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Full-Text Articles in Medical Sciences
Braf Inhibitor Candidate Molecule Usnic Acid Might Use Both Intrinsic And Extrinsic Pathways Of Apoptosis, Burcu Peli̇n Buyuk, Demet Cansaran Duman, Turker Duman
Braf Inhibitor Candidate Molecule Usnic Acid Might Use Both Intrinsic And Extrinsic Pathways Of Apoptosis, Burcu Peli̇n Buyuk, Demet Cansaran Duman, Turker Duman
Turkish Journal of Medical Sciences
Background/aim: Melanoma is one of the most aggressive cancers and treatment methods commonly used for patients with skin cancer include checkpoint and BRAF/MEK inhibitors, traditional chemotherapy drugs, radiation and adjuvant treatment methods. Due to the resistance and toxic effects that the patient develops against the drugs, an effective treatment method has not been developed for melanoma yet. Materials and methods: In this study we evaluated the anti-cancer effect of usnic acid (UA) on A-375 melanoma cells and human epidermal melanocytes by xCELLigence real-time cell analysis system. To determine through which cell death pathway UA exerts its anti-proliferative effect, its apoptotic …
Distribution And Classifications Of Pkhd1 Gene Variants In Turkish Population With Next Generation Sequencing Method, Yüksel Gezgi̇n, Berkay Kirnaz, Rauf Baylarov, Afi̇g Berdeli̇
Distribution And Classifications Of Pkhd1 Gene Variants In Turkish Population With Next Generation Sequencing Method, Yüksel Gezgi̇n, Berkay Kirnaz, Rauf Baylarov, Afi̇g Berdeli̇
Turkish Journal of Medical Sciences
Background/aim: Autosomal recessive polycystic kidney disease is an inherited kidney disease. This study aims to detect rare and common DNA variants of the PKHD1 gene using next-generation sequencing (NGS) and to classify them in terms of being pathogenic according to The American College of Medical Genetics and Genomics. Materials and methods: NGS analysis was performed on the DNA of 304 patients who were referred to Ege University Molecular Medicine Laboratory with suspected polycystic kidney disease. Results: As a result, a total of 82 different DNA variants, 16 of which were novel, were detected. The breakdown of the variants found is …
Are Serum Thrombomodulin And Interleukin-8 Levels Associated With Disease Severity And Mortality In Critically Ill Children With Respiratory Failure?, Di̇lan Akgün Ünlü, Hazal Ceren Tuğrul, Selen Ceren Çakmak, Gürkan Atay, Seher Erdoğan
Are Serum Thrombomodulin And Interleukin-8 Levels Associated With Disease Severity And Mortality In Critically Ill Children With Respiratory Failure?, Di̇lan Akgün Ünlü, Hazal Ceren Tuğrul, Selen Ceren Çakmak, Gürkan Atay, Seher Erdoğan
Turkish Journal of Medical Sciences
Background/aim: Thrombomodulin (TM) is found on endothelial cell surfaces and increases in response to endothelial injury of different organs. Interleukin (IL)-8 regulates pulmonary inflammation. TM and IL-8 are candidate biological markers of acute respiratory distress syndrome (ARDS). The aim of the present study was to compare TM and IL-8 levels in pediatric patients with and without ARDS who received respiratory support and to determine their relationships with prognosis.Materials and methods: This was a prospective observational study of 55 patients who received respiratory support in the pediatric intensive care unit. Eighteen patients without active infection were defined as the control group. …
Clinical Characteristics And Disease Course Before And After Sars-Cov-2 Infection In A Large Cohort Of Systemic Sclerosis Patients, Aslıhan Avanoğlu Güler, Büşra Özçi̇men, Mesude Seda Aydoğdu, Alper Sari, Aliyeva Numune, Nazife Tüzün Ersan, Seda Çolak, Hazan Karadeni̇z, İbrahim Vasi̇, Hamit Küçük, Yasemin Yalçinkaya, Abdulsamet Erden, Mehmet Kayaalp, Mehmet Akif Öztürk, Berna Göker, Ahmet Omma, Sedat Yilmaz, Süleyman Serdar Koca, Murat İnanç, Ali Akdoğan, Abdurrahman Tufan
Clinical Characteristics And Disease Course Before And After Sars-Cov-2 Infection In A Large Cohort Of Systemic Sclerosis Patients, Aslıhan Avanoğlu Güler, Büşra Özçi̇men, Mesude Seda Aydoğdu, Alper Sari, Aliyeva Numune, Nazife Tüzün Ersan, Seda Çolak, Hazan Karadeni̇z, İbrahim Vasi̇, Hamit Küçük, Yasemin Yalçinkaya, Abdulsamet Erden, Mehmet Kayaalp, Mehmet Akif Öztürk, Berna Göker, Ahmet Omma, Sedat Yilmaz, Süleyman Serdar Koca, Murat İnanç, Ali Akdoğan, Abdurrahman Tufan
