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Articles 31 - 60 of 106
Full-Text Articles in Physical Sciences and Mathematics
Gaseous And Dissolved Oxygen Sensing With Stabilized Pyrene In Ionic Liquid Modified Electrospun Slides, Özlem Öter, Gülhan Sabanci Şahi̇n
Gaseous And Dissolved Oxygen Sensing With Stabilized Pyrene In Ionic Liquid Modified Electrospun Slides, Özlem Öter, Gülhan Sabanci Şahi̇n
Turkish Journal of Chemistry
Pyrene dye has many superior characteristics for oxygen sensing studies such as long fluorescence lifetime, high quantum yield, and good sensitivity. It is preferred in some cases over ruthenium dyes for its more lipophilic character and higher sensitivity. However, easy photodegradation of pyrene is a challenging problem. In this study, pyrene dye was for the first time immobilized in an ethyl cellulose matrix and used for oxygen sensing in the form of thin films and electrospun sensing slides. The hydrophobic ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate was used as additive for the first time for dissolved oxygen sensing studies. The oxygen sensitivity …
Synthesis, Characterization, Biological Studies, And Molecular Modeling Of Mixed Ligand Bivalent Metal Complexes Of Schiff Bases Based On $N$-Aminopyrimidine-2-One/2-Thione, Hati̇ce Gamze Soğukömeroğullari, Tuğba Taşkin Tok, Feyza Yilmaz, İsmet Berber, Mehmet Sönmez
Synthesis, Characterization, Biological Studies, And Molecular Modeling Of Mixed Ligand Bivalent Metal Complexes Of Schiff Bases Based On $N$-Aminopyrimidine-2-One/2-Thione, Hati̇ce Gamze Soğukömeroğullari, Tuğba Taşkin Tok, Feyza Yilmaz, İsmet Berber, Mehmet Sönmez
Turkish Journal of Chemistry
New mixed Schiff bases, Cu(II), Co(II), Ni(II), and Mn(II) complexes, were synthesized derived from 5-chloro-2-hydroxyacethophenone and 1-amino-5-benzoyl-4-phenyl-1H-pyrimidine-2-one/thione. These complexes were characterized by elemental analysis, magnetic measurements, molar conductivity, IR, electronic, NMR, and mass spectral studies. All the complexes showed nonelectrolytic behavior. Moreover, the newly synthesized mixed ligand complexes were evaluated for their in vitro antimicrobial efficiency against bacteria and yeast. The compound named Co(L$_{1}$L) had good antifungal activity against Candida species, but no profound antibacterial effect against bacterial strains. In addition, the ground state geometries of the complexes were optimized using a semi-empirical method at PM6 level, which is a …
Synthesis And Biological Evaluation Of Novel Fused Triazolo[4,3-$A$] Pyrimidinones, Ikhlass Abbas, Sobhi Gomha, Mohamed Elneairy, Mahmoud Elaasser, Bazada Mabrouk
Synthesis And Biological Evaluation Of Novel Fused Triazolo[4,3-$A$] Pyrimidinones, Ikhlass Abbas, Sobhi Gomha, Mohamed Elneairy, Mahmoud Elaasser, Bazada Mabrouk
Turkish Journal of Chemistry
The reaction of thione 3 or its 2-methylthio derivative 4 with hydrazonoyl halides 5a-l, in the presence of triethylamine, yielded the corresponding triazolo[4,3-$a$]pyrimidin-5(1$H)$-ones 8a-l. The structure of compounds 8a-l was further confirmed by the reaction of 3 with the appropriate active chloromethylenes 11a-c followed by coupling of the products with benzenediazonium chloride to afford the azo-coupling products 6b, f, and j, which were converted in situ to 8b, f, and j. 2-Hydrazinyl-pyrido[3',2':4,5]thieno[3,2-$d$]pyrimidin-4(3$H)$-one (13) was prepared and condensed with different aldehydes 14a-f to give the corresponding hydrazone derivatives 15a-f. Oxidative cyclization of the hydrazones 15a-f give the corresponding triazolo[4,3-$a$] pyrimidin-5(1$H)$-one derivatives …
Two New Coordination Polymers Containing Dicyanidoargentate(I) And Dicyanidoaurate(I): Synthesis And Characterization, And A Detailed In Vitro Investigation Of Their Anticancer Activities On Some Cancer Cell Lines, Ali̇ Aydin, Ahmet Karadağ, Şaban Teki̇n, Nesri̇n Korkmaz, Aslihan Özdemi̇r
Two New Coordination Polymers Containing Dicyanidoargentate(I) And Dicyanidoaurate(I): Synthesis And Characterization, And A Detailed In Vitro Investigation Of Their Anticancer Activities On Some Cancer Cell Lines, Ali̇ Aydin, Ahmet Karadağ, Şaban Teki̇n, Nesri̇n Korkmaz, Aslihan Özdemi̇r
