Pharmacy and Pharmaceutical Sciences Commons^™

Post Total Hip Arthroplasty Pseudo- Tumour – A Rare Case Report., Dr Harisha H L, Dr Vikram Patil, Dr Gurumurthy B

Radiology Teaching Files

A 62-year-old female came with complaints of slow growing mass in the left hip region for 4-5 months, associated with dull aching pain. Range of movements were restricted due to pain and mass. She underwent Total Hip arthroplasty (THA) 11 months ago.

Caffey Disease – A Rare Case Report., Dr Sudha Kiran Das, Vikram Patil Dr

Radiology Teaching Files

8 month old male infant with localized swelling of the thigh, fever and irritability.

Brivaracetam To Treat Partial Onset Seizures In Adults., Dustin Latimer, David Le, Evan P. Falgoust, Patrick Ingraffia, Alaa Abd-Elsayed, Elyse M. Cornett, Rupin Singh, Joohee Choi, Giustino Varrassi, Adam M. Kaye, Alan D. Kaye, Latha Ganti

School of Pharmacy Faculty Articles

PURPOSE OF REVIEW: Seizures are a hyperexcitable, and hypersynchronous imbalance between excitatory and inhibitory factors (E/I imbalance) in neurotransmission, and epilepsy is the recurrent manifestation of seizures within a reasonable time frame and without being attributable to a reversible cause. Brivaracetam is a derivative of the antiepileptic agent, levetiracetam, that is used as adjuvant therapy for focal onset seizures. It was approved by the FDA in 2016 and has shown promising results with minimal adverse effect reactions in clinical trials.

RECENT FINDINGS: Brivaracetam has been used in multiple clinical trials at various dosages in adults that have partial-onset seizures refractory …

Suvorexant, A Novel Dual Orexin Receptor Antagonist, For The Management Of Insomnia., Andrew H. Han, Carolin R. Burroughs, Evan P. Falgoust, Jamal Hasoon, Grace Hunt, Juyeon Kakazu, Tim Lee, Adam M. Kaye, Alan D. Kaye, Latha Ganti

School of Pharmacy Faculty Articles

PURPOSE OF REVIEW: The present investigation is a comprehensive review regarding the use of Suvorexant for insomnia treatment. It covers the background, pathophysiology, and significance of addressing insomnia, the pharmaceutical details of Suvorexant, and its safety, efficacy, and implications in treating insomnia. We further discuss Suvorexant's role in targeting insomnia with other comorbidities.

RECENT FINDINGS: Insomnia refers to poor quality and/or quantity of sleep. While there are many existing treatments such as benzodiazepines, melatonin agonists, TCAs, and atypical antipsychotics used to target various receptors involved in normal induction and maintenance of sleep, Suvorexant is an antagonist that specifically targets orexin …

Review Of Interventional Therapies For Refractory Pediatric Migraine., Jacquelin Peck, Justin Zeien, Megha Patel, Elyse M. Cornett, Amnon A. Berger, Jamal Hasoon, Hisham Kassem, Jai Won Jung, Giovanni F. Ramírez, Paola Fugueroa, Neil R. Singhal, Jaehong Song, Adam M. Kaye, Alan D. Kaye, Sarang S. Koushik, Natalie H. Strand, Latha Ganti

School of Pharmacy Faculty Articles

This is a review of the latest and seminal evidence in pediatric migraine. It covers the etiology and pathophysiology known today, and then will review treatment options, efficacy and safety, quality of data and indications. Though migraine is usually regarded as an infliction in adults, it is not uncommon in the pediatric population and affects up to 8% of children. Children may experience migraine differently than adults, and present not only with headache but also frequent gastrointestinal symptoms. They are frequently shorter in duration than in adults. Traditional migraine treatment in adults is less effective in children. In this population, …

Global Investments In Pandemic Preparedness And Covid-19: Development Assistance And Domestic Spending On Health Between 1990 And 2026, Angela E. Micah, Kayleigh Bhangdia, Ian E. Cogswell, Dylan Lasher, Brendan Lidral-Porter, Ismaeel Yunusa Ph. D., Et Al.

Faculty Publications

Background The COVID-19 pandemic highlighted gaps in health surveillance systems, disease prevention, and treatment globally. Among the many factors that might have led to these gaps is the issue of the financing of national health systems, especially in low-income and middle-income countries (LMICs), as well as a robust global system for pandemic preparedness. We aimed to provide a comparative assessment of global health spending at the onset of the pandemic; characterise the amount of development assistance for pandemic preparedness and response disbursed in the first 2 years of the COVID-19 pandemic; and examine expectations for future health spending and put …

Pharmacological Management Of Disease By Overcoming Structural Adversity, Richard N Sifers

Center on Aging Staff Publications

In this issue of Cell Chemical Biology, Sun et al. utilize computational and protein expression analyses, plus pharmacological proteostasis network activation, to simultaneously correct two genetic diseases linked to a single protein rather than modify the responsible DNA.

