Physical Sciences and Mathematics Commons^™

Design And Synthesis Of Beta-Hairpin Peptidomimetics For Modulating Integrin Mediated Cell Adhesion, Abeta Fibrillogenesis And P53-Mdm2 Protein-Protein Interactions, Priyesh Jain

USF Tampa Graduate Theses and Dissertations

Inhibiting therapeutically important protein-protein interactions has been a tremendous challenge for medicinal chemists. The folded 3D structures of peptides and proteins, mainly comprise secondary structural elements i.e α-helices and β-sheet have created an opportunity to design small molecules and peptidomimetic inhibitors of protein-protein interaction (PPI). Hence, information about the formation and stabilization of these secondary structures is vital for designing future drugs. In this dissertation, several cyclic beta-hairpin peptidomimetics that mimic the recognition surface have been designed and synthesized as inhibitors for different targets such as integrin mediated extracellular matrix -cell adhesion in multiple myeloma, p53-MDM2 PPI, amyloid beta fibrillogenesis …

A Framework For Determining The Reliability Of Nanoscale Metallic Oxide Semiconductor (Mos) Devices, Wilkistar Otieno

USF Tampa Graduate Theses and Dissertations

An increase in worldwide investments during the past several decades has pro-pelled scienti c breakthroughs in nanoscience and technology research to new and exciting levels. To ensure that these discoveries lead to commercially viable prod-ucts, it is important to address some of the fundamental engineering and scientific challenges related to nanodevices. Due to the centrality of reliability to product integrity, nanoreliability requires critical analysis and understanding to ensure long-term sustainability of nanodevices and systems. In this study, we construct a relia-bility framework for nanoscale dielectric lms used in Metallic Oxide Semiconductor (MOS) devices. The successful fabrication and incorporation of metallic …

Dna Methylation And Its Association With Prenatal Exposures And Pregnancy Outcomes, Jennifer Straughen

USF Tampa Graduate Theses and Dissertations

Altered DNA methylation may lead to suboptimal fetal programming, increasing the risk of adverse pregnancy outcomes such as small for gestational age (SGA); however, few studies have examined the associations between DNA methylation, prenatal exposures, and fetal outcomes. Cross-sectional data from a larger, ongoing study were used to assess the impact of prenatal smoking on gene specific methylation of umbilical cord blood derived DNA and to investigate the association between gene-specific methylation and risk of SGA. The association between gene-specific DNA methylation and birthweight was also assessed. Maternal and infant covariates were abstracted from medical records, cigarette smoke exposure was …

Evaluation Of Common Inherited Variants In Mitochondrial-Related And Microrna-Related Genes As Novel Risk Factors For Ovarian Cancer, Jennifer Permuth Wey

USF Tampa Graduate Theses and Dissertations

Epithelial ovarian cancer (EOC) is a leading cause of morbidity and mortality among women in the United States, and the etiology is incompletely understood. Common, low penetrant genetic variants such as single nucleotide polymorphisms (SNPs) likely contribute to a significant proportion of EOC. We examined whether SNPs in two understudied yet biologically important types of genes, mitochondrial-related and miRNA-related genes, may contribute to EOC susceptibility using data from a large, homogeneous study population of 1,815 EOC cases and 1,900 controls (frequency-matched on age-group and race/ethnicity) genotyped through stage 1 of an ongoing genome-wide association study. Inter-individual variation in genes involved …

Corrole Synthesis And Catalytic Applications Toward Cobalt(Iii)-Catalyzed Epoxidation, N-H Insertion, And Cyclopropanation, Chung Sik Kim

USF Tampa Graduate Theses and Dissertations

A variety of bromocorroles, useful precusors for Pd-based cross coupling, were sucessfully synthesized in moderate to good yields. Chiral corroles were also synthesized through use of chiral amides in the aforementioned cross coupling reactions. Cobalt complexes bearing π-acceptor (CNtBu) and σ-donor (PPh3) ligands were also prepared in excellent yields. In this dissertation, cobalt (III) corrole complexes were applied to three different reaction areas: epoxidation, N-H insertion, and cyclopropanation. Cobalt(III) corroles were found to be efficient catalysts for epoxidation reactions. The epoxidation reactions can be carried out using ethyl phenyldiazoacetate, an acceptor/donor diazo compound, as a carbenoid precusor.The reaction provided highly …

Aspects Of The Life History Of The Snowy Grouper, Epinephelus Niveatus, In The Gulf Of Mexico, Kelley Kowal

