Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- COVID-19 (110)
- Children (97)
- Oxidative stress (90)
- Inflammation (65)
- Rat (62)
-
- Mortality (59)
- Treatment (57)
- Turkey (57)
- Breast cancer (51)
- Prognosis (51)
- Pregnancy (49)
- Apoptosis (47)
- Prevalence (47)
- Magnetic resonance imaging (46)
- Obesity (46)
- Diabetes mellitus (37)
- Quality of life (36)
- Risk factors (36)
- Diagnosis (34)
- Nitric oxide (32)
- Ultrasonography (32)
- Rheumatoid arthritis (31)
- Epidemiology (30)
- Asthma (29)
- Hypertension (29)
- Reliability (29)
- Child (28)
- Validity (28)
- Depression (26)
- Diabetes (26)
- Publication Year
Articles 451 - 480 of 4871
Full-Text Articles in Medical Sciences
The Evaluation Of Oxidative Stress And Inflammation Markers In Serum And Saliva Of The Patients With Temporomandibular Disorders, Di̇lara Kazan, Burcu Baş, Abdurrahman Aksoy, Enes Atmaca
The Evaluation Of Oxidative Stress And Inflammation Markers In Serum And Saliva Of The Patients With Temporomandibular Disorders, Di̇lara Kazan, Burcu Baş, Abdurrahman Aksoy, Enes Atmaca
Turkish Journal of Medical Sciences
Background/aim: Temporomandibular Disorders (TMD), as in the occurrence of many diseases, have been associated with oxidative stress (OS) resulting from the disruption of antioxidant mechanisms and the accumulation of reactive oxygen species in tissues. This study was designed to compare salivary and serum OS and inflammation markers of individuals with TMD and healthy subjects. Materials and methods: A prospective cross-sectional study was conducted. Twenty-seven TMD patients diagnosed with disc displacement (DD) according to Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) and 17 healthy subjects were enrolled in the study. Prior to any treatment, serum, and saliva samples were taken from …
Evaluation Of Sestrin 2 And Tribbles Homolog 3 Levels In Obese And Nonobese Women With Polycystic Ovary Syndrome, Ayşegül Çatal, Evri̇m Ebru Kovalak
Evaluation Of Sestrin 2 And Tribbles Homolog 3 Levels In Obese And Nonobese Women With Polycystic Ovary Syndrome, Ayşegül Çatal, Evri̇m Ebru Kovalak
Turkish Journal of Medical Sciences
Background/aim: This study was designed to evaluate the relationship of two new biomarkers [tribbles homolog 3 (TRB3) and sestrin 2 levels], which were previously associated with obesity, with metabolic parameters in obese and nonobese women with polycystic ovary syndrome (PCOS). Materials and methods: This cross-sectional case control study was conducted between September 2017 and August 2019 in the gynecology department of a tertiary referral hospital. The values of the plasma sestrin 2, TRB3, insulin, fasting plasma glucose, lipid profile, and homeostasis model assessment of insulin resistance (HOMA-IR) were compared in 90 obese women with PCOS (BMI > 30), 90 women with …
Efficacy Of Rituximab On Disease Activity, Severity, And Disease-Related Damage In Patients With Immunosuppressive-Resistant Systemic Sclerosis, Yasemi̇n Yalçinkaya, Bahar Artim Esen, Shirkhan Amikishiyev, Numune Aliyeva, Ahmet Gül, Mahdume Lale Öçal, Murat İnanç
Efficacy Of Rituximab On Disease Activity, Severity, And Disease-Related Damage In Patients With Immunosuppressive-Resistant Systemic Sclerosis, Yasemi̇n Yalçinkaya, Bahar Artim Esen, Shirkhan Amikishiyev, Numune Aliyeva, Ahmet Gül, Mahdume Lale Öçal, Murat İnanç
Turkish Journal of Medical Sciences
Background/aim: B-cell depletion with rituximab (RTX) is widely used as a rescue therapy in patients with systemic sclerosis (SSc). The aim herein was to analyze the progress of disease-related outcomes after RTX therapy in severe SSc patients. Materials and methods: Included in this study were 27 SSc patients who were followed-up between 2012 and 2020 and received at least 1 cycle of RTX for active disease, despite receiving standard immunosuppressives (ISs). In addition to the European Scleroderma Study Group and European Scleroderma Trials and Research Group activity scores, Medsger's severity, and the recently developed Scleroderma Clinical Trials Consortium Damage Index …
