Pharmacy and Pharmaceutical Sciences Commons^™

Insights Into The Role Of Microbial Infection In Recurrent Aphthous Stomatitis, Alaa W. Izzat, Batool Hassan Al-Ghurabi, Lina Sami Adham

Al-Esraa University College Journal for Medical Sciences

Ulcers that form in the oral mucosa are a hallmark of recurrent aphthous stomatitis (RAS), a chronic inflammatory disease. Up to 25% of the population may get aphthous ulcers, and recurrence rates within three months can reach 50%. Among women, it is more prevalent. Although the precise cause of RAS is not yet known, studies have shown that infections caused by microbes may be a major factor in the development of the disease. Infections caused by microorganisms have a complicated and multifaceted function in RAS, influencing the human immune system, the oral microbiota, and environmental variables. The purpose of this …

Anemia And Its Public Health Implications In Population Health, Sahar Abdul Wahab Alshaban, Raghda Shams Akram, Alaa Al-Noori, Noor Thair Tahir

Al-Esraa University College Journal for Medical Sciences

One to three percent of people worldwide suffer from anemia, a condition that impairs brain development, increases illness and mortality, and lowers labor productivity. Developing successful interventions to address specific causes of anemia and evaluating anemia management programs require an understanding of the numerous and diverse causes of anemia. The description and categorization of anemia, the physiological processes by which anemia arises, the importance of inherited hemoglobin abnormalities in specific populations, and a number of circumstances that contribute to the development of anemia are all covered. The conclusion of this review is as follows. Anemia is a significant global health …

Flowable Resin-Based Composites: From Fundamental Science To Modern Restorative Techniques, Farah Badri Mahdi, Hiba Ammar Yahya, Kawther Ali Adnan

Al-Esraa University College Journal for Medical Sciences

The function regarding flowable resin-based composites in restorative dentistry has considerably changed as they have been first introduced as low-viscosity alternatives in late 1990s. Because of the degraded mechanical properties and lower filler content, they were first just suitable for low-stress applications, like cavity liners. However, further advancements in the material science have produced highly-filled, next-generation flowables. The traditional trade-off between durability and fluidity is being challenged by materials’ improved properties, which include higher flexural strength and wear resistance. Furthermore, the development regarding bulk-fill flowables, which use advanced photoinitiators as well as polymerization modulators for the purpose of enabling uniform …

The Efficacy Of Traditional Versus Herbal Extracts Chelating Agents On Dentin Micro-Hardness, Sara Murtadha Abdul Hussein, Raghad A. Al-Hashimi

Al-Esraa University College Journal for Medical Sciences

Aim: To evaluate and compare the effectiveness of different chelating agents including EDTA, citric acid, green tea extract (Camellia sinensis, and chitosan on dentin micro-hardness.Materials and Methods: Fifty palatal roots of maxillary first molars were instrumented using ProTaper Next system and randomly divided into five groups (n = 10) according to the final irrigation protocol: Group A (NaOCl +distilled water - Negative control), Group B (17% EDTA-Positive control), Group C (10% citric acid), Group D (green tea extract), and Group E (0.2% chitosan nanoparticles). Dentin micro-hardness was measured using Vickers hardness tester. Data were analyzed using one-way ANOVA and …

Sport And Athletes Under The Shadow Of Covid-19 Pandemic, Abdul Razzaq Jabr Al Majidi, Rebah N. Algafari, Rehab S. Ramadhan, Rafia S. Fathi

Al-Esraa University College Journal for Medical Sciences

The end of 2019 witnessed the announcement of worldwide pandemic Covid-19 around the world that influenced every part of human life. Sports and athletes were one of these parts affected by the pandemic since many competitions and tournaments were canceled or postponed and put athletes under spotlight as an important category susceptible to infection or as they been admired and loved by the population may help in spreading infection. Following reports dealing with athletes, exercise, immunity, and severity of infection, the following points were concluded: first, moderate practicing boosts immune system and make the human less affected by Covid-19 infection …

Gamma-Ray Knife And Application Features In Medicine, Yaqoob. M. Baqer, Ayad A. Al-Taweel