Turkish Journal of Chemistry
Two novel cyanido-bridged bimetallic polymeric complexes, [Ni(edbea)Ag$_{3}$(CN)$_{5}$]$_{n} $(C1) and [Ni(bishydeten) Au$_{2}$(CN)$_{4}$]$_{n}$ (C2), where edbea = [2,2$' $-(ethylenedioxy)bis(ethylamine)] and bishydeten = [($N$,$N' $-bis(2-hydroxyethyl) ethylenediamine)] are ligands, were synthesized and characterized by elemental, infrared, and thermal measurement techniques and investigated for their biological activity in cultured cancer cell lines. The results show that both compounds and free anions, [Ag(CN)$_{2}$]$^{-}$ and [Au(CN)$_{2}$]$^{-}$, exhibited very high antiproliferative activity compared to the anticancer drug 5FU against the cancer cell lines tested. The antiproliferative and cytotoxic activities of C1 and C2 were significantly lower than those of free anions, indicating that the extreme cytotoxicity of free …
The Effect Of Temperature And Concentration For Methanol Electrooxidation On Pt-Ru Catalyst Synthesized By Microwave Assisted Route, Hi̇lal Demi̇r Kivrak
The Effect Of Temperature And Concentration For Methanol Electrooxidation On Pt-Ru Catalyst Synthesized By Microwave Assisted Route, Hi̇lal Demi̇r Kivrak
Turkish Journal of Chemistry
At present, the methanol electrooxidation reaction (MOR) activities of carbon supported bimetallic Pt-Ru (M-PtRu@C) catalyst and monometallic Pt (M-Pt@C) catalysts prepared via microwave assisted polyol method and carbon supported Pt-Ru (P-PtRu@C) catalysts prepared by conventional polyol were examined to investigate the effect of the preparation method. These catalysts were characterized by X-ray diffraction, X-ray photo electron spectroscopy, and transmission electron microscopy (TEM). From TEM, the particle size of the M-PtRu@C catalyst was estimated as 3.54 nm. The MOR activities of these catalysts were examined at room temperature by cyclic voltammetry and chronoamperometry. Furthermore, stability measurements were performed on these catalysts …
Fabrication Of Silver Nanoparticles In Poly (N-Isopropylacrylamide-Co-Allylacetic Acid) Microgels For Catalytic Reduction Of Nitroarenes, Zahoor Hussain Farooqi, Naghza Tariq, Robina Begum, Shanza Rauf Khan, Zafar Iqbal, Abbas Khan
Fabrication Of Silver Nanoparticles In Poly (N-Isopropylacrylamide-Co-Allylacetic Acid) Microgels For Catalytic Reduction Of Nitroarenes, Zahoor Hussain Farooqi, Naghza Tariq, Robina Begum, Shanza Rauf Khan, Zafar Iqbal, Abbas Khan
Turkish Journal of Chemistry
Poly(N-isopropylacrylamide-co-allyl acetic acid) [p(NIPAM-co-AAAc)] microgels were synthesized in aqueous medium by free radical emulsion polymerization using N-isopropylacrylamide as monomer, allylacetic acid as comonomer, and N,N-methylene-bis-acrylamide as cross-linker. Silver nanoparticles were fabricated inside the microgels by in situ reduction of silver ions. Microgels were analyzed by UV-visible spectroscopy, FTIR, XRD, TEM, and DLS. The formation of silver nanoparticles was confirmed by UV-visible spectroscopy. UV-visible spectra of the Ag-poly(N-isopropylacrylamide-co-allyl acetic acid) hybrid microgels showed a prominent absorption peak at about 411 nm. This peak was due to the surface plasmon resonance effect of silver nanoparticles. The hybrid microgels were used as catalyst …
Preparation And Characterization Of Polyaniline Microrods Synthesized By Using Dodecylbenzene Sulfonic Acid And Periodic Acid, Recep Taş, Muzaffer Can, Savaş Sönmezoğlu
Preparation And Characterization Of Polyaniline Microrods Synthesized By Using Dodecylbenzene Sulfonic Acid And Periodic Acid, Recep Taş, Muzaffer Can, Savaş Sönmezoğlu
Turkish Journal of Chemistry
The preparation of polyaniline (PANI) microrod arrays in the presence of dodecylbenzene sulfonic acid (DBSAH), a structure-directing agent, and in the presence of periodic acid (H$_{5}$IO$_{6})$, an oxidant in aqua-acidic media, was investigated. DBSAH was performed to distinguish the roles of both surfactant and dopant. The method of preparation of DBSAH and H$_{5}$IO$_{6}$ doped PANI (DBSAH-PANI) microrods in a reversed micelle had previously not been reported. The characterizations of the PANI microrods were determined by scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy, (EDX) and X-ray diffraction (XRD). Based on the SEM results, we found that PANI microrods occur in …