Turkish Journal of Medical Sciences
The objective of this study is to evaluate the clinical presentations and adverse outcomes of Coronavirus Disease 2019 (COVID-19) in patients with systemic sclerosis (SSc) and assess the impact of SSc features on the clinical course of COVID-19.Materials and methods: In this multicenter, retrospective study, SSc patients with COVID-19 were included. Clinical features of SSc, along with detailed COVID-19 data, were extracted from medical records and patient interviews.Results: The study included 112 patients (mean age 51.4 ± 12.8 years; 90.2% female). SSc-associated interstitial lung disease (ILD) was evident in 57.1% of the patients. The findings revealed hospitalization in 25.5%, respiratory …
Acute Responses Of Strength-Related Gene Expressions To Maximum Strength And Force Sense Acuity, Muammer Altun, Erdal Balcan, Sevinç Batir, Mehmet Hilmi Gökmen, Şule Özgüneş, Zübeyde Öztel
Acute Responses Of Strength-Related Gene Expressions To Maximum Strength And Force Sense Acuity, Muammer Altun, Erdal Balcan, Sevinç Batir, Mehmet Hilmi Gökmen, Şule Özgüneş, Zübeyde Öztel
Turkish Journal of Medical Sciences
Although high muscle strength worsens the sense of force, it is unknown whether there is a relationship betweenthis deterioration and the underlying molecular mechanisms. This study examined the relationship between decreased force sense (FS)acuity and strength-related gene expressions.Materials and methods: Maximal voluntary isometric contraction (MVIC) and FS (50% MVIC) tests were performed on the kneejoints of twenty-two subjects. The expression analyses were evaluated by qRT-PCR in blood samples taken before, after MVIC, after 50%MVIC, and 15 min after the test.Results: MVIC and FS error values were significantly correlated with each other (r = .659, p = .001). The qRT-PCR analyses …
Rehabilitation Therapy Versus Drug-Only Therapy In Patients With Multiple Sclerosis, Florin Mihai Marcu, Doriana Ciobanu, Ioan Cosmin Boca, Elena Sirbu, Paul Alexandru Deme, Nicolae Catalin Hreniuc, Dorina Ianc
Rehabilitation Therapy Versus Drug-Only Therapy In Patients With Multiple Sclerosis, Florin Mihai Marcu, Doriana Ciobanu, Ioan Cosmin Boca, Elena Sirbu, Paul Alexandru Deme, Nicolae Catalin Hreniuc, Dorina Ianc
Turkish Journal of Medical Sciences
The treatment for multiple sclerosis (MS) does not cure the disease, but it is intended to reduce the intensity, duration, and frequency of symptoms. Rehabilitation therapy (RT), including an individualized physical therapy program (PTP) and adapted occupational therapy (OT), has benefits in terms of aerobic capacity, muscle strength, coordination, and ability to perform activities of daily living (ADL). The primary objective of this study was to examine the efficacy of RT comprising PTP, OT, and drug treatment (DT) versus DT alone in patients with MS. Another objective was to highlight the importance of continuing the PT and OT at home, …
The Relationship Between Trunk Control, Spinal Posture, And Spinal Mobility In Patients With Multiple Sclerosis: A Cross-Sectional Study, Taşkın Özkan, Nezehat Özgül Ünlüer, Mustafa Ertuğrul Yaşa, Buse Korkmaz, Gönül Vural
The Relationship Between Trunk Control, Spinal Posture, And Spinal Mobility In Patients With Multiple Sclerosis: A Cross-Sectional Study, Taşkın Özkan, Nezehat Özgül Ünlüer, Mustafa Ertuğrul Yaşa, Buse Korkmaz, Gönül Vural
Turkish Journal of Medical Sciences
Trunk control, which plays a key role in balance and mobility, decreases in patients with multiple sclerosis (PwMS) and many parameters such as sensory, motor, and musculoskeletal systems affect trunk control. The aim of this study was to compare trunk control, spinal mobility, and spinal posture in PwMS with healthy controls and investigate the relationship between trunk control with spinal posture and spinal mobility in PwMS.Materials and methods: The study was completed with 38 PwMS and 38 healthy controls with matched age and sex. Trunk control was evaluated with the Trunk Impairment Scale (TIS). Spinal posture and mobility were evaluated …