Craniocervical Junction Involvement In Inflammatory Arthritis: A Single-Center Radiologic Study, Fatma Yalçinkaya, Şafak Parlak Sağol, Aynur Azizova, Emre Bi̇lgi̇n, Kader Karli Oğuz, Umut Kalyoncu
Craniocervical Junction Involvement In Inflammatory Arthritis: A Single-Center Radiologic Study, Fatma Yalçinkaya, Şafak Parlak Sağol, Aynur Azizova, Emre Bi̇lgi̇n, Kader Karli Oğuz, Umut Kalyoncu
Turkish Journal of Medical Sciences
Background/aim: Craniocervical junction (CCJ) can be involved in inflammatory arthritis. We aimed to define types of CCJ involvement in rheumatoid arthritis (RA), spondyloarthritis (SpA), and psoriatic arthritis (PsA) and compare them with patients without inflammatory arthritides. Materials and methods: In this retrospective analysis, cervical CT or MRIs of patients with RA, SpA, or PsA, taken for any reason between 2010 and 2020, according to ICD-10 codes, were scanned. Demographic data of the patients were recorded. CCJ involvements (atlantoaxial, vertical, or subaxial subluxation, odontoid process involvement) were reevaluated by an experienced radiologist. The control group consisted of consecutive patients without inflammatory …
Management And Prognosis Of Patients With Cancer Of Unknown Primary: 20 Years Of Experience, Murat Bardakçi, Efnan Algin, Büşra Dügeroğlu, Öznur Bal, Fahri̇ye Tuğba Köş, Doğan Uncu
Management And Prognosis Of Patients With Cancer Of Unknown Primary: 20 Years Of Experience, Murat Bardakçi, Efnan Algin, Büşra Dügeroğlu, Öznur Bal, Fahri̇ye Tuğba Köş, Doğan Uncu
Turkish Journal of Medical Sciences
Background/aim: Cancer of unknown primary (CUP) is a difficult clinical entity to manage. The aim of the study was to investigate the sociodemographic and pathological characteristics, treatment options, and factors affecting overall survival (OS) in CUP patients whose primary tumor was not detected during follow-up. Materials and methods: A total of 243 CUP patients whose primary tumors could not be detected during follow-up were included in the study. Their demographic characteristics, survival outcomes, and prognostic factors were investigated. Results: Of the 243 patients included in this study, 61.7% were male and 38.3% were female, and the median age was 61 …
Prospective Study Of The Effects Of Isotretinoin And Vitamin D Levels On Severe Acne Vulgaris, Ramadan Hussein, Salman Bindayel, Othman Abahussein
Prospective Study Of The Effects Of Isotretinoin And Vitamin D Levels On Severe Acne Vulgaris, Ramadan Hussein, Salman Bindayel, Othman Abahussein
Turkish Journal of Medical Sciences
Background/aim: Acne vulgaris (AV) is a common inflammatory skin condition associated with psychological and social distress. Its pathogenesis involves factors such as sebaceous hypersecretion and Cutibacterium acnes colonization. Vitamin D plays a crucial role in the pathogenesis of various inflammatory skin disorders, including AV, due to its immunomodulatory effects and involvement in keratinocyte growth and maturity. However, adequate sun exposure is required for optimal vitamin D synthesis. Isotretinoin (IOS), a vitamin A derivative, is a commonly used medication for severe acne, acting by binding to retinoid receptors. It can also form heterodimers with vitamin D receptors, potentially increasing vitamin D …
Relationship Between Surgical Rhinoplasty And Demodex Infestation: A Case-Control Study, Abdullah Demi̇rbaş, Di̇lek Bayramgürler, Emrah Kağan Yaşar, Muhammed Adak, Can İlker Demi̇r
Relationship Between Surgical Rhinoplasty And Demodex Infestation: A Case-Control Study, Abdullah Demi̇rbaş, Di̇lek Bayramgürler, Emrah Kağan Yaşar, Muhammed Adak, Can İlker Demi̇r
Turkish Journal of Medical Sciences
Background/aim: Human Demodex mites are parasites that live in the pilosebaceous unit and can cause demodicosis. While demodicosis may occur as a primary skin disease, it may also result from immunosuppression and topical or systemic immunosuppressive therapies. Surgical rhinoplasty is one of the most commonly performed cosmetic procedures, and it is the cause of a variety of cutaneous complications, particularly acne, as it affects the skin's adnexal structures. Thus, this study aimed to investigate whether the cutaneous changes in surgical rhinoplasty patients render them vulnerable to Demodex infestation. Materials and methods: Individuals who had undergone rhinoplasty (patients) and age- and …
