arbitrary fixed set T. Parameter perturbations on the right-hand side of the inequalities are measurable and bounded, and thus the natural parameter space is loo(T). Based on advanced variational analysis, we derive a precise formula for computing the exact Lipschitzian bound of the feasible solution map, which involves only the system data, and then show that this exact bound agrees with the coderivative norm of the aforementioned mapping. On one hand, in this …

Ecological Impacts Of Stream Bank Stabilization In A Great Plains River, Christopher M. Pracheil

School of Natural Resources: Dissertations, Theses, and Student Research

Reduced ecological complexity, decreased water quality, and accelerated stream bank erosion are common disturbances in rivers with agriculturally dominated watersheds. Massive bank failures, increased sediment loads, and decreased riverine habitat are current problems in the agriculturally dominated Cedar River of central Nebraska. In an effort to slow erosion and prevent further ecological degradation, 20 reach scale stream bank stabilization projects were installed on the Cedar River from 2001 to 2004. The objective of this study was to determine the impact of the Cedar River stream bank stabilization projects on the ecological conditions within the Cedar River. Stream bank erosion, suspended …

Random Automata Networks: Why Playing Dice Is Not A Vice, Christof Teuscher

Systems Science Friday Noon Seminar Series

Random automata networks consist of a set of simple compute nodes interacting with each other. In this generic model, one or multiple model parameters, such as the the node interactions and/or the compute functions, are chosen at random. Random Boolean Networks (RBNs) are a particular case of discrete dynamical automata networks where both time and states are discrete. While traditional RBNs are generally credited to Stuart Kauffman (1969), who introduced them as simplified models of gene regulation, Alan Turing proposed unorganized machines as early as 1948. In this talk I will start with Alan Turing's early work on unorganized machines, …

Solving A Generalized Heron Problem By Means Of Convex Analysis, Boris S. Mordukhovich, Nguyen Mau Nam, Juan Salinas Jr

Mathematics Research Reports

The classical Heron problem states: on a given straight line in the plane, find a point C such that the sum of the distances from C to the given points A and B is minimal. This problem can be solved using standard geometry or differential calculus. In the light of modern convex analysis, we are able to investigate more general versions of this problem. In this paper we propose and solve the following problem: on a given nonempty closed convex subset of IR!, find a point such that the sum of the distances from that point to n given nonempty …

Positive Solutions Of Singular Complementary Lidstone Boundary Value Problems, Ravi P. Agarwal, Donal O'Regan, Svatoslav Staněk

Mathematics and System Engineering Faculty Publications

We investigate the existence of positive solutions of singular problem (-1)mx(2m+1) = f(t, x,⋯, x(2m)), x (0) = 0, x(2i-1) (0) = x(2i-1) (T) = 0, 1 ≤ i ≤ m. Here, m ≥ 1 and the Carathéodory function f (t, x0,⋯, x2m) may be singular in all its space variables x0,⋯, x2m. The results are proved by regularization and sequential techniques. In limit processes, the Vitali convergence theorem is used.

Burkholder Integrals, Morrey's Problem And Quasiconformal Mappings, Kari Astala, Tadeusz Iwaniec, Istvan Prause, Eero Saksman

Mathematics - All Scholarship

Inspired by Morrey's Problem (on rank-one convex functionals) and the Burkholder integrals (of his martingale theory) we find that the Burkholder functionals B_p, p > 2, are quasiconcave, when tested on deformations of identity f in Id+C_o^inifinty (omega) with Bp (Df(x)) > 0 pointwise, or equivalently, deformations such that abs[Df]² < (p/(p-2))J_f. In particular, this holds in explicit neighbourhoods of the identity map. Among the many immediate consequences, this gives the strongest possible L^p-estimates for the gradient of a principal solution to the Beltrami equation f_z = mu(z)f_z , for any p in …

Like Mother Like Child: An Investigation Of Mother Characteristics And Child Temperaments, Tempus Fugitt

Statistics

Much research has gone into what biological and social factors raise the risk of children developing cognitive, social, or behavioral problems. This project looks at what characteristics of the mother are significantly associated with different temperaments in the child which may predict problems developed in the child later in life. These characteristics include mother’s age, her education level, household income, parenting attitudes, involvement with the child, and drug and alcohol use. Data was used from the Fragile Families and Child Wellbeing Study conducted by the Office of Population Research at Princeton University. Cumulative logistic regression was used to analyze the …

