Medical Specialties Commons^™

Nmr-Based Structural Studies Of The Glycosylated Muc1 Tandem Repeat Peptide, G. Suryanarayanan, P. A. Keifer, G. Wang, L. Kinarsky, M. A. Hollingsworth, S. Sherman

Journal Articles: Eppley Institute

MUC1 is a glycoprotein that plays an important role in cancer pathogenesis. In order to study the effect of glycosylation on the conformational propensities of the tandem repeat domain of MUC1, we have determined the structure of the MUC1 tandem repeat peptide AHGVTSAPDTRPAPGSTAPP, O-glycosylated with the trisaccharide (α-Glc-1,4-β-Glc-1,4-α-GalNAc-) at Thr5. This glycopeptide was synthesized to model a heavily Oglycosylated threonine residue in the tandem repeat domain. The NMR experiments used in this study included TOCSY, NOESY, ROESY, DQF-COSY, HSQC and 1D NMR. The peak volumes determined using the program SPARKY were converted into distance constraints using the program CALIBA. The …

Oncolog, Volume 49, Number 02, February 2004, Sunni Hosemann, Aurelio Matamoros

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Colorectal Cancer Screening: Encouraging Compliance Today and Looking to the Future
• Despite Its Drawbacks, Mammography Is Still Recommended
• Communication Is Essential When Guiding Patients through the Maze of Genetic Breast Cancer Screening
• House Call: Cancer Epidemiology, Step-by-Step
• DiaLog: On Being a Volunteer, by Anderson Network volunteer

2003 Cancer Care Annual Report, Children's Mercy Hospital

Cancer Center Annual Reports

Annual report of cancer care and oncology services at the Children's Mercy Hospital, Kansas City MO, a pediatric medical center, with a focus on AML.

Meta-Analysis, Spatial, And Temporal Models To Analyze The Possible Association Between Childhood Leukemia In Proximity To Nuclear Facilities, Peter Baker

MUSC Theses and Dissertations

The purpose of this dissertation was to gain a better understanding of the possible association between childhood leukemia and nuclear facilities by conducting a meta-analysis and by the use of spatial and temporal models with respect to Pickering Nuclear Generator (PNG) in Ontario, Canada. The meta-analysis was conducted to combine and statistically analyze the many studies of childhood leukemia in the vicinity of nuclear facilities. Our focus was on studies that calculated SMRs or SIRs for individual nuclear sites. Due to variability between studies in defining age and geographic zones, eight separate analyses were performed based on age and zone …

The Therapeutic Effects Of Exercise On Fatigue, Davina Porock, Mei Fu

Publications and Research

No abstract provided.

Increased Risk For Aplastic Anemia And Myelodysplastic Syndrome In Individuals Lacking Glutathione S-Transferase Genes, Joanne F. Sutton, Michael Stacey, William G. Kearns, Thomas S. Roeg, Neal S. Young, Johnson M. Liu

Bioelectrics Publications

BACKGROUND: Aplastic anemia (AA) and myelodysplastic syndrome (MDS) are marrow failure states that may be associated with chromosomal instability. An absence of the glutathione S-transferase (GST) enzyme may genetically predispose individuals to AA or MDS. PROCEDURE AND RESULTS: To test this hypothesis, we determined the GSTM1 and GSTT1 genotypes in a total of 196 patients using multiplex PCR. The GSTT1 null genotype was found to be overrepresented in Caucasian, Asian, and Hispanic patients with either AA or MDS. We confirmed a difference in the expected frequency of the GSTM1 null genotype in Caucasian MDS patients. The double null GSTM1/GSTT1 …

Oncolog, Volume 49, Number 01, January 2004, David Galloway, Katie Prout Matias, Karin M.E.H. Gwyn Md, Richard L. Theriault Do

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Pregnancy and Cancer Treatment Often Are Not Mutually Exclusive
• Studies of the Viral Origins of Some Cancers Lead to New Prevention, Treatment Strategies
• House Call: Cancer and Your Weight
• DiaLog: Treating Breast Cancer during Pregnancy, by Karin M.E.H. Gwyn, MD, Assistant Professor, and Richard L. Theriault, DO, Professor, Department of Breast Medical Oncology

Albumin Enhanced Morphometric Image Analysis In Cll., Matthew A. Lunning, Vincent E. Zenger, Ricardo Dreyfuss, Maryalice Stetler-Stevenson, Margaret E. Rick, Therese A. White, Wyndham H. Wilson, Gerald E. Marti

Journal Articles: Oncology and Hematology

BACKGROUND: The heterogeneity of lymphocytes from patients with chronic lymphocytic leukemia (CLL) and blood film artifacts make morphologic subclassification of this disease difficult.