Covid-19 In Cancer Patients: Patient Characteristics And Outcomes In The Post-Covid-19 Vaccination Period, Gülşen İskender, Duygu Mert, Göknur Yapar Toros, Funda Yilmaz, Ersi̇n Bozan, Semra Tunçbi̇lek, Ömür Berna Çakmak Öksüzoğlu, Fevzi̇ Altuntaş, Mustafa Ertek
Covid-19 In Cancer Patients: Patient Characteristics And Outcomes In The Post-Covid-19 Vaccination Period, Gülşen İskender, Duygu Mert, Göknur Yapar Toros, Funda Yilmaz, Ersi̇n Bozan, Semra Tunçbi̇lek, Ömür Berna Çakmak Öksüzoğlu, Fevzi̇ Altuntaş, Mustafa Ertek
Turkish Journal of Medical Sciences
Background/aim:It wasaimed herein to investigate coronavirus disease (COVID-19) in cancer patients and compare hematological and solid organ cancer patients in terms of the course and outcome of this disease. Materials and methods:Data from cancer patients with laboratory-confirmed COVID-19 infection were analyzed retrospectively. Risk factors for poor prognosis and the effect of vaccination on the clinical outcomes of the patients were evaluated. Results:A total of 403 cancer patients who were diagnosed with COVID-19 between March 1st, 2021, and November 30th, 2022, were included, of whom 329 (81.6%) had solid and 74 (18.4%) had hematological cancers. Hospitalization and intensive care unit (ICU) …
Positive Effects Of Health Behaviors Acquired During The Covid-19 Pandemic Process On The Prevention Of Other Infectious Diseases, Asi̇ye Çi̇ğdem Şi̇mşek, Turan Buzgan, Fatma Nur Baran Aksakal, Şuayip Bi̇ri̇nci̇, Hülya Şi̇ri̇n
Positive Effects Of Health Behaviors Acquired During The Covid-19 Pandemic Process On The Prevention Of Other Infectious Diseases, Asi̇ye Çi̇ğdem Şi̇mşek, Turan Buzgan, Fatma Nur Baran Aksakal, Şuayip Bi̇ri̇nci̇, Hülya Şi̇ri̇n
Turkish Journal of Medical Sciences
Background/aim: It was aimed to evaluate the positive effects of health behaviors (general hygiene, wearing face masks, physical distancing, and travel restrictions) acquired during the coronavirus disease 2019 (COVID-19) pandemic on the prevention of other infectious diseases in Ankara Province, Türkiye. Materials and methods: This study was designed retrospectively. Among the notifiable group A infectious diseases, acute intestinal infections (AIIs) with International Classification of Diseases, Tenth Revision diagnosis codes A09 (diarrhea and gastroenteritis presumed to be of infectious origin), R11 (nausea and vomiting), and K52 (other noninfectious gastroenteritis and colitis) , as well as influenza, tuberculosis, measles, varicella, malaria, and …
Characterizing Cutaneous Leishmaniasis In A Conflict-Affected Region: A Study From North Waziristan, Pakistan, Zahid Ullah, Fazeelat Samad, Rahila Bano, Sarah Arif, Sher Zamir, Nighat Aziz, Hassan Khan
Characterizing Cutaneous Leishmaniasis In A Conflict-Affected Region: A Study From North Waziristan, Pakistan, Zahid Ullah, Fazeelat Samad, Rahila Bano, Sarah Arif, Sher Zamir, Nighat Aziz, Hassan Khan
Turkish Journal of Medical Sciences
Background/aim: Cutaneous leishmaniasis is an emerging tropical disease that remains a serious public health issue in Pakistan, particularly in North Waziristan. The current research was carried out to investigate the presence of cutaneous leishmaniasis in this region. Materials and methods: This prospective observational study was conducted from October 2018 to December 2020 at District Head Quarter Hospital Miranshah in North Waziristan with the collaboration of the Pathology Department of Gomal Medical College Dera Ismail Khan, Khyber Pakhtunkhwa. Needle aspirates were used for the microscopic Giemsa-stained slides. SPSS was used for data analysis. Results: Of the 5406 clinically-suspected cases, 2603(48.2%) were …
Comprehensive Comparison Of Clinicoradiological, Laboratory, And Prognostic Factors Of Community-Acquired Pneumonia In Diabetic And Nondiabetic Hospitalized Patients, Seyyed Hamid Hashemi, Fatemeh Saki, Shiva Borzouei, Rashed Bawand, Alireza Soltanian
