Psychiatry and Psychology Commons^™

Exploring The Heteromeric Interface Of The 5-Ht2a-Mglu2 Receptor Complex, Mohamed Aarif Abdul Kareem

Theses and Dissertations

Schizophrenia is a serious mental disorder characteristic of several neurotransmitters including dopamine, serotonin, and glutamate being in imbalance. Early therapies focused solely on dopamine antagonism and second-generation antipsychotics focused on the dopamine and serotonin systems and their respective G protein coupled receptor (GPCR) proteins. Although debate for dimerization of certain classes of GPCR exist, the establishment of an mGlu2-5-HT_2A heterocomplex, which is implicated in schizophrenia is of interest. Previous studies have used a mutation-based approach to identify transmembrane domain 4 (TM4) as the domain responsible in mGlu2 for mediating heteromerization before narrowing down the individual amino acids responsible for …

Effects Of (R,S)-Ketamine And (2r,6r)-Hydroxynorketamine: A Preclinical Study, Remington Rice

Theses and Dissertations

In 2017, 7.1% of US adults were diagnosed with depression, and 50% of patients received medication to treat their depression. Depression can cause severe interruptions in an individual's cognitive functioning and behaviors like sleeping, eating, working, and socializing. Unfortunately, approximately 40% of patients do not respond to treatment with monoaminergic medications (e.g. Prozac) and therapeutic effects may be delayed 2-8 weeks. Due to these therapeutic shortcomings, faster acting and more efficacious treatments are needed. Recent preclinical findings indicate potential for glutamatergic drugs like (R,S)-ketamine and (2R,6R) hydroxynorketamine to produce more rapid and longer-acting therapeutic effects. The antidepressant effectiveness of (R,S)-ketamine …

College Students’ Perceptions Of Popular Diets And Orthorexia Nervosa, Madison W. Weinstock

Theses and Dissertations

Data suggest that individuals’ purported dietary patterns influence others’ perceptions of them. However, few studies have investigated how adherence to specific popular diets might influence these perceptions. This study investigated female undergraduates’ (n = 463) perceptions of vignette characters described as adhering to specific dietary practices perceptions of a vignette character in a sample of 463 female undergraduates. Characters described as adhering to a Clean Eating diet were viewed most positively, followed by individuals on the Ketogenic diet or nondieters. Characters following an Intermittent Fasting diet, and those with Orthorexia Nervosa were viewed most negatively. These findings support the …

Signaling Mechanism Responsible For 5-Ht2a Receptor Tolerance To Psychedelic Induced Head-Twitch Behavior In Mice, Audrey R. Mcmurtrie

Theses and Dissertations

In recent years, there has been a growing interest in psychedelic compounds stemming from their promising use as therapeutic agents and research tools that can be used to treat and study several neuropsychiatric disorders. Psychedelics have proven useful in a broad range of these diseases - they serve as models for psychosis in schizophrenia but have also had promising results in treating major depressive disorder, anxiety, and other common disorders. Decreased stigmatization surrounding psychedelics has further increased their use in research and clinical settings. In light of these trends and the promising nature of their use, a thorough understanding of …

Transcriptomic Profiling Of Postmortem Prefrontal Cortex And Nucleus Accumbens From Chronic Alcohol Abusers., Eric S. Vornholt

Theses and Dissertations

Alcohol use disorder (AUD) is a debilitating psychiatric illness that develops from a combination of genetic and environmental factors. While it is well documented that AUD is heritable, the shift from recreational alcohol use to abuse/dependence is poorly understood. In this dissertation, using postmortem brain tissue from individuals with alcohol dependence (AD), we profiled the genome-wide expression of circular RNA (circRNA), microRNA (miRNA), and messenger RNA (mRNA) to better understand the impact of gene expression on the development of AUD. To achieve this, we performed two independent studies that explore transcriptome differences between AD cases and controls. The first of …

Associations Between Stress, Racial Discrimination, And Cytokine Levels In Black Americans, Takia Williams

Theses and Dissertations

Inflammation is a common pathophysiological pathway for a number of chronic diseases and is influenced by exposure to stress. Although there are racial disparities in health outcomes, relatively little is known about factors that may influence the inflammatory response in Black American individuals. This study examined whether racial discrimination and other forms of stress are associated with the balance of pro- and anti- inflammatory cytokines in Black American adults. Data from 22 participants were drawn from a larger study of Black American children (ages 5-12) and their primary caregivers drawn from low income neighborhoods in Richmond, Virginia. Caregivers reported demographics, …