Kinetics Study And Influence Of Water-Soluble Polymer On The Electrodeposition Of Iron From A Citrate-Chloride Electrolyte On The Basis Of Fe(Iii), Vyacheslav Protsenko, Felix Danilov
Kinetics Study And Influence Of Water-Soluble Polymer On The Electrodeposition Of Iron From A Citrate-Chloride Electrolyte On The Basis Of Fe(Iii), Vyacheslav Protsenko, Felix Danilov
Turkish Journal of Chemistry
The kinetics of the iron electrodeposition reaction from a plating bath containing trivalent iron ions is investigated in the present work. The electrochemical reaction is stated to proceed via the formation of relatively stable intermediates: Fe(II) ions. Only a part of the total amount of Fe(II) ions formed at the first stage of Fe(III) discharge is reduced further, producing metal iron. The effect of polyhexamethyleneguanidine hydrochloride (with an average molecular weight of 1000) on the iron deposition is ascertained. The presence of polymer additive in the iron electrolyte appreciably affects the rate of iron deposition, while the polymer additive does …
Synthesis Of Bis-Thiazoles, Bis-Pyrazoles, Bis-Hydrazonates, And Bis-Triazolothiadiazoles Based On Bis-Hydrazonoyl And Bis-Hydrazones, Abdelwahed Sayed
Synthesis Of Bis-Thiazoles, Bis-Pyrazoles, Bis-Hydrazonates, And Bis-Triazolothiadiazoles Based On Bis-Hydrazonoyl And Bis-Hydrazones, Abdelwahed Sayed
Turkish Journal of Chemistry
A facile synthesis of bis-thiazoles, bis-pyrazoles, and bis-hydrazonates from the reaction of bis-hydrazonoyl dichlorides with different moieties is described. Bis-triazolothiadiazoles were synthesized via oxidative cyclization of bis-hydrazones. Structures of the final product were elucidated by elemental analyses and spectral data.
One-Pot And Solvent-Free Synthesis Of 3-(9-Hydroxy-3-Methoxy-7-Aryl-6,7,9,10-Tetrahydro-5$H$-Benzo[$H$]Thiazolo[2,3-$B$]Quinazolin-9-Yl)-2$H$-Chromen-2-Ones And Their Antibacterial Evaluation, Ravibabu Velpula, Janardhan Banothu, Rajitha Gali, Yakaiah Sargam, Rajitha Bavantula
One-Pot And Solvent-Free Synthesis Of 3-(9-Hydroxy-3-Methoxy-7-Aryl-6,7,9,10-Tetrahydro-5$H$-Benzo[$H$]Thiazolo[2,3-$B$]Quinazolin-9-Yl)-2$H$-Chromen-2-Ones And Their Antibacterial Evaluation, Ravibabu Velpula, Janardhan Banothu, Rajitha Gali, Yakaiah Sargam, Rajitha Bavantula
Turkish Journal of Chemistry
A series of 3-(9-hydroxy-3-methoxy-7-aryl-6,7,9,10-tetrahydro-5$H$-benzo[$h$]thiazolo[2,3-$b$]quinazolin-9-yl)-2$H$-chromen-2-ones (5a-j) were synthesized by one-pot multicomponent reaction of 6-methoxy-1-tetralone, aryl aldehydes, and thiourea followed by cyclization with 3-(2-bromoacetyl)-2$H$-chromen-2-one in the presence of a Bronsted solid acid catalyst, poly(4-vinylpyridinium)hydrogen sulfate [P(4-VPH)HSO$_{4}$] (0.015 g), under solvent-free conditions at 120 $^{\circ}$C. All the synthesized compounds were characterized by spectral studies and screened for their in vitro antibacterial activity against S. aureus and B. thuringiensis (gram positive), and E. coli and K. pneumoniae (gram negative) bacterial strains. On comparing with the standard drug gentamicin, compounds derived from 4-methoxy and 3,4,5-trimethoxy benzaldehyde, i.e. 5g and 5h, showed broad spectrum antibacterial activity …
Synthesis And Characterization Of Halogen-Containing Aryl Amide Polymer-Clay Nanocomposites, Ali̇ Deli̇baş, Murat Alparslan
Synthesis And Characterization Of Halogen-Containing Aryl Amide Polymer-Clay Nanocomposites, Ali̇ Deli̇baş, Murat Alparslan
Turkish Journal of Chemistry
Synthesized $N$-(4-bromophenyl)-2-methacrylamide (BrPMAAm) and $N$-(4-fluorophenyl)-2-methacrylamide (FPMAAm) monomers were polymerized via free radical polymerization. Montmorillonite-containing raw clay (NaMT) was purified to obtain pristine clay (SMT). XRF results of the SMT sample showed that sodium amount increased and so it is sodium montmorillonite. Using the SMT and organic surfactant hexadecyltrimethylammonium bromide (CTAB), organoclay (OSMT) was synthesized. d$_{001}$ interlayer distances were 1.4967 nm and 2.0439 nm for SMT and OSMT, respectively. Composites of BrPMAAm and FPMAAm monomers were obtained using 2%, 4%, 6%, and 10% organoclay by in situ polymerization. Molecular weights for poly(BrPMAAm), poly(BrPMAAm)-10%OSMT, poly(FPMAAm), and poly(FPMAAm)-10%OSTM were 91,300, 31,300, 17,400, and …
