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2007

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Articles 5161 - 5190 of 5729

Full-Text Articles in Physical Sciences and Mathematics

Reducing Non-Target Hazards Of Rodenticides In Forest Settings, Wendy M. Arjo, David T. Bryson Jan 2007

Reducing Non-Target Hazards Of Rodenticides In Forest Settings, Wendy M. Arjo, David T. Bryson

United States Department of Agriculture Wildlife Services: Staff Publications

Mammalian damage to forest resources is widespread and causes annual economic loss. Wildlife damage control is very important to the intensified land use practices and the economics of reforestation using seedlings. Reforestation areas provide ideal habitat for many wildlife species. However, animals negatively impact trees more severely during stand establishment than at any other time. While numerous non-lethal and lethal tools are available for large and medium-sized mammals, fewer tools are available for small mammals. The damage caused by these rodent species has in some cases warranted the use of rodenticides to control populations. Rodenticides are effective tools for reducing …


Field Method For Analyzing Birds For Avicide 3-Chloro-P-Toluidine Hydrochloride, Jerome C. Hurley, Patricia A. Pipas, Shelagh K. Tupper, John L. Cummings, Randal S. Stahl Jan 2007

Field Method For Analyzing Birds For Avicide 3-Chloro-P-Toluidine Hydrochloride, Jerome C. Hurley, Patricia A. Pipas, Shelagh K. Tupper, John L. Cummings, Randal S. Stahl

United States Department of Agriculture Wildlife Services: Staff Publications

We developed a fast and simple method to detect presence or absence of DRC-1339 (CPTH: 3-Chloro-p-toluidine Hydrochloride) in birds that fed on DRC-1339 bait sites. We compared the effectiveness of the colorimetric method to the previously published analytical method using birds collected from DRC-1339 bait sites in Louisiana and Texas. We also conducted tests with caged red-winged blackbirds (Agelaius phoeniceus) to determine if time from consumption of DRC-1339-treated bait to death and time from death to colorimetric analysis affected test results. The colorimetric assay was effective in detecting the presence or absence of DRC-1339 in birds …


Avian Use Of Rural Roadsides With Cattail (Typha Spp.), Bryan Safratowich, George M. Linz, William H. Bleier, H. Jeffrey Homan Jan 2007

Avian Use Of Rural Roadsides With Cattail (Typha Spp.), Bryan Safratowich, George M. Linz, William H. Bleier, H. Jeffrey Homan

United States Department of Agriculture Wildlife Services: Staff Publications

We surveyed 30 roadsides in North Dakota’s Prairie Pothole Region for birds and active nests between May and July 2001–2002. Each roadside transect was 1608 m and had ≥200 linear meters of standing cattail (Typha spp.). We recorded 45 bird species; four species of Icteridae dominated the avifauna. Red-winged blackbirds (Agelaius phoeniceus) were both the most abundant species and most abundant nester, averaging 53 birds/10 ha (SE = 7.7) and 30 nests/10 ha (SE = 9.7). Among non-icterid species, song sparrow (Melospiza melodia) and common yellowthroat (Geothlypis trichas) ranked first and second consecutively …


San Andreas Fault Zone Mineralogy, Geochemistry, And Physical Properties From Safod Cuttings And Core, John G. Solum, Stephen Hickman, David A. Lockner, Sheryl Tembe, Jim P. Evans, Sarah D. Draper, D. C. Barton, David L. Kirschner, Judith S. Chester, Frederick M. Chester, Ben A. Van Der Pluijm, Anja M. Schleicher, Diane E. Moore, Carolyn Morrow, Kelly Bradbury, Wendy M. Calvin, Teng-Fong Wong Jan 2007

San Andreas Fault Zone Mineralogy, Geochemistry, And Physical Properties From Safod Cuttings And Core, John G. Solum, Stephen Hickman, David A. Lockner, Sheryl Tembe, Jim P. Evans, Sarah D. Draper, D. C. Barton, David L. Kirschner, Judith S. Chester, Frederick M. Chester, Ben A. Van Der Pluijm, Anja M. Schleicher, Diane E. Moore, Carolyn Morrow, Kelly Bradbury, Wendy M. Calvin, Teng-Fong Wong

United States Geological Survey: Staff Publications

The San Andreas Fault Observatory at Depth (SAFOD), drilled near the town of Parkfield, California (Fig. 1) (Hickmen et al., 2004) as part of the U.S. National Science Foundation's EarthScope Project (see http://www.earthscope.org), provieds a continuous set of samples through the active San Andreas Fault (SAF) zone. These samples can help address decades-old questions such as apparent weakness of the SAF (Zoback, 2000) providing the unparalleled opportunity to contrain the parameters that control the behavior of plate counding faults like the San Andreas.

