Veterinary Toxicology and Pharmacology Commons^™

Effects Of Methylxanthines On Newborn Rat Respiration, Craig Gatto

Masters Theses

Methylxanthines (MX), such as theophylline, are commonly used in the treatment of recurrent apnea due to their stimulant effects on the respiratory center. Structure-activity studies have demonstrated that substitution of alkyl groups on the 3-position of the xanthine nucleus results in increased bronchodilator potency, while substitution on the 1-position is important for adenosine antagonism and CNS stimulation. Three different alkylxanthines were studied to determine the structural requirements for respiratory stimulation. Respiratory rates and volumes were determined in 4- to 7-day-old rats using a volume displacement body plethysmograph. Measurements were made before and at 5 minute intervals after subcutaneous (s.c.) injection …

The Effects Of Xanthine And Adenosine Analogs On Rat Pup Diaphragmatic Contractility, Liam C. Farrell

Masters Theses

Methylxanthines are commonly used in the treatment of respiratory disorders such as asthma, apnea of prematurity and Cheyne-Stokes respiration. Recently, certain methylxanthines have been found to potentiate the contraction of the diaphragm and increase contraction strength of the fatigued diaphragm. The mechanism of action of the methylxanthines is unknown. Three theories have been proposed but each has its supportive and negative points. One theory is that methylxanthines inhibit cyclic AMP phosphodiesterase (PDE) which facilitates contraction by increasing cyclic AMP levels in the cell. Another theory is that methylxanthines antagonize adenosine, thus blocking the adenosine-induced inhibition of contraction. The third theory …

T-61 Use In The Euthanasia Of Domestic Animals: A Survey, Andrew N. Rowan

Veterinary Science and Medicine Collection

A variety of techniques have been proposed and employed for the killing of domestic animals but relatively few have survived as suitable agents for euthanasia-namely, the induction of painless, suffering-free death. Some agents, such as strychnine, curariform agents, or potassium salts cause suffering while others have other disadvantages. 'lbday, dogs and cats are commonly euthanatized with sodium pentobarbital or with T-61 which is a mixture of a central nervous system narcotic, a paralytic agent, and a local anesthetic. The use of T-61 was first reported in the United States in 1963 (Quin 1963). The substance gradually became more popular because …

Review Of Literature On Use Of T-61 As An Euthanasic Agent, Laura Dalia Barocio

Veterinary Science and Medicine Collection

The tools of evaluating the degree of distress in animals being killed include electroencephalography (EEG), electrocardiography (ECG), and measurement of blood pressure and respiration. Sound clinical and behavioral observations should also not be abandoned in the evaIuation process.

There are many methods which may be employed to reach the same end results, but the ideal method should satisfy several criteria: 1. It should be painless; 2. It should cause unconsciousness instantaneously and death within minutes; 3. It should not cause undue anxiety, alarm, fear, panic, behavior, struggling, vocalization, muscle spasms or clinical signs of automatic activation (e.g., convulsions) before unconsciousness; …

Prostaglandin F2a Induced Nest Building Behavior In The Non-Pregnant Sow, And Some Welfare Considerations, Judith K. Blackshaw

Agribusiness Collection

Nest building behavior, induced with intramuscular injections of prostaglandin F2_a (PGF2_a), was studied in non-pregnant sows. Acute effects, which included salivation, scratching, vomiting, defaecation and ataxia, were also recorded. Sows (Large White x Landrace) were housed in two different environments; six sows in bare pens and six sows in pens provided with bedding material. In all cases except one (bare pen) nest building sequences of differing intensities were recorded. Welfare suggestions include questioning the justification of using a drug (PGF2_a) in pig husbandry, which has unpleasant acute effects, and the suggestion that the provision of …

Toxic Ferns Of Western Australia, T E H Aplin, P Steele, M C. Nottle

Technical Bulletins

Botanical descriptions and notes on the distribution of six species of ferns are given. These plants contain the enzyme thiaminase, which may induce thiamin deficiency, or other constituents toxic to animals. The clinical signs of both thiamin deficiency and fern toxicity in affected livestock are described.

