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Articles 31 - 60 of 191
Full-Text Articles in Physical Sciences and Mathematics
Shell Artefacts And Shell-Working Within The Lapita Cultural Complex, Katherine A. Szabo
Shell Artefacts And Shell-Working Within The Lapita Cultural Complex, Katherine A. Szabo
Faculty of Science - Papers (Archive)
Despite a consistent presence in the archaeological record of the Lapita cultural complex, and their omnipresence in the associated literature, the nature and range of shell artefacts recovered from Lapita sites has only been partially summarized at best. Considering the categories of raw material choice, working techniques, formal artefact types and curation, this article summarizes our current knowledge and points to areas for further research.
Response Of Coral Reefs To Climate Change: Expansion And Demise Of The Southernmost Pacific Coral Reef, Colin D. Woodroffe, Brendan P. Brooke, Michelle Linklater, David M. Kennedy, Brian G. Jones, Cameron Buchanan, Richard Mleczko, Quan Hua, Jian-Xin Zhao
Response Of Coral Reefs To Climate Change: Expansion And Demise Of The Southernmost Pacific Coral Reef, Colin D. Woodroffe, Brendan P. Brooke, Michelle Linklater, David M. Kennedy, Brian G. Jones, Cameron Buchanan, Richard Mleczko, Quan Hua, Jian-Xin Zhao
Faculty of Science - Papers (Archive)
Coral reefs track sea level and are particularly sensitive to changes in climate. Reefs are threatened by global warming, with many experiencing increased coral bleaching. Warmer sea surface temperatures might enable reef expansion into mid latitudes. Here we report multibeam sonar and coring that reveal an extensive relict coral reef around Lord Howe Island, which is fringed by the southernmost reef in the Pacific Ocean. The relict reef, in water depths of 25-50 m, flourished in early Holocene and covered an area more than 20 times larger than the modern reef. Radiocarbon and uranium-series dating indicates that corals grew between …
Extracellular Chaperones Modulate The Effects Of Alzheimer's Patient Cerebrospinal Fluid On A Beta(1-42) Toxicity And Uptake , Justin J. Yerbury, Mark R. Wilson
Extracellular Chaperones Modulate The Effects Of Alzheimer's Patient Cerebrospinal Fluid On A Beta(1-42) Toxicity And Uptake , Justin J. Yerbury, Mark R. Wilson
Faculty of Science - Papers (Archive)
Alzheimer's disease is characterised by the inappropriate death of brain cells and accumulation of the A beta peptide in the brain. Thus, it is possible that there are fundamental differences between Alzheimer's disease patients and healthy individuals in their abilities to clear A beta from brain fluid and to protect neurons from A beta toxicity. In the present study, we examined (1) the cytotoxicity of Alzheimer's disease cerebrospinal fluid (CSF) compared to control CSF, (2) the ability of Alzheimer's disease and control CSF to protect cells from A beta toxicity and to promote cell-mediated clearance of A beta and lastly …
Population And Breeding Trends Of An Urban Coloniser: The Australian White Ibis, John Martin, Kris French, Richard Major
Population And Breeding Trends Of An Urban Coloniser: The Australian White Ibis, John Martin, Kris French, Richard Major
Faculty of Science - Papers (Archive)
Context. In the Sydney region, the population of Australian white ibis has dramatically increased from rare observations in the 1950s to a breeding season peak of 8900 in 2008, resulting with human -wildlife conflicts. Within natural habitats across the eastern states, the ibis population has declined, yet within urban environments ibis have been lethally managed for over 30 years. However, limited ecological and no regional population data are available for the Sydney region. Aims. The present study of ibis in the Sydney region aims to (1) establish the abundance of the population during the breeding and non-breeding seasons, (2) determine …
Ionic Liquid Electrolyte Porphyrin Dye Sensitised Solar Cells, Vanessa Armel, Jennifer Pringle, Maria Forsyth, Douglas Macfarlane, David L. Officer, Pawel W. Wagner
Ionic Liquid Electrolyte Porphyrin Dye Sensitised Solar Cells, Vanessa Armel, Jennifer Pringle, Maria Forsyth, Douglas Macfarlane, David L. Officer, Pawel W. Wagner
Faculty of Science - Papers (Archive)
Ionic liquid electrolytes based on a number of imidazolium, quaternary ammonium and phosphonium cations have been developed for porphyrin dye sensitised solar cells yielding efficiencies of up to 5.2% at 0.68 Sun.
