Open Access. Powered by Scholars. Published by Universities.®
Physical Sciences and Mathematics Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Methodology (23)
- Evggfp exc/vgood/good/fair/poor/(dead) self-rated health (20)
- Proteomics (18)
- Cardiovascular Health Study (CHS) (17)
- Health Status and Years of Healthy Life (15)
-
- General Biostatistics (13)
- Genomics (13)
- Aging and Older Adults (12)
- Functional Data Analysis (12)
- Computational Biology/Bioinformatics (11)
- Health Insurance and Utilization (11)
- Statistical Theory and Methods (11)
- Microarrays (9)
- Causal Inference (7)
- Death in Longitudinal Studies (7)
- Multiple Comparisons (7)
- Transition Probabilities and Multistate Life Tables (7)
- Health Behaviors (6)
- Human Genetics (6)
- Self-rated health (6)
- Virology (6)
- Applied Research (5)
- Causal inference (5)
- Community Randomized Trials (5)
- Survival Analysis (5)
- Biomarkers (4)
- CHPGP (Kaiser) (4)
- Cancer (4)
- Clinical Trials (4)
- False Discovery Rate (4)
- Publication Year
- Publication
-
- Paula Diehr (47)
- Jeffrey S. Morris (34)
- Debashis Ghosh (22)
- Confluence Journal Environmental Studies (CJES), Kogi State University, Nigeria (14)
- Joseph Lucke (12)
-
- Dr. Torstein Tengs (11)
- Shuo Jiao (11)
- Oliver Bembom (8)
- Emmanuel Mario B Santos aka Marc Guerrero (6)
- Kent M Koprowicz (5)
- Maya Petersen (5)
- Elián P. Cabrera-Nguyen (4)
- Maxine G Schmidt (3)
- Peter F. Thall (3)
- Shahadat Uddin (3)
- Uwe Muegge (3)
- R. W. Hndoosh (2)
- Adeshina I. Adekunle MR (1)
- Agricola Odoi (1)
- Alexia Iasonos (1)
- Andrew G. West (1)
- Charis P. Kaite (1)
- Florin C MIHAI (1)
- Joe Walsh (1)
- Kok Hoong Leong (1)
- Michael Rosenblum (1)
- Mithat Gönen (1)
- Mohammad Oves (1)
- Pantelis Bagos (1)
- Radhakrishnan Nagarajan (1)
Articles 31 - 60 of 208
Full-Text Articles in Physical Sciences and Mathematics
Rainfall Variability And Crop Zones Classification For The Federal Capital Territory, Nigeria, Shaibu M. Hassan Phd
Rainfall Variability And Crop Zones Classification For The Federal Capital Territory, Nigeria, Shaibu M. Hassan Phd
Confluence Journal Environmental Studies (CJES), Kogi State University, Nigeria
This study aims at analyzing agro-climatological parameters and establishing a link between some selected agro-climatological indices and sustainability of agricultural production in the Federal Capital Territory (FCT). Two sets of data, climatic and crop yield data were collected and subjected to various agro-climatological analyses. Agro-climatological analyses include the derivation of Onset, Cessation and Length of Rainy Season (LRS), Seasonality Index, Drought Index and Precipitation Periodicity Index. The statistical analyses include monthly and annual means, deviation from the mean, trend line. The result of moisture index in line with crops optimum moisture requirement was used to classify the Territory into agro-climatic …
Statistical Methods For Proteomic Biomarker Discovery Based On Feature Extraction Or Functional Modeling Approaches, Jeffrey S. Morris
Statistical Methods For Proteomic Biomarker Discovery Based On Feature Extraction Or Functional Modeling Approaches, Jeffrey S. Morris
Jeffrey S. Morris
In recent years, developments in molecular biotechnology have led to the increased promise of detecting and validating biomarkers, or molecular markers that relate to various biological or medical outcomes. Proteomics, the direct study of proteins in biological samples, plays an important role in the biomarker discovery process. These technologies produce complex, high dimensional functional and image data that present many analytical challenges that must be addressed properly for effective comparative proteomics studies that can yield potential biomarkers. Specific challenges include experimental design, preprocessing, feature extraction, and statistical analysis accounting for the inherent multiple testing issues. This paper reviews various computational …
Integrative Bayesian Analysis Of High-Dimensional Multi-Platform Genomics Data, Wenting Wang, Veerabhadran Baladandayuthapani, Jeffrey S. Morris, Bradley M. Broom, Ganiraju C. Manyam, Kim-Anh Do
Integrative Bayesian Analysis Of High-Dimensional Multi-Platform Genomics Data, Wenting Wang, Veerabhadran Baladandayuthapani, Jeffrey S. Morris, Bradley M. Broom, Ganiraju C. Manyam, Kim-Anh Do
Jeffrey S. Morris
Motivation: Analyzing data from multi-platform genomics experiments combined with patients’ clinical outcomes helps us understand the complex biological processes that characterize a disease, as well as how these processes relate to the development of the disease. Current integration approaches that treat the data are limited in that they do not consider the fundamental biological relationships that exist among the data from platforms.