Al-Esraa University College Journal for Medical Sciences

Gamma Knife radiosurgery (GKR) is a sophisticated procedure that delivers a concentrated dose of ionizing radiation to a pre-identified therapeutic target. A non-invasive radiation therapy intended to address numerous disorders impacting the brain and upper spine. The inaugural GKR facility was established by Leksell in 1951, during an era when intracranial surgical interventions resulted in significant morbidity and mortality. Initially intended for the management of functional problems, it was first employed to treat a patient with a craniopharyngioma and another with a pituitary adenoma. Initially, gamma radiation from radioactive cobalt sources was used instead of proton beams and linear accelerators. …

Comprehensive Review Of Facial Asymmetry: Etiology, Diagnosis, And Management Strategies, Hiba Ammar Yahya, Sara M. Al-Mashhadany

Al-Esraa University College Journal for Medical Sciences

A certain degree of facial asymmetry is not only a normal biological variation but can also contribute positively to perceived beauty. However, delineating the precise boundary between ‘normal’ asymmetry and ‘abnormal’ asymmetry, the latter necessitating clinical intervention, remains a complex and subjective endeavor. Minor facial asymmetry is commonly observed even in individuals with aesthetically attractive faces, typically remaining indiscernible and thus not requiring any treatment. The determination of when ‘normal’ asymmetry transitions into ‘abnormal’ is frequently influenced by clinician’s aesthetic judgment and, critically, the patient’s perception of imbalance. The perceived abnormality of facial asymmetry is, therefore, highly dependent on individual …

Genetic Basis Of Diabetic Retinopathy: Uncovering Molecular Links And Risk Factors—A Review Article, Ammar Kadhim Alzubaidi

Al-Esraa University College Journal for Medical Sciences

Genetics play a major role in diabetic retinopathy DR, which is a leading cause of blindness worldwide. Although the factors such as how long a person has had diabetes and high blood sugar are important, the wide variation and progression of DR indicates to a clear genetic influence. Early studies focusing on a few candidate genes (such as VEGF) produced conflicting and population-dependent results. This confirmed the multifactorial nature of the disease and the limitations of small-scale studies. Conversely, genome wide association studies (GWAS) have provided more consistent findings in detection a new genes related to DR. For example, rs2239785 …

Relationship Between Hashimoto Thyroiditis And Some Immunogenic Markers, Amani Mahmood Tuama, Aliyaa Taresh Obaid

Al-Esraa University College Journal for Medical Sciences

Hashimoto thyroiditis (HT) is a common autoimmune disorder, affecting women 7–10 times more often than men, that develops because of genetic susceptibility, X chromosome inactivation patterns modulated by environmental factors as well as micro biome composition, and leads to an imbalance in self-tolerance mechanisms. The consequential thyroid infiltration by lymphocytes, potentiated by antibody-mediated autoimmune response through the antibodies against thyroid peroxidase (TPO Abs), leads to a destruction of thyrocytes. The presence of TPO Abs is associated with a 2 to 4-fold increase in the risk of recurrent miscarriages and preterm birth in pregnant women. Aim: The aim of the study …

Wettability Assessment Of Room-Temperature Soft Liners Incorporated With Strontium Titanate Nanoparticles, Zakaria Azzam Alabed, Aseel Mohammed Al-Khafaji

Al-Esraa University College Journal for Medical Sciences

Background: Soft denture liners are widely used in prosthodontics for their ability to cushion masticatory forces and enhance comfort in patients with compromised oral mucosa. However, conventional liners often exhibit limitations such as poor adhesion to the denture base, microbial colonization, and inadequate mechanical stability. Materials and Methods: Strontium titanate (SrTiO₃) nanoparticles were incorporated into a self-cured soft denture liner. Three equal groups of fifteen specimens were created, each of which contained 0%, 1%, and 1.5% SrTiO₃ by weight. All procedures were conducted under simulated intraoral temperature, following manufacturer guidelines. Results: The analysis revealed statistically significant differences …

Gpbb And Tg/Hdl Ratio As Emerging Indicators In Iraqi Patients Diagnosed With Acute Coronary Syndrome, Alzahraa Ahmed Ammash, Walaa Ismael Jassim, Mohammed Mezher Hussien