Prescription Drug Retail Sales In The Mountain West, Caren Royce Yap, Caitlin J. Saladino, William E. Brown Jr.

Health

This fact sheet synthesizes data on prescription drug retail sales in the Mountain West (Arizona, Colorado, Nevada, New Mexico, and Utah). "Retail Sales for Prescription Drugs Filled at Pharmacies by Payer," a 2019 report by the Kaiser Family Foundation, includes data on the amount of retail sales for prescription drugs made in each state by dollar amount, along with the method of coverage, including commercial, Medicare, Medicaid and cash payment.

Evaluation Of Perceived Stress And Lifestyle Choices At The Beginning Of The Covid-19 Pandemic Among Students At A School Of Pharmacy In The United States, Crystal Deas, Melanie Manis

Health Professions Education

Purpose: Academic stress is a well-known component of life as a healthcare professional student, with the COVID-19 pandemic ushering in additional challenges. This study investigated trends in perceived stress, in relation to demographic and lifestyle choice variables among pharmacy students, during the initial months of the COVID-19 pandemic, at a U.S. school of pharmacy. Methods: A cross-sectional, descriptive study was conducted at Samford University’s McWhorter School of Pharmacy utilizing a web-based questionnaire that was distributed to all enrolled second-, third-, and fourth-year Doctor of Pharmacy students. The survey instrument contained 22 items and was arranged into three sections to characterize …

Potential Of Biduri Fiber (Calotropis Gigantea) As Material For Oil Spill Absorbent, Anne Sukmawati, Wulan Septiani

Journal of Materials Exploration and Findings

Biduri fiber (Calotropis gigantea) is a natural hollow fiber with hydrophobic and oleophilic properties potentially used as oil spilled sorbent from seawater. This study aims to determine the absorption capacity and efficiency of the Biduri fiber and membrane to fuel oil. Measurement of oil absorption to seawater was carried out at various fiber weights (0.5-1.5 g), fiber composition (50-95%), contact time (10-90 minutes), temperature (30 and 50°C), and compared with commercial products. The results showed that the fiber weight variation of 0.5-1.5 g has an average absorption efficiency of 96.67%, and the highest absorption was obtained in a weight of …

Exploring The Potential Of Intranasally Administered Naturally Occurring Quercetin Loaded Into Polymeric Nanocapsules As A Novel Platform For The Treatment Of Anxiety, Shady Swidan, Khaled Younis Mahmoud, Nahla Ahmed Elhesaisy, Abdelrahman Rashed, Ebram Mikhael, Mahmoud Fadl, Mahmoud Elsadek, Merna Mohamed, Merna Mostafa, Mohamed Hassan, Omar Halema, Youssef Elnemer

Pharmacy

Anxiety is one of the most prevalent forms of psychopathology that afects millions worldwide. It gained more importance under the pandemic status that resulted in higher anxiety prevalence. Anxiolytic drugs such as benzodiazepines have an unfavorable risk/beneft ratio resulting in a shift toward active ingredients with better safety profle such as the naturally occurring quercetin (QRC). The delivery of QRC is hampered by its low water solubility and low bioavailability. The potential to enhance QRC delivery to the brain utilizing polymeric nanocapsules administered intranasally is investigated in the current study. Polymeric nanocapsules were prepared utilizing the nanoprecipitation technique. The best …

A Longitudinal Observational Study Of Medical Cannabis Use And Polypharmacy Among Patients Presenting To Dispensaries In Pennsylvania, Emily R. Hajjar, Allison Herens, Erin L. Kelly, Kayla Madden, Jessica M. Lungen, Brooke K. Worster

College of Pharmacy Faculty Papers

Background: Cannabis use is increasing among adults to treat a variety of health conditions. Given the potential for interactions and adverse events, it is important to assess the use of medical cannabis along with other concomitant medications when assessing for polypharmacy. Methods: The objective of this observational, longitudinal study was to examine medical cannabis (MC) use along with concomitant medications over 12 months in patients with serious medical conditions enrolled in the Pennsylvania (PA) Department of Health’s (DOH) Medical Marijuana Program and to collect and catalog which forms of MC patients are taking along with their concomitant medications. Results: There …

Design And Synthesis Of Substituted N,3,3-Triphenylpropanamide And 1-Benzhydryl-N-Phenylazetidine-3-Carboxamide Analogs And Their Biological Evaluation, Michael Dorogan

Theses and Dissertations

As D₁R agonism has significant implications in the treatment of cognitive deficits, we sought to develop novel D₁R PAMs, through the derigidification of BMS D₁R PAM hit compound. While we were able to synthesize derigidified analogs of the BMS hit compound, derigidification did not produce active D₁R ligands.