Evaluation Of Accompanying Allergic Disease In Children With Proven Drug Allergies, Şule Büyük Yaytokgi̇l, Kezban İpek Demi̇r, Özge Yılmaz Topal, Azize Pınar Metbulut, İlknur Külhaş Çeli̇k, Müge Toyran, Ersoy Ci̇velek, Emine Di̇bek Misirlioğlu
Evaluation Of Accompanying Allergic Disease In Children With Proven Drug Allergies, Şule Büyük Yaytokgi̇l, Kezban İpek Demi̇r, Özge Yılmaz Topal, Azize Pınar Metbulut, İlknur Külhaş Çeli̇k, Müge Toyran, Ersoy Ci̇velek, Emine Di̇bek Misirlioğlu
Turkish Journal of Medical Sciences
Data on the prevalence of allergic diseases in children with proven drug allergies are limited. We aim to evaluate thefrequency of allergic comorbidity in children with proven common drug allergies.Materials and methods: Children with drug hypersensitivity confirmed by diagnostic allergy tests at our center between January 2010and December 2020 were screened retrospectively. Patients with the most common drug allergies (due to antibiotics, nonsteroidalantiinflammatory drugs [NSAIDs], and antiepileptic drugs) were selected for analysis. Age, sex, the culprit drug, initial reactioncharacteristics, diagnostic test results, and the study physician who diagnosed concomitant allergic diseases were noted.Results: A total of 168 patients (boys, 51.2%) …
The Right Ventricle Outflow Tract Systolic Function Could Predict The Severity Of The Cirrhosis, İbrahim Dönmez, Güray Can, Emrah Acar
The Right Ventricle Outflow Tract Systolic Function Could Predict The Severity Of The Cirrhosis, İbrahim Dönmez, Güray Can, Emrah Acar
Turkish Journal of Medical Sciences
The distinctive liver framework is converted into structurally abnormal nodules as a consequence of tissue fibrosis in cirrhosis. Cardiac dysfunction in cirrhosis was described, and the term “cirrhotic cardiomyopathy (CCM)” was coined to describe this syndrome. Recent research has shown that the contractile characteristics of the right ventricular outflow tract (RVOT) have a significant impact on right ventricular functions. The right ventricular outflow tract-systolic excursion is an important systolic function marker of RVOT (RVOT-SE). There has yet to be published research on RVOT function in cirrhotic patients. We looked at the relationship between cirrhosis severity and the RVOT-SE.Materials and methods: …
The Effect Of Parity, Breastfeeding History, And Duration On Clinical And Pathological Characteristics Of Breast Cancer Patients, Naziye Ak, Zeynep Tuz, Esra Aydin, Ferhat Ferhatoğlu, Murat Sari, Nail Paksoy, İzzet Doğan, Anıl Yildiz, Rian Di̇şçi̇, Pınar Mualla Sai̇p
The Effect Of Parity, Breastfeeding History, And Duration On Clinical And Pathological Characteristics Of Breast Cancer Patients, Naziye Ak, Zeynep Tuz, Esra Aydin, Ferhat Ferhatoğlu, Murat Sari, Nail Paksoy, İzzet Doğan, Anıl Yildiz, Rian Di̇şçi̇, Pınar Mualla Sai̇p
Turkish Journal of Medical Sciences
The study is aimed to determine the relationship between the delivery and breastfeeding history of the patients andthe clinicopathological properties of breast cancer.Materials and methods: A questionnaire was utilized for the study, which included the age of diagnosis, the number of children at thetime of diagnosis, the age of the children, and the breastfeeding period of each child.Results: The study included 828 patients. The median age at diagnosis was 47 years for parous women and 42 years for nonparouswomen (p < 0.001). The tumor size of the patients diagnosed within the breastfeeding period was significantly larger compared to theother patients. Estrogen and progesterone receptor positivity were lower in patients diagnosed during breastfeeding. Additionally, themean number of positive lymph nodes, dissected lymph nodes, and positive lymph node/dissected lymph node ratio in parous andbreastfed patients with a nonmetastatic disease were statistically significantly higher in multivariable analysis than those patients whowere nulliparous and have not breastfed.Conclusion: Breast cancer is seen at a later age in patients who are parous than those who have never given birth. Patients who areparous and have breastfed tend to present with a higher stage of the disease.