METHODS: We reviewed paired blood films prepared from ethylene-diamine-tetraacetic acid (ETDA) samples with and without bovine serum albumin (BSA) from 82 CLL patients. Group 1 adhered to NCCLS specifications for the preparations of EDTA blood films. Group 2 consisted of blood films containing EDTA and a 1:12 dilution of 22% BSA. Eight patients were selected for digital photomicroscopy and statistical analysis. Approximately 100 lymphocytes from each slide were digitally captured.

RESULTS: The mean cell area +/- standard …

Pulmonary Infiltrates During Chemotherapy-Induced Febrile Neutropenia: Incidence, Patterns And Outcomes, N. Gangat, M.A.A. Khan, M. Mujib, Mohammad Khurshid

Section of Haematology/Oncology

OBJECTIVE: To analyze the incidence, etiologies, radiographic patterns, and clinical outcomes of adult leukemics with prolonged febrile neutropenia and pneumonia.
METHODS: A retrospective study was conducted at a tertiary care hospital. The medical records of adult patients with acute myeloid leukemia diagnosed between January 1989 and June 2000 and undergoing induction chemotherapy were included. Only the patients who presented with a pulmonary infiltrate, secondary leukemia (e.g., transformed chronic myeloid leukemia underlying myelodysplastic syndrome, or disease following alkylating agent therapy) were included and those developing infiltrates following consolidation chemotherapy were excluded.
RESULTS: A total of 124 patients were admitted …

Expression Of Ps2 In Prostate Cancer Correlates With Grade And Chromogranin A Expression But Not With Stage, Hammad Ather, Farhat Abbas, Nuzhat Faruqui, M Israr, Shahid Pervez

Department of Pathology and Laboratory Medicine

Background: The biological potential of prostate cancer is extremely variable. Particular interest is focused on markers not expressed in normal prostatic tissues. pS2 protein expression has been demonstrated in a range of malignant tissues in an oestrogen-independent pathway. Recently, it has been demonstrated that pS2, in prostate cancer, is closely associated with neuro-endocrine differentiation. In the present study, we have analyzed, the potential of Neuro-endocrine and pS2 (TFF1) expression in human prostate cancer determined by immunohistochemistry, in primary adenocarcinoma of the prostate and attempted to correlate this with the clinico-pathologic features of the patient and neuroendocrine expression.

Methods: Ninety-five malignant …

Imaging Genome Abnormalities In Cancer Research, Henry Hq Heng, Joshua B. Stevens, Guo Liu, Steven W. Bremer, Christine J. Ye

Wayne State University Associated BioMed Central Scholarship

Abstract

Increasing attention is focusing on chromosomal and genome structure in cancer research due to the fact that genomic instability plays a principal role in cancer initiation, progression and response to chemotherapeutic agents. The integrity of the genome (including structural, behavioral and functional aspects) of normal and cancer cells can be monitored with direct visualization by using a variety of cutting edge molecular cytogenetic technologies that are now available in the field of cancer research. Examples are presented in this review by grouping these methodologies into four categories visualizing different yet closely related major levels of genome structures. An integrated …

Determination Of The Optimal Form Of A Dna Vaccine To Induce An Effective Immune Response Against A Murine B-Cell Lymphoma, Deepti Aurora

All-Inclusive List of Electronic Theses and Dissertations

Tumor vaccines are a promising alternative to chemotherapy for the treatment of cancer. To be effective and safe, a cancer vaccine should specifically target antigens expressed only on tumor cells. The B-cell tumor-derived Ig receptor may be considered a model tumor antigen for cancer vaccine development. Specifically the immunoglobulin idiotype (ld) encoded by the variable region genes (VH and VL) provides a target antigen. Promising results have been obtained in clinical studies of ld vaccination using ld proteins. However, ld protein is laborious and time-consuming to produce. Gene-based vaccines, on the other hand, are inexpensive and offer ease of manipulation …

Oncolog, Volume 48, Number 12, December 2003, Karen Stuyck, Dawn Chalaire, Martha A. Askins, Martha Aschenbrenner