Samples collected form SAFOD also complement studies of exhumed fault zones. While studies of exhumed fault zones …


Factors Influencing Ground-Water Recharge In The Eastern United States, Bernard T. Nolan, Richard W. Healy, Patrick E. Taber, Kimberlie Perkins, Kerie J. Hitt, David M. Wolock Jan 2007

Factors Influencing Ground-Water Recharge In The Eastern United States, Bernard T. Nolan, Richard W. Healy, Patrick E. Taber, Kimberlie Perkins, Kerie J. Hitt, David M. Wolock

United States Geological Survey: Staff Publications

Ground-water recharge estimates for selected locations in the eastern half of the United States were obtained by Darcian and chloride-tracer methods and compared using statistical analyses. Recharge estimates derived from unsaturated-zone (RUZC) and saturated-zone (RSZC) chloride mass balance methods are less variable (interquartile ranges or IQRs are 9.5 and 16.1 cm/yr, respectively) and more strongly correlated with climatic, hydrologic, land use, and sediment variables than Darcian estimates (IQR = 22.8 cm/yr). The unit-gradient Darcian estimates are a nonlinear function of moisture content and also reflect the uncertainty of pedotransfer functions used to estimate hydraulic parameters. Significance …


New Insights Into Marine Migration And Winter Habitat Of Gulf Sturgeon, Randy E. Edwards, Frank M. Parauka, Kenneth J. Sulak Jan 2007

New Insights Into Marine Migration And Winter Habitat Of Gulf Sturgeon, Randy E. Edwards, Frank M. Parauka, Kenneth J. Sulak

United States Geological Survey: Staff Publications

Migrations and movements of Gulf sturgeon Acipenser oxyrinchus desotoi were determined using satellite pop-up archival transmitting (PAT) tags and acoustic telemetry. Adult Gulf sturgeon from four rivers in northwestern Florida were caught with gill nets and were tagged with PAT and acoustic tags in the fall of 2001 and 2002. PAT tags were programmed to release in early February 2002 and 2003 to provide information about location of late-winter marine habitats. However, only 5 of 25 provided meaningful location information. Three of the PAT-tagged fish were relocated acoustically near the PAT tag pop-up locations, one of which was in Choctawhatchee …


An Epidemiological Model Of Rift Valley Fever, Holly D. Gaff, David M. Hartley, Nicole P. Leahy Jan 2007

An Epidemiological Model Of Rift Valley Fever, Holly D. Gaff, David M. Hartley, Nicole P. Leahy

Biological Sciences Faculty Publications

We present and explore a novel mathematical model of the epidemiology of Rift Valley Fever (RVF). RVF is an Old World, mosquito-borne disease affecting both livestock and humans. The model is an ordinary differential equation model for two populations of mosquito species, those that can transmit vertically and those that cannot, and for one livestock population. We analyze the model to find the stability of the disease-free equlibrium and test which model parameters affect this stability most significantly. This model is the basis for future research into the predication of future outbreaks in the Old World and the assessment of …


A Landscape-Level Survey Of Feral Hog Impacts To Natural Resources Of The Big Thicket National Preserve, Pedro M. Chavarria, Roel R. Lopez, Gillian Bowser, Nova J. Silvy Jan 2007

A Landscape-Level Survey Of Feral Hog Impacts To Natural Resources Of The Big Thicket National Preserve, Pedro M. Chavarria, Roel R. Lopez, Gillian Bowser, Nova J. Silvy

Human–Wildlife Interactions

We conducted a survey of the impact of feral hog (Sus scrofa) on the natural resources of the Big Thicket National Preserve (BTNP), a unit of the National Park Service. We worked in 3 management units: Lance Rosier, Big Sandy, and Turkey Creek. Random stratified sampling was conducted to assess impacts from hog damage on resources by vegetation type at a landscape scale. Landscape features such as topography, soil moisture, soil type, and dominant vegetative cover types were used to predict hog damage. The overall damage to vegetation from hog rooting or wallowing averaged 28% within the 3 …


Hogs Gone Wild, William H. Clay Jan 2007

Hogs Gone Wild, William H. Clay

Human–Wildlife Interactions

Wildlife damage management professionals deal with very few animals that pose as many conflicts or threats as those caused by feral hogs. Whether it’s crop damage, livestock predation, environmental degradation, or disease transmission, feral hogs play a substantial role. Earlier this year, headlines in major newspapers and other media outlets highlighted the latest incidence of an E. coli outbreak in California; more than 200 people across the United States became sick, and 3 people died as a result of eating fresh spinach contaminated with this bacteria. The source of the outbreak was traced back to feral hogs in California.