Bulletin 3967 - Cyanogenetic Plants Of Western Australia, T E H Aplin

Bulletins - 3000 - 3999

This article deals with those native, naturalized and cultivated plants, which by virtue of contained cyanogenetic glycosides, are known to be poisonous or potentially poisonous to livestock in Western Australia.

Cyanogenetic glycosides are chemical compounds which contain a cyanogen (cyanide) radical combined with a sugar molecule. The sugar moiety may differ in glycosides obtained from different plants, and as a consequence glycosides from different plants, containing different sugar moieties, may be given different names.

When a cyanogenetic glycoside is broken down by enzyme action, through injury to the plant or by microbial action in the digestive system of the animal, …

Lupinosis : A Disease Still With Us, Jeremy G. Allen, P. Mcr. Wood, K. P. Crocker, J. Hamblin

Journal of the Department of Agriculture, Western Australia, Series 4

Current research on lupinosis continues to reveal what a complex problem it is, but the improved understanding should help to reduce losses.

Controlling Annual Ryegrass Toxicity, C H. Trotman

Journal of the Department of Agriculture, Western Australia, Series 4

Eight years of intensive work has changed annual ryegrass toxicity from an unknown killer to a manageable problem.

Ryegrass Disease Could Spread, Department Of Agriculture, Western Australia

Journal of the Department of Agriculture, Western Australia, Series 4

The disease annual ryegrass toxicity kills sheep and cattle grazing pastures which contain infected annual ryegrass. In Western Australia the first confirmed outbreak was in 1968 in the Gnowangerup area.

The disease has noe spread over a range of 450 kilometres and with a total area of perhaps 100 000 hectares. because annual ryegrass is the major sown pasture grass in W.A. the disease could spread throughout the South-West.

There are some precautions that can be taken.

Bulletin No 3863 - Plants Which Cause Kimberley Horse Disease, A. L. Payne

Bulletins - 3000 - 3999

Crotalaria crispata and Crotalaria retusa (Rattlepod), two plants responsible for Kimberley horse disease*, are, unfortunately, fairly widespread throughout the Kimberleys. Both species are apparently toxic in all stages of growth.

This bulletin is to assist pastoralists to:-

• Identify the two plants;

• Recognise the type of country and conditions under which they grow; and

• Locate horse paddocks on country where the plants are least likely to occur.

Lupinosis And Rates Of Stocking Of Lupin Stubbles, K P. Croker, J. G. Allen, C. R. Lester, R. B. Guthrie

Journal of the Department of Agriculture, Western Australia, Series 4

Lupin stubbles provide valuable summer sheep feed but under some conditions the fungus Phomopsis rossiana (for which lupins are the host plant) produces a toxin that causes lupinosis. Results from research at Badaingarra Research Station over the 1973-74 and 1974- 75 summers have shown that sheep liver damage associated with lupin stubble grazing is likely to be more severe at high than low stocking rates.

Treflan And The Oxygen Consumption Of Green Sunfish (Lepomis Cyanellus), Barbara Jo Warner

Masters Theses

Oxygen consumption rates of 51 green sunfish (Lepomis cyanellus, Rafinesque) were monitored over five hours exposure to Treflan E.C. concentrations of 0, 0.32, 0.56, 1.0, and 2.0 ppm. There was a great variation in the responses of the fish at each concentration; and Student's t-tests revealed no significant differences. However, graphs of the mean hourly oxygen consumption rates showed certain trends. During the fifth hour of exposure, there appears to be an acclimation to the Treflan at concentrations of 0.32 and 0.56 ppm; but no such acclimation at the higher concentrations of 1.0 and 2.0 ppm. Hourly oxygen …

Pesticide Residues In The Illinois Wild Turkey, John M. Bridges

Masters Theses

Adipose tissue from 55 turkeys, killed during the 1974 hunting season in southern Illinois, was grouped by age and location of the birds, and the pesticide concentrations in them were determined by gas/liquid chromatography. Twelve different pesticides were identified in the samples with only four, total DDT, heptachlor epoxide, toxaphene, and linuron, being present in all samples. Concentrations ranged from 0.02 ppm to 0.88 ppm.

