Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Science & Technology (9)
- Life Sciences & Biomedicine (8)
- Urology & Nephrology (5)
- APOL1 RISK VARIANTS (2)
- FOCAL SEGMENTAL GLOMERULOSCLEROSIS (2)
-
- KIDNEY-DISEASE (2)
- ANAPHYLACTOID REACTIONS;; PARENTERAL IRON;; DEXTRAN;; GUIDELINES;; SAFETY;; ANEMIA;; SEVERITY;; PRODUCTS;; UPDATE;; Hematology (1)
- ANCA - associated vasculitis;; Anti-GBM disease;; Gpa;; Necrotizing RPGN;; dual antibody-positive disease (1)
- APOL1 (1)
- APOL1 risk variants;; kidney disease;; podocyte;; necrosis;; lysosomal;; membrane permeability;; HIV-ASSOCIATED NEPHROPATHY;; TRYPANOSOME LYTIC FACTOR;; CHRONIC;; KIDNEY-DISEASE;; LIPID-BINDING PROTEIN;; AUTOPHAGIC CELL-DEATH;; STAGE;; RENAL-DISEASE;; AFRICAN-AMERICANS;; HUMAN SERUM;; TRYPANOLYTIC FACTOR;; APOLIPOPROTEIN-L;; Physiology;; Urology & Nephrology (1)
- APOL1;; Risk variants;; Domain;; Integrity;; Toxicity;; hiv-associated nephropathy;; lipid-binding protein;; autophagic;; cell-death;; apolipoprotein-l gene;; kidney-disease;; african-americans;; l1;; association;; expression;; tissue;; Pathology (1)
- Actin cytoskeleton;; IQ domain GTPase-activating protein 1;; Nephrin;; Podocyte;; focal segmental glomerulosclerosis;; nephropathy;; components;; proteins;; disease;; phosphorylation;; mechanisms;; binding;; models;; Cell Biology (1)
- Acute kidney injury;; alveolar hemorrhage;; starry-sky;; subepithelial deposits (1)
- Adaptive cell transfer (1)
- Administration (1)
- Aflibercept (Eylea) (1)
- Aged;; Cohort Studies;; Disease Progression;; *Electronic Health Records;; Female;; Glomerular Filtration Rate;; Humans;; Longitudinal Studies;; Male;; Middle Aged;; Models (1)
- Albumin infusion;; cirrhosis;; hypervolemic hyponatremia;; hyponatremia;; salt poor albumin (1)
- Anemia;; erythropoiesis-stimulating agent;; ferric pyrophosphate citrate;; hemodialysis;; iron (1)
- Angiotensin II;; angiotensin II type 1 receptor blockade;; glucose;; silencing mediator of retinoic acid and thyroid hormone receptor;; vitamin D receptor;; vitamin-d-receptor;; hiv-associated nephropathy;; nuclear;; hormone-receptors;; co-repressor;; diabetic-nephropathy;; podocytes;; activation;; hdac3;; d-3;; phosphorylation;; Physiology;; Urology & Nephrology (1)
- Antineoplastic Agents/*adverse effects;; Glomerulonephritis/*etiology;; Hematopoietic Stem Cell Transplantation/*adverse effects;; Humans;; Kidney Glomerulus/*drug effects;; Neoplasms/*complications/*therapy;; Paraneoplastic Syndromes/*etiology (1)
- Apol1;; HIV-associated nephropathy;; heroin nephropathy;; opiates;; podocytes (1)
- Apolipoprotein L1;; autophagy;; endocytosis;; cytotoxicity;; RNA splicing;; hiv-associated nephropathy;; chaperone-mediated autophagy;; trypanosome;; lytic factor;; lipid-binding protein;; l gene-cluster;; cell-death;; lysosomal biogenesis;; kidney-disease;; apol1;; variants;; Cell Biology;; Physiology (1)
- Apolipoproteins/genetics/*metabolism;; Cell Line;; Culture Media (1)
- Apoptosis;; hypomagnesemia;; inflammation;; nephrotoxicity;; oxidative;; stress;; ORGANIC CATION TRANSPORTER-2;; INDUCED RENAL INJURY;; INDUCED;; NEPHROTOXICITY;; OXIDATIVE STRESS;; INFLAMMATORY RESPONSE;; TESTICULAR;; CANCER;; GENE-EXPRESSION;; DEFICIENT RATS;; CELL APOPTOSIS;; BLOOD-PRESSURE;; Physiology;; Urology & Nephrology (1)
- Arginine vasopressin;; cell proliferation;; chronic kidney disease;; hypertension;; inflammation;; metabolic syndrome;; osteopenia;; social behavior (1)
- Attitude to Computers;; *Data Display;; *Electronic Health Records;; Humans;; Natural Language Processing;; Software;; Surveys and Questionnaires;; *User-Computer Interface;; electronic health record;; summarization;; visualization (1)
- BEVACIZUMAB (1)
- BLOCKER USE (1)
- BLOOD-PRESSURE (1)
Articles 91 - 92 of 92
Full-Text Articles in Nephrology
Magnesium Protects Against Cisplatin-Induced Acute Kidney Injury By Regulating Platinum Accumulation, M. H. Solanki, P. K. Chatterjee, M. Gupta, X. Y. Xue, A. Plagov, M. H. Metz, R. Mintz, P. C. Singhal, C. N. Metz
Magnesium Protects Against Cisplatin-Induced Acute Kidney Injury By Regulating Platinum Accumulation, M. H. Solanki, P. K. Chatterjee, M. Gupta, X. Y. Xue, A. Plagov, M. H. Metz, R. Mintz, P. C. Singhal, C. N. Metz
Journal Articles
Despite its success as a potent antineoplastic agent, similar to 25% of patients receiving cisplatin experience acute kidney injury (AKI) and must discontinue therapy. Impaired magnesium homeostasis has been linked to cisplatin-mediated AKI, and because magnesium deficiency is widespread, we examined the effect of magnesium deficiency and replacement on cisplatin-induced AKI in physiologically relevant older female mice. Magnesium deficiency significantly increased cisplatin-associated weight loss and markers of renal damage (plasma blood urea nitrogen and creatinine), histological changes, inflammation, and renal cell apoptosis and modulated signaling pathways (e.g., ERK1/2, p53, and STAT3). Conversely, these damaging effects were reversed by magnesium. Magnesium …
Mutations In The Gene That Encodes The F-Actin Binding Protein Anillin Cause Fsgs, R. A. Gbadegesin, G. Hall, A. Adeyemo, N. Hanke, I. Tossidou, J. Burchette, G. H. Wu, A. Homstad, P. C. Singhal, M. P. Winn, +17 Additional Authors
Mutations In The Gene That Encodes The F-Actin Binding Protein Anillin Cause Fsgs, R. A. Gbadegesin, G. Hall, A. Adeyemo, N. Hanke, I. Tossidou, J. Burchette, G. H. Wu, A. Homstad, P. C. Singhal, M. P. Winn, +17 Additional Authors
Journal Articles
FSGS is characterized by segmental scarring of the glomerulus and is a leading cause of kidney failure. Identification of genes causing FSGS has improved our understanding of disease mechanisms and points to defects in the glomerular epithelial cell, the podocyte, as a major factor in disease pathogenesis. Using a combination of genome-wide linkage studies and whole-exonne sequencing in a kindred with familial FSGS, we identified a missense mutation R431C in anillin (ANLN), an F-actin binding cell cycle gene, as a cause of FSGS. We screened 250 additional families with FSGS and found another variant, G618C, that segregates with disease in …