Source Attribution Of Ozone In Southeast Texas Before And After The Deepwater Horizon Accident Using Satellite, Sonde, Surface Monitor, And Air Mass Trajectory Data, Gary A. Morris, Barry Lefer, Bernhard Rappenglueck, Christine Haman, Marc Taylor, Mark R. Schoeberl

Physics and Astronomy Faculty Presentations

Since the summer of 2004, over 300 ozonesondes have been launched from Rice University (29.7 N, 95.4 W) or the University of Houston (29.7 N, 95.3 W), each < 5 km from downtown Houston. The Texas Commission on Environmental Quality maintains a large database of hourly surface ozone observations in Southeast Texas. In this study, we identify the contributions to surface ozone pollution levels from natural and anthropogenic sources, both local and remote in nature. This source identification is performed two ways: 1) through an analysis of sonde data, including ozone concentrations, wind speed and direction, and relative humidity data, and 2) through an analysis that combines trajectory calculations with surface monitor data. We also examine regional changes in Ozone Monitoring Instrument (OMI) measurements of formaldehyde and ozone from 2004 – 2010. In particular, we compare the 2010 sonde, surface monitor, and satellite data after the Deepwater Horizon accident with data from previous years to determine the impact, if any, of the large source of hydrocarbons in the Gulf of Mexico on air quality in Southeast Texas.

The Human Population Growth And Its Ecological Consequences On Kenya And Tanzania, Lauren Noll

Student Theses 2001-2013

The world population is growing at an alarming rate. The rapid growth in population numbers and density along with the steady increase in the rates are causing issues in many countries. Although every country is experiencing many consequences of the growth, the countries of Kenya and Tanzania in East Africa seem to be suffering immensely. Not only does the increasing human population in these third world countries create an overarching competition for natural resources such as food, water, and land, the growth also has detrimental effects on the surrounding environment, wildlife populations, ecotourism, and traditional African cultures.

Feedback Control Of A Bioinspired Plate-Beam System, Cody W. Ray, Belinda A. Batten, John R. Singler

Mathematics and Statistics Faculty Research & Creative Works

In this paper we present a model for a plate-beam system to represent a bioinspired flexible wing. Using a Galerkin based finite element approximation to the system, we compute functional gains that can be used for sensor placement and show that a piezoceramic actuator on the beam can be used for camber control

Sfa Weather Station-December 2010, Arthur Temple College Of Forestry And Agriculture, Stephen F. Austin State University

Weather Station Data

No abstract provided.

The Green, Blue And Grey Water Footprint Of Farm Animals And Animal Products. Volume 1: Main Report, Mesfin Mekonnen, Arjen Y. Hoekstra

Daugherty Water for Food Global Institute: Faculty Publications

The projected increase in the production and consumption of animal products is likely to put further pressure on the globe’s freshwater resources. The size and characteristics of the water footprint vary across animal types and production systems. The current study provides a comprehensive account of the global green, blue and grey water footprints of different sorts of farm animals and animal products, distinguishing between different production systems and considering the conditions in all countries of the world separately. The following animal categories were considered: beef cattle, dairy cattle, pig, sheep, goat, broiler chicken, layer chicken and horses. The study shows …

The Green, Blue And Grey Water Footprint Of Farm Animals And Animal Products. Volume 2: Appendices, Mesfin Mekonnen, Arjen Y. Hoekstra

Daugherty Water for Food Global Institute: Faculty Publications

Contents

Appendix I: Feed conversion efficiencies – in kg of feed (dry mass) per kg of output – per animal category and region

Appendix II: Estimated consumption of feed per animal category and world region (10³ ton dry mass/yr)

Appendix III. Estimated consumption of feed per production system and world region (10³ ton dry mass/yr)

Appendix IV. Drinking and service water footprint per animal

Appendix V. Water footprint of animals and animal products (m³/ton). Period 1996-2005

On Relativistic Disk Spectroscopy In Compact Objects With X-Ray Ccd Cameras, J. M. Miller, A. D'Aì, M. W. Bautz, S. Bhattacharyya, D. N. Burrows, E. M. Cackett, A. C. Fabian, M. J. Freyberg, F. Haberl, J. Kennea, M. A. Nowak, R. C. Reis, T. E. Strohmayer, M. Tsujimoto