USF Tampa Graduate Theses and Dissertations

Knowledge of many life history parameters are essential to properly assess and manage fish species. Although the snowy grouper, Epinephelus niveatus, is a commercially valuable fish, which is harvested throughout the Gulf of Mexico, little is known about its age, growth, and reproduction from this region. In this study, snowy grouper from the northern and eastern regions of the Gulf of Mexico were examined primarily using commercially-derived samples that were collected between 1984 and 2004. A total of 1,200 snowy grouper with fork lengths between 242 and 1,190 mm were collected. Sectioned saggital otoliths were used to determine the age …

Discovery Of Novel Viruses From Animals, Plants, And Insect Vectors Using Viral Metagenomics, Terry Fei Fan Ng

USF Tampa Graduate Theses and Dissertations

Understanding emerging viruses is critical for disease monitoring and prediction; however, surveys of novel viruses are hindered by the lack of a universal assay for viruses. Viral metagenomics, consisting of viral particle purification and shotgun sequencing, is a powerful technique for discovering viruses in a wide variety of sample types. However, current protocols are not effective on tissue samples (e.g., lungs, livers and tumors), where they are hindered by the high amount of host nucleic acids which limits the percentage of sequences that originate from viruses. In this dissertation, a modified viral metagenomics protocol was developed and utilized to effectively …

Ua6/1/1 Lost River Cave & Valley - Oral History Project, Wku Archives

WKU Archives Collection Inventories

Unprocessed oral history files regarding Lost River Cave & Valley.

Ua1b1/3 University Lecture Series, Wku Archives

WKU Archives Collection Inventories

Records created by the University Lecture Series committee which invites distinguished and prominent individuals to lecture at the university. The records include correspondence with potential speakers and programs, posters and recordings of lectures.

Ua1c11/25 Lost River Cave Photo Collection, Wku Archives

WKU Archives Collection Inventories

Photographs and postcards created by Lost River Cave & Valley.

When Curiosity Kills More Than The Cat: The Perils Of Unchecked Scientific Inquiry, Jamie Shannon

Pomona Senior Theses

This work analyzes the ecological, physical, emotional and health impacts of the US nuclear testing done in the Marshall Islands in the mid-20th century.

The John Muir Newsletter, Winter 2010/2011, The John Muir Center

Muir Center Newsletters, 1981-2015

Page 1 transcription missing

PAGE 2 John Muir Back and Newsletter Going Digital After a year, we are back! Last year we announced that we would become an "occasional" newsletter, projecting two issues per year. We only released one issue this past year. In an age of high cost of reproduction and mailing we have decided to follow the trail of other newsletters by going digital. Those with e mail can continue to receive at no charge the newsletter as part of a web serve list. Simply e mail us at iohnmuir@pacific.edu and we will include you in our future …

Minerva 2010, The Honors College

Minerva

This issue of Minerva celebrates the 75th anniversary of Honors at the University of Maine! It includes an article on the college's 75th anniversary celebration; a look into the inaugural Center for Undergraduate Research (CUGR) symposium; and discussions on 2010 Honors Read, Persepolis, as well as 2011 Honors Read, The Omnivore's Dilemma. Other highlights include an article on Honors graduate and historian, Kristen Gwinn, and her book Emily Greene Balch: The Long Road to Internationalism.

Leaching Mechanism Of Semiconducting Minerals, Fathi Habashi

Fathi Habashi

The mechanism of leaching of semiconducting minerals such as PbS, ZnS, UO2, etc., has been the subject of intensive speculation by hydrometallurgists in the early 1950s. The electrochemical mechanism proposed in 1970 by the author in volume 2 of his Principles of Extractive Metallurgy avoids the assumption of forming intermediate complexes that cannot be isolated or identified.

The Update, December 2010, University Of Northern Iowa. College Of Humanities, Arts And Sciences.

Update

Inside this issue:

-- American Chemical Society, a student affiliate group
-- Department News
-- Iowa Writing Project
-- UNI School of Music to Host 50th Anniversary Celebration: Varsity Men's Glee Club Christmas Variety Shows
-- Communication Studies: Student Showcased on the Jay Leno Show
-- Dmitri Vorobiev: An All Beethoven Recital Series
-- Student Spotlight: Philosophy: Joel Anderson
-- Student Spotlight: World Religions: Elizabeth Wiedenheft
-- Student Spotlight: Industrial Technology: Hannah Loan
-- UNI Students attend and participate in sixth Annual Multicultural Conference
-- Student Spotlights Continued
-- School of Music Events
-- UNI Forensics
-- Communication Studies Students …

Changing Mutual Perception Of Television News Viewers And Program Makers In India- A Case Study Of Cnn-Ibn And Its Unique Initiative Of Citizen Journalism, Ratnesh Dwivedi Mr

