Physical Sciences and Mathematics Commons^™

Synthesis, Physicochemical Properties, And In Vitro Antibacterial Screening Of Palladium(Ii) Complexes Derived From Thiosemicarbazone, Mohammad Oves

Mohammad Oves

No abstract provided.

Global Quantitative Assessment Of The Colorectal Polyp Burden In Familial Adenomatous Polyposis Using A Web-Based Tool, Patrick M. Lynch, Jeffrey S. Morris, William A. Ross, Miguel A. Rodriguez-Bigas, Juan Posadas, Rossa Khalaf, Diane M. Weber, Valerie O. Sepeda, Bernard Levin, Imad Shureiqi

Jeffrey S. Morris

Background: Accurate measures of the total polyp burden in familial adenomatous polyposis (FAP) are lacking. Current assessment tools include polyp quantitation in limited-field photographs and qualitative total colorectal polyp burden by video.

Objective: To develop global quantitative tools of the FAP colorectal adenoma burden.

Design: A single-arm, phase II trial.

Patients: Twenty-seven patients with FAP.

Intervention: Treatment with celecoxib for 6 months, with before-treatment and after-treatment videos posted to an intranet with an interactive site for scoring.

Main Outcome Measurements: Global adenoma counts and sizes (grouped into categories: less than 2 mm, 2-4 mm, and greater than 4 mm) were …

Adaptive Randomization To Improve Utility-Based Dose-Finding With Bivariate Ordinal Outcomes., Peter F. Thall

Peter F. Thall

No abstract provided.

Using Joint Utilities Of The Times To Response And Toxicity To Adaptively Optimize Schedule-Dose Regimes, Peter F. Thall

Peter F. Thall

No abstract provided.

Binomial Theorem, Adeshina I. Adekunle Mr

Adeshina I. Adekunle MR

No abstract provided.

Sberia: Set Based Gene Environment Interaction Test For Rare And Common Variants In Complex Diseases, Shuo Jiao, Li Hsu, Stéphane Bézieau, Hermann Brenner, Andrew T. Chan, Jenny Chang-Claude, Loic Le Marchand, Mathieu Lemire, Polly A. Newcomb, Martha L. Slattery, Ulrike Peters

Shuo Jiao

Identification of gene-environment interaction (GxE) is important in understanding the etiology of complex diseases. However, partially due to the lack of power, there have been very few replicated GxE findings compared to the success in marginal association studies. The existing GxE testing methods mainly focus on improving the power for individual markers. In this paper, we took a different strategy and proposed a Set Based gene EnviRonment InterAction test (SBERIA), which can improve the power by reducing the multiple testing burdens and aggregating signals within a set. The major challenge of the signal aggregation within a set is how to …

Mixtures Of Receiver Operating Characteristic Curves, Mithat Gonen

Mithat Gönen

Rationale and Objectives: ROC curves are ubiquitous in the analysis of imaging metrics as markers of both diagnosis and prognosis. While empirical estimation of ROC curves remains the most popular method, there are several reasons to consider smooth estimates based on a parametric model.

Materials and Methods: A mixture model is considered for modeling the distribution of the marker in the diseased population motivated by the biological observation that here is more heterogeneity in the diseased population than there is in the normal one. It is shown that this model results in an analytically tractable ROC curve which is itself …

The Predictive Hazard Ratio For Biomarker Evaluation Studies, Debashis Ghosh

Debashis Ghosh

There is tremendous scientific and medical interest in the use of biomarkers to better facilitate medical decision making. In this article, we present a simple framework for assessing the predictive ability of a biomarker. The methodology requires use of techniques from a subfield of survival analysis termed semicompeting risks; results are presented to make the article self-contained. A crucial parameter for evaluating is the predictive hazard ratio, which is different from the usual hazard ratio from Cox regression models for right-censored data. This quantity will be defined; its estimation, inference and adjustment for covariates will be discussed. Aspects of censoring …

Mobile Elderly Living Community (Melco): The Development Of The Social Community Model: A Case Study, Christiana Kouta, Charis P. Kaite, George Samaras

Charis P. Kaite

Background: Elderly prefer to be in their own homes rather than being in hospital or residential homes. Communication between elderly and community nurses is essential in caring and mutual interaction and modern technologies like MELCO provides the elderly the feeling of independence and safety. Aim: The aim of this paper is to describe the development of the social community model within the objectives of the MELCO project and its application within the community. Methodology: Three axes were taken in consideration: a) ontology, b) ecological theory and c) social network and information systems analyses for the development of the social community …