Effi Cacy Of Cpth-Treated Egg Baits For Removing Ravens, Peter S. Coates, Jack O. Spencer, Jr., David J. Delehanty Jan 2007

Effi Cacy Of Cpth-Treated Egg Baits For Removing Ravens, Peter S. Coates, Jack O. Spencer, Jr., David J. Delehanty

Human–Wildlife Interactions

Human-altered landscapes have provided resource subsidies for common ravens (Corvus corax) resulting in a substantial increase in raven abundance and distribution throughout the United States and Canada in the past 25 years. Ravens are effective predators of eggs and young of ground-nesting birds. During 2002–2005, we tested whether chicken egg baits treated with CPTH (3-chloro-p-toluidine hydrochloride) could be used to manage raven numbers in an area where raven depredation was impacting sharp-tailed grouse (Tympanuchus phasianellus columbianus) and greater sage-grouse (Centrocercus urophasianus) populations in Nevada. We performed multiple raven surveys at a treatment site and …


A Tribute To Frederick F. Knowlton, William H. Clay Jan 2007

A Tribute To Frederick F. Knowlton, William H. Clay

Human–Wildlife Interactions

Dr. Fredrick F. Knowlton officially retired on March 31, 2007, with well over 45 years of service to the USDA/Wildlife Services. Fred worked at Wildlife Services’ National Wildlife Research Center Field Station in Logan, Utah, for 35 years alone! His work on coyotes and other species has had an extraordinary impact on the science and management of coyotes. Things that we take for granted today about the life history of coyotes were the result of Fred’s tireless ambition to understand these animals and to improve our ability to manage them. One of our agency’s first Ph.D. hires, Fred produced about …


Hazing Of Canada Geese Is Unlikely To Reduce Nuisance Populations In Urban And Suburban Communities, Robin A. Holevinski, Paul D. Curtis, Richard A. Malecki Jan 2007

Hazing Of Canada Geese Is Unlikely To Reduce Nuisance Populations In Urban And Suburban Communities, Robin A. Holevinski, Paul D. Curtis, Richard A. Malecki

Human–Wildlife Interactions

Growing populations of resident Canada geese (Branta canadensis) have caused increased nuisance problems in urban and suburban communities. Hazing, or persistent harassment, is often recommended as a nonlethal management strategy to alleviate these problems. Does hazing simply cause a local redistribution of birds, or can it solve nuisance problems by pushing geese to rural areas where hunting mortality could reduce the population? To answer this question, we marked 368 adult and 400 juvenile geese with leg bands in 1 urban and 1 suburban community in western New York State during June 2002 and 2003. This sample included 30 …


In The News, Fall 2007, Joe N. Caudell Jan 2007

In The News, Fall 2007, Joe N. Caudell

Human–Wildlife Interactions

The Tribune-Democrat of Johnstown, Pennsylvania, reported several disturbing trends about the state’s 2006 feral hog hunt. Initially, it was thought that feral hogs existed only in small, isolated pockets within the state, consisting of <30 individuals per pocket. But, during the fall 2006 hunting season, at least 200 hogs were taken from 2 counties. USDA/ APHIS Wildlife Services has been studying the feral hog population and believes that there are at least 3,000 hogs in the state, and it has found evidence that the hogs are breeding in several counties. Wildlife biologists theorize that additional hunting pressure put on the hogs by large hunting parties is causing the hogs to disperse over a larger area than when they are pursued by individual hunters.


Berryman Institute Addresses Feral Hog Problems, Bruce D. Leopold Jan 2007

Berryman Institute Addresses Feral Hog Problems, Bruce D. Leopold

Human–Wildlife Interactions

Congratulations to Dr. Conover for such a great inaugural issue of our journal!! I have received nothing but very positive accolades about the quality of our first issue. Mike and our managing editor, Phil Parisi, have done a fantastic job!!! This second issue is equally as radical as the first. This issue deals with a subject that is growing in importance throughout the southeastern United States: feral hogs. Being in Mississippi, I am all too familiar with the importance (and negative impact) of this invasive species. Berryman East has consistently funded numerous research projects on this subject. We also have …