Statistical Model: We propose an integrative Bayesian analysis of genomics data (iBAG) framework for identifying important genes/biomarkers that are associated with clinical outcome. This framework uses a hierarchical modeling technique to combine the data obtained from multiple platforms …
A Systematic Mapping Approach Of 16q12.2/Fto And Bmi In More Than 20,000 African Americans Narrows In On The Underlying Functional Variation: Results From The Population Architecture Using Genomics And Epidemiology (Page) Study
Shuo Jiao
Genetic variants in intron 1 of the fat mass– and obesity-associated (FTO) gene have been consistently associated with body mass index (BMI) in Europeans. However, follow-up studies in African Americans (AA) have shown no support for some of the most consistently BMI–associated FTO index single nucleotide polymorphisms (SNPs). This is most likely explained by different race-specific linkage disequilibrium (LD) patterns and lower correlation overall in AA, which provides the opportunity to fine-map this region and narrow in on the functional variant. To comprehensively explore the 16q12.2/FTO locus and to search for second independent signals in the broader region, we fine-mapped …
Genome-Wide Search For Gene-Gene Interactions In Colorectal Cancer
Genome-Wide Search For Gene-Gene Interactions In Colorectal Cancer
Shuo Jiao
Genome-wide association studies (GWAS) have successfully identified a number of single-nucleotide polymorphisms (SNPs) associated with colorectal cancer (CRC) risk. However, these susceptibility loci known today explain only a small fraction of the genetic risk. Gene-gene interaction (GxG) is considered to be one source of the missing heritability. To address this, we performed a genome-wide search for pair-wise GxG associated with CRC risk using 8,380 cases and 10,558 controls in the discovery phase and 2,527 cases and 2,658 controls in the replication phase. We developed a simple, but powerful method for testing interaction, which we term the Average Risk Due to …
James-Stein Estimation And The Benjamini-Hochberg Procedure, Debashis Ghosh
James-Stein Estimation And The Benjamini-Hochberg Procedure, Debashis Ghosh
Debashis Ghosh
For the problem of multiple testing, the Benjamini-Hochberg (B-H) procedure has become a very popular method in applications. Based on a spacings theory representation of the B-H procedure, we are able to motivate the use of shrinkage estimators for modifying the B-H procedure. Several generalizations in the paper are discussed, and the methodology is applied to real and simulated datasets.
Shrinkage In Adaptive Procedures For False Discovery Rate Estimation In Multiple Testing: Structure And Synthesis, Debashis Ghosh
Shrinkage In Adaptive Procedures For False Discovery Rate Estimation In Multiple Testing: Structure And Synthesis, Debashis Ghosh
Debashis Ghosh
There has been much interest in the study of adaptive estimation procedures for controlling the false discovery rate (FDR). In this article, we take the direct approach to estimation of FDR of Storey (2002) and show how it can reexpressed as a particular type of shrinkage estimator. This representation leads to natural conditions on finite-sample FDR control for a general class of shrinkage estimators. In addition, many previous proposals from the literature can be unified under this framework for which finite-sample FDR results can be developed. Some asymptotic results are also provided.