Dynamic Contrast-Enhanced Mammography And Breast Mri In The Diagnosis Of Breast Cancer And Detection Of Tumor Size, Muhammed Teki̇nhatun, Nuran Sabi̇r, Ergun Erdem, Sevda Yilmaz, Furkan Ufuk
Dynamic Contrast-Enhanced Mammography And Breast Mri In The Diagnosis Of Breast Cancer And Detection Of Tumor Size, Muhammed Teki̇nhatun, Nuran Sabi̇r, Ergun Erdem, Sevda Yilmaz, Furkan Ufuk
Turkish Journal of Medical Sciences
The aim of this study is to evaluate the performance of contrast-enhanced mammography (CEM) and dynamic breast MRI techniques for diagnosing breast lesions, assess the diagnostic accuracy of CEM’s using histopathological findings, and compare lesion size measurements obtained from both methods with pathological size.Materials and methods: This prospective study included 120 lesions, of which 70 were malignant, in 104 patients who underwent CEM and MRI within a week. Two radiologists independently evaluated the MR and CEM images in separate sessions, using the BI-RADS classification system. Additionally, the maximum sizes of lesion were measured. Diagnostic accuracy parameters and the receiver operating …
Adjunctive Use Of Laser Biostimulation With Nonsurgical Periodontal Therapy: A Split Mouth, Randomized, Case-Control Study In Diabetic And Nondiabetic Periodontitispatients, Funda Akansel, Umur Sakallioğlu, Müge Lütfi̇oğlu, Feyza Otan Özden, Adil Karadağ
Adjunctive Use Of Laser Biostimulation With Nonsurgical Periodontal Therapy: A Split Mouth, Randomized, Case-Control Study In Diabetic And Nondiabetic Periodontitispatients, Funda Akansel, Umur Sakallioğlu, Müge Lütfi̇oğlu, Feyza Otan Özden, Adil Karadağ
Turkish Journal of Medical Sciences
Laser biostimulation therapy (LBT) is suggested to have positive effects on periodontal healing. This study evaluatedLBT with nonsurgical periodontal therapy (NSPT) in diabetes mellitus (DM) and systemic health (SH) conditions.Materials and methods: Thirty periodontitis patients (15 with DM and 15 with SH) were included in the study, which had a split-mouthdesign, by applying LBT in the mouth of the same systemic condition. Thus, 4 study groups were formed, as 1) NSPT – DM: NSPT alonein DM, 2) NSPT + LBT – DM: NSPT + LBT application in DM, 3) NSPT – SH: NSPT alone in SH, and 4) NSPT + …
Letter To The Editor: Serum Amylase On Postoperative Day One Is A Strong Predictor Of Pancreatic Fistula After Pancreaticoduodenectomy: A Retrospective Cohort, Cengiz Ceylan
Turkish Journal of Medical Sciences
No abstract provided.
Assessing Depression, Anxiety, Stress, And Occupational Decision Regret Levels Among Resident Physicians Working At Ankara University Faculty Of Medicine Hospital, Emrah Emi̇ral, Bari̇s Örs, Nergi̇s Cantürk
Assessing Depression, Anxiety, Stress, And Occupational Decision Regret Levels Among Resident Physicians Working At Ankara University Faculty Of Medicine Hospital, Emrah Emi̇ral, Bari̇s Örs, Nergi̇s Cantürk
Turkish Journal of Medical Sciences
Background/aim: Physicians work under high stress levels due to factors such as excessive workload, emotional factors, and economic variables. This situation leads to various health problems such as depression, burnout, fatigue, and hopelessness, resulting in decreased interest in a medical career and an increase in career choice regret. Materials and methods: 300 volunteer resident physicians from Ankara University Medical Faculty Hospital participated in the study. The data for the research was collected using a survey form prepared by reviewing the literature. The survey consisted of three parts, which questioned the physicians' socio-demographic characteristics and professional choices, including the Depression, Anxiety, …
Gastrointestinal Bleeding Among Oral Anticoagulant Users: A Comprehensive 7-Year Retrospective Review Using Türkiye’S National Health Data System, Nuray Yi̇lmaz Çakmak, Nai̇m Ata, Serdar Can Güven, Emi̇n Gemci̇oğlu, Murat Çağlayan, Mustafa Mahi̇r Ülgü, Şuayi̇p Bi̇ri̇nci̇
Gastrointestinal Bleeding Among Oral Anticoagulant Users: A Comprehensive 7-Year Retrospective Review Using Türkiye’S National Health Data System, Nuray Yi̇lmaz Çakmak, Nai̇m Ata, Serdar Can Güven, Emi̇n Gemci̇oğlu, Murat Çağlayan, Mustafa Mahi̇r Ülgü, Şuayi̇p Bi̇ri̇nci̇
Turkish Journal of Medical Sciences