A New And Simple Procedure For The Trace Determination Of Mercury Using Differential Pulse Polarography And Application To A Salt Lake Sample, Güler Somer, A. Cengi̇z Çalişkan, Olcay Şendi̇l
A New And Simple Procedure For The Trace Determination Of Mercury Using Differential Pulse Polarography And Application To A Salt Lake Sample, Güler Somer, A. Cengi̇z Çalişkan, Olcay Şendi̇l
Turkish Journal of Chemistry
A new and simple differential pulse polarographic procedure was established for the trace determination of mercury(II). An indirect method had to be used since no polarographic peak can be observed for its direct determination. According to their standard potentials, the reaction between SO$_{3}^{2-}$ and Hg(II) was suitable. The peak height of sulfite at about -0.70 V (pH 6, 7) was sharp, high, and very reproducible, enabling the accurate determination of low concentrations of Hg(II). It was found that sulfite concentration had to be 3 times larger than mercury at pH 6, in order to have a quantitative reaction. The procedure …
Dinitrogen Reduction On A Polypyrrole Coated Pt Electrode Under High-Pressure Conditions: Electrochemical Impedance Spectroscopy Studies, Di̇dem Balun Kayan, Fati̇h Köleli̇
Dinitrogen Reduction On A Polypyrrole Coated Pt Electrode Under High-Pressure Conditions: Electrochemical Impedance Spectroscopy Studies, Di̇dem Balun Kayan, Fati̇h Köleli̇
Turkish Journal of Chemistry
The electrochemical impedance spectroscopy (EIS) responses of a polypyrrole (PPy)-coated platinum electrode were investigated during N$_{2}$-reduction to ammonia in aqueous medium. Kinetic parameters such as film resistance, pore resistance, and double layer capacitance were analyzed as a function of applied potential and polymer film thickness. The relation between kinetic parameters was discussed by combining electrolysis results. It was found that the optimum film thickness of polypyrrole was 0.73 $\mu $m and optimum potential for ammonia synthesis was -0.150 V under 60 bar N$_{2}$-pressure. The impedance responses under these conditions presented the lowest pore resistance value of ca. 2 $\Omega $ …
Green Synthesis Of 2-Amino-7-Hydroxy-4-Aryl-4$H$-Chromene-3-Carbonitriles Using Zno Nanoparticles Prepared With Mulberry Leaf Extract And Zncl$_{2}$, Akbar Mobinikhaledi, Atisa Yazdanipour, Majid Ghashang
Green Synthesis Of 2-Amino-7-Hydroxy-4-Aryl-4$H$-Chromene-3-Carbonitriles Using Zno Nanoparticles Prepared With Mulberry Leaf Extract And Zncl$_{2}$, Akbar Mobinikhaledi, Atisa Yazdanipour, Majid Ghashang
Turkish Journal of Chemistry
A highly efficient and environmentally benign protocol for the synthesis of 2-amino-7-hydroxy-4-aryl-4$H$-chromene-3-carbonitrile derivatives in good to high yields (77%-97%) by one-pot three-component coupling reaction of aromatic aldehydes, malononitrile, and resorcinol under reflux condition was developed in aqueous media using ZnO nanoparticles that were prepared in the presence of mulberry leaf extract under mild conditions.
Acid-Free Synthesis Of S-Nitrosothiols At Neutral Ph By Shock-Freezing In Liquid Nitrogen, Dimitrios Tsikas, Anke Böhmer, Arne Trettin, Arslan Arinç Kayaçelebi̇
Acid-Free Synthesis Of S-Nitrosothiols At Neutral Ph By Shock-Freezing In Liquid Nitrogen, Dimitrios Tsikas, Anke Böhmer, Arne Trettin, Arslan Arinç Kayaçelebi̇
Turkish Journal of Chemistry
A laboratory method for the acid-free synthesis of S-nitrosothiols (RSNO) from NaNO$_{2}$ and thiols in aqueous buffer of neutral pH is reported. Equimolar amounts of NaNO$_{2}$ and thiol are added to a 100-$\mu $M Na$_{4}$EDTA-containing Na$_{2}$HPO$_{4}$ buffer (100 mM, pH 7.4). Samples are set into liquid nitrogen for 1 min and then thawed to room temperature or in an ice bath. Dependent upon the RSNO, repetition of the procedure may be required. This method may be of particular importance when the classical acid-based method fails or releases harmful gases such as H$_{2}$S.