Comprehensive Comparison Of Clinicoradiological, Laboratory, And Prognostic Factors Of Community-Acquired Pneumonia In Diabetic And Nondiabetic Hospitalized Patients, Seyyed Hamid Hashemi, Fatemeh Saki, Shiva Borzouei, Rashed Bawand, Alireza Soltanian
Turkish Journal of Medical Sciences
Background/aim: Community-acquired pneumonia (CAP) is one of the leading infectious causes of mortality, and diabetes mellitus is a globally prevalent disease. Consequently, the cooccurrence of these two disorders can be common and create challenging medical conditions. Therefore, it was aimed to compare the various aspects of CAP in diabetic and nondiabetic patients, in order to have a comprehensive and comparative picture of the differences. Materials and methods: In this cross-sectional study, CAP patients with and without diabetes were assessed for clinicoradiological signs, laboratory features, disease severity, and pneumonia outcomes. Results: Analyzed herein were 172 CAP patients (77 had diabetes and …
Neurodevelopmental Evaluation Of Newborns Who Underwent Hypothermia With A Diagnosis Of Hypoxic Ischemic Encephalopathy Based On The Bayley-Iii Scale, Mehmet Fati̇h Deveci̇, Şenay Güven Baysal, Meral Alagöz, İsmai̇l Kürşad Gökçe, Derya Doğan, Ramazan Özdemi̇r
Neurodevelopmental Evaluation Of Newborns Who Underwent Hypothermia With A Diagnosis Of Hypoxic Ischemic Encephalopathy Based On The Bayley-Iii Scale, Mehmet Fati̇h Deveci̇, Şenay Güven Baysal, Meral Alagöz, İsmai̇l Kürşad Gökçe, Derya Doğan, Ramazan Özdemi̇r
Turkish Journal of Medical Sciences
Background/ aim: Hypoxic ischemic encephalopathy (HIE) is one of the common causes of mortality and morbidity in newborns. Despite therapeutic hypothermia, an important treatment with proven efficacy, the morbidity and mortality rates remain high. The aim of this study was to neurodevelopmentally evaluate patients who underwent therapeutic hypothermia. Material and method: Included herein were patients who underwent hypothermia between 2018 and 2020. Their medical files were reviewed retrospectively, and their demographic and clinical information was recorded. Patients whose contact information was available were called to the developmental pediatrics outpatient clinic for a neurodevelopmental evaluation. The Bayley Scales of Infant and …
Electroencephalographic Abnormalities In Children With Type 1 Diabetes Mellitus: A Prospective Study, Ruken Yildirim, Ceren Günbey
Electroencephalographic Abnormalities In Children With Type 1 Diabetes Mellitus: A Prospective Study, Ruken Yildirim, Ceren Günbey
Turkish Journal of Medical Sciences
Background/aim: The aim herein was to investigate epileptiform discharges on electroencephalogram (EEG), their correlation with glutamic acid decarboxylase 65 autoantibody (GAD-ab) in newly diagnosed pediatric type 1 diabetes mellitus (T1DM) patients and interpret their medium-term utility in predicting epilepsy. Materials and methods: Children presenting with T1DM between July 2018 and December 2019 were included in this prospective longitudinal study. Patients with a history of head injury, chronic illness, neurological disorder, seizure, autism, or encephalopathy were excluded. EEGs were obtained within the first 7 days of diagnosis and later reviewed by a pediatric neurologist. All of the children were clinically followed-up …
Is Electrophysiological Study A Novel Predictor For Permanent Pacemaker Implantation After Transcatheter Aortic Valve Implantation?, Zeki̇ Çeti̇nkaya, Deni̇z Elçi̇k, Şaban Keleşoğlu, Burak Cesur, Mustafa Yaşan, Uğur Karabiyik, Bi̇lge Bi̇ngöl, Ni̇hat Kalay, Ramazan Topsakal, Aydin Tunçay, Ali̇ Doğan, Mehmet Tuğrul İnanç
Is Electrophysiological Study A Novel Predictor For Permanent Pacemaker Implantation After Transcatheter Aortic Valve Implantation?, Zeki̇ Çeti̇nkaya, Deni̇z Elçi̇k, Şaban Keleşoğlu, Burak Cesur, Mustafa Yaşan, Uğur Karabiyik, Bi̇lge Bi̇ngöl, Ni̇hat Kalay, Ramazan Topsakal, Aydin Tunçay, Ali̇ Doğan, Mehmet Tuğrul İnanç
Turkish Journal of Medical Sciences