Al-Esraa University College Journal for Medical Sciences

Background: ACS is one of the most critical health challenge worldwide. It consists of several conditions resulting from a sudden reduction in blood flow to the heart muscle. The early diagnosis is essential to improve the diagnostic accuracy and risk stratification. This relies on finding early, sensitive and specific biomarkers. Among these biomarkers are GPBB (glycogen phosphorylase isoenzyme BB), also referred to as the brain-type isoform (PYGB), which is primarily expressed in the brain and heart tissues and the triglyceride-to-HDL cholesterol ratio (TG/HDL). GPBB has recently gained interest as a potential early marker for myocardial ischemia with high novelty, whereas …

The Effect Of VItex Agnus-Castus L. Medium On In Vitro Oocyte Maturation Rate, Nabaa Al-Nawab

Al-Esraa University College Journal for Medical Sciences

In vitro maturation (IVM) of oocytes offers a possible alternative to traditional in vitro fertilization (IVF) for individuals susceptible to ovarian hyperstimulation syndrome (OHSS). The use of plant-derived bioactive composites as supplements in culture media has attracted attention for their potential to enhance oocyte developmental competence in the absence of synthetic hormones. This investigation aims to examine the effect of Vitex agnus-castus L. (VAC) aqueous extract on the in vitro maturation rate of murine oocytes. A total of 16 mature female mice were divided into two groups, 8 animals in each group. Immature oocytes were collected and cultivated for …

Detection Of Uropathogenic Bacteria In The Samples Of Iraqi Male Patients, Marwa M. Al-Attar

Al-Esraa University College Journal for Medical Sciences

Prostate disease is found in elderly persons, the prostate is a male reproduction organ. It is approximately the size of a plum that may be found near the bladder’s base. It is the primary cause of the three commonest diseases: prostatitis, benign prostatic hyperplasia (BPH), and prostate cancer (PC). This study designed to identify the uropathogenic bacteria that caused prostate disorders in Iraqi male samples. A current study included 180 subjects from the Iraqi population, 135 patients were divided into three groups (prostate cancer, benign prostate hyperplasia and prostatitis), according to signs, symptoms and diagnosis by the physician each group …

Prevalence Of Aminoglycoside Resistance Genes Among Esβl Producer P. Aeruginosa In Burn Cases, Yasser Rabee Ibraheem, Majida Malik Alshammari

Al-Esraa University College Journal for Medical Sciences

Pseudomonas aeruginosa recurrently develops resistant towards aminoglycosides by gaining of aminoglycoside modifying enzyme (AME) genes. The study aimed to assess the antibiotic susceptibility profile of P. aeruginosa isolated from burn infections in hospitals in Baquba, AL Najaf and Karbala. Detection of genes that mediate the production of AMEs. 175 Burn swab (110 males and 65 females) were collected then cultured on MacConkey‘s and Blood agar for primary culture, and Cetrimide agar was used to isolate and purify the bacteria and incubated aerobically at 37°C for 24 hours. Then, Vitek 2 system to validate the results. Results revealed that 70 (40%) …

Antimicrobial Resistance Trends And Sccmec Typing Among Mrsa-Infected Diabetic Foot Cases In The Al-Najaf Community, Zahraa Hashim Abd Zaid Al-Sharoofi, Majida Malik Alshammari, Mohammed Abdzaid Akool

Al-Esraa University College Journal for Medical Sciences

Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of healthcare-associated infections worldwide, often linked to multidrug resistance and limited treatment options. This cross-sectional study aimed to investigate the molecular characteristics and antimicrobial resistance profiles of MRSA isolates recovered from diabetic foot ulcers in Al-Najaf Governorate, Iraq. A total of 76 S. aureus isolates were collected from patients attending three major hospitals. Identification was conducted using conventional microbiological methods, and methicillin resistance was confirmed phenotypically via cefoxitin disc diffusion and genotypically through PCR amplification of the mecA gene. SCCmec typing was performed using multiplex PCR. The findings revealed that 92.1% of …

Biological Impact Of Chemical-Based Medications On Human Dna: Mechanisms, Clinical Consequences, And Research Gaps, Israa M. Ali Alameen, Sumayah Mahmood Rafid, Baqer Khaled Hothefa

