Physical Sciences and Mathematics Commons^™

Data Analytics And Visualization For Virtual Simulation, Sri Lekha Koppaka

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Healthcare organizations attract a diversity of caregivers and patients by providing essential care. While interacting with people of various races, ethnicity, and economical background, caregivers need to be empathetic and compassionate. Proper training and exposure are needed to understand the patient’s background and handle different situations and provide the best care for the patient. With social determinants of health (SDOH) as the basis, the thesis focuses on providing exposure through “Wright LIFE (Lifelike Immersion for Equity) - A simulation-based training tool” to two such scenarios covering patients from the LGBTQIA+ community & autism spectrum disorder (ASD). This interactive tool helps …

Computer Enabled Interventions To Communication And Behavioral Problems In Collaborative Work Environments, Ashutosh Shivakumar

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Task success in co-located and distributed collaborative work settings is characterized by clear and efficient communication between participating members. Communication issues like 1) Unwanted interruptions and 2) Delayed feedback in collaborative work based distributed scenarios have the potential to impede task coordination and significantly decrease the probability of accomplishing task objective. Research shows that 1) Interrupting tasks at random moments can cause users to take up to 30% longer to resume tasks, commit up to twice the errors, and experience up to twice the negative effect than when interrupted at boundaries 2) Skill retention in collaborative learning tasks improves with …

Topological Hierarchies And Decomposition: From Clustering To Persistence, Kyle A. Brown

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Hierarchical clustering is a class of algorithms commonly used in exploratory data analysis (EDA) and supervised learning. However, they suffer from some drawbacks, including the difficulty of interpreting the resulting dendrogram, arbitrariness in the choice of cut to obtain a flat clustering, and the lack of an obvious way of comparing individual clusters. In this dissertation, we develop the notion of a topological hierarchy on recursively-defined subsets of a metric space. We look to the field of topological data analysis (TDA) for the mathematical background to associate topological structures such as simplicial complexes and maps of covers to clusters in …

Modulation Of Human Gut Microbiota Through Dietary Associations, Sumudu Sasanka Rajakaruna

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Study of human gut microbiota is becoming widely popular in recent years, especially due to numerous beneficial aspects attributed to this diverse and complex microbial communities. Followingly, there is a keen interest in understanding the dynamics and subsequent modulation of human gut microbiota, from a health perspective. Diet is considered significant in shaping gut microbiota community and functions, predominantly due to dietary macro and micronutrient content. Subsequently, a plethora of research is carried out on the effects of dietary nutrients on gut microbiota. Dietary patterns, quality of the diet, differences in food preparation methods, physiological and chemical changes occurred during …

Virtual Reality-Based Serious Role-Playing Games As Digital Experiential Learning Tools To Deliver Healthcare Skills Through Mobile Devices, Dixit Bharatkumar Patel

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Inadequate professional training and practices related to health care may result in severe complications to care experiences and outcomes. Moreover, healthcare professionals are as susceptible to the possibility of implicit biases as any other group. Importantly, the health care training is critical and challenging as minor prejudicial beliefs have an adverse influence or serious consequences on patients' health outcomes. Thus, facilitating serious role-playing virtual care practices along with raising awareness of healthcare professionals about the enduring impact of implicit/explicit biases and Social Determinants of Health (SDH) on health outcomes assist to advance the patient-provider relation, care experiences (e.g., healthcare experience …

Automatically Inferring Image Bases Of Arm32 Binaries, Daniel T. Chong

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Reverse engineering tools rely on the critical image base value for tasks such as correctly mapping code into virtual memory for an emulator or accurately determining branch destinations for a disassembler. However, binaries are often stripped and therefore, do not explicitly state this value. Currently available solutions for calculating this essential value generally require user input in the form of parameter configurations or manual binary analysis, thus these methods are limited by the experience and knowledge of the user. In this thesis, we propose a user-independent solution for determining the image base of ARM32 binaries and describe our implementation. Our …