Impact Of Sickle Cell Disease On Executive Functioning In An Adult Population, Christina Wade

Theses and Dissertations

Children diagnosed with sickle cell disease (SCD) struggle with executive functions (EF); however, there is a paucity of research on neuropsychological outcomes in adults with SCD. This study aimed to examine differences in EF between adults with SCD and healthy controls. Thirty- one patients with SCD and 34 healthy controls (ages 18-45) participating in an IRB-approved Children’s Hospital Los Angeles (CHLA) study of cerebral blood flow underwent neuropsychological evaluation using the Delis–Kaplan Executive Function System (D-KEFS) Trail Making and Color Word Interference Tests and the Wechsler Adult Intelligence Scale - Fourth Edition (WAIS-IV) Digit Span subtest to assess various aspects …

Contexts Of Recovery And Displacement: Investigating The Impact Of The 2015 South Carolina Floods Across Communities, Van Phan

Theses and Dissertations

In October 2015, South Carolina was devastated by weather complications related to hurricane Joaquin that lead to historic amounts of rainfall and flash floods that destroyed local communities and infrastructure, ultimately displacing over 400,000 people. Natural disasters are destructive and have shown to be correlated with a variety of negative outcomes, including high levels of stress and hopelessness. These effects can be even more pronounced when compounded with displacement as these victims not only have to deal with the usual consequences in the aftermath of a natural disaster, but also the stress of integrating themselves into a different community and …

Validity Of A Functional Assessment For Smoking Treatment Recommendations Questionnaire, Connor Andrew Burrows

Theses and Dissertations

Smoking is the leading cause of preventable death in the United States and imposes a substantial economic cost. Despite the well-established potential harm, relapse rates remain high during quit attempts. In the realm of applied behavior analysis, functional assessment has long been recognized as a reliable method to increase effectiveness of treatments for a variety of problem behaviors. Functional assessment may aid in designating targeted treatment for smokers based on the maintaining function(s) of the behavior. The current study (N = 414) sought to assess the reliability and validity of the Functional Assessment of Smoking for Treatment Recommendations (FASTR) and …

Structure-Activity Relationship Studies Of Synthetic Cathinones And Related Agents, Rachel A. Davies

Theses and Dissertations

Synthetic cathinones and related agents represent an international drug abuse problem, and at the same time an important class of clinically useful compounds. Structure-activity relationship studies are needed to elucidate molecular features underlying the pharmacology of these agents. Illicit methcathinone (i.e., MCAT), the prototype of the synthetic cathinone class, exists as a racemic mixture. Though the differences in potency and target selectivity between the positional and optical isomers of synthetic cathinones and related agents have been demonstrated to have important implications for abuse and therapeutic potential, the two MCAT isomers have never been directly compared at their molecular targets: the …

An Investigation Of Neurological Soft Signs As A Discriminating Factor Between Veterans With Post-Traumatic Stress Disorder, Mild Traumatic Brain Injury, And Co-Occurring Post-Traumatic Stress Disorder And Mild Traumatic Brain Injury, David J. Rothman

Theses and Dissertations

While multiple Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn veterans suffer from mild Traumatic Brain Injury (mTBI), Post-traumatic Stress Disorder (PTSD), and co-morbid mTBI and PTSD, there remains difficulty disentangling the specific symptoms associated with each disorder using self-report and neurocognitive assessments. We propose that neurological soft signs (NSS), which are tasks associated with general neurologic compromise, may prove useful in this regard. Based on our review of the literature we hypothesized that individuals with PTSD would present with a greater number of NSS than controls or individuals with mTBI. Further, we hypothesized a synergistic effect, such that individuals with …

Translational Insights Into The Genetic Etiology Of Mental Health Disorders: Examining Risk Factor Models, Neuroimaging, And Current Dissemination Practices, Jessica L. Bourdon