Ratnesh Dwivedi

The Indian television system is one of the most extensive systems in the world. Terrestrial broadcasting, which has been the sole preserve of the government, provides television coverage to over 90% of India's 900 million people. By the end of 1996 nearly 50 million households had television sets. International satellite broadcasting, introduced in 1991, has swept across the country because of the rapid proliferation of small scale cable systems. By the end of 1996, Indians could view dozens of foreign and local channels and the competition for audiences and advertising revenues was one of the hottest in the world. In …

Rethinking Geometrical Exactness, Marco Panza

MPP Published Research

A crucial concern of early modern geometry was fixing appropriate norms for deciding whether some objects, procedures, or arguments should or should not be allowed into it. According to Bos, this is the exactness concern. I argue that Descartes’s way of responding to this concern was to suggest an appropriate conservative extension of Euclid’s plane geometry (EPG). In Section 2, I outline the exactness concern as, I think, it appeared to Descartes. In Section 3, I account for Descartes’s views on exactness and for his attitude towards the most common sorts of constructions in classical geometry. I also explain in …

Modern Variation In Predation Intensity: Constraints On Assessing Predator-Prey Relationships In Paleoecologic Reconstructions, James Funderburk

USF Tampa Graduate Theses and Dissertations

The complex interaction between predators and their prey is rarely preserved in the fossil record. However, predation of marine mollusks by drilling gastropods leaves a diagnostic hole in the shell of the prey, possibly allowing for quantitative analysis of this ecological interaction. Drilling frequency, as measured in marine mollusks both in the Modern and fossil record, has been heralded as a potential opportunity to quantify these ecological interactions and use these values in the testing of hypotheses.

This study employed the collection, tallying, and analysis of bulk samples derived from shelly deposits on 45 Modern beaches along the contiguous coast …

Design, Synthesis & Biological Activity Of Novel Protein Tyrosine Phosphatase (Ptp) Mimetics, Sridhar Reddy Kaulagari

USF Tampa Graduate Theses and Dissertations

Protein phosphorylation is a post translational modification of proteins in which a serine, a threonine or a tyrosine residue is phosphorylated by an enzyme, kinase. Phosphorylation of proteins is a reversible and very important regulatory mechanism that occurs in both prokaryotes and eukaryotes. Phosphorylation turns many protein enzymes on and off, preventing or causing many diseases such as diabetes, cancer and rheumatoid arthritis. The phosphorylation on tyrosine residues of proteins is essential for transmission of signals for cell growth, proliferation and differentiation. Protein tyrosine phosphatases (PTPs) in concert with protein tyrosine kinases (PTKs) regulate many signal transduction pathways by controlling …

Libs And Lite Emission Based Laser Remote Sensing Of Chemical Species And Enhanced Modeling Of Atmospheric Absorption, Dzianis V. Pliutau

USF Tampa Graduate Theses and Dissertations

Laser-Induced Breakdown spectroscopy (LIBS) and Laser-Induced Thermal Emission (LITE) emission based laser remote sensing were investigated with the application to the remote measurements of trace chemical species. In particular, UVvisible LIBS and Mid-IR LITE systems were developed and measurements of remote targets and chemical surfaces were studied. The propagation through the atmosphere of the multi-wavelength backscattered LIBS and LITE optical spectrum with atmospheric absorption effects on the returned lidar signal was investigated. An enhanced model of the atmospheric effects on emission-based laser-remote sensing was developed and found to be consistent and in agreement with our experimental results.

LITE measurements were …

Linking Soil Loss To Sediment Delivery In Two Estuaries In Puerto Rico, Nekesha Bernadette Williams

USF Tampa Graduate Theses and Dissertations

Enhanced soil loss from the watershed is a major environmental issue. Increased soil loss from a watershed can potentially increase sediment delivery and loading to aquatic ecosystems such as rivers and estuaries. An increase in sediment delivery and loading to freshwater and transitional marine ecosystems can impact water quality and supply specifically by: (1) reducing water clarity, (2) transporting nutrient and pollutant laden sediments and (3) reducing the storage capacity of reservoirs. To address these broader environmental impacts of increased sediment delivery and loading to aquatic ecosystems it is imperative that potential source areas of sediments available for transport are …

Exploring Evaluation In School Districts: School District Evaluators And Their Practice, Susan Hibbard

USF Tampa Graduate Theses and Dissertations

This study explored the evaluation practices of internal evaluators in public school districts in a large southern state. The individuals who conduct evaluations in school districts as internal evaluators were identified and background information was collected. The education and training in evaluation was investigated and the types of evaluations typically conducted by those individuals. Respondents (n = 134) revealed conducting evaluations was a secondary role and part of their main job responsibilities. The types of evaluations carried out and the way in which evaluation was practices were revealed. A descriptive framework of the individuals who conduct evaluations in school districts …