Validating Software States Using Reverse Execution, Nathaniel Christian Boland

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A key feature of software analysis is determining whether it is possible for a program to reach a certain state. Various methods have been devised to accomplish this including directed fuzzing and dynamic execution. In this thesis we present a reverse execution engine to validate states, the Complex Emulator. The Complex Emulator seeks to validate a program state by emulating it in reverse to discover if a contradiction exists. When unknown variables are found during execution, the emulator is designed to use constraint solving to compute their values. The Complex Emulator has been tested on small assembly programs and is …

Synthetic Aperture Ladar Automatic Target Recognizer Design And Performance Prediction Via Geometric Properties Of Targets, Jacob W. Ross

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Synthetic Aperture LADAR (SAL) has several phenomenology differences from Synthetic Aperture RADAR (SAR) making it a promising candidate for automatic target recognition (ATR) purposes. The diffuse nature of SAL results in more pixels on target. Optical wavelengths offers centimeter class resolution with an aperture baseline that is 10,000 times smaller than an SAR baseline. While diffuse scattering and optical wavelengths have several advantages, there are also a number of challenges. The diffuse nature of SAL leads to a more pronounced speckle effect than in the SAR case. Optical wavelengths are more susceptible to atmospheric noise, leading to distortions in formed …

Detection And Identification Of Prevalent Cutting Agents In 'Street' Samples Utilizing Handheld And Benchtop Raman Spectroscopy And Surface-Enhanced Raman Spectroscopy (Sers), Nicole Kenny

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Illicit and licit drugs continue to have a negative impact on the public’s health even with new regulations and laws. At local, state, and federal levels, crime laboratories analyze samples in a variety of mixtures and concentrations. Raman spectroscopy is a molecular fingerprinting, multiplex technique, which is considered a category A forensic characterization tool by the Scientific Working Group for the Analysis of Seized Drugs (SWGDRUG). The sensitivity of the Raman technique can be further enhanced down to the single-molecule detection level when analytes of interest are located at the interstitial sites of aggregated silver nanoparticles (i.e., the “hot spots” …

The Role Of Action Potential Changes In Depolarization-Induced Failure Of Excitation Contraction Coupling In Mouse Skeletal Muscle, Xueyong Wang, Murad Nawaz, Chris Dupont, Jessica H. Myers, Steve R.A. Burke, Roger A. Bannister, Brent D. Foy, Andrew A. Voss, Mark M. Rich

Physics Faculty Publications

Excitation-contraction coupling (ECC) is the process by which electrical excitation of muscle is converted into force generation. Depolarization of skeletal muscle resting potential contributes to failure of ECC in diseases such as periodic paralysis, intensive care unit acquired weakness and possibly fatigue of muscle during vigorous exercise. When extracellular K+ is raised to depolarize the resting potential, failure of ECC occurs suddenly, over a narrow range of resting potentials. Simultaneous imaging of Ca2+ transients and recording of action potentials (APs) demonstrated failure to generate Ca2+ transients when APs peaked at potentials more negative than –30mV. An AP property that closely …

Investigation Of Thz Absorptive Signatures In Opioids, Weidong Zhang, Alexei Bykhovski, Elliott R. Brown

Physics Faculty Publications

We investigate the possibility of sensing opioid drugs, such as fentanyl, by their THz electromagnetic signatures. The methods include both computer modeling and experiments. Molecular dynamics simulations predict that fentanyl should display THz resonances, with several of them occurring below 1.0 THz; the lowest one is at around 0.337 THz (337 GHz). Spectroscopy measurements were conducted on oxycodone, which was used as a surrogate for fentanyl. They display vibrational absorption resonances between ∼1.4 and 1.6 THz.