Characterization, Antibacterial, Antioxidant, Antidiabetic, And Anti-Inflammatory Activities Of Green Synthesized Silver Nanoparticles Using Phragmanthera Austroarabica A. G. Mill And J. A. Nyberg Extract, Shady Swidan, Dina Khodeer, Sarah Shabayek, Ali Nasr, Roaa Khinkar, Mohammed Aldurdunji, Maryam Ramadan, Jihan Badr

Pharmacy

Introduction: Diabetes mellitus is a chronic metabolic disorder that exhibited great expansion all over the world. It is becoming an epidemic disease adding a major burden to the health care system, particularly in developing countries.

Methods: The plant under investigation in the current study Phragmanthera austroarabica A. G. Mill and J. A. Nyberg is traditionally used in Saudi Arabia for the treatment of diabetes mellitus. The methanolic extract (200 mg/kg) of the plant and pure gallic acid (40 mg/kg), a major metabolite of the plant, as well as their silver nanoparticle formulae (AgNPs) were evaluated for their antidiabetic activity.

Results …

Everything Won’T Be Okay: The Impact Of Therapists’ Justification Of The Mental Healthcare System On Their Racially Minoritized Patients, Rachel Ruth Buxbaum

Selected Full-Text Dissertations 2020-

Despite advances in mitigating explicit biases, research finds that therapists’ implicit bias has not significantly decreased in magnitude or impact on their clinical work over the past several decades. This bias propels, among other harms, misdiagnosis and overdiagnosis, weaker therapeutic alliances, poorer quality of care, and re-activation of racialized trauma among patients of color. Because of these disparities, many individuals develop experience-based cultural mistrust toward the healthcare system, which clinicians often misinterpret as psychopathology, perpetuating the mistreatment-to-mistrust cycle. This dissertation was the first to apply system justification theory to clinical process research, investigating whether and how therapists’ justification of the …

Effects Of Disulfiram On The Metabolome Of Mrsa, Surya Teja Naidu

Theses, Dissertations and Capstones

Disulfiram, known as Antabuse®, is an oral drug for the treatment of alcohol dependence. Previous studies have indicated that disulfiram (DSF) exhibits antibacterial effects, particularly against Gram-positive bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA). Our study delves into the antibacterial mechanism of DSF in MRSA through High-Pressure Liquid Chromatography (HPLC) metabolomics, investigating the underlying mechanism of DSF effects on thiamine and amino acid metabolism. Thiamine pyrophosphate (TPP) plays a crucial role as a cofactor for critical enzymes such as transketolase, pyruvate dehydrogenase, and 2-oxoglutarate dehydrogenase. These enzymes are integral to the carbohydrate metabolism process within bacterial cells. TPP also contributes …

Calcium Involvement In The Mechanism Of Action Of Limonene As A Penetration Enhancer For Topical/Transdermal Drug Products, Rucha Suresh Pathak

Selected Full-Text Dissertations 2020-

The addition of chemical permeation enhancers (CPE) to a topical dermatological formulation is the prevalent approach to improve permeability of active pharmaceutical ingredients (API) across the stratum corneum. Terpenes have been used as CPEs for a long time since they are safe and non-irritating. Limonene is one such terpene majorly found in essential oils extracted from citrus fruits and many varieties of cannabis. Studies performed using Limonene as PE show that Limonene was able to increase the flux of the drug by many folds. Limonene acts as an agonist to transient receptor potential ankyrin 1 (TRPA1) receptor – the activity …

Investigation Of Dosing Interval Differences For Nepafenac Ophthalmic Suspensions: A Suspension-Specific Pbpk Model With Improved In Vitro Dissolution Data, Xu Sun