BackgroundThe comparative risk of gastrointestinal bleeding (GIB) among users of direct-acting oral anticoagulants (DOACs) versus vitamin K antagonists (VKAs) is a topic of ongoing debate. This study leverages a comprehensive national health database to evaluate the incidence of GIB, associated risk factors, and post-bleeding management strategies among anticoagulated patients.MethodsUtilizing the Turkish Ministry of Health's e-Nabız system, we conducted a retrospective analysis of patients treated with DOACs and warfarin from January 2017 to July 2023. GIB events were identified using ICD codes, and comorbidities, prior medication use, interventions, and mortality rates were analyzed. Drug survival and switch patterns post-GIB were also …
Evaluation Of Single-Layer Versus Double-Layer Suturing Of Low Transverse Uterine Incisions In Cesarean Section And Follow-Up Of Scars By Ultrasound: A Prospective Randomized Controlled Study, Erhan Demi̇rdağ, Hazal Kutlucan, Anil Tutal, Bi̇lge Çalişkan Keski̇nsoy, Gülşah Karakuyu, Recep Karabacak
Evaluation Of Single-Layer Versus Double-Layer Suturing Of Low Transverse Uterine Incisions In Cesarean Section And Follow-Up Of Scars By Ultrasound: A Prospective Randomized Controlled Study, Erhan Demi̇rdağ, Hazal Kutlucan, Anil Tutal, Bi̇lge Çalişkan Keski̇nsoy, Gülşah Karakuyu, Recep Karabacak
Turkish Journal of Medical Sciences
Background/aim: Cesarean section(CS) is a widely performed operation worldwide. Data about uterine closure is lacking. We aimed to evaluate scar niches and compare the single and double-layer uterine closure after six months following CS.Materials-Methods: A prospective, randomized trial assessed 56 women undergoing single or double-layer uterine closure. None of the patients had previous uterine surgery. The CSs were elective cases. Transvaginal ultrasound was performed six months after CS to assess uterine scar by measuring the width, depth, and length of scar niche and residual myometrial thickness. An experienced sonographer was blinded to the uterine closure technique and the ultrasounds were …
Medical And Advanced Heart Failure Therapies In Türkiye, Sanem Nalbantgi̇l, Emre Demi̇r, Ahmet Çeli̇k, İnci̇ Tuğçe Çöllüoğlu, Nai̇m Ata, Mehmet Bi̇rhan Yilmaz, Anil Şahi̇n, Di̇lek Ural, Mustafa Mahi̇r Ülgü, Emi̇ne Arzu Kanik, Lale Di̇nç Asarcikli, Yüksel Çavuşoğlu, Selda Murat, Şuayi̇p Bi̇ri̇nci̇
Medical And Advanced Heart Failure Therapies In Türkiye, Sanem Nalbantgi̇l, Emre Demi̇r, Ahmet Çeli̇k, İnci̇ Tuğçe Çöllüoğlu, Nai̇m Ata, Mehmet Bi̇rhan Yilmaz, Anil Şahi̇n, Di̇lek Ural, Mustafa Mahi̇r Ülgü, Emi̇ne Arzu Kanik, Lale Di̇nç Asarcikli, Yüksel Çavuşoğlu, Selda Murat, Şuayi̇p Bi̇ri̇nci̇
Turkish Journal of Medical Sciences
Background/aim: Effective management of heart failure involves evidence-based use of multiple medications and their combinations. Furthermore, dosage escalation of the recommended medications is advised. In cases of advanced heart failure, long-term mechanical assistance devices or heart transplantation surgery may be necessary. The socio-economic situation creates unequal chances for people to access these treatments.The study aimed to analyze and compare medical and advanced heart failure treatments recommended by guidelines across various regions in Türkiye.Materials and methods: About 85 million citizen medical treatment records were utilized between January 1, 2016, and December 31, 2022. Medical and heart replacement treatment opportunities used in …
Oral Small Molecule Agents In Management Of Ulcerative Colitis: Fact Or Fancy, Benan Kasapoğlu, Ati̇lla Ertan
Oral Small Molecule Agents In Management Of Ulcerative Colitis: Fact Or Fancy, Benan Kasapoğlu, Ati̇lla Ertan
Turkish Journal of Medical Sciences
Ulcerative colitis is a chronic, immune-mediated disease characterized by recurring episodes of mucosal inflammation in the colon and rectum. The primary pathogenic mechanism of ulcerative colitis is the dysregulation of the mucosal immune response. The disease follows a relapsing-remitting course, and the goal of management is to successfully induce and then maintain remission. Effectively managing this chronic disease requires addressing all aspects of it. Currently, we have various antitumor necrosis factor agents and novel biologics available for treating ulcerative colitis patients with moderate-to-severe disease. However, none of the existing treatments are considered entirely satisfactory or ideal in these cases. After …
Musculoskeletal Ultrasonography In Rheumatic Diseases, Erhan Çapkin
Musculoskeletal Ultrasonography In Rheumatic Diseases, Erhan Çapkin
Turkish Journal of Medical Sciences