A Cloud Computing-Based Dashboard For The Visualization Of Motivational Interviewing Metrics, E Jinq Heng

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Motivational Interviewing (MI) is an evidence-based brief interventional technique that has been demonstrated to be effective in triggering behavior change in patients. To facilitate behavior change, healthcare practitioners adopt a nonconfrontational, empathetic dialogic style, a core component of MI. Despite its advantages, MI has been severely underutilized mainly due to the cognitive overload on the part of the MI dialogue evaluator, who has to assess MI dialogue in real-time and calculate MI characteristic metrics (number of open-ended questions, close-ended questions, reflection, and scale-based sentences) for immediate post-session evaluation both in MI training and clinical settings. To automate dialogue assessment and …

Evaluating Energy-Based Trait Shifts And Population Level Impacts Of Big Brown Bats (Eptesicus Fuscus) With Long-Term Exposure To Pseudogymnoascus Destructans, Molly C. Simonis

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Disturbances in environment can lead to a wide range of host physiological responses. These responses can either allow hosts to adjust to new conditions in their environment or can reduce their survival, and can subsequently cause host traits to shift. Small mammals are particularly vulnerable to stochastic disturbances, like a pathogen introduction, because of their high energy demands. Studies examining host responses to pathogens often focus on species highly susceptible to infection that typically have high mortality rates, leading to a gap in understanding the responses of less susceptible species. My dissertation evaluates the energy balance of Eptesicus fuscus (big …

Novel Natural Language Processing Models For Medical Terms And Symptoms Detection In Twitter, Farahnaz Golrooy Motlagh

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This dissertation focuses on disambiguation of language use on Twitter about drug use, consumption types of drugs, drug legalization, ontology-enhanced approaches, and prediction analysis of data-driven by developing novel NLP models. Three technical aims comprise this work: (a) leveraging pattern recognition techniques to improve the quality and quantity of crawled Twitter posts related to drug abuse; (b) using an expert-curated, domain-specific DsOn ontology model that improve knowledge extraction in the form of drug-to-symptom and drug-to-side effect relations; and (c) modeling the prediction of public perception of the drug’s legalization and the sentiment analysis of drug consumption on Twitter. We collected …

A Solder-Defined Computer Architecture For Backdoor And Malware Resistance, Marc W. Abel

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This research is about securing control of those devices we most depend on for integrity and confidentiality. An emerging concern is that complex integrated circuits may be subject to exploitable defects or backdoors, and measures for inspection and audit of these chips are neither supported nor scalable. One approach for providing a “supply chain firewall” may be to forgo such components, and instead to build central processing units (CPUs) and other complex logic from simple, generic parts. This work investigates the capability and speed ceiling when open-source hardware methodologies are fused with maker-scale assembly tools and visible-scale final inspection.

The …

Few-Shot Malware Detection Using A Novel Adversarial Reprogramming Model, Ekula Praveen Kumar

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The increasing sophistication of malware has made detecting and defending against new strains a major challenge for cybersecurity. One promising approach to this problem is using machine learning techniques that extract representative features and train classification models to detect malware in an early stage. However, training such machine learning-based malware detection models represents a significant challenge that requires a large number of high-quality labeled data samples while it is very costly to obtain them in real-world scenarios. In other words, training machine learning models for malware detection requires the capability to learn from only a few labeled examples. To address …

Evaluating Similarity Of Cross-Architecture Basic Blocks, Elijah L. Meyer

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Vulnerabilities in source code can be compiled for multiple processor architectures and make their way into several different devices. Security researchers frequently have no way to obtain this source code to analyze for vulnerabilities. Therefore, the ability to effectively analyze binary code is essential. Similarity detection is one facet of binary code analysis. Because source code can be compiled for different architectures, the need can arise for detecting code similarity across architectures. This need is especially apparent when analyzing firmware from embedded computing environments such as Internet of Things devices, where the processor architecture is dependent on the product and …

Locality Analysis Of Patched Php Vulnerabilities, Luke N. Holt

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The size and complexity of modern software programs is constantly growing making it increasingly difficult to diligently find and diagnose security exploits. The ability to quickly and effectively release patches to prevent existing vulnerabilities significantly limits the exploitation of users and/or the company itself. Due to this it has become crucial to provide the capability of not only releasing a patched version, but also to do so quickly to mitigate the potential damage. In this thesis, we propose metrics for evaluating the locality between exploitable code and its corresponding sanitation API such that we can statistically determine the proximity of …

Has Winter Weather In Southwest Ohio Been Affected By The El Niño Southern Oscillation, The North Atlantic Oscillation, The Pacific Decadal Oscillation, And The Atlantic Multidecadal Oscillation?, John A. Blue