Evidence For Specific Subunit Distribution And Interactions In The Quaternary Structure Of Α-Crystallin, Amie M. Morris, J Andrew Aquilina
Evidence For Specific Subunit Distribution And Interactions In The Quaternary Structure Of Α-Crystallin, Amie M. Morris, J Andrew Aquilina
Faculty of Science - Papers (Archive)
The quaternary structure of alpha-crystallin is dynamic, a property which has thwarted crystallographic efforts towards structural characterization. In this study, we have used collision-induced dissociation mass spectrometry to examine the architecture of the polydisperse assemblies of alpha-crystallin. For total alpha-crystallin isolated directly from fetal calf lens using size-based chromatography, the alpha B-crystallin subunit was found to be preferentially dissociated from the oligomers, despite being significantly less abundant overall than the alpha A-crystallin subunits. Furthermore, upon mixing molar equivalents of purified alpha A- and alpha B-crystallin, the levels of their dissociation were found to decrease and increase, respectively, with time. Interestingly …
Microsecond Dye Regeneration Kinetics In Efficient Solid State Dye-Sensitized Solar Cells Using A Photoelectrochemically Deposited Pedot Hole Conductor, Attila J. Mozer, Dillip K. Panda, Sanjeev Gambhir, B. Winther-Jensen, Gordon G. Wallace
Microsecond Dye Regeneration Kinetics In Efficient Solid State Dye-Sensitized Solar Cells Using A Photoelectrochemically Deposited Pedot Hole Conductor, Attila J. Mozer, Dillip K. Panda, Sanjeev Gambhir, B. Winther-Jensen, Gordon G. Wallace
Faculty of Science - Papers (Archive)
Microsecond dye-regeneration kinetics was observed in efficient solid state dye-sensitized solar cells using photoelectrochemically deposited poly(3,4-ethylenedioxythiophene (PEDOT) hole conductors using transient absorption spectroscopy. The dye-regeneration rate is orders of magnitude slower than the case using the I-/I3- redox couple or commonly used small molecule hole conductor and is attributed to the low dye to PEDOT ratio within the films.
Effects Of Soil Temperature Regimes After Fire On Seed Dormancy And Germination In Six Australian Fabaceae Species, Victor Santana, Ross A. Bradstock, Mark Ooi, Andrew J. Denham, Tony D. Auld, M Baeza
Effects Of Soil Temperature Regimes After Fire On Seed Dormancy And Germination In Six Australian Fabaceae Species, Victor Santana, Ross A. Bradstock, Mark Ooi, Andrew J. Denham, Tony D. Auld, M Baeza
Faculty of Science - Papers (Archive)
In addition to direct fire cues such as heat, smoke and charred wood, the passage of fire leads indirectly to changes in environmental conditions which may be able to break physical dormancy in hard-coated seeds. After a fire, the open canopy and the burnt material lying on the surface alter the thermal properties of the soil, resulting in elevated soil temperatures for long periods of time. We simulated daily temperature regimes experienced at different depths of soil profile after a summer fire. Our aim was to determine whether these temperature regimes and the duration of exposure (5, 15 and 30 …
Sex Ratio Of Breeding Common Toads (Bufo Bufo) - Influence Of Survival And Skipped Breeding, Jon Loman, Thomas R. Madsen
Sex Ratio Of Breeding Common Toads (Bufo Bufo) - Influence Of Survival And Skipped Breeding, Jon Loman, Thomas R. Madsen
Faculty of Science - Papers (Archive)
Anuran sex ratio at breeding sites is typically male biased. Such sex ratios may be due to poor female survival, to females not breeding as frequently as males and/or to males becoming sexually mature earlier than females. In the present study, the first two factors are analyzed in a common toad (Bufo bufo) population in southern Sweden. Toads were captured, marked and recaptured at the breeding site during 5 years. Within season capture patterns were analyzed using the Jolly-Seber model and among-year captures using the Closed robust design model. Population estimates of males and females yielded an among year variation …