Optical Design Of Beam Shaping Optics For Camera Probe And Led Light Illumination Used For Minimally Invasive Abdominal Surgery, Weiyi He

USF Tampa Graduate Theses and Dissertations

The optical design of a LED illuminator and camera imaging system were studied for potential use in a small medical "robotic type" probe to be used for minimally invasive abdominal surgery. Beam shaping optical reflectors were studied to increase the intensity distribution of the LED beam directed toward a close-by target surface. A CMOS/CCD camera and lens was used to image the targeted area. In addition, extensive optical ray tracing simulations were made to predict the intensity patterns. The experimental measurements and ray tracing simulations were in good agreement, and indicated that 20 degree cone reflectors for the LED sources …

Breathing Fresh Air Into The Philosophy Of Mathematics, Marco Panza

MPP Published Research

A review of Paolo Mancosu (ed.): The Philosophy of Mathematical Practice.

Morphogrammatics Of Reflection, Rudolf Kaehr

Rudolf Kaehr

Turning back from the studies of morphogrammatics to some open questions of reflectional programming, the recountered problematics might be put into a different light and new methods of handling formal aspects of reflection and reflectionality shall be introduced. Albeit the use of light-metaphors, morphogrammatic reflection is not sketched along the paradigm of optical metaphors. Morphograms are presenting neither propositions nor perceptions able for mirroring (representation). Exercises in defining morphogrammatic retro-grade recursion and reflection schemata are continued from the paper “Sketches to Morphogrammatic Programming”.

The Update, November 2010, University Of Northern Iowa. College Of Humanities, Arts And Sciences.

Update

Inside this issue:

-- Working to Recover: Geology Professor, Community Actor Becomes 'Super Volunteer'
-- Department News
-- Graphic Communications Name Change
-- Film Screening: Living Downstream
-- Action is Eloquence
-- Color and Camouflage
-- Regents Award
-- Student Spotlights
-- Get Your Green On
-- WCF Symphony & School of Music Events
-- UNI Art Students Study Abroad in Berlin
-- UNI's Cyber Defense Team
-- Student Spotlights Continued...
-- Students and Faculty Attend Major Graphics Trade Show in Chicago
-- UNI Teacher Wins Prestigious Award

-- WCF Symphony & School of Music Events Continued...
-- UNI Forensics …

Autonomous Underwater Vehicles As Tools For Deep-Submergence Archaeology, Christopher N. Roman, Ian Roderick Mather

Graduate School of Oceanography Faculty Publications

Marine archaeology beyond the capabilities of scuba divers is a technologically enabled field. The tool suite includes ship-based systems such as towed side-scan sonars and remotely operated vehicles, and more recently free-swimming autonomous underwater vehicles (AUVs). Each of these platforms has various imaging and mapping capabilities appropriate for specific scales and tasks. Broadly speaking, AUVs are becoming effective tools for locating, identifying, and surveying archaeological sites. This paper discusses the role of AUVs in this suite of tools, outlines some specific design criteria necessary to maximize their utility in the field, and presents directions for future developments. Results are presented …

Loring-Greenough House, North Yard Archaeogeophysics, Jamaica Plain, Massachusetts, John M. Steinberg, Christa M. Beranek, John Schoenfelder, Kathryn A. Catlin

Andrew Fiske Memorial Center for Archaeological Research Publications

An archaeogeophysical survey was carried out in May 2010 using Geonics EM-38 RT and a Malå Ground Penetrating Radar (GPR) system with a 500 MHz antenna over an 28x26 m grid immediately northeast of the Loring-Greenough house in Jamaica Plain, MA. Three major anomalies were identified. These anomalies have not been ground truthed, but they appear to be archaeological features. First, we suggest that there is builders trench just north of the house. Second, we suggest that there could be three east-west garden paths or other landscape features about 30 cm below the surface crossing the entire length of the …

Ua35/1 Doers & Deeds Vol. 7, No. 17, Wku Provost

WKU Archives Records

Newsletter created by the WKU Provost & Vice President of Academic Affairs to highlight the activities of faculty, staff and alumni.

Topics In Random Knots And R-Matrices From Frobenius Algebras, Enver Karadayi

USF Tampa Graduate Theses and Dissertations

In this dissertation, we study two areas of interest in knot theory: Random knots in the unit cube, and the Yang-Baxter solutions constructed from Frobenius algebras.

The study of random knots can be thought of as a model of DNA strings situated in confinement. A random knot with n vertices is a polygonal loop formed by selecting n distinct points in the unit cube, for a positive integer n, and connecting these points by straight line segments successively, such that the last point selected is joined with the first one. We present a step by step description of our algorithm …