Selected Full-Text Dissertations 2020-

Nepafenac is a nonsteroidal anti-inflammatory drug (NSAID) for the treatment of inflammation associated with cataract surgery. It is marketed as two ophthalmic suspensions—NEVANAC® (0.1% administered three times a day) and ILEVRO® (0.3% administered once a day). The primary mediator of pain relief is amfenac, which is a metabolite of nepafenac. The primary goal of this project was to explain how was the dosing interval affected by changes in formulation properties. The approach incorporated three novel elements. 1) A physiologically based pharmacokinetic (PBPK) model that is specific to this application for nepafenac and amfenac was constructed, which allowed tracking the specific …

Carboxylic Acids And Light Interact To Affect Nanoceria Stability And Dissolution In Acidic Aqueous Environments, Matthew L. Hancock, Eric A. Grulke, Robert Yokel

Nanobiotechnology Center Faculty Publications

Cerium atoms on the surfaces of nanoceria (i.e., cerium oxide in the form of nanoparticles) can store or release oxygen, cycling between Ce³⁺ and Ce⁴⁺; therefore, they can cause or relieve oxidative stress within living systems. Nanoceria dissolution occurs in acidic environments. Nanoceria stabilization is a known problem even during its synthesis; in fact, a carboxylic acid, namely citric acid, is used in many synthesis protocols. Citric acid adsorbs onto nanoceria surfaces, limiting particle formation and creating stable dispersions with extended shelf life. To better understand factors influencing the fate of nanoceria, its dissolution and stabilization have …

Gnetin C For Chemoprevention And Therapy Of Prostate Cancer, Gisella Campanelli

Selected Full-Text Dissertations 2020-

Prostate cancer is common among aging men. Despite current management, it continues to be associated with a high mortality rate. A need, therefore, exists for improved treatment approaches that target every stage of the disease. In this study, we investigated the efficacy of Gnetin C, a resveratrol dimer found abundantly in melinjo (Gnetum gnemon) seeds, across three different treatment modalities. The first involved a Gnetin C-supplemented diet as a chemopreventive strategy in a high-risk transgenic mouse model which overexpresses MTA1 on a background of Pten heterozygosity (R26MTA1; Pten+/f). The second involved the administration of Gnetin C by intraperitoneal (i.p.) injection …

Utilization Of Physiological Based Pharmacokinetic Modeling To Predict Systemic Exposure And Guide Dosing Decisions For Therapeutic Drug Monitoring Of Beta-Lactams In Critically Ill Patients, Hui Wei

Selected Full-Text Dissertations 2020-

Sepsis leads to a continuous pathophysiologic process that dysregulates host response which potentially causes significant organ damage and even death, especially respiratory, renal and cardiac failure. Changes in the clearance and volume of distribution are typically result in pharmacokinetic variabilities and often make it challenging for clinicians to appropriately dose beta-lactam antibiotics. Therapeutic drug monitoring (TDM) is necessary to further optimize beta-lactam pharmacokinetic/pharmacodynamic (PK/PD) parameters to improve clinical outcomes and reduce therapeutic failure.

Cefepime (CEF) and meropenem (MEM) primarily excreted by the kidney, and altered the kidney function of the ICU patients would affect the clearance of the medications. On …

Management Of Patients Treated With Antithrombotic Drugs In Dentistry: Comparison Of Sfco And Baos Recommendations, Meryem Lahlou, Yousef Naji, Ossama Nabih, Ihsane Ben Yahya

Health Sciences

Background Patients on antithrombotic drugs are at risk of thrombosis; when prescribed these medications they develop a risk of haemorrhage. To our knowledge, there is no published global consensus on the management of these patients and only expert panels guidelines exist. Objectives The aims of this study were to (1) compare the clinical guidelines issued by the French Society of Oral Surgery (SFCO) and the clinical guidelines issued by the British Association of Oral Surgery (BAOS), and (2) to summarize the guidelines recommendations. Methods This article is a descriptive comparative review based on published clinical guidelines issued by the French …

2023 Apothecary, Southwestern Oklahoma State University

Apothecary

It is with great honor that we present the 2023 Apothecary issue. This year's Apothecary was made possible by generous financial contributions from many stores, businesses, and Southwestern College of Pharmacy alumni. We greatly appreciate and thank you for your continued support.