Ultrasonography is an imaging technique based on sound waves used for the evaluation of soft tissues. Sound waves have been used for a long time in nonmedical fields, including military defense systems, radar systems, and detection of icebergs. Technological advances resulted in new techniques becoming available for medical imaging, including ultrasonography, magnetic resonance imaging, and computed tomography. Nowadays, the use of imaging has become a gold standard protocol in the diagnosis of many diseases, and recently developed diagnosis and therapy options provide more efficient treatment of rheumatic diseases. Thus, it has become possible to prevent structural damage and disability in …
Long Noncoding Rnas In Pancreas Cancer: From Biomarkers To Therapeutic Targets, Esra Güzel Tanoğlu, Seyfure Adigüzel, Alpaslan Tanoğlu, Zehra Betül Aydin, Güli̇zar Hocaoğlu, Samet Ebi̇nç
Long Noncoding Rnas In Pancreas Cancer: From Biomarkers To Therapeutic Targets, Esra Güzel Tanoğlu, Seyfure Adigüzel, Alpaslan Tanoğlu, Zehra Betül Aydin, Güli̇zar Hocaoğlu, Samet Ebi̇nç
Turkish Journal of Medical Sciences
Long noncoding RNAs (lncRNAs) are noncoding RNA molecules with a heterogeneous structure consisting of 200 or more nucleotides. Because these noncoding RNAs are transcribed by RNA polymerase II, they have properties similar to messenger RNA (mRNA). Contrary to popular belief, the term "ncRNA" originated before the discovery of microRNAs. LncRNA genes are more numerous than protein-coding genes. They are the focus of current molecular research because of their pivotal roles in cancer-related processes such as cell proliferation, differentiation, and migration. The incidence of pancreatic cancer (PC) is increasing around the world and research on the molecular aspects of PC are …
Expression Of Pfkfb Isoenzymes During In Vitro Differentiation Of Mouse Embryonic Stem Cells Into Insulin-Producing Cells, Sai̇me Güzel, Abdullah Yalçin, Yunus Gürpinar, Sabi̇re Güler
Expression Of Pfkfb Isoenzymes During In Vitro Differentiation Of Mouse Embryonic Stem Cells Into Insulin-Producing Cells, Sai̇me Güzel, Abdullah Yalçin, Yunus Gürpinar, Sabi̇re Güler
Turkish Journal of Medical Sciences
Background/aim: Type 1 diabetes mellitus (T1DM) is caused by the autoimmune-mediated destruction of insulin-producing cells (IPCs) and still has no effective cure. Better understanding of the molecular mechanisms involved in the differentiation of embryonic stem cells (ESCs) into IPCs may help us improve the therapeutic strategies for treating T1DM. 6-phosphofructo-2-kinase/fructose-2,6- bisphosphatases (Pfkfb1-4) are key regulators of glucose metabolism. Although Pfkfb3 has been shown to be required for the growth of early differentiated mouse ESCs (mESCs), more studies are needed to further assess the roles of Pfkfb isoenzymes in embryonic development and differentiation, particularly into specific cell types. In this study, …
Protective Effects Of Swimming Exercises And Metformin On Cardiac And Aortic Damage Caused By A High-Fat Diet In Obese Rats With Type 2 Diabetes, By Regulating The Bcl2/Bax Signaling Pathway, Ebru Özüdoğru, Emrah Atay, Mehtap Savran, Hali̇l Aşci, Özlem Özmen, Şenay Topsakal
Protective Effects Of Swimming Exercises And Metformin On Cardiac And Aortic Damage Caused By A High-Fat Diet In Obese Rats With Type 2 Diabetes, By Regulating The Bcl2/Bax Signaling Pathway, Ebru Özüdoğru, Emrah Atay, Mehtap Savran, Hali̇l Aşci, Özlem Özmen, Şenay Topsakal
Turkish Journal of Medical Sciences
Background/aim: Due to the increasing mortality and morbidity rates in diabetes mellitus (DM), which is one of the biggest health problems of our age, many treatment modalities are still being tried. The positive effects of metformin (MET) and physical exercise (EXE) on the pathophysiology of diabetes are well known. In this study, it was aimed to detail these positive effects of MET and EXE in combination on the basis of inflammation, apoptosis mechanisms, and endogen nesfatin-1 (NES-1) synthesis. Materials and methods: Twenty-seven type 2 DM (DM-2) male Wistar Albino rats were divided into 4 groups, as the high-fat diet (HFD), …
[6]-Shogaol And [6]-Gingerol Active Ingredients May Improve Neuropathic Pain By Suppressing Cytokine Levels In An Experimental Model, Fi̇kri̇ Özdemi̇r, Güven Akçay, Sevi̇l Özkinali, Çağla Çeli̇k
[6]-Shogaol And [6]-Gingerol Active Ingredients May Improve Neuropathic Pain By Suppressing Cytokine Levels In An Experimental Model, Fi̇kri̇ Özdemi̇r, Güven Akçay, Sevi̇l Özkinali, Çağla Çeli̇k
Turkish Journal of Medical Sciences