A Positive Trait Item Response Model, Joseph F. Lucke
A Positive Trait Item Response Model, Joseph F. Lucke
Joseph Lucke
All current models from item response theory (IRT) assume the latent trait follows a standard normal distribution. While this assumption is appropriate for traits such as ability or attitude, it creates both conceptual and technical problems traits such as addiction (alcohol, drugs, gambling). The distribution of an addiction trait is better assumed to be anchored at zero (no addiction) and positively skewed. A small change to the usual IRT model yields a class of positive-trait item response models (PTIRMs). I discuss PTIRMs and present one model in detail, including item characteristic curves and item information curves. I present an example …
Social Networks Enabled Coordination Model For Cost Management Of Patient Hospital Admissions, Shahadat Uddin, Liaquat Hossain
Social Networks Enabled Coordination Model For Cost Management Of Patient Hospital Admissions, Shahadat Uddin, Liaquat Hossain
Shahadat Uddin
In this study, we introduce a social networks enabled coordination model for exploring the effect of network position of “patient,” “physician,” and “hospital” actors in a patient-centered care network that evolves during patient hospitalization period on the total cost of coordination. An actor is a node, which represents an entity such as individual and organization in a social network. In our analysis of actor networks and coordination in the healthcare literature, we identified that there is significant gap where a number of promising hospital coordination model have been developed (e.g., Guided Care Model, Chronic Care Model) for the current healthcare …
Assessment Of Organic And Inorganic Phosphorus In Soils Derived From Cretaceous Sediments And Basement Complex Soils Of Guinea Savannah Of Kogi State, North Central Nigeria, Sunday I. Amhakhian, H H. Isitekhale, Charles I. Oyewole
Assessment Of Organic And Inorganic Phosphorus In Soils Derived From Cretaceous Sediments And Basement Complex Soils Of Guinea Savannah Of Kogi State, North Central Nigeria, Sunday I. Amhakhian, H H. Isitekhale, Charles I. Oyewole
Confluence Journal Environmental Studies (CJES), Kogi State University, Nigeria
A pot experiment was carried out using 20 surface soils (0-15cm depth) in 2008 to assess soil organic phosphorus and some fraction of inorganic phosphorus in other to know their availability in the soils of the studied area and also work have not been done in this areas in respect to organic and in-organic phosphorus. The experiment was conducted using 20 soils 10 from each geological formation (Cretaceous sediments and Basement complex soils), respectively. The mean organic phosphorus of 63.51 mgkg 1 soil was obtained for Cretaceous sediment soils and 158.54 mgkg 1 soil for the basement complex soils respectively. …
Development Of Functional Indices Of Facility Occurrence Towards The Distribution Of Social Services In Lagos Island Nigeria., Augustus O. Atubi
Development Of Functional Indices Of Facility Occurrence Towards The Distribution Of Social Services In Lagos Island Nigeria., Augustus O. Atubi
Confluence Journal Environmental Studies (CJES), Kogi State University, Nigeria
Proper coordination of transport and public facilities provision is vital to any balanced regional development strategy. The central aim of this study, therefore, is to find out what the relationship is between access to the transport network and the provision of functional indices of facility occurrence towards the distribution of social services in Lagos Island, Nigeria. In particular it seeks to find out areas that have below or above average level of facility occurrences relative to the level of accessibility. However, a pair wise correlation matrix of the eleven (11) variables employed in the index construction was carried out. The …
Identifying Unique Neighborhood Characteristics To Guide Health Planning For Stroke And Heart Attack: Fuzzy Cluster And Discriminant Analyses Approaches, Ashley Pedigo, William Seaver, Agricola Odoi
Identifying Unique Neighborhood Characteristics To Guide Health Planning For Stroke And Heart Attack: Fuzzy Cluster And Discriminant Analyses Approaches, Ashley Pedigo, William Seaver, Agricola Odoi
Agricola Odoi
Background: Socioeconomic, demographic, and geographic factors are known determinants of stroke and myocardial infarction (MI) risk. Clustering of these factors in neighborhoods needs to be taken into consideration during planning, prioritization and implementation of health programs intended to reduce disparities. Given the complex and multidimensional nature of these factors, multivariate methods are needed to identify neighborhood clusters of these determinants so as to better understand the unique neighborhood profiles. This information is critical for evidence-based health planning and service provision. Therefore, this study used a robust multivariate approach to classify neighborhoods and identify their socio-demographic characteristics so as to provide …
The Use Of Imputed Values In The Meta-Analysis Of Genome-Wide Association Studies., Shuo Jiao, Li Hsu, Carolyn Hutter, Ulrike Peters
The Use Of Imputed Values In The Meta-Analysis Of Genome-Wide Association Studies., Shuo Jiao, Li Hsu, Carolyn Hutter, Ulrike Peters
Shuo Jiao
In genome-wide association studies (GWAS), it is a common practice to impute the genotypes of untyped single nucleotide polymorphism (SNP) by exploiting the linkage disequilibrium structure among SNPs. The use of imputed genotypes improves genome coverage and makes it possible to perform meta-analysis combining results from studies genotyped on different platforms. A popular way of using imputed data is the "expectation-substitution" method, which treats the imputed dosage as if it were the true genotype. In current practice, the estimates given by the expectation-substitution method are usually combined using inverse variance weighting (IVM) scheme in meta-analysis. However, the IVM is not …
Meta-Analysis Of New Genome-Wide Association Studies Of Colorectal Cancer Risk.