Background/aim: Despite advancements in valve technology and increased clinical experience, complications related to conduction defects after transcatheter aortic valve implantation (TAVR) have not improved as rapidly as expected. In this study, we aimed to predict the development of complete atrioventricular (AV) block and bundle branch block during and after the TAVR procedure and to investigate any changes in the cardiac conduction system before and after the procedure using electrophysiological study. Materials and methods: A total of 30 patients who were scheduled for TAVR at our cardiovascular council were planned to be included in the study. TAVR was performed on patients …
Assessment Of Changes In Macular Structural Retinal Layers In Patients With Pathological Myopia, Mehmet Çitirik, Kami̇l Yavuzer, Fatma Bağci
Assessment Of Changes In Macular Structural Retinal Layers In Patients With Pathological Myopia, Mehmet Çitirik, Kami̇l Yavuzer, Fatma Bağci
Turkish Journal of Medical Sciences
Background/aim: This study aimed to examine changes in the thickness of individual macular retinal layers in eyes with pathological myopia (PM) and to compare the thickness of each retinal layer between the PM and control groups to gain insights into retinal perfusion. Materials and methods: The study included 51 eyes in the PM group and 51 eyes in the control group. Optical coherence tomography (OCT) was used to measure the thickness of each retinal layer in the central fovea, parafoveal, and perifoveal regions. Optical coherence tomography angiography (OCT-A) was used to evaluate the retinal capillary density. Results: In the PM …
What Is The Impact Of Intraperitoneal Surfactant Administration Against Postoperative Intraabdominal Adhesion Formation? An Experimental Study, Şehmus Pala, Tuncay Kuloğlu, Remzi̇ Atilgan, Zehra Sema Özkan, Serhat Hançer
What Is The Impact Of Intraperitoneal Surfactant Administration Against Postoperative Intraabdominal Adhesion Formation? An Experimental Study, Şehmus Pala, Tuncay Kuloğlu, Remzi̇ Atilgan, Zehra Sema Özkan, Serhat Hançer
Turkish Journal of Medical Sciences
Background/Aim: Surfactant is a surface-active substance that, in addition to its detergent effect, also has effects that reduce inflammation and fibrosis. Because of these effects, it was aimed herein to investigate the effect of intraperitoneal surfactant application on preventing postoperative peritoneal adhesion formation in a uterine horn adhesion model. Materials and methods: Twenty-one Wistar albino rats were randomly divided into 3 groups (G1-G3), as follows: G1 (n = 7): control group. The abdomen was opened and then closed; G2 (n = 7): adhesion group. The abdomen was opened. Then, a 2-cm linear incision was made over the right uterine horn, …
Comparison Of The Effectiveness Of Instrument-Assisted Soft Tissue Mobilization And Extracorporeal Shock Wave Therapy In Myofascial Pain Syndrome, Şeyda Candeni̇z, Seyi̇t Çitaker, Gökhan Maraş, Hati̇ce Esra Yavuzer, Hasan Yildirim, Zafer Günendi̇
Comparison Of The Effectiveness Of Instrument-Assisted Soft Tissue Mobilization And Extracorporeal Shock Wave Therapy In Myofascial Pain Syndrome, Şeyda Candeni̇z, Seyi̇t Çitaker, Gökhan Maraş, Hati̇ce Esra Yavuzer, Hasan Yildirim, Zafer Günendi̇
Turkish Journal of Medical Sciences
Background/aim: To compare the effectiveness of instrument-assisted soft tissue mobilization (IASTM) and extracorporeal shock wave therapy (ESWT) used in myofascial pain syndrome (MPS) and to determine whether they are superior to conservative treatment (CT). Materials and methods: A total of 42 female patients (aged 18-60 years) diagnosed with MPS were enrolled and randomly assigned to either the CT (n = 14), CT+IASTM (n = 14), or CT+ESWT group (n = 14). All of the groups received treatment for 3 weeks (CT: 5 sessions per week, 15 sessions in total, ESWT and IASTM: 2 sessions per week, 6 sessions in total). …
Development Of A Gestational Diabetes Risk Assessment Scale: A Validity And Reliability Study, Selma Dağci, Besey Ören
Development Of A Gestational Diabetes Risk Assessment Scale: A Validity And Reliability Study, Selma Dağci, Besey Ören