Sustainable Activity Of Hydrothermally Synthesized Mesoporous Silicates In Acetic Acid Esterification, Veli̇ Şi̇mşek, Levent Deği̇rmenci̇, Kirali̇ Mürtezaoğlu
Sustainable Activity Of Hydrothermally Synthesized Mesoporous Silicates In Acetic Acid Esterification, Veli̇ Şi̇mşek, Levent Deği̇rmenci̇, Kirali̇ Mürtezaoğlu
Turkish Journal of Chemistry
A hydrothermal method was applied in the synthesis of mesoporous silicates containing silicotungstic acid (STA). The synthesis procedures were developed by modification of procedures previously applied in the synthesis of MCM-41 and SBA-15. The synthesized catalysts were named MCM-41-S and SBA-15-S based on MCM-41 and SBA-15. Their activities were investigated in ethyl acetate production, which was selected as the model reaction. The results indicated that the activity of SBA-15-S catalysts increased with increasing STA in the catalyst. Reaction experiments were also conducted in identical conditions in the presence of catalysts recovered after the reaction. The results indicated that sustainable activity …
Functional Gold Nanoparticle Coated Surfaces For Ca 125 Cancer Biomarker Detection, İlknur Tunç, Hepi̇ Hari̇ Susapto, Mustafa Özgür Güler
Functional Gold Nanoparticle Coated Surfaces For Ca 125 Cancer Biomarker Detection, İlknur Tunç, Hepi̇ Hari̇ Susapto, Mustafa Özgür Güler
Turkish Journal of Chemistry
Here we describe the detailed characterization of gold nanoparticle (Au Np) functionalized surfaces as a biosensing platform by studying a model streptavidin (SA)-biotin interaction. Conjugation of SA on Au Np immobilized on silicon (Si) and quartz surfaces and its interaction with biotin were characterized by X-ray photoelectron spectroscopy (XPS), UV-Vis spectroscopy, circular dichromism (CD) spectroscopy, and contact angle measurements. The immobilization method and atomic concentrations of Si 2p, Au 4f, S 2p, C 1s, N 1s, and O 1s of the resulting SA-biotin modified Si surface were determined by XPS. The CD spectrum and confocal microscopy imaging confirmed that step-by-step …
Simultaneous Analysis Of Losartan, Its Active Metabolite, And Hydrochlorothiazide In Human Plasma By A Uplc-Ms/Ms Method, Priyanka A. Shah, Primal Sharma, Jaivik V. Shah, Mallika Sanyal, Pranav S. Shrivastav
Simultaneous Analysis Of Losartan, Its Active Metabolite, And Hydrochlorothiazide In Human Plasma By A Uplc-Ms/Ms Method, Priyanka A. Shah, Primal Sharma, Jaivik V. Shah, Mallika Sanyal, Pranav S. Shrivastav
Turkish Journal of Chemistry
A selective and sensitive ultra performance liquid chromatography-tandem mass spectrometry method was developed for the simultaneous determination of losartan (LOS), EXP-3174, which is an active metabolite LOS carboxylic acid, and hydrochlorothiazide (HCTZ) in human plasma. Solid-phase extraction was carried out on Oasis HLB cartridges with 100 $\mu $L of plasma to give an extraction recovery in the range of 88.5%-102.5% for the three analytes. Chromatography on a BEH C18 column afforded baseline separation of all the analytes within 2.4 min using 1.0% formic acid in water and acetonitrile (15:85, v/v) as the mobile phase. Quantitation was performed with multiple reaction …
Optimization Of The Adsorption Of A Textile Dye Onto Nanoclay Using A Central Composite Design, Aydin Hassani, Murat Kiranşan, Reza Darvishi Cheshmeh Soltani, Alireza Khataee, Semra Karaca
Optimization Of The Adsorption Of A Textile Dye Onto Nanoclay Using A Central Composite Design, Aydin Hassani, Murat Kiranşan, Reza Darvishi Cheshmeh Soltani, Alireza Khataee, Semra Karaca
Turkish Journal of Chemistry
The main aim of this study was to evaluate the efficacy of montmorillonite clay for the adsorption of C.I. Basic Yellow 2 (BY2) dye from aqueous media. The experimental results were processed by response surface methodology based on a central composite design (CCD). The effect of four main variables, including initial BY2 concentration, adsorbent dosage, reaction time, and temperature on the removal of BY2 was evaluated by the model. The accuracy of the model and regression coefficients was appraised by employing analysis of variance. The results demonstrated a good agreement between the predicted values obtained by the model and the …