Background/aim: Neuropathic pain (NP) is a type of chronic pain usually caused by damage to the somatosensory system. Bioactive antioxidant compounds, such as curcumin and ginger, are widely preferred in the treatment of NP. However, the ingredient-based mechanism that underlies their pain-relieving activity remains unknown. The aim of this study was to investigate the therapeutic effects of trans-[6]-Shogaol and [6]-Gingerol active ingredients of the Zingiber officinale Roscoe extract on the spinal cord and cortex in the neuroinflammatory pathway in rats with experimental sciatic nerve injury. Materials and methods: Forty-six volatile phenolic components were identified in ginger samples using gas chromatography-mass …
Cochlear Pathology In Preeclamptic Rats: Protective Effects Of Vitamin D And Magnesium Sulfate, Mustafa Altintaş, Eni̇s Hi̇di̇şoğlu, Alexandra Cernomorceno, Nuray Ensari̇, Nevreste Di̇dem Sonbay Yilmaz, Özer Erdem Gür, Hülya Eyi̇gör, Züleyha Di̇lek Gülmez, Erdoğan Bulut, Serap Şi̇rvanci, Selahatti̇n Kumru
Cochlear Pathology In Preeclamptic Rats: Protective Effects Of Vitamin D And Magnesium Sulfate, Mustafa Altintaş, Eni̇s Hi̇di̇şoğlu, Alexandra Cernomorceno, Nuray Ensari̇, Nevreste Di̇dem Sonbay Yilmaz, Özer Erdem Gür, Hülya Eyi̇gör, Züleyha Di̇lek Gülmez, Erdoğan Bulut, Serap Şi̇rvanci, Selahatti̇n Kumru
Turkish Journal of Medical Sciences
Background/aim: This study investigated the possible degeneration in cochlear morphology induced by preeclampsia (PE) and the therapeutic/preventive effect of vitamin D (Vit D) and magnesium sulfate (MgSO4) used separately and together on feto-maternal outcomes. Materials and methods: We created PE in rats using a reduced uterine perfusion pressure (RUPP) animal model and recorded blood pressure (BP), embryonic survival (ES), and embryonic weight (EW) and evaluated cochlear morphology by electron microscopy. Results: The PE group had elevated BP, a decreased number and weight of live pups, and significant degeneration in the cochlea compared to the sham group. In the PEV group, …
Ss-D-Glucan Promotes Nf-Κb Activation And Ameliorates High-Let Carbon-Ion Irradiation-Induced Human Umbilical Vein Endothelial Cell Injury, Fang Liu, Yanting Wei, Zhuanzi Wang
Ss-D-Glucan Promotes Nf-Κb Activation And Ameliorates High-Let Carbon-Ion Irradiation-Induced Human Umbilical Vein Endothelial Cell Injury, Fang Liu, Yanting Wei, Zhuanzi Wang
Turkish Journal of Medical Sciences
Background/aim: Heavy-ion irradiation seriously perturbs cellular homeostasis and thus damages cells. Vascular endothelial cells (ECs) play an important role in the pathological process of radiation damage. Protecting ECs from heavy-ion radiation is of great significance in the radioprotection of normal tissues. In this study, the radioprotective effect of ß-D-glucan (BG) derived from Saccharomyces cerevisiae on human umbilical vein endothelial cell (EA.hy926) cytotoxicity produced by carbon-ion irradiation was examined and the probable mechanism was established. Materials and methods: EA.hy926 cells were divided into seven groups: a control group; 1, 2, or 4 Gy radiation; and 10 µg/mL BG pretreatment for 24 …
Smpdl3b Contributes To Gastric Adenocarcinoma Cells Progression By Promoting The Infiltration Of M2 Macrophages, Li Su, Jian Hao, Na Zhang, Shan Wu, Xiuhua Wu, Wei Wei
Smpdl3b Contributes To Gastric Adenocarcinoma Cells Progression By Promoting The Infiltration Of M2 Macrophages, Li Su, Jian Hao, Na Zhang, Shan Wu, Xiuhua Wu, Wei Wei
Turkish Journal of Medical Sciences
Background/aim: The common disease gastric adenocarcinoma (GAC) has a high morbidity and mortality, so there is an urgent need for research to explore new diagnostic markers and therapeutic targets. This investigation was carried out to investigate the expression of sphingomyelin phosphodiesterase acid-like 3b (SMPDL3B) in GAC and its effects on tumor progression. Materials and methods: Samples were collected from patients who underwent radical gastrectomy from January 2021 to December 2022. Along with the normal gastric epithelial cell lines GES-1 and SGC-7901, the AGS, MGC-803, and MSN-45 human gastric cancer cell lines were used to confirm SMPDL3B expression. RT-qPCR, Western blot, …
Evaluation Of The Cytotoxic Effect Of Titanium Dioxide Nanoparticles In Human Embryonic Lung Cells, Olkan Afşar, Çağatay Oltulu
Evaluation Of The Cytotoxic Effect Of Titanium Dioxide Nanoparticles In Human Embryonic Lung Cells, Olkan Afşar, Çağatay Oltulu
Turkish Journal of Medical Sciences