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to develop a gestational diabetes risk assessment scale (GEDRISK). Materials and methods: This methodological study included 652 pregnant women who presented to six public health institutions in İstanbul between September 2021 and February 2022. Content validity was evaluated using the content validity index, while construct validity was assessed through exploratory and confirmatory factor analyses. Item discrimination was examined using Cronbach's alpha coefficients, Spearman-Brown and Guttman coefficients, item-total correlation tests, and 27% lower and upper quartile t tests. Reliability was determined through test-retest analysis methods. Results: The scale-level content validity index demonstrated strong coherence …
Individualized Hemodialysis: Is Similar Hemodialysis Adequacy Possible Using Less Water?, Ali̇ Aktaş, Hakan Özer, İsmai̇l Baloğlu, Hali̇l Zeki̇ Tonbul, İbrahi̇m Güney, Nedi̇m Yilmaz Selçuk
Individualized Hemodialysis: Is Similar Hemodialysis Adequacy Possible Using Less Water?, Ali̇ Aktaş, Hakan Özer, İsmai̇l Baloğlu, Hali̇l Zeki̇ Tonbul, İbrahi̇m Güney, Nedi̇m Yilmaz Selçuk
Turkish Journal of Medical Sciences
Background and aim: There are over 60,000 hemodialysis (HD) patients in Türkiye, and the number of patients is increasing yearly. Dialysate flow rate (Qd) is a factor in HD adequacy. Approximately 150 L of water are consumed per session to prepare the dialysate. We aimed to investigate whether HD effectiveness can be achieved at a low Qd in different patient groups for the purpose of saving water. Materials and methods: This prospective study included 81 HD patients from 2 centers. The patients underwent an aggregate total of 486 HD sessions, including 3 sessions at a Qd of 500 mL/min and …
Vital Indicators In Predicting Burn Mortality: A Comparison Of Shock Indices And Burn Shock Indices, Mustafa İçer, Ercan Gündüz, Cahfer Güloğlu, Serkan Erbatur, Di̇cle Polat, Hali̇me Özkan, Tuğçe Bayrak, Şi̇lan Göger Ülgüt
Vital Indicators In Predicting Burn Mortality: A Comparison Of Shock Indices And Burn Shock Indices, Mustafa İçer, Ercan Gündüz, Cahfer Güloğlu, Serkan Erbatur, Di̇cle Polat, Hali̇me Özkan, Tuğçe Bayrak, Şi̇lan Göger Ülgüt
Turkish Journal of Medical Sciences
Background/aim: In many studies, shock indices have proven to be good tools for predicting mortality. In the present study, burn shock index (BSI), percentage of total body surface area burned (TBSA%) multiplied by shock index; burn modified shock index (BMSI), TBSA% multiplied by modified shock index; burn age shock index (BASI), TBSA% multiplied by age shock index; burn rivers shock index (BrSI), TBSA% multiplied by rivers shock index; burn rivers shock index multiplied by Glasgow Coma Scale score (BrSIG) were examined in burn patients. We defined these burn shock indices for the first time. This study aimed to evaluate the …
Suicide Attempt Management Among Turkish And American Adolescents: A Comparison Of Two Pediatric Emergency Departments, Ali̇ Yurtseven, Caner Turan, Deborah Mary Ort, Mehrin Islam, Sezen Köse, Eylem Ulaş Saz, Hali̇m Hennes
Suicide Attempt Management Among Turkish And American Adolescents: A Comparison Of Two Pediatric Emergency Departments, Ali̇ Yurtseven, Caner Turan, Deborah Mary Ort, Mehrin Islam, Sezen Köse, Eylem Ulaş Saz, Hali̇m Hennes
Turkish Journal of Medical Sciences
Background/aim: Suicide is one of the leading causes of death among adolescents. This study aimed to compare the characteristics and short-term outcomes of Turkish and American adolescents with suicide attempts and determine the differences in management and resource utilization between two pediatric emergency departments; one in Türkiye and one in the United States of America. Materials and methods: Adolescents who presented to the emergency departments with a chief complaint of suicide attempt between October 2017 and September 2018 were eligible for including in the study. Characteristics and other information of 217 (131 American and 86 Turkish) suicide attempter adolescents were …