Al-Esraa University College Journal for Medical Sciences

Background: Not long ago DNA has become the subject of interest for the pharmaceutical companies, that because its proven by medical and scientifical fields, that it’s the fundamental sources of proteins, which is the basic element in the cell, therefore, the interaction between the Drug and the deoxyribonucleic acid (DNA) is very important to therapeutic regimens success but in other side it has a dangerous effect like toxicity, and long-term genomic instability. Objective: The aim of this review is to focus on the different studies which examines the effect of different drug like the chemotherapy, antivirals, antibiotics, and immune-suppressants on …

Uses Of Digital Technologies For Maxillofacial Prosthesis Manufacturing, Reem Abdulrahim Alobaidy

Al-Esraa University College Journal for Medical Sciences

Digital technologies play a great role in prosthodontics generally and specifically in maxillofacial prosthetics, this revolutionary approach has become an important way for rehabilitation of different modalities in maxillofacial prosthetic field. In this article we will summarize many contents of dental researches, web researches, on-line data bases, discussions of experts and clinicians with the most recent publications and new products releases and evaluate them. Describing the techniques in designing and fabrication for facial prosthesis applying computer aided method and manufacturing (CADCAM). As the development of digital dentistry took apart to overcome complexity of prosthesis construction and the limited expertise in …

Distribution Of Secretor Status In A Sample Of Iraqi Population Based On Their Gender, Blood Groups And Body Mass Index, Ola Amer Jasim

Al-Esraa University College Journal for Medical Sciences

The ABO blood group system was divided into four phenotypes i.e., A, B, AB, and O following its discovery by Karl Landsteiner in 1990. Antigens of the ABO blood group can be found in bodily fluids such as the salivary and digestive fluids. Furthermore, People are classified as ``secretors'' or ``non-secretors'' based on their ability to secrete (ABO blood group) antigens in body fluids. The control-based study was conducted on 342 Iraqi adults who were presented at educational institutions. The study lasted from October 2022 to February 2023 and aimed to determine the relationship between secretor status with (gender, blood …

Synthesis Of A New Composite Nanomaterial Consisting Of Bentonite-Polyethylene Glycolphthalate, Tariq Yassin Mahmoud

Al-Esraa University College Journal for Medical Sciences

In this study, a new composite material was characterized and prepared by polymerizing ethylene glycol located among bentonite layers with phthalic anhydride. The results showed that the polymer bonds with the clay structure through hydrogen bonding. The polymerization process led to the destruction of the three-dimensional crystal structure of the clay and the isolation of its layers in the form of two-dimensional nanoscale shells. The growth of the polymer around the isolated clay layers increased the total particle size at the microscopic scale.

Comparative Study Between Attendance Patients To Babylon Teaching Hospital In Babylon And Al-Alawiyah Teaching Hospital In Baghdad Infected With Intestinal Parasites, I. M. Al-Saqur, E. M. Abdul Ameer, A. N. Al-Thwani, S. S. Hassan, Z. J. Mazher, A. A. Abd Al-Hussein, R. A. Aziz, N. M. Butrus

Al-Esraa University College Journal for Medical Sciences

This study included detecting the rate of human infection with intestinal parasites on patients arriving the laboratories of Babylon Teaching Hospital and Al-Alawiya Children's Hospital In Baghdad for the period from beginning of January 2023 to the end of December 2023. The total number of examined people in the former hospital was 796, infected patients were (384 with 48.49%), The highest percentage of parasites recorded were Endameba coli (85.47%) followed by E. histolytica (63.44%) then Trichuris trichura (45.9%) the others parasites were Giardia lambelia (39.09%) Enterobius vermicularis (34.71%), Chilomastix mesnili (31.5%), Ancylostoma duodenale (19.04%), Hymenolpis nana (18.48%), Ascaris lunmbricoides …

Study Of Urinary Tract Infection Among Pregnant Women Attending Al Elywiah Maternity Hospital In Baghdad/Iraq, Abass T. Al-Joudi, Randa Abdal Jaleel Habeeb, Ali Dawoud Ramadan, Hussein Ibrahim Aliwi