Theses and Dissertations

Psychiatric genetics is a basic science field that has potential for practical application and effective translation. To date, translational frameworks utilized by this field have been linear (e.g., sequential) in nature, focusing on molecular genetic information. It is proposed that non-linear (e.g., socio-ecological) frameworks are a better way to immediately translate non-molecular genetic information. This dissertation explored the translation of psychiatric genetic information in two ways. First, a survey was sent to academic stakeholders to assess the state of the science regarding the translation of genetic information to the clinical care of mental health disorders. Findings from this indicate a …

Predictors Of Experimental And Control Group Attendance: Findings From An Hiv/Std Prevention Rct With Pregnant Women At Risk For Substance Use, Jaclyn S. Sadicario

Theses and Dissertations

Efforts to improve inclusion in research have included mandating the recruitment of ethnic minorities and women into NIH funded studies. However, little research has been completed on who attends such interventions. This is particularly worrisome in populations for which attendance to interventions can have dire consequences. HIV is a public health concern for pregnant women in substance using communities, as pregnant women are much less likely to use condoms during intercourse to prevent HIV. Group modular HIV prevention interventions have long been the standard for HIV prevention. However, little attention in research on HIV prevention interventions RCTs has been focused …

Examining Sleep And Family Functioning In Pediatric Craniopharyngioma Using Ecological Momentary Assessment, Nour Al Ghriwati

Theses and Dissertations

Craniopharyngiomas are among the most common brain tumors in children and are associated with greater rates of sleep problems compared to other pediatric cancers. However, research examining sleep among youth with craniopharyngioma has been limited by a reliance on retrospective reports or sleep studies. Families also play a crucial role in children’s adjustment following a pediatric cancer diagnosis, yet remarkably little is known about transactional associations between family functioning and sleep in pediatric cancer. This study examined cross-sectional and daily associations among family functioning, affect, and sleep difficulties for youth with pediatric craniopharyngioma using retrospective reports and ecological momentary assessment …

Construction And Validation Of A Non-Medical Use Of Prescription Opioids Outcome Expectancies Scale Among College Students In China, Cheuk Chi Tam

Theses and Dissertations

Background:Non-medical use of prescription opioids (NMUPO) has become a clear threat to public health. Young adults (aged 18 to 25) have a high risk of NMUPO. My prior work on Chinese undergraduates indicates a high prevalence of lifetime NMUPO (49.2%). Health behavior theories propose that outcome expectancies are robust psychosocial determinants of substance use. Literature has identified the influence of outcome expectancies on alcohol and drug use. However, the role of outcome expectancies in NMUPO in China is unknown, and a scarcity of a valid measures for NMUPO outcome expectancies may be a barrier. Our previous research also found …

Pharmacological Assessment Of Adjuncts To Enhance Mu-Opioid Receptor Agonist Antinociception In Male Rhesus Monkeys: Does One + One = Three?, Jeremy Cornelissen

Theses and Dissertations

Mu-opioid receptor (MOR) agonists are effective agents for pain management, but are also limited by a number of undesirable effects. One approach to enhance the therapeutic effects and minimize the undesirable effects of MOR agonists may be to combine MOR agonists with an adjunct targeting a different receptor system. This targeted medical approach, known as “combination therapy”, aims to augment the desired effects of the MOR agonist (i.e. antinociception) and/or diminish the undesirable deleterious side effects of the MOR agonist. This dissertation investigated the utility of this approach in an assay of thermal nociception and schedule-controlled responding in male rhesus …

A Qualitative Study Exploring Motivation And Engagement Among Millennial Volunteers In Nonprofit Organizations, Joanne Quinones

Theses and Dissertations

This applied dissertation focused on capturing the lived experiences of Millennials and explore their motivation and engagement for volunteering in a nonprofit organization. This study illustrates the importance of civic and social engagement in our society. The Millennials have been labeled as “Genme or the me generation” (Twenge, Campbell, Hoffman, & Lance, 2010, p. 1117; Twenge, 2006, p. 1), as they have been criticized for focusing on their own self-interest. While millennials have been considered as being technologically savvy, since they grew up with the internet. The millennials, have a social interest in offering support to a cause versus an …

Roller Derby As A Form Of Self-Empowerment: An Examination Of Female Athletes' Resilience To Intimate Partner Violence, Esmeralda Castillo