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• On the Move: Efforts Under Way to Improve Outcomes for Patients with Renal Cancer
• Protocols: Studies Examine Treatments for Renal Cell Carcinoma
• Art Therapy Helps Children Affected by Cancer Express Their Emotions
• Children's Art Project Has Been Improving the Lives of Children with Cancer for 30 Years
• DiaLog: When a Parent Is Sick: Talking to Children about Cancer, by Martha A. Askins, PhD, Division of Pediatrics, and Martha Aschenbrenner, Director, Child Life Services

Oncolog, Volume 48, Number 11, November 2003, Sunni Hosemann, Don Norwood

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Laparoscopy Shows a Benefit in a Growing Number of Oncologic Procedures
• Collaboration and Creativity Lead to a New Approach to Spinal Surgery
• Protocols: Studies Test New Surgical Procedures
• House Call: Telling Fact from Fiction on the Internet

Ua61/6 Newsletter, Issue 2, Wku Institute For Rural Health Development & Research

WKU Administration Documents

Newsletter created by and about the Institute for Rural Health Development & Research. This issue contains:

• College of Health & Human Services Has New Dean – John Bonaguro
• Simpson, Staci. Institute Aims to Improve Oral Health of Children
• Whitfield, Beth. WKU Mobile Unit KICS Off Dental Event with Webster County – Kentucky Interdisciplinary Community Screening
• Stone, Glynda. TEACH KY: Teachers Exploring & Advocating Careers in Health in Kentucky
• Institute Sponsors Hispanic Health Fair
• HIV Prevention Counseling & Testing Training Program Initiated at WKU
• New Web-based Course Offered Through Communications Disorders Department at WKU
• Lashley, Donita. Child Passenger Safety Training
• Handy, …

Oncolog, Volume 48, Number 10, October 2003, Katie Prout Matias, Mariann Crapanzano, Leslie R. Schrover Phd

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• 'Hitting Bladder Cancer on All Fronts': Researchers Focus on Improving Therapies and Identifying Biomarkers Restoring Erectile Function in Patients Treated for Prostate Cancer: Efforts across Disciplines Address Physical, Psychological, and Emotional Factors Related to Sexual Potency
• House Call: Note to Self: Get Screened for Colon Cancer
• DiaLog: Sexual Function and Prostate Cancer: The Importance of Realistic Expectations, by Leslie R. Schover, PhD, Professor, Department of Behavioral Science

Il-7 Enhances Peripheral T Cell Reconstitution After Allogeneic Hematopoietic Stem Cell Transplantation., Onder Alpdogan, Stephanie J Muriglan, Jeffrey M Eng, Lucy M Willis, Andrew S Greenberg, Barry J Kappel, Marcel R M Van Den Brink

Department of Medical Oncology Faculty Papers

We used clinically relevant murine allogeneic bone marrow transplantation (BMT) models to study the mechanisms by which IL-7 administration can improve posttransplant peripheral T cell reconstitution. After transplant we could distinguish two populations of mature donor T cells: (a) alloreactive T cells with decreased expression of CD127 (IL-7 receptor alpha chain) and (b) nonalloreactive T cells, which express CD127 and undergo homeostatic proliferation. IL-7 administration increased the homeostatic proliferation of nonalloreactive T cells, but had no effect on alloreactive T cells and the development of graft-versus-host disease. Allogeneic transplant of purified hematopoietic stem cells and adoptive transfer of thymocytes into …

Oncolog, Volume 48, Number 09, September 2003, Katie Prout Matias, David Galloway, Jeffrey E. Lee Md

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Sentinel Lymph Node Biopsy: Detection of Micrometastases Leads to More Precise Staging of Breast and Melanoma Tumors
• Sentinel Lymph Node Biopsy Shows Promise in Eye and Colon Cancers
• New Research Promotes a More Dynamic View of Adult Stem Cell Differentiation: Hematopoietic Stem Cells May One Day Be Used to Repair Tissue Damage Caused by Radiation Therapy or Chemotherapy
• House Call: Understanding the Buzz over Stem Cells
• DiaLog: Directed Parathyroid Surgery, by Jeffrey E. Lee, MD, Professor, Department of Surgical Oncology