Meta-Analysis Of New Genome-Wide Association Studies Of Colorectal Cancer Risk.
Shuo Jiao
Colorectal cancer is the second leading cause of cancer death in developed countries. Genome-wide association studies (GWAS) have successfully identified novel susceptibility loci for colorectal cancer. To follow up on these findings, and try to identify novel colorectal cancer susceptibility loci, we present results for GWAS of colorectal cancer (2,906 cases, 3,416 controls) that have not previously published main associations. Specifically, we calculated odds ratios and 95% confidence intervals using log-additive models for each study. In order to improve our power to detect novel colorectal cancer susceptibility loci, we performed a meta-analysis combining the results across studies. We selected the …
Urban Climate And Challenges Of Tropical Cities, B E. Omogbai
Urban Climate And Challenges Of Tropical Cities, B E. Omogbai
Confluence Journal Environmental Studies (CJES), Kogi State University, Nigeria
This study examines the nature of urban climate, features and the challenges on the developing tropical cities in the 21st century. It argues that the use of principles of urban climate would help in providing comfortable living conditions and problem immune working environments for the inhabitants of tropical cities. The findings reveal that owing to poor environmental planning, inadequate geotechnical landscape surveys prior to the development of urban infrastructures, and non-adherence to the principles of urban climate, challenges of landscape degradation, excessive flooding of the built infrastructures, heat-island effects, and collapse of buildings have emerged. Suggested measures to avert these …
Detecting Changes In Landuse/Cover Of Umuahia, South-Eastern Nigeria Using Remote Sensing And Gis Techniques, Fanan Ujoh, Olarewaju Oluseyi Ifatimehin, Adams Ndalai Baba
Detecting Changes In Landuse/Cover Of Umuahia, South-Eastern Nigeria Using Remote Sensing And Gis Techniques, Fanan Ujoh, Olarewaju Oluseyi Ifatimehin, Adams Ndalai Baba
Confluence Journal Environmental Studies (CJES), Kogi State University, Nigeria
Since 1991 when it became the capital city of Abia State, Umuahia has undergone tremendous transformation in its land use and land cover due to rapid urbanization. The main materials employed for this study are a land use map (1991) and Landsat ETM+satellite image (2007) of the study area. These, combined with field survey/checks, were brought into a GIS environment using ILWIS 3.2 Academic image classification software to map the land use/land cover and to estimate the rate of urban expansion and loss of rural land at the peri-urban fringes of Umuahia between 1991 and 2007. The study revealed significant …
Gender Participation In The Management Of Tricycle Transport For Youth Empowerment And Sustainable Development In Kano State, Nigeria, Nuratu Muhammed
Gender Participation In The Management Of Tricycle Transport For Youth Empowerment And Sustainable Development In Kano State, Nigeria, Nuratu Muhammed
Confluence Journal Environmental Studies (CJES), Kogi State University, Nigeria
The research examined gender participation in the management of tricycle for youth empowerment and sustainable development in Kano state, Nigeria. Stratified random sampling technique was used to select samples of drivers(150), passengers (150) and owners/managers the female tricycle owners fell under this category and they numbered(65).All together a total of 365 samples were selected for the study. Data obtained from the primary data was analyzed using simple statistical techniques and chi square test to ascertain whether there was any significant differences in some of the variables tested. The results of the analysis revealed that the main difference was found in …
U.S. Cultural Involvement And Its Association With Co-Occurring Substance Abuse And Sexual Risk Behaviors Among Youth In The Dominican Republic, Elián P. Cabrera-Nguyen, Juan B. Peña
U.S. Cultural Involvement And Its Association With Co-Occurring Substance Abuse And Sexual Risk Behaviors Among Youth In The Dominican Republic, Elián P. Cabrera-Nguyen, Juan B. Peña