Differential Endocytosis Of Tissue Plasminogen Activator By Serpins Pai-1 And Pai-2 On Human Peripheral Blood Monocytes, Jodi A. Lee, David Croucher, Marie Ranson
Differential Endocytosis Of Tissue Plasminogen Activator By Serpins Pai-1 And Pai-2 On Human Peripheral Blood Monocytes, Jodi A. Lee, David Croucher, Marie Ranson
Faculty of Science - Papers (Archive)
Generation of the broad spectrum protease plasmin is facilitated by the tissue (t-PA) and urokinase (u-PA) plasminogen activators, within multiple physiological and disease states. Finely tuned control of this proteolytic cascade is exerted by the plasminogen activator inhibitors type-1 (PAI-1/SERPINE1) and 2 (PAI-2/SERPINB2). Expression of this network of activators and inhibitors by cells of myeloid lineage appears to be highly interchangeable between physiological environments, and whilst the role of PAI-1 and PAI-2 in regulating u-PA-dependent functions is well established, the interaction between t-PA and PAI-2 on these cell types is poorly characterised. To this end, we used freshly isolated peripheral …
New Data On Occurrences Of The Devonian Rugose Coral Calceola In Belgium, Anthony J. Wright, M Coen-Aubert, P Bultynck, A P. Van Viersen
New Data On Occurrences Of The Devonian Rugose Coral Calceola In Belgium, Anthony J. Wright, M Coen-Aubert, P Bultynck, A P. Van Viersen
Faculty of Science - Papers (Archive)
Opercula and corallites of Calceola sandalina from the late Eifelian and early Givetian (Middle Devonian) Hanonet Formation of Belgium are illustrated. The few previous illustrations of calceoloid corals from the Devonian of Belgium did not include opercula showing the generically diagnostic morphological features, so for the first time the presence of the genus and species in Belgium is confirmed. One important corallite shows the alar septum and insertion of septa on the external surface of the counter face adjacent to the alar septum.
What Did Grinding Stones Grind? New Light On Early Neolithic Subsistence Economy In The Middle Yellow River Valley, China, Li Liu, Judith Field, Richard Fullagar, Sheahan Bestel, Xingcan Chen, Xiaolin Ma
What Did Grinding Stones Grind? New Light On Early Neolithic Subsistence Economy In The Middle Yellow River Valley, China, Li Liu, Judith Field, Richard Fullagar, Sheahan Bestel, Xingcan Chen, Xiaolin Ma
Faculty of Science - Papers (Archive)
Grinding stones have provided a convenient proxy for the arrival of agriculture in Neolithic China. Not any more. Thanks to high-precision analyses of use-wear and starch residue, the authors show that early Neolithic people were mainly using these stones to process acorns. This defines a new stage in the long transition of food production from hunter-gatherer to farmer.
Sustainability Potential Of Suburban Gardens: Review And New Directions, Sumita Ghosh
Sustainability Potential Of Suburban Gardens: Review And New Directions, Sumita Ghosh
Faculty of Science - Papers (Archive)
Gardens, as important elements of Australian suburban residential environments, could have significant sustainability potential similar to that of dwellings. Research to identify the cumulative (social, cultural, environmental and ecological) sustainability values of suburban domestic gardens has been very limited. Australian suburbs are likely to retain their typical characteristics for a considerable period of time as their rapid intensification is not likely. Therefore, it is immensely important to understand the role and performance of the suburban garden in this discourse. This article reviews the sustainability potential of domestic gardens and their links to suburban forms, sustainable design, social processes, and environmental …
Catchments And Waterways, Bob Bourman, Nick Harvey, Simon Bryars
Catchments And Waterways, Bob Bourman, Nick Harvey, Simon Bryars
Faculty of Science - Papers (Archive)
No abstract provided.