Book Review: The Beast In The Garden: A Modern Parable Of Man And Nature, Nicole Mccoy Jan 2007

Book Review: The Beast In The Garden: A Modern Parable Of Man And Nature, Nicole Mccoy

Human–Wildlife Interactions

When I first read The Beast in the Garden shortly aft er the release of the hardback edition in 2004, I was reminded of the exchange quoted above in the movie, “The Matrix.” Neo (Mr. Anderson) survived. Scott Lancaster, a teenage athlete running in the hills outside of his Colorado high school, died. He probably never heard the mountain lion that stalked and killed him, but after reading David Baron’s book, I believe we should have. Had our ears been attuned to the proper frequency, the mountain lion’s approach would have been as loud as the subway train that spelled …


Appreciating Feral Hogs: Extension Education For Diverse Stakeholders In Texas, Dale Rollins, Billy J. Higginbotham, Kenneth A. Cearly, R. Neal Wilkins Jan 2007

Appreciating Feral Hogs: Extension Education For Diverse Stakeholders In Texas, Dale Rollins, Billy J. Higginbotham, Kenneth A. Cearly, R. Neal Wilkins

Human–Wildlife Interactions

Texas harbors the largest population of feral hogs (Sus scrofa) in the United States, with populations estimated at >2 million. Depending on one’s perspective, feral hogs are either a pariah (from the farmer’s standpoint) or a popular sporting animal (from a hunter’s standpoint). As feral hogs increase in range and density, conflicts among stakeholders are sure to increase. Texas Cooperative Extension (TCE) initiated educational programs in 1991 to address concerns regarding the presence and management of feral hogs. Since that time, we have developed various workshops, symposia, and educational materials (e.g., print, videotape, and website) as means of …


Book Review: Living With Coyotes: Managing Predators Humanely Using Food Aversion Conditioning, John A. Shivik Jan 2007

Book Review: Living With Coyotes: Managing Predators Humanely Using Food Aversion Conditioning, John A. Shivik

Human–Wildlife Interactions

I was initially worried after receiving a phone call from a predator advocate who told me that I must see the new book that explained how conditioned food avoidance (CFA) could be used to solve the problem of coyote predation. “New?” I thought, recalling the acrimonious debates over CFA in the journal Appetite and elsewhere in the 1980s. On reading the book, however, I was pleasantly surprised to find that Living with coyotes by Stuart Ellins is not an extension of the ongoing diatribes that started so long ago. Instead, the book acknowledges that many of the previous heated debates …


Land-Use Pattern, Urbanization, And Deer–Vehicle Collisions In Alabama, Anwar Hussain, James B. Armstrong, David B. Brown, John Hogland Jan 2007

Land-Use Pattern, Urbanization, And Deer–Vehicle Collisions In Alabama, Anwar Hussain, James B. Armstrong, David B. Brown, John Hogland

Human–Wildlife Interactions

With the rise in deer–vehicle collisions across the United States, the associated costs also have risen. Increasingly, however, researchers are learning that these collisions are not a random phenomena but follow a systematic pattern. Building on this insight, we explored the role of county characteristics in influencing the pattern and incidence of white-tailed deer- (Odocoileus virginianus) related auto collisions. Using county level data from 1994 to 2003 in Alabama, we tested several data models with the above mentioned factors …


Developing People Skills In The Human–Wildlife Conflict Community, Ben C. West Jan 2007

Developing People Skills In The Human–Wildlife Conflict Community, Ben C. West

Human–Wildlife Interactions

As I travel across the country talking with wildlife professionals about leadership and communication, I often ask groups this question: “How many of you decided to become a wildlife biologist because you just love working with people?” Believe it or not, I’ve never witnessed the raising of a single hand.


Pto Performance And Nox Emissions With D2, B20, And B100 Fuels In A John Deere 3203 Compact Tractor, Matthew Hardin, Tonya Brown, Melanie Roller, Donald Johnson, George Wardlow Jan 2007

Pto Performance And Nox Emissions With D2, B20, And B100 Fuels In A John Deere 3203 Compact Tractor, Matthew Hardin, Tonya Brown, Melanie Roller, Donald Johnson, George Wardlow

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

Tests were conducted in fall 2006 on a John Deere 3203 diesel tractor to determine differences in specific fuel consumption, power take-off (PTO) torque, PTO power, thermal efficiency, and oxides of nitrogen (NOx) emissions between No. 2 diesel (D2), 20% biodiesel (B20), and 100% biodiesel (B100). Four 1-hour tests were conducted on each fuel. The results indicated no statistically significant differences (p≤.05) between D2 or B20 on any variable of interest. However, B100 resulted in significantly (p≤.05) increased, specific fuel consumption and thermal efficiency and decreased PTO torque and PTO power over both D2 and B20. These data suggest that …