Synthesis Of Metal-Free And Metallophthalocyanines Containing 18- And 21-Membered Macrocycles With Mixed Donor Atoms And Their Metal-Ion Binding Properties, Hali̇l Zeki̇ Gök
Synthesis Of Metal-Free And Metallophthalocyanines Containing 18- And 21-Membered Macrocycles With Mixed Donor Atoms And Their Metal-Ion Binding Properties, Hali̇l Zeki̇ Gök
Turkish Journal of Chemistry
This paper describes the synthesis of a series of metal-free phthalocyanines and metallophthalocyanines peripherally substituted by macrocycles of different ring sizes with the same donor atom sets. The effects of varying ring size of the macrocycle on the spectroscopic and metal ion binding properties of phthalocyanines were examined. For these purposes, electronic absorption properties for metal-free phthalocyanines and metallophthalocyanines were studied in dimethylformamide and tetrahydrofuran. The liquid-liquid extraction of metal picrates such as Ag(I), Hg(II), Cd(II), Zn(II), Cu(II), Ni(II), Pb(II), and Co(II) from the aqueous phase to the organic phase was carried out using metallophthalocyanines. All new compounds were characterized …
Microwave-Assisted Regioselective [1,3]-Dipolar Cycloaddition Of 3-Methyl-2-(Substitutedbenzylidene)-5-Oxopyrazolidin-2-Ium-1-Ides To Benzothiophene 1,1-Dioxide, Yaşar Dürüst, Eda Sağirli, Akin Sağirli
Microwave-Assisted Regioselective [1,3]-Dipolar Cycloaddition Of 3-Methyl-2-(Substitutedbenzylidene)-5-Oxopyrazolidin-2-Ium-1-Ides To Benzothiophene 1,1-Dioxide, Yaşar Dürüst, Eda Sağirli, Akin Sağirli
Turkish Journal of Chemistry
A series of pyrazolidinium ylides was reacted with benzothiophene 1,1-dioxide to afford (3R,5S,5aS,10bS)-3-methyl-5-substitutedphenyl-2,3,5,5a-tetrahydrobenzo[4,5]thieno[3,2-c]pyrazolo[1,2-a]pyrazol-1(10bH)-one 6,6-dioxides under microwave irradiation and their structures were identified by means of spectral/physical characteristics including X-ray diffraction data and HRMS measurements.
A Case Study On In Vitro Investigations Of The Potent Biological Activities Of Wheat Germ And Black Cumin Seed Oil, Di̇dem Ağ Şeleci̇, Zi̇nar Pinar Gümüş, Murat Yavuz, Muharrem Şeleci̇, Rebecca Bongartz, Frank Stahl, Hakan Coşkunol, Suna Ti̇mur, Thomas Scheper
A Case Study On In Vitro Investigations Of The Potent Biological Activities Of Wheat Germ And Black Cumin Seed Oil, Di̇dem Ağ Şeleci̇, Zi̇nar Pinar Gümüş, Murat Yavuz, Muharrem Şeleci̇, Rebecca Bongartz, Frank Stahl, Hakan Coşkunol, Suna Ti̇mur, Thomas Scheper
Turkish Journal of Chemistry
The objectives of this study were to investigate the potential biological activities of black cumin seed oil (BCSO) and wheat germ oil (WGO) on different cell lines. Initially, commercially available BCSO and WGO obtained by supercritical carbon dioxide extraction were analyzed in terms of tocopherol, aliphatic alcohols, and thymoquinone content via HPLC and GC analysis. Cell free antioxidant activities and total phenolic content of both oils were detected by DPPH assay and Folin-Ciocalteu method, respectively. As well as the DPPH assay, the protective effect against reactive oxygen species (ROS) was determined by microscopic observation of ROS generation in NIH-3T3 cells …
Conversion Of Racemic Allylic Hydroperoxides Into Corresponding Chiral 1/2,3-Triols By Using Catalytic Oso$_{4}$ And Chiral Cinchona Ligands In The Absence Of Co-Oxidant, Haydar Göksu, Mehmet Serdar Gülteki̇n
Conversion Of Racemic Allylic Hydroperoxides Into Corresponding Chiral 1/2,3-Triols By Using Catalytic Oso$_{4}$ And Chiral Cinchona Ligands In The Absence Of Co-Oxidant, Haydar Göksu, Mehmet Serdar Gülteki̇n
Turkish Journal of Chemistry
For the first time, removal of oxygen atoms from allylic hydroperoxide functionality and reintroduction to the double bond was achieved using catalytic OsO$_{4}$ and chiral cinchona alkaloid derivatives in an acetone-water mixture to give corresponding chiral 1/2,3-triol with an enantioselectivity up to 99% ee. The hydroperoxide group was used as both a co-oxidant and a source of hydroxyl groups. This protocol is thought to have potential to provide opportunities for chiral synthesis of 1/2,3-triols from corresponding allylic hydroperoxides in the absence of co-oxidant in one stage for the first time in the literature.