A Petrological, Mineralogical And Geochemical Analysis Of Listwaenite Alteration At Spring Creek Bingara In The Great Serpentinite Belt, New England, Nsw, E Holcroft, Solomon Buckman, I Neuss
A Petrological, Mineralogical And Geochemical Analysis Of Listwaenite Alteration At Spring Creek Bingara In The Great Serpentinite Belt, New England, Nsw, E Holcroft, Solomon Buckman, I Neuss
Faculty of Science - Papers (Archive)
No abstract provided.
Silica-Carbonate (Listwanites) Related Gold Mineralisation Associated With Epithermal Alteration Of Serpentinite Bodies, Solomon Buckman, P Ashley
Silica-Carbonate (Listwanites) Related Gold Mineralisation Associated With Epithermal Alteration Of Serpentinite Bodies, Solomon Buckman, P Ashley
Faculty of Science - Papers (Archive)
No abstract provided.
Co-Located Column And In Situ Measurements Of Co2 In The Tropics Compared With Model Simulations, T Warneke, A K. Petersen, C Gerbig, A Jordan, C Rodenbeck, M Rothe, Ronald Macatangay, J Norholt, O Schrems
Co-Located Column And In Situ Measurements Of Co2 In The Tropics Compared With Model Simulations, T Warneke, A K. Petersen, C Gerbig, A Jordan, C Rodenbeck, M Rothe, Ronald Macatangay, J Norholt, O Schrems
Faculty of Science - Papers (Archive)
The first ground-based remote sensing measurements of the column averaged volume mixing ratio of CO2 (XCO2) in tropical South America have been obtained at Paramaribo, Suriname (5.8 N, 55.2 W). The remote sensing observations are complemented by surface air-samples collected at the site, analyzed for CO2 and 13CO2. The surface in-situ measurements are strongly influenced by local sources. From the isotopic composition of the air samples the local source component is suggested to be dominated by the terrestrial biosphere. Using 13C from the NOAA/ESRL stations Ascension Is. (ASC), 7.9 S, 14.4W, and Ragged Point (RPB), 13.2 N, 59.4W, the data …
In Vivo Measurement Of Plant Respiration, Miquel Ribas-Carbo, Jaume Flexas, Sharon A. Robinson, Guillaume G. B Tcherkez
In Vivo Measurement Of Plant Respiration, Miquel Ribas-Carbo, Jaume Flexas, Sharon A. Robinson, Guillaume G. B Tcherkez
Faculty of Science - Papers (Archive)
Respiration is vital; it is the essence of life. Respiration is the mechanism by which energy obtained during the photosynthesis process is transformed into biochemical energy, in the form of ATP. This transformation of energy keeps all cells in all organisms alive. While energy conversion is the main function of respiration in animals, respiration has several other functions in plants. Among them, interactions with photosynthesis such as photorespiration and the production of carbon skeletons for the many compounds synthesized in plants (e.g., pigments, proteins and secondary metabolites). Therefore, it comes as no surprise that such a key role of respiration …
Influence Of Polyunsaturated Fatty Acids On Intestinal Barrier Function During Colitis, Bianca Knoch, Warren C. Mcnabb, Nicole Roy
Influence Of Polyunsaturated Fatty Acids On Intestinal Barrier Function During Colitis, Bianca Knoch, Warren C. Mcnabb, Nicole Roy
Faculty of Science - Papers (Archive)
Tight junction proteins are important for intestinal homeostasis. They prevent paracellular transport of large molecules and maintain cell polarity. Impaired tight junction function leads to a more permeable intestinal epithelial barrier and therefore potentially increases disease risk. Limited information is available concerning the effects of food components on the intestinal barrier, particularly paracellular permeability and tight junction proteins. In vitro studies with intestinal epithelial cells and in vivo studies using animal models have demonstrated that dietary n-3 and n-6 polyunsaturated fatty acids (PUFAs), particularly n-3, can reduce intestinal inflammation and permeability. PUFAs can induce transcriptional regulators which may act in …
The Interaction Of Alphab-Crystallin With Mature Alpha-Synuclein Amyloid Fibrils Inhibits Their Elongation, Christopher A. Waudby, Tuomas P. J Knowles, Glyn L. Devlin, Jeremy N. Skepper, Heath Ecroyd, John A. Carver, Mark E. Welland, John Christodoulou, Christopher M. Dobson, Sarah Meehan