Investigation Of The Catalytic And Structural Roles Of Conserved Histidines Of Human Coproporphyrinogen Oxidase Using Site-Directed Mutagenesis, Shani J. Gitter, Christopher L. Cooper, Jon A. Frieson, Timothy D. Lash, Marjorie A. Jones Jan 2007

Investigation Of The Catalytic And Structural Roles Of Conserved Histidines Of Human Coproporphyrinogen Oxidase Using Site-Directed Mutagenesis, Shani J. Gitter, Christopher L. Cooper, Jon A. Frieson, Timothy D. Lash, Marjorie A. Jones

Faculty Publications – Chemistry

Background: The catalytic contribution of four conserved histidines of human coproporphyrinogen oxidase (CPO) has been investigated using site-directed mutagenesis to change histidine (H) into alanine (A). Material/Methods: The wild-type and mutant enzyme forms were analyzed for their ability to utilize coproporphyrinogen-III, mesoporphvrinogen-VI, and harderoporphyrinogen as substrates. Results: Wild-type CPO had specific activities of 4.9 +/- 0.9 nmole product/min/mg for coproporphyrinogen-III, 1.7 +/- 0.7 nmole ptoduct/min/mg for mesoporphyrinogen-VI, and 5.1 +/- 1.8 nmole product/min/mg for harderoporphyrinogen. The four mutant enzymes were catalytically competent With all three substrates, but to varying degrees. The most affected Mutant was the H158A enzyme which exhibited …


Demonstration Of Magnetoelectric Scanning Probe Microscopy, Jason R. Hattrick-Simpers, Liyang Dai, Manfred Wuttig, Ichiro Takeuchi, Eckhard Quandt Jan 2007

Demonstration Of Magnetoelectric Scanning Probe Microscopy, Jason R. Hattrick-Simpers, Liyang Dai, Manfred Wuttig, Ichiro Takeuchi, Eckhard Quandt

Faculty Publications

A near-field room temperature scanning magnetic probe microscope has been developed using a laminated magnetoelectric sensor. The simple trilayer longitudinal-transverse mode sensor, fabricated using Metglas as the magnetostrictive layer and polyvinylidene fluoride as the piezoelectric layer, shows an ac field sensitivity of 467±3μV∕Oe in the measured frequency range of 200Hz–8kHz. The microscope was used to image a 2mm diameter ring carrying an ac current as low as 10−5A. ac fields as small as 3×10−10T have been detected.


Rapid Structural Mapping Of Ternary Metallic Alloy Systems Using The Combinatorial Approach And Cluster Analysis, C. J. Long, Jason R. Hattrick-Simpers, M. Murakami, R. C. Srivastava, I. Takeuchi, V. L. Karen, X. Li Jan 2007

Rapid Structural Mapping Of Ternary Metallic Alloy Systems Using The Combinatorial Approach And Cluster Analysis, C. J. Long, Jason R. Hattrick-Simpers, M. Murakami, R. C. Srivastava, I. Takeuchi, V. L. Karen, X. Li

Faculty Publications

We are developing a procedure for the quick identification of structural phases in thin film composition spread experiments which map large fractions of compositional phase diagrams of ternary metallic alloy systems. An in-house scanning x-ray microdiffractometer is used to obtain x-ray spectra from 273 different compositions on a single composition spread library. A cluster analysissoftware is then used to sort the spectra into groups in order to rapidly discover the distribution of phases on the ternary diagram. The most representative pattern of each group is then compared to a database of known structures to identify known phases. Using this method, …


The Systemic Nature Of Critical Infrastructure Protection Using A Medium Sized Company As The Case Study, Jeffery Sewell Jan 2007

The Systemic Nature Of Critical Infrastructure Protection Using A Medium Sized Company As The Case Study, Jeffery Sewell

Theses : Honours

Critical infrastructure can be defined as privately and publicly run organisations such as energy systems, water systems, transportation, telecommunications, emergency services, banking and finance. The critical infrastructure (CI) on which society relies is now dependent on the interconnected communication networks the information age has spawned. With the evolution of the information age, not only has the communications landscape changed dramatically, the security landscape has changed too. With information technology being so ubiquitous, it has created new underlying concerns about the systems now reliant on them. The reliance and complexity of these interconnected systems has increased vulnerabilities confronting critical infrastructure. This …