Theses and Dissertations

The purpose of this study is to explore if playing roller derby can yield one more resilient to Intimate Partner Violence (IPV). IPV is a major wellness concern to our present lives. However, there are many who experience violence, yet do not develop debilitating symptoms. The subject of resilience has emerged to account for this. Resilience can be interpreted as “bouncing back” from adversity, and adapting well to sources of stress (American Psychological Association, n.d.). Sport psychologists have recognized sport as a site for the development of resilient qualities. For females, team sports offer a context to experience empowerment. The …

Reanalyzing The Activity Anorexia Protocol Using An Addiction Theory, Rolando Alfredo Botello

Theses and Dissertations

One researched and developed phenomenon is activity anorexia (AA) in rats and its resemblance to the human pathology anorexia nervosa (AN). Researchers have long relied on this comparative model for AN as AA. This study aims to reanalyze the overt physiological phenomena of AA to test an addictive theory against the prevalent AA theory. Equal numbers of subjects could eat or run during a one hour feeding period and all activity was monitored per 30 minutes. Results showed that daily running correlated with an increase in food consumption with no effect of food suppression. The only factor that regressed to …

Cognitive Effects Of Short Duration Short Wavelength Visible Light, Sarah J. Bolton

Theses and Dissertations

This thesis research looks at the effects of short duration, high intensity, short wavelength light with the goal of determining if converting typically white colored lights in breakrooms and bathrooms to blue will cause workers who normally work in a low light environment to be more alert and productive. Sixteen participants were outfitted with Electroencephalography (and Electrooculography (EOG) equipment before being exposed to 200 lux of either 460 nm blue light or D6500 white light for 30 minutes. Afterwards, the light levels were changed to 3.5 lux of D6500 light and the participants were asked to perform six cognitive tests …

Is Self-Interest At The Root Of Political Behavior? An Examination Of The Effects Of Dark Personality And Demographics On Political Beliefs And Actions, Nathan A. S. Frishberg

Theses and Dissertations

Prediction of political behavior is of interest to scientists in the fields of psychology, sociology, and politics, as well as to the lay public. Previous research has connected personality to broad political leanings, but little if any published research has examined how personality relates to voting behavior. The current study built on earlier work by examining the connections among the Dark Triad of personality (psychopathy, narcissism, and Machiavellianism), demographics, specific political beliefs, and political behaviors. We hypothesized that dark personality would relate to political beliefs such that those higher on the Dark Triad would show stronger support for policies that …

Molecular Brain Adaptations To Ethanol: Role Of Glycogen Synthase Kinase-3 Beta In The Transition To Excessive Consumption, Andrew D. Van Der Vaart

Theses and Dissertations

Alcoholism is a complex neuropsychiatric disease that is characterized by compulsive alcohol use and intensifying cravings and withdrawals, often culminating in physiologic dependency. Fundamental alterations in brain chemistry underlie the transition from initial ethanol exposure to repetitive excessive use. Key mediators of this adaptation include changes in gene expression and signal transduction. Here we investigated gene expression pathways in prefrontal cortex and nucleus accumbens following acute or chronic ethanol treatment, to identify genes with potentially conserved involvement in the long-term response of the corticolimbic system to repeated ethanol exposure. We investigated Gsk3b, which encodes glycogen synthase kinase 3-beta, as a …

Aerobic Exercise Exposure Targeting Anxiety Sensitivity: Effects On Associated Health Behaviors In Young Adults, Autumn Lanoye

Theses and Dissertations

Anxiety sensitivity (AS) is associated with health behaviors such as low rates of physical activity, overeating, alcohol use, and poor sleep; however, interventions targeting AS via exercise-based interoceptive exposure have not assessed these as outcomes. In addition, previous studies are limited by brief follow-up periods. This study aimed to replicate previous aerobic exercise interoceptive exposures with an extended (6-week) follow-up and measurement of health behaviors.