Background/aim: Titanium dioxide nanoparticles are widely used in a variety of products, including sunscreens, paints, and ceramics. However, their increasing use has raised concerns about their potential health risks. Titanium dioxide nanoparticles have been shown to have the ability to enter the bloodstream and accumulate in various tissues, reaching the fetus via the placenta. The aim of this study was to investigate the cytotoxic effects of titanium dioxide nanoparticles on a human embryonic lung cell line (HEL 299/An1) and the formation of oxidative DNA damage. Materials and methods: The cytotoxic effects of brookite-based titanium dioxide nanoparticles (<100 nm) were assessed using the 3-(4,5-dimethyldiazol-2-yl)-2,5 diphenyl tetrazolium bromide (MTT) assay for 24 and 48 h. Cell titanium levels were determined using inductively coupled plasma mass spectrometry. Oxidative DNA damage was assessed by measuring the levels of 8-hydroxy-2- deoxyguanosine (8-OHdG) as a biomarker. Results: Titanium dioxide nanoparticles caused dose-dependent cytotoxicity in HEL 299/An1 cells. The IC50 values were 25.93 μM and 0.054 μM after 24 h and 48 h of exposure, respectively. Cell titanium levels were found to be 25,967 ppb after 24 h and 210,353 ppb after 48 h (p < 0.01). 8-OHdG was detected at 32.96 ng/mL after 24 h of exposure and 17.89 ng/mL after 48 h of exposure. Conclusion: In our study, it was shown that titanium nanoparticles caused dose-dependent cytotoxicity and oxidative DNA damage in human embryonic lung cells. The nanoparticles also accumulated in cells and were taken up in higher amounts after 48 h of exposure. These findings suggest that titanium dioxide nanoparticles may pose a health risk, especially for pregnant women who may not be aware of their pregnancy. Therefore, it is important to take preventive measures to reduce exposure to these nanoparticles.
Effect Of Humanine On The Notch Signaling Pathway In Myocardial Infarction, Eli̇f Onat, Ebru Önalan, Berna Özdem, Merve Kavak Balgeti̇r, Tuncay Kuloğlu
Effect Of Humanine On The Notch Signaling Pathway In Myocardial Infarction, Eli̇f Onat, Ebru Önalan, Berna Özdem, Merve Kavak Balgeti̇r, Tuncay Kuloğlu
Turkish Journal of Medical Sciences
Background/aim: By applying humanin (HN) before myocardial infarction (MI), its protection in myocardial injury and the possible roles of its cellular mechanism in the Notch pathway were investigated. Materials and methods: The study was carried out at Fırat University Experimental Research Center (12/24/2018-12/23/2019). Spraque-Dawley rats were divided into 10 groups: I (control) (n = 6), II (HN 6 h) (n = 6), III (HN 24 h) (n = 6), IV (HN day 7) (n = 6), V (MI 6 h) (n = 7), VI (MI 24 h) (n = 7), VII (MI day 7) (n = 7), VIII (MI+HN 6 …
Different Roles Of Endothelial Cell-Derived Fibronectin And Plasma Fibronectin In Endothelial Dysfunction, Xiaoxin Luo, Weixiong Jian
Different Roles Of Endothelial Cell-Derived Fibronectin And Plasma Fibronectin In Endothelial Dysfunction, Xiaoxin Luo, Weixiong Jian
Turkish Journal of Medical Sciences
MDABackground/ aim: Atherosclerosis is significantly influenced by endothelial cell activation and dysfunction. Studies have demonstrated the substantial presence of fibronectin (Fn) within atherosclerotic plaques, promoting endothelial inflammation and activation. However, cellular Fn (cFn) secreted by various cell types, including endothelial cells and smooth muscle cells, and plasma Fn (pFn) produced by hepatocytes. They are distinct forms of Fn that differ in both structure and function. The specific contribution of different types of Fn in promoting endothelial cell activation and dysfunction remain uncertain. Therefore, this study aimed to investigate the respective roles of pFn and endothelial cell-derived Fn (FnEC) in promoting …
Csrp1 Expression Is Associated With A Mesenchymal, Stroma-Rich Tumor Profile And Poor Prognosis In Colon Cancer, Seçi̇l Demi̇rkol Canli
Csrp1 Expression Is Associated With A Mesenchymal, Stroma-Rich Tumor Profile And Poor Prognosis In Colon Cancer, Seçi̇l Demi̇rkol Canli
Turkish Journal of Medical Sciences
Background/aim: Cysteine and glycine-rich protein 1 (CSRP1) is involved in the cysteine-rich protein family and is a marker of smooth muscle lineages. In colon cancer, the expression of this gene is associated with poor prognosis. In this study, the aim was to reevaluate its prognostic relationship in independent cohorts and explore potential underlying biological processes that are linked to aggressive behavior in tumors with high CSRP1 expression, such as epithelial-to-mesenchymal transition (EMT), stromal fractions in the tumor microenvironment, and consensus molecular subtypes (CMSs). Materials and methods: RNA sequencing (RNAseq)-, microarray-, and single-cell RNAseq (scRNAseq)-based transcriptomic data were obtained from public …