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Zucker School of Medicine at Hofstra/Northwell
Apolipoprotein L1;; autophagy;; endocytosis;; cytotoxicity;; RNA splicing;; hiv-associated nephropathy;; chaperone-mediated autophagy;; trypanosome;; lytic factor;; lipid-binding protein;; l gene-cluster;; cell-death;; lysosomal biogenesis;; kidney-disease;; apol1;; variants;; Cell Biology;; Physiology
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Full-Text Articles in Nephrology
Exon 4-Encoded Sequence Is A Major Determinant Of Cytotoxicity Of Apolipoprotein L1, A. K. Khatua, A. M. Cheatham, E. D. Kruzel, P. C. Singhal, K. Skorecki, W. Popik
Exon 4-Encoded Sequence Is A Major Determinant Of Cytotoxicity Of Apolipoprotein L1, A. K. Khatua, A. M. Cheatham, E. D. Kruzel, P. C. Singhal, K. Skorecki, W. Popik
Journal Articles
The apolipoprotein L1 (APOL1) gene (APOL1) product is toxic to kidney cells, and its G1 and G2 alleles are strongly associated with increased risk for kidney disease progression in African Americans. Variable penetrance of the G1 and G2 risk alleles highlights the significance of additional factors that trigger or modify the progression of disease. In this regard, the effect of alternative splicing in the absence or presence of G1 or G2 alleles is unknown. In this study we investigated whether alternative splicing of non-G1, non-G2 APOL1 (APOL1 G0) affects its biological activity. Among seven APOL1 exons, exons 2 and 4 …