Genetic Polymorphisms Of The Interleukin-1 Gene And Early Marginal Bone Loss Around Endosseous Dental Implants, Hitomi Shimpuku, Yasuhiro Nosaka, Tatsuya Kawamura, Yoichi Tachi, Mitsuko Shinohara, Kiyoshi Ohura

Faculty, Staff and Student Publications

Dental implant surgery commonly proceeds in two stages. It is generally accepted that bone loss around implants does not occur at stage-II surgery because implants do not receive mechanical loading. However, early marginal bone loss around implants occasionally does occur during the healing period. Genetic polymorphisms in the interleukin-1 (IL-1) gene have been reported to be important for bone homeostasis and susceptibility to bone disease. We therefore investigated whether the idiopathic early marginal bone loss around implants is related to polymorphisms in the IL-1 gene. We performed a case-control study. Patients demonstrating marginal bone loss around implants at stage-II surgery …

Requirement For The Betai And Betaiv Tubulin Isotypes In Mammalian Cilia., Heather C Jensen-Smith, Richard F Ludueña, Richard Hallworth

Journal Articles: Eppley Institute

Nielsen et al., [2001: Curr Biol 11:529-533], based on studies in Drosophila, have proposed that beta tubulin in axonemal microtubules must contain a specific acidic seven amino acid sequence in its carboxyl terminus. In mammals, the two betaIV isotypes (betaIVa and betaIVb) contain that sequence. In order to test the application of this hypothesis to mammals, we have examined the expression of beta tubulin isotypes in four different ciliated tissues (trachea, ependyma, uterine tube, and testis) using isotype-specific antibodies and indirect immunofluorescence. We find that betaIV tubulin is present in all ciliated cell types examined, but so is betaI tubulin. …

Oncolog, Volume 48, Number 07/08, July/August 2003, Ann Sutton, Karen Stuyck, Gayle Nesom

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Researchers Explore Possible Applications of Nanotechnology in Cancer Treatment
• Sharing the Burden: Palliative Care Team Helps Patients, Families Through Difficult Times
• UPDATE: Study of Tamoxifen and Raloxifene (STAR) Nearing Completion Recruitment Efforts Focus on Women in Minority, Medically Underserved Populations
• House Call: Getting the Best Treatment

Oncolog, Volume 48, Number 06, June 2003, Dawn Chalaire, Sunni Hosemann, Kate O'Suilleabhain, Kerry L. Wright, Daniel J. Booser Md

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Largest-Ever NCI Trial to Study Lung Cancer Screening
• “What Choices Do I Have?” Breast Reconstruction Book and CD-ROM Help Patients Make Complicated Decisions
• House Call: Coping with the Adverse Effects of Cancer Treatment
• New Proton Therapy Center to Deliver Radiation with Precision, Few Side Effects
• DiaLog: Treating Breast Cancer with Hormone Therapy: Past, Present, and Future, by Daniel J. Booser, MD, FRCPC, Associate Professor, Department of Breast Medical Oncology

Photodynamic Therapy, Ashley Thomas

McCabe Thesis Collection

Photodynamic therapy is a new treatment that is being introduced into the veterinary community. Photodynamic therapy is the use of light activated chemotherapy to kill cancer cells (Dougherty, 1998). It has already been approved by the US Food and Drug Administration to be used as a form of cancer treatment in humans, but has not been carried over to the veterinary community. That is until now. Photodynamic therapy is now being tested in the veterinary community in hopes to find the same results that the human medical community has when dealing with certain types of cancer. They also hope to …

Oncolog, Volume 48, Number 05, May 2003, Katie Prout Matias, David Galloway, Ryuji Kobayashi Phd

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Proteomics May One Day Revolutionize Cancer Detection, Staging, and Prognosis
• Depression in Patients with Cancer Is a Separate—and Treatable—Illness
• House Call: Facing Fatigue When You Have Cancer: What Can You Do?
• DiaLog: Proteomics: The Creation of a New Field of Study, by Ryuji Kobayashi, PhD, Professor, Department of Molecular Pathology, Director, Proteomics Program

Oncolog, Volume 48, Number 04, April 2003, Katie Prout Matias, Karen Stuyck

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Study of Epigenetic Changes Leads to Treatment Advances in Adult Leukemias
• Protocols: Studies Examine Treatment of Leukemia
• The Cost of Caring: Dealing with the Stress of Being an Oncologist
• Excerpts from Focus Groups Featured in Video to Help Oncologists Cope with Stress
• House Call: Chemoprevention: Preventing Cancer with a Pill