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Winter temperature and precipitation in Southwest Ohio over the last century were examined for anomalies attributable to teleconnections with large-scale atmospheric perturbations caused by the El Niño Southern Oscillation (ENSO), the North Atlantic Oscillation (NAO), the Pacific Decadal Oscillation (PDO), and the Atlantic Multidecadal Oscillation (AMO). The record of temperature gives evidence of a teleconnection with the NAO, ENSO, and PDO, with the strongest link being for phases of the NAO. Most winters during positive NAO phases had mean monthly temperature warmer than the century long mean, and the majority of negative NAO phase winters had colder temperatures. The difference …

The Effects Of An Ultrafast Pulsed Laser On Ybco Thin Film Circuit Transients, Matthew L. Rustad

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Terahertz (THz) frequency light has shown promise for a wide variety of applications due to its material characterization and imaging capabilities. Its nondestructive nature coupled with its submillimeter spatial resolution provides the most value for terahertz light as an imaging tool. The application of terahertz technology has been limited by a lack of novel and powerful sources. It has been shown that that Yttrium Barium Copper Oxide (YBCO), a type II superconductor, has certain properties that would allow YBCO to be an effective source for THz light. Recent microwave work has shown that when a persistent supercurrent is placed on …

Building An Understanding Of Human Activities In First Person Video Using Fuzzy Inference, Bradley A. Schneider

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Activities of Daily Living (ADL’s) are the activities that people perform every day in their home as part of their typical routine. The in-home, automated monitoring of ADL’s has broad utility for intelligent systems that enable independent living for the elderly and mentally or physically disabled individuals. With rising interest in electronic health (e-Health) and mobile health (m-Health) technology, opportunities abound for the integration of activity monitoring systems into these newer forms of healthcare. In this dissertation we propose a novel system for describing ’s based on video collected from a wearable camera. Most in-home activities are naturally defined by …

Fabrication And Characterization Of Novel Agnps Functionalized With Chlorothymol (C@Agnps), Lirim Sopaj

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In this study, novel silver nanoparticles (AgNPs) were successfully synthesized and functionalized with an antibacterial agent, namely chlorothymol (denoted C@AgNPs). The resulting colloid (C@AgNPs) was purified by two comparative methods: ultrafiltration and ultracentrifugation. Ultrafiltration proved to be more efficient in purifying and size selecting (10 kD filter) and concentrating the C@AgNPs than ultracentrifugation. The physicochemical properties of the filtered C@AgNPs were then characterized by UV-Vis absorption spectroscopy, inductively coupled plasma optical emission spectroscopy (ICP-OES), Raman spectroscopy, Cytoviva hyperspectral imaging, and Scanning electron microscopy. These measurements confirmed the functionalization of the core AgNPs with chlorothymol and suggest the proposed mechanism of …

Secure Authenticated Key Exchange For Enhancing The Security Of Routing Protocol For Low-Power And Lossy Networks, Sarah Mohammed Alzahrani

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The current Routing Protocol for Low Power and Lossy Networks (RPL) standard provides three security modes Unsecured Mode (UM), Preinstalled Secure Mode (PSM), and Authenticated Secure Mode (ASM). The PSM and ASM are designed to prevent external routing attacks and specific replay attacks through an optional replay protection mechanism. RPL's PSM mode does not support key replacement when a malicious party obtains the key via differential cryptanalysis since it considers the key to be provided to nodes during the configuration of the network. This thesis presents an approach to implementing a secure authenticated key exchange mechanism for RPL, which ensures …

Bedrock Anisotropy At Sycamore Farms: An Investigation Using Azimuthal Resistivity And Electromagnetic Induction, Cody M. Kessler

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Azimuthal resistivity surveys coupled with an electromagnetic survey were completed at Sycamore Farms with the goal of investigating bedrock fracturing at the site. Previous work on this subject matter was completed at the site using similar geophysical tools, however, this study utilizes a unique method of azimuthal resistivity and higher resolution electromagnetic data. 72 azimuthal surveys were completed, and the electromagnetic survey covered all fields in which azimuthal surveys were completed. The results from the two methods were compared to identify zones of bedrock fracturing. Although correlation between the two data sets was limited it was found that the electromagnetic …