The Interaction Of Alphab-Crystallin With Mature Alpha-Synuclein Amyloid Fibrils Inhibits Their Elongation, Christopher A. Waudby, Tuomas P. J Knowles, Glyn L. Devlin, Jeremy N. Skepper, Heath Ecroyd, John A. Carver, Mark E. Welland, John Christodoulou, Christopher M. Dobson, Sarah Meehan
Faculty of Science - Papers (Archive)
alphaB-Crystallin is a small heat-shock protein (sHsp) that is colocalized with alpha-synuclein (alphaSyn) in Lewy bodies—the pathological hallmarks of Parkinson's disease—and is an inhibitor of alphaSyn amyloid fibril formation in an ATP-independent manner in vitro. We have investigated the mechanism underlying the inhibitory action of sHsps, and here we establish, by means of a variety of biophysical techniques including immunogold labeling and nuclear magnetic resonance spectroscopy, that alphaB-crystallin interacts with alphaSyn, binding along the length of mature amyloid fibrils. By measurement of seeded fibril elongation kinetics, both in solution and on a surface using a quartz crystal microbalance, this binding …
Alphab-Crystallin Inhibits The Cell Toxicity Associated With Amyloid Fibril Formation By Kappa-Casein And The Amyloid-Beta Peptide, Francis C. Dehle, Heath Ecroyd, Ian F. Musgrave, John A. Carver
Alphab-Crystallin Inhibits The Cell Toxicity Associated With Amyloid Fibril Formation By Kappa-Casein And The Amyloid-Beta Peptide, Francis C. Dehle, Heath Ecroyd, Ian F. Musgrave, John A. Carver
Faculty of Science - Papers (Archive)
Amyloid fibril formation is associated with diseases such as Alzheimer’s, Parkinson’s, and prion diseases. Inhibition of amyloid fibril formation by molecular chaperone proteins, such as the small heat-shock protein αB-crystallin, may play a protective role in preventing the toxicity associated with this form of protein misfolding. Reduced and carboxymethylated κ-casein (RCMκ-CN), a protein derived from milk, readily and reproducibly forms fibrils at physiological temperature and pH. We investigated the toxicity of fibril formation by RCMκ-CN using neuronal model PC12 cells and determined whether the inhibition of fibril formation altered its cell toxicity. To resolve ambiguities in the literature, we also …
Plate Driven Extension And Convergence Along The East Gondwana Active Margin: Late Silurian–Middle Devonian Tectonics Of The Lachlan Fold Belt, Southeastern Australia, Christopher L. Fergusson
Plate Driven Extension And Convergence Along The East Gondwana Active Margin: Late Silurian–Middle Devonian Tectonics Of The Lachlan Fold Belt, Southeastern Australia, Christopher L. Fergusson
Faculty of Science - Papers (Archive)
The Lachlan Fold Belt of southeastern Australia developed along the Panthalassan margin of East Gondwana. Major silicic igneous activity and active tectonics with extensional, strike-slip and contractional deformation have been related to a continental backarc setting with a convergent margin to the east. In the Early Silurian (Benambran Orogeny), tectonic development was controlled by one or more subduction zones involved in collision and accretion of the Ordovician Macquarie Arc. Thermal instability in the Late Silurian to Middle Devonian interval was promoted by the presence of one or more shallow subducted slabs in the upper mantle and resulted in widespread silicic …
A Golden Garment? Identifying New Ways Of Looking At The Past Through A Preliminary Report Of Textile Fragments From The Pafos ‘Erotes’ Sarcophagus, Adriana Garcia, Diana Wood Conroy
A Golden Garment? Identifying New Ways Of Looking At The Past Through A Preliminary Report Of Textile Fragments From The Pafos ‘Erotes’ Sarcophagus, Adriana Garcia, Diana Wood Conroy
Faculty of Science - Papers (Archive)
A golden garment? A preliminary report of textile fragments from the Pafos ‘Erotes’ Sarcophagus Diana Wood Conroy and Adriana Garcia Remnants of very fine gold thread and reddish fibre were found among bone fragments in the ‘pillow’ end of the interior of the Pafos marble sarcophagus in 2001. The placement of the threads suggested a cloth laid over the upper part of the body. The excavator, Dr Eustathios Raptou has described how the sarcophagus had been looted in antiquity, leaving only one jewel and a finial from what must have been rich funerary goods. The textile fragments demonstrated the opulence …
