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Eti‐385 As A Novel Anti‐Emetic Against Drug Induced Emesis, Theresa Fennell, James Lucot, Samantha Spitak, Emily Smith, Teresa Garret

Symposium of Student Research, Scholarship, and Creative Activities Materials

Drugs currently used to prevent emesis (nausea and vomiting) target only one or a few of the pathways used by emetic stimuli to trigger the reflex. Thus, an anti-emetic drug will only be effective against some stimuli. Prior work determined that 8-OH-DPAT (DPAT, a 5-HT1A agonist) was a universally effective anti-emetic. Although DPAT prevented emesis, it also elicited an extreme anxiety response making it unsuitable for therapeutic use. Presently, there exists no universal anti-emetic drug. We tested a proprietary drug developed from DPAT, ETI-385, which successfully prevented emesis in musk shrews against chemotherapy, drug and motion stimuli. For FDA purposes, …