Purification, Refolding, And Characterization Of Recombinant Human Paraoxonase-1, Yeli̇z Demi̇r, Şükrü Beydemi̇r
Purification, Refolding, And Characterization Of Recombinant Human Paraoxonase-1, Yeli̇z Demi̇r, Şükrü Beydemi̇r
Turkish Journal of Chemistry
A high density lipoprotein (HDL)-linked enzyme with antioxidant and antiatherogenic properties, paraoxonase-1(PON1), prevents the formation of atherosclerotic lesions in humans. In the present study, a recombinant hPON1 gene was produced using a small ubiquitin-related modifier (SUMO) fusion protein expression system. To that end, the hPON1 gene was amplified from human liver-ready cDNA, cloned into the expression vector pET SUMO, and expressed in Escherichia coli BL21 (DE3). The predominance of the expressed fusion SUMO-hPON1 protein was inclusion bodies and purified using 6xHis affinity chromatography under natural and denaturing conditions. Subsequently, the enzyme was purified and refolded directly on the affinity matrix …
Microwave-Assisted Synthesis Of Novel 8-Chloro-[1,2,4]Triazolo[4,3-$A$]Pyridine Derivatives, Linjiong Zhang, Mingyan Yang, Beizhen Hu, Zhaohui Sun, Xinghai Liu, Jianquan Weng, Chengxia Tan
Microwave-Assisted Synthesis Of Novel 8-Chloro-[1,2,4]Triazolo[4,3-$A$]Pyridine Derivatives, Linjiong Zhang, Mingyan Yang, Beizhen Hu, Zhaohui Sun, Xinghai Liu, Jianquan Weng, Chengxia Tan
Turkish Journal of Chemistry
A series of novel 1,2,4-triazolo[4,3-$a$]pyridine derivatives were synthesized from 2,3-dichloropyridine and hydrazine hydrate as starting materials by multistep reactions under microwave assistance, and their structures were characterized by $^{1}$H NMR, MS, and elemental analysis. This method provides several advantages such as high yields, facile work-up, and environmental friendliness.
Synthesis And Biological Evaluation Of A New Series Of 4-Alkoxy-2-Arylquinoline Derivatives As Potential Antituberculosis Agents, Gonca Tosun, Tayfun Arslan, Zeynep İskefi̇yeli̇, Murat Küçük, Şengül Alpay Karaoğlu, Nuretti̇n Yayli
Synthesis And Biological Evaluation Of A New Series Of 4-Alkoxy-2-Arylquinoline Derivatives As Potential Antituberculosis Agents, Gonca Tosun, Tayfun Arslan, Zeynep İskefi̇yeli̇, Murat Küçük, Şengül Alpay Karaoğlu, Nuretti̇n Yayli
Turkish Journal of Chemistry
Three new series of 33 quinolone compounds, 2-(2-, 3-, and 4-fluorophenyl)-4-O-alkyl(C$_{5-15})$quinolines (7a-k, 8a-k, and 9a-k), were synthesized from 2-(2-, 3-, and 4-fluorophenyl)-2,3-dihydroquinolin-4(1H)-one (4, 5, and 6) by the reaction of alkyl halides under basic conditions in DMF. The new compounds 7a-k, 8a-k, and 9a-k were synthesized from flavonones 4-6, which can be considered new precursors for quinoline synthesis through a one-step reaction. All the target compounds (7a-k, 8a-k, and 9a-k) were evaluated for their in vitro antimicrobial activity against nine test microorganisms. They showed the most activity against Mycobacterium smegmatis with minimum inhibitory concentrations (MIC) of 62.5-500 $\mu $g/mL, indicating …
Palladium Nanoparticles Supported On Modified Polystyrene Resin As A Polymeric Catalyst For Sonogashira-Hagihara Coupling Reactions, Bahman Tamami, Fatemeh Nowroozi Dodeji, Soheila Ghasemi
Palladium Nanoparticles Supported On Modified Polystyrene Resin As A Polymeric Catalyst For Sonogashira-Hagihara Coupling Reactions, Bahman Tamami, Fatemeh Nowroozi Dodeji, Soheila Ghasemi
Turkish Journal of Chemistry
Pd(0) nanoparticles supported on modified crosslinked polystyrene were synthesized and characterized. Crosslinked polystyrene was reacted with trioxane and chlorotrimethylsilane in the presence of SnCl$_{4}$ to form Merrifield resin. The Merrifield resin was then converted to polymer-bound $\beta $-aminoalcohol and subsequently to $\beta$-aminophosphinite ligand. This polymeric ligand was reacted with PdCl$_{2}$ to obtain a polymeric Pd(0) complex. The TEM image of the Pd catalyst showed good dispersion of catalytic sites. The Pd catalyst exhibits excellent activity and stability in copper-free Sonogashira-Hagihara cross-coupling reactions under aerobic conditions. This protocol can be applied efficiently to the coupling reactions of chloro- as well as …