Elián P. Cabrera-Nguyen
We examined the relationship of US cultural involvement with substance abuse and sexual risk behavior profiles from our nationally representative sample of public high school students in the Dominican Republic. Using a novel methodological approach to control for selection bias, we examined explanations for the so-called Latino or Hispanic immigrant paradox. A latent class regression analysis with manifest and latent covariates found that US cultural involvement indicators were independent and robust predictors of increased risk of co-ocurring substance abuse and sexual risk behaviors. Implications for prevention efforts targeting risk behaviors among Latino/a adolescents in the US and abroad are considered.
Science Boot Camp For Librarians: Cpd On A Shoestring, Maxine G. Schmidt, Rebecca Reznik-Zellen
Science Boot Camp For Librarians: Cpd On A Shoestring, Maxine G. Schmidt, Rebecca Reznik-Zellen
Maxine G Schmidt
Science Boot Camp for Librarians was envisioned as a casual but intensive immersion event into selected scientific subjects that employ networked computing capabilities for research and collaboration. The goal of the event is to provide librarians with networking opportunities, but more importantly, to give them some of the context and ocabulary of a discipline to enable them to better engage faculty and research scientists with regard to escience. A half-day is devoted to each of three topics chosen for that year’s camp. A local faculty member provides an overview of the research area, and a second describes a single project …
Social Marketing, Stages Of Change, And Public Health Smoking Interventions, Paula Diehr
Social Marketing, Stages Of Change, And Public Health Smoking Interventions, Paula Diehr
Paula Diehr
As a "thought experiment," the authors used a modified stages of change model for smoking to define homogeneous segments within various hypothetical populations. The authors then estimated the population effect of public health interventions that targeted the different segments. Under most assumptions, interventions that emphasized primary and secondary prevention, by targeting the Never Smoker, Maintenance, or Action segments, resulted in the highest nonsmoking life expectancy. This result is consistent with both social marketing and public health principles. Although the best thing for an individual smoker is to stop smoking, the greatest public health benefit is achieved by interventions that target …
Environmental Problems Of Industrialization And Sustainable Development In Nigeria - A Review, Adejoh Iyaji
Environmental Problems Of Industrialization And Sustainable Development In Nigeria - A Review, Adejoh Iyaji
Confluence Journal Environmental Studies (CJES), Kogi State University, Nigeria
The main objective of this paper is to examine the impact of the quest for industrialization on the environment in Nigeria; others include, the identification of the objectives of sustainable development as well as making recommendations that will lead to the much needed sustainable environment both for the present generation and generations yet unborn. The researcher relied principally on secondary sources of data for this paper which is theoretical in approach. Findings revealed the emergence of a host of environmental problems such as air pollution, deforestation, desertification, solid and hazardous waste problems in the wake of the quest for industrialization. …
Prevalence Of Piscine Myocarditis Virus (Pmcv) In Marine Fish Species, Torstein Tengs Dr.
Prevalence Of Piscine Myocarditis Virus (Pmcv) In Marine Fish Species, Torstein Tengs Dr.
Dr. Torstein Tengs
No abstract.
Static Versus Dynamic Topology Of Complex Communications Network During Organizational Crisis, Shahadat Uddin
Static Versus Dynamic Topology Of Complex Communications Network During Organizational Crisis, Shahadat Uddin
Shahadat Uddin
No abstract provided.
Power-Law Behavior In Complex Organizational Communication Networks During Crisis, Shahadat Uddin
Power-Law Behavior In Complex Organizational Communication Networks During Crisis, Shahadat Uddin
Shahadat Uddin
No abstract provided.