Development Of A Selective Bait For Rabbits, A J. Oliver, S. H. Wheeler

Journal of the Department of Agriculture, Western Australia, Series 4

It has long been recognised that a means of killing rabbits selectively in the presence of stock would be a major advance in rabbit control. It would enable a whole farm to be treated for rabbit control at one time, saving operational costs and cutting down reinfestation of rabbits into treated areas from untreated areas.

A literature search and some pilot trials indicated that indandione derivatives were more toxic to rabbits than to ruminants.

Pindone (2- pivalyl-l,3-indandione) was selected for evaluation.

Annual ('Wimmera') Ryegrass Toxicity, Geoffrey A. Pearce, O. M. Goss, P. H. Berry, J. L. Wise

Journal of the Department of Agriculture, Western Australia, Series 4

Because annual ryegrass is one of the most widespread pasture plants in Western Australia, annual ryegrass toxicity is a threat to livestock in many agricultural areas—even though the area now affected is small.

The problem is being intensively studied by the Department of Agriculture and a working group has been set up to investigate potential control measures.

In this article the group reviews the problem and reports progress in its investigations to the end of 1973.

Wimmera Ryegrass Toxicity, Department Of Agriculture, Western Australia

Journal of the Department of Agriculture, Western Australia, Series 4

Wimmera ryegrass toxicity has been reported for many years to affect sheep and occasionally cattle in New Zealand, South Australia and the United States of America.

In Western Australia, occasional reports since 1959 and severe outbreaks of staggers in the Katanning- Gnowangerup areas over the last two years prompted the investigation reported below.

Fumigation And Rabbit Control, Department Of Agriculture, Western Australia

Journal of the Department of Agriculture, Western Australia, Series 4

Fumigation has been a valuable tool in Australian rabbit control for over 70 years, because of its economy and efficiency compared with methods such as shooting and trapping.

Even now, while it is not as economical as 'one-shot' baiting, fumigation remains a valuable initial control effort because it is not affected by season and does not require shifting of stock.

Poison Plants Of Western Australia : The Toxic Species Of The Genera Gastrolobium And Oxylobium : Thick-Leaf Poison (Gastrolobium Crassifolium Benth.), Narrow-Leaf Poison (Gastrolobium Stenophyllum Turcz.), Mallet Poison (Gastrolobium Densifolium C.A. Gardn.), Wall-Flower Poison (Gastrolobium Grandifolorum F. Muell), T E H Aplin

Journal of the Department of Agriculture, Western Australia, Series 4

THIS article deals with three species of Gastrolobium which are found in the south-west region of Western Australia. Two of these extend into the Eyre District, the third species is found in the Lake Grace area. The fourth species, Wall-flower poison, is the only toxic species of the genus found outside the State.

Wildlife Hazards From 1080 Baiting, A R. Tomlinson, C. D. Gooding

Journal of the Department of Agriculture, Western Australia, Series 4

ONE-SHOT oat baiting with sodium fluoroacetate (1080) is a relatively safe method of trail baiting rabbits.

The hazard to wildlife is small and every effort is made to further reduce the hazard by selective application of the poison.

Poison Plants Of Western Australia : The Toxic Species Of The Genera Gastrolobium And Oxylobium : Net-Leaf Poison (O. Racemosum (Turcz.) C.A. Gardn.), Brother-Brother (O. Tetragonophyllum E. Pritzel), Rigid-Leaf Poison (O. Rigidum C.A. Gardn.), Slender Poison (O. Heterophyllum (Turcz.) Benth.), Round-Leaf Poison (G. Pycnostachyum Benth.), T E H Aplin

Journal of the Department of Agriculture, Western Australia, Series 4

THIS article deals with five toxic species, all of which are found in the Eyre district of the South-Western region of Western Australia.