Modulation Of Amyloid Precursor Protein Processing By Synthetic Ceramide Analogues, Hongyun Li, Woojin Scott Kim, Gilles Guillemin, Andrew F. Hill, Genevieve Evin, Brett Garner
Modulation Of Amyloid Precursor Protein Processing By Synthetic Ceramide Analogues, Hongyun Li, Woojin Scott Kim, Gilles Guillemin, Andrew F. Hill, Genevieve Evin, Brett Garner
Faculty of Science - Papers (Archive)
Previous studies suggest that membrane lipids may regulate proteolytic processing of the amyloid precursor protein (APP) to generate amyloid-beta peptide (Abeta). In the present study, we have assessed the capacity for a series of structurally related synthetic ceramide analogues to modulate APP processing in vitro. The compounds tested are established glucosylceramide synthase (GS) inhibitors based on the D-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) structure. PDMP and related compounds PPMP and EtDO-P4 inhibited Abeta secretion from Chinese hamster ovary cells expressing human APP (CHO-APP) with approximate IC50 values of 15, 5, and 1 mu M, respectively. A trend for reduced secretion of the APP alpha-secretase …
Berberine-Inf55 (5-Nitro-2-Phenylindole) Hybrid Antimicrobials: Effects Of Varying The Relative Orientation Of The Berberine And Inf55 Components, Danuta Tomkiewicz, Gabriele Casadei, Jonah Larkins-Ford, Terence I. Moy, James A. Garner, John B. Bremner, Frederik M. Ausubel, Kim Lewis, Michael J. Kelso
Berberine-Inf55 (5-Nitro-2-Phenylindole) Hybrid Antimicrobials: Effects Of Varying The Relative Orientation Of The Berberine And Inf55 Components, Danuta Tomkiewicz, Gabriele Casadei, Jonah Larkins-Ford, Terence I. Moy, James A. Garner, John B. Bremner, Frederik M. Ausubel, Kim Lewis, Michael J. Kelso
Faculty of Science - Papers (Archive)
Hybrid antimicrobials containing an antibacterial linked to a multidrug resistance (MDR) pump inhibitor make up a promising new class of agents for countering efflux-mediated bacterial drug resistance. This study explores the effects of varying the relative orientation of the antibacterial and efflux pump inhibitor components in three isomeric hybrids (SS14, SS14-M, and SS14-P) which link the antibacterial alkaloid and known substrate for the NorA MDR pump berberine to different positions on INF55 (5-nitro-2-phenylindole), an inhibitor of NorA. The MICs for all three hybrids against wild-type, NorA-knockout, and NorA-overexpressing Staphylococcus aureus cells were found to be similar (9.4 to 40.2 mu …
The Effect Of Fuel Age On The Spread Of Fire In Sclerophyll Forest In The Sydney Region Of Australia., Ross A. Bradstock, Owen F. Price
The Effect Of Fuel Age On The Spread Of Fire In Sclerophyll Forest In The Sydney Region Of Australia., Ross A. Bradstock, Owen F. Price
Faculty of Science - Papers (Archive)
We investigated the effect of fuel age on the truncation of spread of unplanned fires using a set of 1473 patches in the Sydney region of Australia. Twenty-two percent of patches derived from prescribed fire experienced a subsequent unplanned fire within 5 years, compared with 42% of patches derived from unplanned fires. Among those encounters, the subsequent unplanned fire stopped at the leading edge of 18% of prescribed patches and 11% of unplanned patches. In comparison, the subsequent fire stopped somewhere in the patch for 44% of both prescribed and unplanned fires. Overall, there was a 10% chance that a …
Reaction Of The C2h Radical With 1-Butyne (C4h6): Low Temperature Kinetics And Isomer-Specific Product Detection, Satchin Soorkia, Adam J. Trevitt, Talitha M. Selby, David L. Osborn, Craig A. Taatjes, Kevin R. Wilson, Stephen R. Leone
Reaction Of The C2h Radical With 1-Butyne (C4h6): Low Temperature Kinetics And Isomer-Specific Product Detection, Satchin Soorkia, Adam J. Trevitt, Talitha M. Selby, David L. Osborn, Craig A. Taatjes, Kevin R. Wilson, Stephen R. Leone
Faculty of Science - Papers (Archive)
No abstract provided.