Al-Esraa University College Journal for Medical Sciences

Urinary tract infection is a vary series symptom that pregnant women must be looking for treat as it effects in pregnant woman health baby for a long of 9 months of pregnant, this symptoms effect in different way on baby and mother health. The study on pregnant women carried out by examination of fresh samples taken from registered mothers in Maternity hospital and then carried varies analysis, physical, chemical and microscopic tests with bacterial and antibiotic sensitivity tests About 70 Urine sample taken from pregnant women that follow up their health in Al Elywiah maternity Hospital, the rested women …

Evaluation Of Phytotoxicity Of Greenly Treated Domestic Wastewater By Spent Plant Leaf Powders, Adnan Ahmad Ali-Nizam, Magdi Amin, Isam Shaker Hemza

Al-Esraa University College Journal for Medical Sciences

Health and ecosystems face widespread, impactful problems. Untreated wastewater is discharged into waterways and lands in most developing countries, containing harmful substances and pathogens. WHO estimates that nearly 1.7 billion people drink contaminated water in developing countries, and that contamination leads to nearly 500,000 diarrheal deaths each year. However, existing treatment methods are insufficient to remove dissolved substances and specific pollutants; they are very expensive, energy-intensive, require advanced technologies, and high operational skills. The process of removing pollutants from wastewater using plant waste powders involves a combination of mechanisms, including adsorption, complexation, and ion exchange. These processes are characterized by …

Identification Of Milk And Milk Product Adulteration By Molecular Methods, Isam Shaker Haza, Saad Sabah Fakhry

Al-Esraa University College Journal for Medical Sciences

The polyacrylamide gel electrophoresis sodium dodecylsulfate (SDS-PAGE) has been extensively used to separate native and denaturalized proteins. In various countries this has been useful to detect milk adulteration with whey, which is a fraud according to the current legal standards. The presence of glycomacropeptide (GMP) constitutes a marker of adulteration. It is released to the serum due to the hydrolysis of --casein peptide catalyzed by rennin incheese elaboration. In this work, the GMP detection was standardized as a pasteurized milk adulteration index, by means of GMP isolation with sequential precipitation in trichloroacetic acid at 24% and 50%, treatment with ethanol-ether …

Impact Of Hypocalcemia On Dickkopf-Related Protein 1 And Hmgb1 In Transfusion-Dependent Thalassemia Patients, Haneen Azeez Falih

Al-Esraa University College Journal for Medical Sciences

Background: Transfusion-dependent thalassemia (TDT) is associated with various symptoms including anaemia and bone problems. There is a need for more biomarkers of calcium disorders in TDT patients. In the present study, DKK 1 and HMGB1 are studied in TDT patients with hypocalcemia (TDT+Hypocalcemia) and normocalcemia (TDT+Normocalcemia) as a function of inflammation. Methods: TDT patients were classified according to the cut-off value (2.12 mM) of the adjusted serum calcium (Adj.T.Ca) into TDT+Normocalcemia (n = 54) and TDT+Hypocalcemia (n = 41) groups. Forty healthy controls have participated in the present study. DKK1 and HMGB1 were measured using the ELISA technique. Results: Both …

The Impact Of Utilizing Injectable Platelet-Rich Fibrin And Collagen Plugs For Maintaining The Tooth Extraction Socket: A Review Study, Esraa Hameed Hassan, Ali H. Abbas Alhussaini

Al-Esraa University College Journal for Medical Sciences

Tooth extraction initiates a cascade of biological changes that result in alveolar bone resorption, compromising both the esthetic and functional outcomes of future dental rehabilitations, particularly implant placement. Socket preservation strategies have emerged as crucial interventions aimed at minimizing post-extraction ridge collapse. This review explores the synergistic effects of injectable platelet-rich fibrin (I-PRF) and collagen plugs in enhancing socket preservation outcomes. Collagen plugs serve as biocompatible scaffolds, promoting hemostasis, cellular migration, and angiogenesis, while supporting soft tissue healing and bone regeneration. Concurrently, I-PRF-an autologous, growth factor-rich biomaterial-provides a dynamic reservoir of platelets, leukocytes, and key cytokines such as Platelet-Derived Growth …

Impact Of Insulin Resistance In Pcos (Lh/Fsh) In A Group Of Woman In Baghdad City, Roua Shehab-Aldeen Ahmed, Fatima Amer Abd Aljabar, Nadia Mohammed Mahdi Al-Shakir