Using Network Analysis To Contrast Three Models Of Student Forum Discussions, Hannah N. Benston

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There is much research about how actors and events in social networks affect each other. In this research, three network models were created for discussion forums in three semesters of undergraduate general physics courses. This study seeks to understand what social network measures are most telling of a online forum classroom dynamic. That is, I wanted to understand more about things like what students are most central to the networks and whether this is consistent across different network models. I also wanted to better understand how students may or may not group together. What relationships (student to student, student to …

Realistic Virtual Human Character Design Strategy And Experience For Supporting Serious Role-Playing Simulations On Mobile Devices, Sindhu Kumari

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Promoting awareness of social determinants of health (SDoH) among healthcare providers is important to improve the patient care experience and outcome as it helps providers understand their patients in a better way which can facilitate more efficient and effective communication about health conditions. Healthcare professionals are typically educated about SDoH through lectures, questionaries, or role-play-based approaches; but in today’s world, it is becoming increasingly possible to leverage modern technology to create more impactful and accessible tools for SDoH education. Wright LIFE (Lifelike Immersion for Equity) is a simulation-based training tool especially created for this purpose. It is a mobile app …

Design, Analysis, And Optimization Of Traffic Engineering For Software Defined Networks, Mohammed Ibrahim Salman

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Network traffic has been growing exponentially due to the rapid development of applications and communications technologies. Conventional routing protocols, such as Open-Shortest Path First (OSPF), do not provide optimal routing and result in weak network resources. Optimal traffic engineering (TE) is not applicable in practice due to operational constraints such as limited memory on the forwarding devices and routes oscillation. Recently, a new way of centralized management of networks enabled by Software-Defined Networking (SDN) made it easy to apply most traffic engineering ideas in practice. \par Toward creating an applicable traffic engineering system, we created a TE simulator for experimenting …

Gene Vectors With Fluorescence Tracking Capabilities, Sophia Despina Angelopoulos

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This project focuses on the optimization of benzothiazole-based chromophores to utilize them as fluorescent tags functionalized onto stimuli-responsive, or “smart,” polymers as non-viral gene delivery vectors for gene therapy applications. Blue-fluorescent emissive chromophores will allow tracking capabilities for the transfection pathway of the vector to be monitored as it delivers the DNA payload within intercellular space. The most appropriate chromophore must be covalently bound to a free amine within the vector, which is accomplished through NAS chemistry from fluorophenyl-benzothiazoles (F-BTZ-CBz) derivatives to amidated hyperbranched poly(ethyleneimine)(HPEI-IBAm0.61). HPEI is considered to be a synthetic polycation, which promotes tunable solubility through characteristics of …

Mercury Concentrations And Mercury Methylation Along The Freshwater To Marine Continuum, Lindsay D. Starr

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Mercury (Hg) is a neurotoxin that can have detrimental impacts on the human nervous system and on brain development in infants. Methylmercury (MeHg) is the most toxic form of Hg and can concentrate to potentially harmful levels in higher levels of marine food webs. Production of MeHg in oxic water columns is poorly understood due to lack of knowledge of the mechanisms of formation and distribution. Recent work has reported widespread, putative Hg methylation genes in nitrite oxidizers, but any relationship with nitrifiers is unknown. This work focuses on Hg water column distribution, speciation, and methylation. The aims of this …

Automatically Generating Searchable Fingerprints For Wordpress Plugins Using Static Program Analysis, Chuang Li

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This thesis introduces a novel method to automatically generate fingerprints for WordPress plugins. Our method performs static program analysis using Abstract Syntax Trees (ASTs) of WordPress plugins. The generated fingerprints can be used for identifying these plugins using search engines, which have support critical applications such as proactively identifying web servers with vulnerable WordPress plugins. We have used our method to generate fingerprints for over 10,000 WordPress plugins and analyze the resulted fingerprints. Our fingerprints have also revealed 453 websites that are potentially vulnerable. We have also compared fingerprints for vulnerable plugins and those for vulnerability-free plugins.