Protective Effects Of Safranal On Kidney Tissue In A Rat Model Of Distant Ischemiareperfusion Injury With Infrarenal Aortic Occlusion, Mehmet Tort, Hülya Sevi̇l, Fehi̇m Can Sevi̇l, Neci̇p Beci̇t, Uğur Aksu, Zülfükar Kadi̇r Saritaş, Hasan Hüseyi̇n Demi̇rel, Azi̇z Bülbül, Zehra Yaşar, Merve Beci̇t Kizilkaya, Hazen Saritaş
Protective Effects Of Safranal On Kidney Tissue In A Rat Model Of Distant Ischemiareperfusion Injury With Infrarenal Aortic Occlusion, Mehmet Tort, Hülya Sevi̇l, Fehi̇m Can Sevi̇l, Neci̇p Beci̇t, Uğur Aksu, Zülfükar Kadi̇r Saritaş, Hasan Hüseyi̇n Demi̇rel, Azi̇z Bülbül, Zehra Yaşar, Merve Beci̇t Kizilkaya, Hazen Saritaş
Turkish Journal of Medical Sciences
Background/aim: Ischemia-reperfusion (IR) injury to a part of the body can cause damage to distant organs such as the kidney and heart. This study investigated the protective effects of safranal against IR-induced renal injury. Materials and methods: Used in this study were 24 Wistar Albino male rats, which were divided into 3 equal and randomised groups. The sham group underwent laparotomy only. In the IR group, the infrarenal aorta was clamped for 1 h, and then reperfused for 2 h. In the IR-safranal group, safranal was administered 30 min before the procedure and IR injury was induced in the same …
Effects Of Acetylsalicylic Acid And Ultrasound Elastography On Testicular Torsion In Rats, Ezgi̇ Gün Soytürk, Ünal Biçakci, Serdar Aslan, Tolga Güvenç, Meltem Neci̇be Ceyhan Bi̇lgi̇ci̇
Effects Of Acetylsalicylic Acid And Ultrasound Elastography On Testicular Torsion In Rats, Ezgi̇ Gün Soytürk, Ünal Biçakci, Serdar Aslan, Tolga Güvenç, Meltem Neci̇be Ceyhan Bi̇lgi̇ci̇
Turkish Journal of Medical Sciences
Background/aim: To investigate the effects of acetylsalicylic acid (ASA) and the use of ultrasound elastography on testicular torsion. Materials and methods: Herein, 6 equal groups of rats were formed (n: 48): control group, sham group, torsion/detorsion (T/D)-1 h group, T/D-1 h + ASA group, T/D-8 h group, and T/D-8 h + ASA group. Testicular torsion was created by rotating the left testis 720° clockwise. At 30 min before torsion, 100 mg/kg of ASA was injected intraperitoneally. Elastography was performed at 8 and 24 h. After orchiectomy, specimens were collected for histopathological evaluation. Results: When comparing the left testicular volume (LV) …
Tripartite Motif Protein 6 Promotes Hepatocellular Carcinoma Progression Via Multiple Pathways, Yifeng Zhang, Lin Yuan, Shanshan Cui, Song Wu
Tripartite Motif Protein 6 Promotes Hepatocellular Carcinoma Progression Via Multiple Pathways, Yifeng Zhang, Lin Yuan, Shanshan Cui, Song Wu
Turkish Journal of Medical Sciences
Background/aim: Hepatocellular carcinoma (HCC) ranks among the most prevalent malignancies worldwide and the third leading cause of cancer-related death. The TRIM (tripartite motif-containing) protein family members had been reported to be involved in carcinogenesis and tumor progression. Here we aimed to explore the expression profile of TRIM6 in HCC and investigate its clinical significance as well as underlying mechanisms. Materials and methods: We retrospectively enrolled 138 HCC patients that underwent surgical resection in our hospital and tested protein expression level of TRIM6 through immunohistochemical staining. The correlation between TRIM6 and patients? characteristics was assessed by Chi-square test. Log-rank test and …
Propofol Mitigates Brain Injury And Oxidative Stress, And Enhances Gabaa Receptor ?1 Subunit Expression In A Rat Model Of Lithium Chloride-Pilocarpine Induced Status Epilepticus, Lei Li, Xiu Liu, Juan Du, Wangyan Yang, Runqiao Fu, Yunfeng Li, Wei Zhao, Henglin Wang
Propofol Mitigates Brain Injury And Oxidative Stress, And Enhances Gabaa Receptor ?1 Subunit Expression In A Rat Model Of Lithium Chloride-Pilocarpine Induced Status Epilepticus, Lei Li, Xiu Liu, Juan Du, Wangyan Yang, Runqiao Fu, Yunfeng Li, Wei Zhao, Henglin Wang
Turkish Journal of Medical Sciences