Compound Treatments, Transportability, And The Structural Causal Model: The Power And Simplicity Of Causal Graphs., Maya Petersen
Compound Treatments, Transportability, And The Structural Causal Model: The Power And Simplicity Of Causal Graphs., Maya Petersen
Maya Petersen
No abstract provided.
Football: An Intransitive Endeavour, Joe Walsh, Ian Timothy Heazlewood
Football: An Intransitive Endeavour, Joe Walsh, Ian Timothy Heazlewood
Joe Walsh
It has long been established that competitions should be structured to give each team a fair chance of winning. The aim of this research paper was, considering similarities of shared parameters between codes, to investigate intransitivity in football codes. Variables effecting probabilistic outcomes of games were identified for the football codes: soccer, gridiron, rugby union, rugby league and touch football. An algebraic probabilistic model for obtaining tactical advantage in individual transition states was developed. Hypothetical teams were constructed in order to test the possibility of intransitive games states. It was clear that intransitivity could logically exist for a variety of …
Adaptive Responses To Flooding Incidents In Ilorin, Kwara State, Nigeria, Habiba I. Jimoh, Kayode A. Iroye
Adaptive Responses To Flooding Incidents In Ilorin, Kwara State, Nigeria, Habiba I. Jimoh, Kayode A. Iroye
Confluence Journal Environmental Studies (CJES), Kogi State University, Nigeria
Incidents of floods which are mainly caused by changes in landuse is fast becoming a city life experience in Ilorin as in most urban centres in Nigeria causing untold hardships and sometimes loss of lives. This extreme hydro-meteorological event is also being exacerbated by climate change which thus calls for adaptive response by residents towards reducing its risks, hence this study. Data used were generated from direct field measurements and questionnaire administration. Descriptive statistics and cross tabulations were used in analyzing the data. Results obtained indicate that most respondents use a wide range of non-structural adaptive response to flood. The …
An Assessment Of Socio-Economic Impact Of Waste Scavenging As A Means Of Poverty Alleviation In Gwagwalada, Abuja., John Yakubu Magaji, Samuel Panse Dakyes
An Assessment Of Socio-Economic Impact Of Waste Scavenging As A Means Of Poverty Alleviation In Gwagwalada, Abuja., John Yakubu Magaji, Samuel Panse Dakyes
Confluence Journal Environmental Studies (CJES), Kogi State University, Nigeria
Waste scavengers are usually perceived as being among the poor, and scavenging is considered a marginal activity. They tend to have low incomes, but can obtained decent earning when they are not exploited by middlemen. This study was conducted in Gwagwalada town with the aim of assessing the socio-economic impact of scavenging on the people. A structured questionnaire was constructed to capture the demographic characteristics of the scavengers, their experiences, types of items scavenged, the economic gains and the challenges being faced. The target pollution is waste scavengers and a random sampling technique was adopted in selecting the respondents for …
Generalized Benjamini-Hochberg Procedures Using Spacings, Debashis Ghosh
Generalized Benjamini-Hochberg Procedures Using Spacings, Debashis Ghosh
Debashis Ghosh
For the problem of multiple testing, the Benjamini-Hochberg (B-H) procedure has become a very popular method in applications. We show how the B-H procedure can be interpreted as a test based on the spacings corresponding to the p-value distributions. Using this equivalence, we develop a class of generalized B-H procedures that maintain control of the false discovery rate in finite-samples. We also consider the effect of correlation on the procedure; simulation studies are used to illustrate the methodology.
A Causal Framework For Surrogate Endpoints With Semi-Competing Risks Data, Debashis Ghosh
A Causal Framework For Surrogate Endpoints With Semi-Competing Risks Data, Debashis Ghosh
Debashis Ghosh
In this note, we address the problem of surrogacy using a causal modelling framework that differs substantially from the potential outcomes model that pervades the biostatistical literature. The framework comes from econometrics and conceptualizes direct effects of the surrogate endpoint on the true endpoint. While this framework can incorporate the so-called semi-competing risks data structure, we also derive a fundamental non-identifiability result. Relationships to existing causal modelling frameworks are also discussed.