Pov-It: The Pov-Ray Interactive Tutorial, Eleanor O'Rourke Jan 2007

Pov-It: The Pov-Ray Interactive Tutorial, Eleanor O'Rourke

Honors Theses

The Persistence of Vision Ray Tracer, commonly known as POV-Ray, is a computer graphics package that can be used to produce highly sophisticated and photorealistic images and animations. POV-Ray is widely used in the computer graphics community for a diverse variety of applications, including teaching college courses, creating visual music animations, and generating computer art. Although the popularity of POV-Ray is apparent, the teaching materials available for the package are confusing, disorganized, and inaccessible. In this project, I have designed an online system that provides a series of interactive tutorials that teach users how to create images using the POV-Ray …


Multi-Phase Flow Analysis In Oil And Gas Engineering Systems And Its Modelling, Orlando F. Ayala, Luis F. Ayala, Orlando M. Ayala Jan 2007

Multi-Phase Flow Analysis In Oil And Gas Engineering Systems And Its Modelling, Orlando F. Ayala, Luis F. Ayala, Orlando M. Ayala

Engineering Technology Faculty Publications

[Introduction] Two-phase flow is very common in industrial processes and its applications were already in use in ages as remote as the era of Archimedes. At the present time, many industrial processes rely on multi-phase phenomena for the transport of energy and mass or for material processing. During the last century, the nuclear, chemical and petroleum industries propelled intense research activity in the area. Their efforts have been aimed at the demystification of the mechanisms taking place during this complex flow situation.


สัมภาษณ์พิเศษ : ดร. อานนท์ สนิทวงศ์ ณ อยุธยา "ภาวะโลกร้อน" มหันตภัยใกล้ตัว, สิริพร แก่นสียา Jan 2007

สัมภาษณ์พิเศษ : ดร. อานนท์ สนิทวงศ์ ณ อยุธยา "ภาวะโลกร้อน" มหันตภัยใกล้ตัว, สิริพร แก่นสียา

Thai Environment

No abstract provided.


Hutgyi-สาละวิน, ผ่องศรี จั่นท้าว Jan 2007

Hutgyi-สาละวิน, ผ่องศรี จั่นท้าว

Thai Environment

No abstract provided.


Modular Polyketide Synthases And Cis Double Bond Formation:  Establishment Of Activated Cis-3-Cyclohexylpropenoic Acid As The Diketide Intermediate In Phoslactomycin Biosynthesis, Mamoun M. Alhamadsheh, Nadaraj Palaniappan, Suparna Daschouduri, Kevin A. Reynolds Jan 2007

Modular Polyketide Synthases And Cis Double Bond Formation:  Establishment Of Activated Cis-3-Cyclohexylpropenoic Acid As The Diketide Intermediate In Phoslactomycin Biosynthesis, Mamoun M. Alhamadsheh, Nadaraj Palaniappan, Suparna Daschouduri, Kevin A. Reynolds

Chemistry Faculty Publications and Presentations

The majority of modular polyketide synthase (PKS) systems which generate unsaturated products do so with trans double bonds. Phoslactomycin B (PLM B) presents a class of antitumor and antiviral natural polyketide products that have unique structural features, including a linear unsaturated backbone with one trans and three cis double bonds. There is substantial evidence that trans double bonds are established by ketoreductase-dehydratase (KR-DH) didomains within a PKS module. In cases where modules containing these didomains appear to generate product containing a cis double bond there is no experimental evidence to determine if they do so directly, or if they also …


Antibacterial Targets In Fatty Acid Biosynthesis, H. Tonie Wright, Kevin A. Reynolds Jan 2007

Antibacterial Targets In Fatty Acid Biosynthesis, H. Tonie Wright, Kevin A. Reynolds

Chemistry Faculty Publications and Presentations

The fatty acid biosynthesis pathway is an attractive but still largely unexploited target for development of new anti-bacterial agents. The extended use of the anti-tuberculosis drug isoniazid and the antiseptic triclosan, which are inhibitors of fatty acid biosynthesis, validates this pathway as a target for anti-bacterial development. Differences in subcellular organization of the bacterial and eukaryotic multi-enzyme fatty acid synthase systems offer the prospect of inhibitors with host vs. target specificity. Platensimycin, platencin, and phomallenic acids, newly discovered natural product inhibitors of the condensation steps in fatty acid biosynthesis, represent new classes of compounds with antibiotic potential. An almost complete …