Participants were 44 sedentary young adults with elevated AS randomized to intervention (6 20-minute sessions of moderate-intensity treadmill walking) or assessment-only control. Assessments took place at baseline, week 2 (post-treatment), week 4, and week 8 …

Shared Genetic And Environmental Influences On Fear, Anxiety, Posttraumatic Stress, And Brain Morphometry, Chelsea Sawyers

Theses and Dissertations

Anxiety disorders (ADs) and stress-related disorders are some of the most common psychiatric disorders in the United States. Like other c0mplex psychiatric illness, genetics and neuroimaging research has focused on understanding their underlying neurobiology. Areas within the fear-network play important roles in threat perception, fear conditioning/learning, cognitive processing, and modulation of fear responses including contextual modulation and extinction and have been implicated in ADs as well as stress disorders such as posttraumatic stress disorder (PTSD). The primary gap in the current search for underlying biological mechanisms is in whether biomarkers associated with disorders share genetic influences with the disorders they …

Genetic And Environmental Influences Of Bullying Involvement: A Longitudinal Twin Study, Ellyn Dunbar

Theses and Dissertations

Introduction—Bullying involvement is associated with many long-term adverse outcomes. Bullied children are at risk for internalizing disorders including anxiety, depression and suicidal behavior in childhood and adulthood. Bullies are also at risk for psychiatric disorders, specifically externalizing disorders. Bully victims—children who are both bullied and bullies—have a particularly poor prognosis, with a higher risk for internalizing and externalizing disorders. The purpose of this study is to study the epidemiology, risk of psychiatric disorders, and genetic and environmental influences of being bullied, a bully, and a bully victim—in the sample and individually in males and females.

Methods—Twins (N=2,844, aged …

Referential Indexing: The Role Of Space In Reference Processing, Cameron Smith

Theses and Dissertations

A number of studies have suggested that spatial representations are used during language comprehension in a number of different paradigms (e.g. Ferreira et al., 2008; Gunter et al., 2015). These studies have largely focused on the visual modality, suggesting that people may use spatial cues in the visual environment to aid them in language comprehension. Importantly, the primary modality of spoken language is audition, which raises the question of whether the reliance on spatial information is specific to referents that are visible or at least were visible at some point. Thus, in this study, we examined whether spatial representations are …

The Relationship Between Auditory Habituation And Anxiety In Autism Spectrum Disorder, David Nicholas Top

Theses and Dissertations

Many individuals with autism spectrum disorder (ASD) have atypical sensory processing and behaviors including sensory sensitivity and low registration of sensory stimuli as well as sensory seeking and avoiding behaviors. Additionally, many individuals with ASD have clinically distressing levels of anxiety. Previous research suggests that there is a link between abnormal sensory processing, anxiety, and ASD. The purpose of this study was to experimentally observe auditory sensory processing using pupillometry methods, between ASD, control, and high-anxious control groups. While a difference in tonic pupil size was observed, there were no reactivity or habituation differences between the groups. There were no …

Do Adults Diagnosed With Autism Spectrum Disorders Have An Advantage In Real-World Visual Search Tasks?, Nicholas Charles Russell

Theses and Dissertations

Individuals with Autistic Spectrum Disorders (ASD) often perform better than typically developing (TD) individuals in simple, albeit difficult, visual search tasks. This ability is often attributed to a lack of drive for coherence or superior local processing. We compare thirty adults with ASD with forty-nine TD individuals and twenty-seven adults with anxiety (ANX) across two real-world visual search tasks. Individuals had to find either a number superimposed over a real-world scene ("œno context" condition) or an object located in a contextually relevant location ("œcontext" condition). Each participant completed forty-one trials in each condition, each with a unique scene. Eye movements …

Investigating Motivations For Using Dating Websites And Geosocial Apps, Sean Calvin Aaron

Theses and Dissertations

Using the internet to meet dating partners is increasingly popular and may have ramifications that are not yet fully realized. Although many dating sites have been operating for years, new online dating platforms continue to draw millions of new users. By using a large sample of people who use online dating platforms (n=1,286) we identified similarities and differences in what motivates people to use geosocial apps and dating sites. Motivations previously considered in the literature were supported and brought together in a single theory driven confirmatory factor analysis for each type of dating platform. A motivation to seek amusement was …

Predictors Of Attitudes Towards Law Enforcement Among Hispanics Living In The U.S.-Mexico Border Region, Ivan Avila

Theses and Dissertations

Previous research has shown that minorities hold negative attitudes towards members of law enforcement. Contact with law enforcement has been shown as a major predictor of attitudes towards law enforcement among minorities. Research on this subject has primarily focused on Blacks’ attitudes towards police. Hispanics have been the focus of only a small amount of research on police contact and attitudes towards law enforcement. This study examined contact and attitudes towards several law enforcement entities: local police, state troopers, and border patrol agents. The current study took place along the U.S.-Mexico border, an area with a high population of Hispanics, …