Al-Esraa University College Journal for Medical Sciences

Background: Polycystic ovarian syndrome is an endocrinological disorder influencing ladies, and it is the foremost common cause of menstrual unsettling influence amid the regenerative age. Polycystic ovary disorder (PCOS) is in fact a chronic form of anovulation that is usually observed besides a large spectrum of clinical symptoms and signs. Objectives: The study's main goal is to evaluate the hormonal indicators of ``PCOS'' and insulin resistance and determine how insulin resistance affects these hormones. Materials and methods: This study included 130 women, aged 19--38, who were separated into three bunches: 40 women with ``PCOs'' who were treated with metformin and …

Exploring The Role Of Hepcidin And Some Biochemical Indicators In Β-Thalassemia Major Patients With Negative And Positive Entamoeba Histolytica, Jafar Jamal Abdullah, Mohammed Mezher Hussain, Abdul Rasool Kh. Saeed

Al-Esraa University College Journal for Medical Sciences

Thalassemia syndromes encompass a wide range of hemoglobin disorders characterized by either the absence or diminished production of normal globin chains. Hepcidin, a peptide produced by the liver with antimicrobial properties, is mainly synthesized by hepatocytes situated near the portal veins, which are responsible for transporting dietary iron, as well as by Kupffer cells. Before blood transfusions, increased erythropoietic activity leads to a reduction in hepcidin, resulting in lower hepcidin levels that enhance the absorption of dietary iron. Parasite protozoa depend on iron for their survival, as it plays a crucial role in the growth and enzymatic functions of E. …

Estimation Of The Immunological Markers (Ctla4 And Vegf) Of The Adjuvant Ovarian Cancer In Iraqi Women Patients, Yasir Naeem Khlaif, Mayada Noori Iqbal, Hind Jaber Hassoon

Al-Esraa University College Journal for Medical Sciences

Background: The most frequent cause of death for females with gynecological cancer diagnoses is ovarian cancer (OC). Furthermore, generally speaking, it ranks as the 5^th most frequent cause of death for females. The majority of cases had advanced diagnoses, which worsens the disease's prognosis. Objectives: The aims of the study is to Estimate the immunological markers “cytotoxic T lymphocyte associated antigen 4” (CTLA4) and “Vascular Endothelial Growth Factor” (VEGF) in Adjuvant women (OC). Materials and methods: 90 Adjuvant women OC were included in this study (30 of them were taking (1-6) dose of biotherapy Bevacizumab (Avastin) Group 1 (G1), …

Determination Of The Hematological And Biochemical Parameters Associated With Liver Cancer, Hepatitis Types B, And C In Iraqi Patients, Saja Khudhier Essa Al-Juboori, Shaymaa Ismael Kadhum Al-Juboori

Al-Esraa University College Journal for Medical Sciences

Hepatocellular carcinoma (HCC) is the second most common cancer in humans and the fifth most prevalent worldwide. Although the survival rate of HCC has increased over time, postoperative recurrences remain high after a decade. HCC can be caused by both viral and non-viral diseases. There are two major global risk factors for HCC these are: hepatitis B virus (HBV) and hepatitis C virus (HCV). As part of routine health exams, complete blood counts can detect a variety of disorders, including infections, anemia, immune system disorders, and blood cancers. A complete blood count (CBC) can be used to perform a biochemical …

High-Performance Liquid Chromatography Analytical Techniques For Determining The Various Diabetic Type 2 Medications: A Review Article, Mohammed Abdullah Ahmed, Mohammed J.M. Hassan, Hayder O. Hashim, Ashour H. Dawood

Al-Esraa University College Journal for Medical Sciences

A metabolic illness known as diabetes mellitus (DM) is brought on by the body's decreased secretion and/or activity of the hormone insulin. The condition worsens, pathological alterations in the body, such as nephropathy, retinopathy, and cardiovascular problems, become inevitable. Type I and II DM are the two primary subtypes of DM. Oral hypoglycaemics are used to treat type II diabetes, while insulin replacement therapy is typically used to treat type I diabetes. Patients typically receive dual drug treatments. Despite using oral hypoglycemic medications as monotherapy, have not been able to accomplish their therapeutic goals with first-line therapy.

In the current …