Microwave-Assisted Synthesis Of Condensed 1,4-Dihydropyridines As Potential Calcium Channel Modulators, Erdem Kami̇l Özer, Mi̇yase Gözde Gündüz, Ahmed El-Khouly, Mehmet Yildirim Sara, Rahi̇me Şi̇mşek, Alper Bektaş İski̇t, Osman Ci̇hat Şafak
Microwave-Assisted Synthesis Of Condensed 1,4-Dihydropyridines As Potential Calcium Channel Modulators, Erdem Kami̇l Özer, Mi̇yase Gözde Gündüz, Ahmed El-Khouly, Mehmet Yildirim Sara, Rahi̇me Şi̇mşek, Alper Bektaş İski̇t, Osman Ci̇hat Şafak
Turkish Journal of Chemistry
This study reports the design, synthesis, and calcium channel modulatory activity evaluation of a series of 14 novel fused 1,4-dihydropyridine derivatives. The molecular design of the compounds was based on modifications of nifedipine, which is a calcium channel blocker. The compounds were achieved by one-pot microwave-assisted reaction of 4,4-dimethyl-1,3-cyclohexanedione, 5-chlorosalicylaldehyde/3,5-dichlorosalicylaldehyde, an appropriate alkyl acetoacetate, and ammonium acetate in ethanol according to a modified Hantzsch reaction. The structures of the compounds were confirmed by spectral methods and elemental analysis. To evaluate their relaxant activities, the maximum relaxant response (E$_{\max})$ and pD$_{2}$ values of the compounds and nifedipine were determined on isolated …
A Comparative Study On Fabrication Of Cu$_{2}$Znsns$_{4}$ (Czts) Nanofibers Using Acetate And Chloride Metal Precursors, Burak Zafer Büyükbekar, Faruk Özel, Hüseyi̇n Şakalak, Hali̇t Çavuşoğlu, Mustafa Ersöz, Mahmut Kuş, Mustafa Selman Yavuz
A Comparative Study On Fabrication Of Cu$_{2}$Znsns$_{4}$ (Czts) Nanofibers Using Acetate And Chloride Metal Precursors, Burak Zafer Büyükbekar, Faruk Özel, Hüseyi̇n Şakalak, Hali̇t Çavuşoğlu, Mustafa Ersöz, Mahmut Kuş, Mustafa Selman Yavuz
Turkish Journal of Chemistry
This study reports, for the first time, the fabrication of electrospun Cu$_{2}$ZnSnS$_{4}$ (CZTS) nanofibers using metal acetate precursors. Viscous poly(vinyl pyrrolidone) (PVP) solution containing acetate or chloride salts of copper, zinc, and tin was electrospun onto a conductive substrate. The PVP nanofibers that have a mixture of metal salts were annealed at elevated temperatures. After calcination, these nanofibers were treated with the sulfur source and then annealed again in order to generate CZTS nanofibers. The CZTS nanofibers generated from acetate and chloride salts were characterized and compared. Belt-like and wire-like nanofibers were obtained when using metal acetate and chloride precursors, …
Tetraphenylsilane Group Containing Carbazoles As High Triplet Energy Host Materials For Solution-Processable Pholeds, Sali̇ha Öner, İlker Öner, Haydar Akdağ, Canan Varlikli
Tetraphenylsilane Group Containing Carbazoles As High Triplet Energy Host Materials For Solution-Processable Pholeds, Sali̇ha Öner, İlker Öner, Haydar Akdağ, Canan Varlikli
Turkish Journal of Chemistry
A series of solution processable, wide band-gap host materials composed of carbazole and tetraphenylsilane groups were designed and synthesized. Their thermal, electrochemical, and photophysical properties were fully investigated. The introduction of bulky tetraphenylsilane and \textit{tert}-butyl groups around the carbazole led to high glass transition temperatures (T$_{g})$ between 120 and 204 $^{\circ}$C. The triplet energies (E$_{T})$ of the synthesized materials were examined by low temperature (77 K) photoluminescence studies and determined as E$_{T}>$ 2.6 for all compounds. Phosphorescent organic light-emitting devices with the ITO/PEDOT:PSS/EML/TPBi/Cs$_{2}$CO$_{3}$/Al device structure were fabricated by using synthesized materials as the host and two kinds of phosphorescent …