Expression Of Glutathione-S-Transferase Mu 1 (Gstm1) And Glutathione-S-Transferase Theta 1 (Gstt1) In Patients With Aplastic Anemia And Myelodysplastic Syndromes, Aaron Conrad Spivey

Theses and Dissertations in Biomedical Sciences

Aplastic Anemia is a disorder of the hematopoietic bone marrow stem cells that is frequently associated with drug or chemical exposures. Reduced ability to detoxify drugs or chemicals may result in an increased risk of disease. Glutathione S-transferases are Phase II enzymes, which help detoxify xenobiotics. Many patients who have developed aplastic anemia and myelodysplastic syndrome have the null genotype for GSTMI and/or GSTTI. For patients with GSTMI and GSTTI positive genotypes, non-expression of these enzymes may cause an increased risk in developing aplastic anemia or myelodysplastic syndrome. To test whether genotype positive patients have GSTMI or GSTTI null …

Characterization Of Mouse Prostate Tumor-Infiltrating Leukocytes, Daniel Alan Holterman

Theses and Dissertations in Biomedical Sciences

Prostate cancer is the most common form of non-cutaneous cancer among men in the United States and the second most common cause of cancer-related death among men with approximately 189,000 new cases diagnosed and 30,200 deaths of the disease in 2002. Prostate cancer can be a treatable disease but once it becomes metastatic there are no acceptable therapies. For this reason, immunotherapy has been attempted but the results have been disappointing. The TRAMP model was used to evaluate specific interactions between an intact murine immune system and a prostate tumor that expressed a naturally processed weak tumor antigen. Vaccination trials …

High Dietary Level Of Synthetic Vitamin E On Lipid Peroxidation, Membrane Fatty Acid Composition And Cytotoxicity In Breast Cancer Xenograft And In Mouse Host Tissue, Ivan L. Cameron, Jesus Munoz, Christopher J. Barnes, W. Elaine Hardman

Biochemistry and Microbiology

Background

d-α-tocopherol is a naturally occurring form of vitamin E not previously known to have antitumor activity. Synthetic vitamin E (sE) is a commonly used dietary supplement consisting of a mixture of d-α-tocopherol and 7 equimolar stereoisomers. To test for antilipid peroxidation and for antitumor activity of sE supplementation, two groups of nude mice bearing a MDA-MB 231 human breast cancer tumor were fed an AIN-76 diet, one with and one without an additional 2000 IU/kg dry food (equivalent to 900 mg of all-rac-α-tocopherol or sE). This provided an intake of about 200 mg/kg body weight per day. The mice …

Oncolog, Volume 48, Number 03, March 2003, David Galloway, Ann Sutton, Katie Prout Matias, Donna R. Copeland Phd

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Pediatric Oncologists Search for More Effective Drugs to Treat an ‘Orphan Disease’
• Collaborative Studies Lead to Better Survival Rates in Young Patients with Rhabdomyosarcoma
• Protecting the Heart and Gastrointestinal Tract from Treatment-Associated Damage Is an Important Element of Cancer Care
• House Call: Conquering the Pain of Cancer
• DiaLog: Recognizing and Treating Cognitive Dysfunctions in Survivors of Childhood Cancers, by Donna R. Copeland, PhD, Professor, Department of Pediatrics

Breast Diseases: A Histopathological Analysis Of 3279 Cases At A Tertiary Care Center In Pakistan, M. S. Siddiqui, Naila Kayani, Shahid Pervez, S. A. Aziz, S. Muzaffar, Z. Setna, M. Israr, S. H. Hasan, M. S. Gill

Department of Pathology and Laboratory Medicine

Objective: To know the frequency of breast diseases in Pakistani females.

Methods: A retrospective analysis of 3279 breast specimens received over a period of 4 years (1 993-1996) at the department of pathology, the Aga Khan University Hospital.

Results: Out of a total of 3279 breast specimens, common breast lesions included infiltrating duct carcinoma 37%, followed by fibro adenoma 16.95%, fibrocystic change13.96%, mastitis 6.83% and duct ectasia 5.33%. Majority of the cases of infiltrating duct carcinoma were encountered in the 5th and 6th decades of life. Tumour size was 2 or >2 cms. in 93% of cases and 40% of …