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Articles 31 - 35 of 35

Full-Text Articles in Physical Sciences and Mathematics

Wright State University Celebration Of Research, Scholarship And Creative Activities Book Of Abstracts Friday, April 13, 2012, Wright State University Office Of Undergraduate Research And Stemm Activities Apr 2012

Wright State University Celebration Of Research, Scholarship And Creative Activities Book Of Abstracts Friday, April 13, 2012, Wright State University Office Of Undergraduate Research And Stemm Activities

Symposium of Student Research, Scholarship, and Creative Activities Materials

The student abstract booklet is a compilation of abstracts from students' oral and poster presentations at Wright State University's second annual Celebration of Research, Scholarship and Creative Activities on April 13, 2012.


Eti‐385 As A Novel Anti‐Emetic Against Drug Induced Emesis, Theresa Fennell, James Lucot, Samantha Spitak, Emily Smith, Teresa Garret Apr 2012

Eti‐385 As A Novel Anti‐Emetic Against Drug Induced Emesis, Theresa Fennell, James Lucot, Samantha Spitak, Emily Smith, Teresa Garret

Symposium of Student Research, Scholarship, and Creative Activities Materials

Drugs currently used to prevent emesis (nausea and vomiting) target only one or a few of the pathways used by emetic stimuli to trigger the reflex. Thus, an anti-emetic drug will only be effective against some stimuli. Prior work determined that 8-OH-DPAT (DPAT, a 5-HT1A agonist) was a universally effective anti-emetic. Although DPAT prevented emesis, it also elicited an extreme anxiety response making it unsuitable for therapeutic use. Presently, there exists no universal anti-emetic drug. We tested a proprietary drug developed from DPAT, ETI-385, which successfully prevented emesis in musk shrews against chemotherapy, drug and motion stimuli. For FDA purposes, …


Wright State University Celebration Of Research, Scholarship And Creative Activities Book Of Abstracts Friday, April 8, 2011, Wright State University Office Of Undergraduate Research And Stemm Activities Apr 2011

Wright State University Celebration Of Research, Scholarship And Creative Activities Book Of Abstracts Friday, April 8, 2011, Wright State University Office Of Undergraduate Research And Stemm Activities

Symposium of Student Research, Scholarship, and Creative Activities Materials

The student abstract booklet is a compilation of abstracts from students' oral and poster presentations at Wright State University's second annual Celebration of Research, Scholarship and Creative Activities on April 8, 2011.


Role Of The 3'Lghrr In Tcdd-Induced Suppression Of The Immunoglobulin Heavy Chain, Jayharsh L. Panchal, Eric J. Romer, David Ellis, Tharu Fernando, Courtney E. W. Sulentic Apr 2011

Role Of The 3'Lghrr In Tcdd-Induced Suppression Of The Immunoglobulin Heavy Chain, Jayharsh L. Panchal, Eric J. Romer, David Ellis, Tharu Fernando, Courtney E. W. Sulentic

Symposium of Student Research, Scholarship, and Creative Activities Materials

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) inhibits antibody secretion and immunoglobulin heavy chain (IgH) expression. Our previous work has shown that a possible mechanism for inhibition of IgH expression could be inhibition of the 3’IgH regulatory region (3’IgHRR). The 3’IgHRR has four enhancer regions (hs3a; hs1,2; hs3b; hs4) which are purported to control IgH gene expression. Previously we demonstrated a sensitive inhibition by TCDD of LPS-induced 3’IgHRR activity which is correlated with an inhibition of LPS-induced hs1,2 enhancer activity; however, the hs4 enhancer showed TCDD-induced activation following the co-treatment of TCDD and LPS. Therefore, the objective of the current study was to determine if …


Wright State University Celebration Of Research, Scholarship And Creative Activities 2010 Book Of Abstracts, Wright State University Office Of Undergraduate Research And Stemm Activities Apr 2010

Wright State University Celebration Of Research, Scholarship And Creative Activities 2010 Book Of Abstracts, Wright State University Office Of Undergraduate Research And Stemm Activities

Symposium of Student Research, Scholarship, and Creative Activities Materials

The student abstract booklet is a compilation of abstracts from students' oral and poster presentations at Wright State University's inaugural Celebration of Research, Scholarship and Creative Activities on April 16, 2010.