Physics and Astronomy Faculty Research Publications

X-ray charge-coupled devices (CCDs) are the workhorse detectors of modern X-ray astronomy. Typically covering the 0.3-10.0 keV energy range, CCDs are able to detect photoelectric absorption edges and K shell lines from most abundant metals. New CCDs also offer resolutions of 30-50 (E/ΔE), which is sufficient to detect lines in hot plasmas and to resolve many lines shaped by dynamical processes in accretion flows. The spectral capabilities of X-ray CCDs have been particularly important in detecting relativistic emission lines from the inner disks around accreting neutron stars and black holes. One drawback of X-ray CCDs is that spectra can be …

Rock Properties And Internal Structure Of The San Andreas Fault Near ~ 3 Km Depth In The Safod Borehole Based On Meso- To Micro-Scale Analyses Of Phase Iii Whole Rock Core, Kelly Keighley Bradbury, James P. Evans

Geosciences Presentations

We examine the relationships between rock properties and structure within ~ 41 m of PHASE III whole-rock core collected from ~ 3 km depth along the SAF in the San Andreas Fault Observatory at Depth (SAFOD) borehole, near Parkfield, CA.

Efficacy Of The United States Safe Harbor Framework, Margaret M. Beck

Regis University Student Publications (comprehensive collection)

This study assessed the efficacy of the United States Safe Harbor Framework by approximating the size of a population of large United States organizations (50,000 - 500,000 employees) that were eligible to participate in the Safe Harbor that did not participate. The Safe Harbor Framework, administered by the United States Department of Commerce, is a voluntary program that assists United States organizations in complying with the European Union Data Privacy Directive. Out of a population of 337 large organizations, 168 were potentially eligible to participate in the Safe Harbor Framework. One hundred and ten, or 66%, of these organizations did …

The John Muir Newsletter, Winter 2010/2011, The John Muir Center

Muir Center Newsletters (1981-2015)

Page 1 transcription missing

PAGE 2 John Muir Back and Newsletter Going Digital After a year, we are back! Last year we announced that we would become an "occasional" newsletter, projecting two issues per year. We only released one issue this past year. In an age of high cost of reproduction and mailing we have decided to follow the trail of other newsletters by going digital. Those with e mail can continue to receive at no charge the newsletter as part of a web serve list. Simply e mail us at [email protected] and we will include you in our future …

Reference Priors For Exponential Families With Increasing Dimension, Bertrand Clarke, Subhashis Ghosal

Department of Statistics: Faculty Publications

In this article, we establish the asymptotic normality of the posterior distribution for the natural parameter in an exponential family based on independent and identically distributed data. The mode of convergence is expected Kullback-Leibler distance and the number of parameters p is increasing with the sample size n. Using this, we give an asymptotic expansion of the Shannon mutual information valid when p = pm increases at a sufficiently slow rate. The second term in the asymptotic expansion is the largest term that depends on the prior and can be optimized to give Jeffrey's prior as the reference prior in …

Analysis Of A Database Insider Threat Model, Andrea Samuel

Computer Science and Computer Engineering Undergraduate Honors Theses

According to Silicon.com's CIO Insight - Beware the Insider Security Threat, insiders are bigger threats to corporate security than external threats such as denial of service attacks or malware. Statistics show that 70% of fraud is perpetrated by staff and that the main data security threat comes from poorly trained or disgruntled employees who are authorized to have access to data and file stores [4]. This research project focuses specifically on the problem of insider threat in relational database systems. The project involves simulating research conducted in Qussai Yaseen and Brajendra Panda's research paper, Predicting and Preventing Insider Threat in …

Completeness Of Ordered Fields, James Forsythe Hall

Mathematics

The main goal of this project is to prove the equivalency of several characterizations of completeness of Archimedean ordered fields; some of which appear in most modern literature as theorems following from the Dedekind completeness of the real numbers, while a couple are not as well known and have to do with other areas of mathematics, such as nonstandard analysis. Continuing, we study the completeness of non-Archimedean fields, and provide several examples of such fields with varying degrees of properties, using nonstandard analysis to produce some relatively "nice" (in particular, they are Cantor complete) final examples. As a small detour, …