West Midlands Development : Poison Plants In The West Midlands, T E H Aplin

Journal of the Department of Agriculture, Western Australia, Series 4

TOXIC plants have caused considerable economic loss to stock raisers since the early days of settlement in Western Australia.

Although much is now known of the toxic materials contained in such plants, and although most of the plants have been thoroughly publicised, losses are still occurring in many areas.

Amsinckia Or Yellow Burr-Weed (Amsinckia Spp.), G R W Meadly

Journal of the Department of Agriculture, Western Australia, Series 4

YELLOW BURR-WEED is widely established in the Wimmera and Mallee districts in Victoria, presumably introduced with fodder brought to this country from the United States about 1914.

It is a problem in Oregon and other north west wheat areas of America.

The weed is also widespread in New South Wales, being most troublesome in the wheat-growing sections of the Riverina. It is not established to the same extent in South Australia and Queensland.

The recent discovery of areas infested with yellow burr-weed at Merredin prompted the Agriculture Protection Board to declare it a primary noxious weed for Western Australia.

Common Heliotrope : (Heliotropum Europaeum L.), G R W Meadly

Journal of the Department of Agriculture, Western Australia, Series 4

THE Borage family, to which common heliotrope belongs, includes several other plants which are troublesome weeds in Australia.

Patersons curse is widespread in several States, yellow burr-weed is a problem in wheat growing areas, particularly in Victoria, and corn gromwell also causes concern to some wheat farmers.

Heart-Leaf Poison, River Poison, Stirling Range Poison, T E H Aplin

Journal of the Department of Agriculture, Western Australia, Series 4

THIS article deals with heart-leaf poison, river poison and Stirling Range poison, all more or less restricted to the lower South-Western Region of Western Australia.

Poison Plants Of Western Australia : Crinkle-Leaf Poison (Gastrolobium Villosum Benth.), Runner Poison (G. Ovalifolium Henfr.), Horned Poison And Hill River Poison (G. Polystachyum Meissn.), Woolly Poison (G. Tomentosum C.A. Gardn.), T E H Aplin

Journal of the Department of Agriculture, Western Australia, Series 4

THIS article deals with four toxic species of the genus Gastrolobium which are superficially similar to one other.

Two of these species are prostrate in habit; the other two are more upright but are generally short in stature.

Poison Plants Of Western Australia : The Toxic Species Of The Genera Gastrolobium And Oxylobium : Rock Poison (Gastrobolium Callistachys Meissn.), T E H Aplin

Journal of the Department of Agriculture, Western Australia, Series 4

ROCK POISON, so called because it is commonly found on granitic soils, usually among granite rocks, occurs from the Irwin River, southwards to the Dale River and eastwards to Mount Stirling, south of Kellerberrin.

Poison Plants Of Western Australia : The Toxic Species Of The Genera Gastrolobium And Oxylobium : York Road Poison And Box Poison, T E H Aplin

Journal of the Department of Agriculture, Western Australia, Series 4

YORK ROAD poison and box poison are two of the most important members of the group of poison plants belonging to the genera Gastrolobium and Oxylobium—the toxic pea-flowered plants.

Stinkwort (Inula Graveolens Desf.), G R W Meadly

Journal of the Department of Agriculture, Western Australia, Series 4

THE original home of stinkwort is the Mediterranean region, including northern France. Apparently the first Australian record was at Onkaparinga in South Australia about 90 years ago.

Efforts were made to keep it in bounds during the years immediately following introduction, but it continued to spread and is now f i r m ly established in all agricultural districts of South Australia.

It also covers large tracts of land in New South Wales and Victoria and occurs in most districts of Western Australia.

One Shot Baiting, C D. Gooding, L. A. Harrison

Journal of the Department of Agriculture, Western Australia, Series 4

THE Agriculture Protection Board introduced the first of its contract poisoning schemes in 1955 in the lower South-West when three units undertook the first "1080" poisoning for farmers in Western Australia.

The originators of one-shot baiting describe this new technique and explain how it should be used for best results on the farm.