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Articles 1 - 4 of 4
Full-Text Articles in Physical Sciences and Mathematics
Silica-Carbonate (Listwanites) Related Gold Mineralisation Associated With Epithermal Alteration Of Serpentinite Bodies, Solomon Buckman, P Ashley
Silica-Carbonate (Listwanites) Related Gold Mineralisation Associated With Epithermal Alteration Of Serpentinite Bodies, Solomon Buckman, P Ashley
Faculty of Science - Papers (Archive)
No abstract provided.
Alphab-Crystallin Inhibits The Cell Toxicity Associated With Amyloid Fibril Formation By Kappa-Casein And The Amyloid-Beta Peptide, Francis C. Dehle, Heath Ecroyd, Ian F. Musgrave, John A. Carver
Alphab-Crystallin Inhibits The Cell Toxicity Associated With Amyloid Fibril Formation By Kappa-Casein And The Amyloid-Beta Peptide, Francis C. Dehle, Heath Ecroyd, Ian F. Musgrave, John A. Carver
Faculty of Science - Papers (Archive)
Amyloid fibril formation is associated with diseases such as Alzheimer’s, Parkinson’s, and prion diseases. Inhibition of amyloid fibril formation by molecular chaperone proteins, such as the small heat-shock protein αB-crystallin, may play a protective role in preventing the toxicity associated with this form of protein misfolding. Reduced and carboxymethylated κ-casein (RCMκ-CN), a protein derived from milk, readily and reproducibly forms fibrils at physiological temperature and pH. We investigated the toxicity of fibril formation by RCMκ-CN using neuronal model PC12 cells and determined whether the inhibition of fibril formation altered its cell toxicity. To resolve ambiguities in the literature, we also …
Myriocin-Mediated Up-Regulation Of Hepatocyte Apoa-I Synthesis Is Associated With Erk Inhibition, Elias N. Glaros, Woojin Scott Kim, Brett Garner
Myriocin-Mediated Up-Regulation Of Hepatocyte Apoa-I Synthesis Is Associated With Erk Inhibition, Elias N. Glaros, Woojin Scott Kim, Brett Garner
Faculty of Science - Papers (Archive)
Sphingolipids including sphingomyelin have been implicated as potential atherogenic lipids. Studies in apoE (apolipoprotein E)-null mice have revealed that the serine palmitoyltransferase inhibitor myriocin reduces plasma levels of sphingomyelin, ceramide, sphingosine-I-phosphate and glycosphingolipids and that this is associated with potent inhibition of atherosclerosis. Interestingly, hepatic apoA-I (apolipoprotein A-I) synthesis and plasma HDL (high-density lipoprotein)cholesterol levels were also increased in apoE-null mice treated with myriocin. Since myriocin is a known inhibitor of ERK (extracellular-signal-related kinase) phosphorylation, we assessed the possibility that myriocin may be acting to increase hepatic apoA-I production via this pathway. To address this, HepG2 cells and primary mouse …
Soil Geochemistry And Pathfinder Element Distribution Associated With The Hillgrove Antimony-Gold-Tungsten Deposit, New England Orogen, Nsw, R Ellsmore, Solomon Buckman, C Simpson
Soil Geochemistry And Pathfinder Element Distribution Associated With The Hillgrove Antimony-Gold-Tungsten Deposit, New England Orogen, Nsw, R Ellsmore, Solomon Buckman, C Simpson
Faculty of Science - Papers (Archive)
No abstract provided.