The Apothecary staff would like to thank Dr. Les Ramos and Adina Foust. This process would not have been possible without their continuous support, patience, and behind-the-scenes efforts. We also want to thank the SWOSU Design Studio for their hard work in creating this year's fantastic cover and dividers. You always help bring our ideas to life and …

Artificial Intelligence In Dentistry : Knowledge And Perceptions Of Moroccan Students, Manal Elhijazi, Ihsane Benyahya

Health Sciences

Introduction: Artificial intelligence (AI) is a revolution in education, research and health. The aim of this study is to assess the views and perceptions of dental students regarding artificial intelligence and its impact on their future professional practice. Methods: A voluntary anonymous e-questionnaire was sent to all 4th and 5th year dental students of the Faculty of Dentistry after receiving a course on artificial intelligence. The questionnaire consisted of sections to assess students' knowledge of artificial intelligence and its possible applications in dentistry as well as ethical considerations. Statistical analysis of the data was carried out using SPSS version 23 …

Prepubertal Periodontitis In Children: For An Adequate Diagnosis And Optimal Care, F.Z. El Mouatarif, S. Chemlali, M. Hamza, J. Kissa, S. El Arabi

Health Sciences

Prepubertal periodontitis (PP) is a rare and rapid progressive condition found a young cohort of patients that results in destruction of the periodontal support of the primary dentition. Its generalized form, prepubertal periodontitis is often associated with a significant gingival tissue inflammation and fast bone loss with attachment loss leading to the tooth loss. The localized form of PP is characterized by a much more discreet inflammation and slow evolution. It can be associated with a known underlying systemic disease or may occur as part of a recognized syndrome or as an isolated finding. Different treatment modalities can be used …

Biological Parameters And The Histological Response In Rectal Cancer Treated By Neoadjuvant Chemoradiotherapy: A Moroccan Cohort, A. Naim, N. Bouanani, F. Safini, S. Mounaime, Soumaya Rafii, L. Lachker, F. Guessous, M. Khaliss, N. Tawfiq, A. Badou

Health Sciences

Introduction: Multimodal management of rectal cancer, combining neoadjuvant Radio chemotherapy followed by total Mesorectal therapy (TME), has been shown to improve locoregional control. However, the histological response is variable independently of the initial tumor stage. Some recent data suggest the usefulness of the lymphocyte-monocyte ratio (LMR), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) in predicting the histological response to neoadjuvant therapy. This study aimed to investigate the correlation between the complete histological response (pCR) after neoadjuvant radio chemotherapy and biological parameters (LMR, NLR and PLR) in rectal cancer patients.

PATIENTS AND METHODS: This retrospective study was conducted in three Moroccan …

Research News, Publications, 2023, Volume 1, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period of January 1 through March 31, 2023

Pharmacology Of Disulfiram As An Antibacterial Agent, Yogesh Meka

Theses, Dissertations and Capstones

Disulfiram (Antabuse®) is an oral prescription drug used to treat alcohol abuse disorder (AUD). Disulfiram (DSF) and its metabolites act on the body by inhibiting multiple enzymes involved in alcohol metabolism. This study aims to understand the pharmacology of disulfiram as an antibacterial medication. Previous studies on DSF showed antibiotic activity against multidrug-resistant Staphylococcus aureus strains (MRSA). The initial aim of this study was to decipher the mechanisms involved in inhibiting bacterial growth by DSF, which was done by performing biochemical studies. The studies revealed that DSF had antagonistic effects on redox buffering and energy production. Another aim of this …

Cancer Immunotherapy: A Breakthrough In Patient Care, Abdou-Samad Kone, Nour El Imane Issam Salah, Amina Ghouzlani, Abdallah Badou

Health Sciences

Cancer is one of the world's leading causes of death. Conventional therapies, such as surgical resection, radiotherapy, and chemotherapy, have improved patient management and have shown overwhelming progress. However, the incidence and mortality rates among cancer patients are still extremely high, at approximately 20,5 % and 10,6 % for both sexes, respectively. This may be due to the heterogeneity of tumors, their special microenvironment, and the development of resistance to certain conventional therapies. The concept of immunotherapy provided a new perspective on patient treatment. The interaction of tumor cells with their microenvironment depends on different factors and conditions that promote …

Medication Cost Reduction And Substitution Strategies Through The Mymetrx Program At Catholic Hospice, Ana M. Sanchez Monroig, Tracy Romanello, Joseph Solien, Sanaz Kashan, Angel E. Sanchez Artiles

East Florida Division GME Research Day 2023

Please see supplemental content for full abstract with references.

Introduction: As healthcare costs continue to rise, and with the growing awareness of the potential harms of polypharmacy, there is an ongoing need to explore strategies to optimize medication use in hospice settings. Strategies include deprescribing and medication substitutions, which ensure the safety and comfort of patients but can also lead to significant medication cost reduction.

Objectives: The primary objective of this study was to evaluate the impact of the MyMetRx program on medication cost reduction and medication substitutions within the context of Catholic Hospice. The program aimed to optimize medication …