Infectious Disease Commons^™

Two Attempted Investigations Into The Complexities Of Staphylococcal Disease, Harriet M. Sands

Loma Linda University Electronic Theses, Dissertations & Projects

Two investigations were attempted to add insight into the multiple problems related to staphylococcal infections. A comparison study was made of the hospital expenses of a group of hospitalized patients whose apparently clean surgical wounds developed staphylococci, and a comparable group whose surgical wounds healed without infection.

A review of approximately one hundred medical records for the pilot study revealed three instances of staphylococcal infection in apparently clean surgical wounds. The three patients required 239 days of hospitalization at a total hospital cost of $13,702.11. The three comparable patients whose surgical wounds remained clean required 27 days hospitalization at a …

Identification Of Emotional Needs Of Patients With Infectious Hepatitis, Elizabeth Tidmore Shafqat

Loma Linda University Electronic Theses, Dissertations & Projects

It was the purpose of this study to identify the emotional needs of patients with infectious hepatitis through the use of nursing process studies. The information obtained, it was hoped, would be helpful in giving nurses better insight into the emotional needs of these patients and to give a basis for planning nursing care.

The descriptive survey was the method used; the tool, the nursing process study. Nursing care was given to six patients between the ages of 18 and 45 who had infectious hepatitis without other complications.

The nursing process studies were filled out by the investigator on each …

Evaluation Of The Photometric Assay Method To Quantitate The Bactericidal Action Of Normal And Immune Rabbit Sera On Salmonella Pullorum, Alice Margaret Rahn

Loma Linda University Electronic Theses, Dissertations & Projects

The bactericidal antibody test depends on the presence of sufficient complement, magnesium ions, and specific antibody to produce killing of certain gram negative bacilli. This study was undertaken to demonstrate whether or not Salmonella pullorum is an organism which is susceptible to this killing action.

Different amounts of test serum containing antibody, constant amounts of complement and magnesium saline diluent were placed together and held in a 37°C water bath for a one hour reaction time. During this interval, the antibody-complement system was given an opportunity to kill the susceptible bacteria. Then, a constant volume of nutrient broth was added …

Replicating Single-Cycle Adenovirus Vectors Generate Amplified Influenza Vaccine Responses, Catherine M. Crosby, William E. Matchett, Stephanie S. Anguiano-Zarate, Christopher A. Parks, Eric A. Weaver, Larry R. Pease, Richard J. Webby, Michael A. Barry

Nebraska Center for Virology: Faculty Publications

Head-to-head comparisons of conventional influenza vaccines with adenovirus (Ad) gene-based vaccines demonstrated that these viral vectors can mediate more potent protection against influenza virus infection in animal models. In most cases, Ad vaccines are engineered to be replication-defective (RD-Ad) vectors. In contrast, replication-competent Ad (RC-Ad) vaccines are markedly more potent but risk causing adenovirus diseases in vaccine recipients and health care workers. To harness antigen gene replication but avoid production of infectious virions, we developed “single-cycle” adenovirus (SC-Ad) vectors. Previous work demonstrated that SC-Ads amplify transgene expression 100-fold and produce markedly stronger and more persistent immune responses than RD-Ad vectors …