Nanometer-Scale Distance Measurements In Proteins Using Gd3+ Spin Labeling, Alexey Potapov, Hiromasa Yagi, Thomas Huber, Slobodan Jergic, Nicholas E. Dixon, Gottfried Otting, Daniella Goldfarb
Nanometer-Scale Distance Measurements In Proteins Using Gd3+ Spin Labeling, Alexey Potapov, Hiromasa Yagi, Thomas Huber, Slobodan Jergic, Nicholas E. Dixon, Gottfried Otting, Daniella Goldfarb
Faculty of Science - Papers (Archive)
Methods for measuring nanometer-scale distances between specific sites in proteins are essential for analysis of their structure and function. In this work we introduce Gd3+ spin labeling for nanometer-range distance measurements in proteins by high-field pulse electron paramagnetic resonance (EPR). To evaluate the performance of such measurements, we carried out four-pulse double-electron electron resonance (DEER) measurements on two proteins, p75ICD and τC14, labeled at strategically selected sites with either two nitroxides or two Gd3+ spin labels. In analogy to conventional site-directed spin labeling using nitroxides, Gd3+ tags that are derivatives of dipicolinic acid were covalently attached to cysteine thiol groups. …
Synthesis Of Reaction-Ready 6,6 '-Biindole And 6,6 '-Biisatin Via Palladium(Ii)-Catalysed Intramolecular C-H Functionalisation, Allan B. Gamble, Paul A. Keller
Synthesis Of Reaction-Ready 6,6 '-Biindole And 6,6 '-Biisatin Via Palladium(Ii)-Catalysed Intramolecular C-H Functionalisation, Allan B. Gamble, Paul A. Keller
Faculty of Science - Papers (Archive)
The first synthesis of a 6,6'-biindole and 6,6'-biisatin scaffold is reported with the penultimate step being the formation of the di-heterocyclic ring by Pd(II)-catalysed intramolecular C-H functionalisation and Sandmeyer cyclisation, respectively.
Female Choice For Males With Greater Fertilization Success In The Swedish Moor Frog, Rana Arvalis, Craig D. Sherman, Jorgen Sagvik, Mats M. Olsson
Female Choice For Males With Greater Fertilization Success In The Swedish Moor Frog, Rana Arvalis, Craig D. Sherman, Jorgen Sagvik, Mats M. Olsson
Faculty of Science - Papers (Archive)
Background: Studies of mate choice in anuran amphibians have shown female preference for a wide range of male traits despite females gaining no direct resources from males (i.e. non-resource based mating system). Nevertheless, theoretical and empirical studies have shown that females may still gain indirect genetic benefits from choosing males of higher genetic quality and thereby increase their reproductive success. Methodology/Principal Findings: We investigated two components of sexual selection in the Moor frog (Rana arvalis), precopulatory female choice between two males of different size ('large' vs. 'small'), and their fertilization success in sperm competition and in isolation. Females' showed no …