Background/aim: Propofol is a positive allosteric modulator of GABAA receptor (GABAAR) and has potent antioxidant activity. The aim of this study was to investigate the effect of propofol on damage to the cerebral cortex and hippocampus in a lithium chloride (LiCl)- pilocarpine animal model of status epilepticus (SE). Materials and methods: Adult male Sprague Dawley rats were injected with LiCl-pilocarpine to induce SE. They were then randomized and injected 30 min later with vehicle saline (SE+saline), propofol (SE+PPF, 50 mg/kg), Diazepam (SE+DZP, 10 mg/kg), Scopolamine (SE+SCOP, 10 mg/kg), or MK-801 (SE+MK-801, 2 mg/kg). Another group of rats received saline only …
Cd39 Expression On Immune Cells Predicts Methotrexate Response In Rheumatoid Arthritis Patients, Bariş Boral, İbrahi̇m Tuncer, Fi̇li̇z Ki̇bar, Sali̇h Çeti̇ner, Suade Özlem Badak, Emrah Salman, Emrah Koç, Eren Erken, Akgün Yaman
Cd39 Expression On Immune Cells Predicts Methotrexate Response In Rheumatoid Arthritis Patients, Bariş Boral, İbrahi̇m Tuncer, Fi̇li̇z Ki̇bar, Sali̇h Çeti̇ner, Suade Özlem Badak, Emrah Salman, Emrah Koç, Eren Erken, Akgün Yaman
Turkish Journal of Medical Sciences
Background/aim: Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting mostly small joints, such as hand and foot joints symmetrically with irreversible joint destruction. In this study, the relationship between CD39 expression and the treatment response of RA patients was examined to investigate its potential as a biomarker that demonstrates treatment response. Materials and methods: This study included 77 RA patients and 40 healthy controls (HC). The RA patients were divided into 2 groups based on their response to RA treatment, those with a good response to methotrexate (MTX) monotherapy and those with an inadequate response based on the American …
Should Valgus-Impacted Proximal Humerus Fractures Necessarily Be Operated On? Radiological Versus Functional Results, Muhli̇k Akyürek, Emre Koraman, Yusuf İyeti̇n, Mehmet Akan
Should Valgus-Impacted Proximal Humerus Fractures Necessarily Be Operated On? Radiological Versus Functional Results, Muhli̇k Akyürek, Emre Koraman, Yusuf İyeti̇n, Mehmet Akan
Turkish Journal of Medical Sciences
Background/aim: Impacted valgus proximal humerus fracture has been known to be challenging in terms of treatment and outcomes since it was defined. Moreover, it is a type of fracture that is difficult to treat. In addition, exact limits have not yet been determined regarding which parameters affect patients? functional and reported outcomes. The purpose of this study was to compare the radiological results of patients with impacted valgus proximal humerus fractures treated conservatively and surgically and to evaluate the effect of these radiological parameters on functional outcomes. Materials and methods: A total of 79 patients who were treated between 2015 …
Clinical Characteristics And Predictors For Recurrence In Chronic Nonbacterial Osteomyelitis: A Retrospective Multicenter Analysis, Kadi̇r Ulu, Rana İşgüder, Şeri̇fe Gül Karadağ, Esra Bağlan, Gülşah Kavrul Kayaalp, Gülçi̇n Otar Yener, Kübra Öztürk, Hafi̇ze Emi̇ne Sönmez, Semanur Özdel, Ferhat Demi̇r, Balahan Makay, Şevket Erbi̇l Ünsal, Betül Sözeri̇, Nuray Aktay Ayaz, Mustafa Çakan
Clinical Characteristics And Predictors For Recurrence In Chronic Nonbacterial Osteomyelitis: A Retrospective Multicenter Analysis, Kadi̇r Ulu, Rana İşgüder, Şeri̇fe Gül Karadağ, Esra Bağlan, Gülşah Kavrul Kayaalp, Gülçi̇n Otar Yener, Kübra Öztürk, Hafi̇ze Emi̇ne Sönmez, Semanur Özdel, Ferhat Demi̇r, Balahan Makay, Şevket Erbi̇l Ünsal, Betül Sözeri̇, Nuray Aktay Ayaz, Mustafa Çakan
Turkish Journal of Medical Sciences
Background/aim: Chronic nonbacterial osteomyelitis (CNO) is a rare disease of unknown etiology and most commonly occurs during childhood or adolescence. The purpose of this study is to collect data on the clinical features, outcomes, and management of the disease and to identify the factors affecting recurrence. Materials and methods: This is a retrospective multicenter cross-sectional study of pediatric patients diagnosed with CNO. A total of 87 patients with a diagnosis of CNO followed for at least 6 months in 8 pediatric rheumatology centers across the country between January 2010 and December 2021 were included in this study. Results: The study …
The Effect Of Natural Surfactants On The Development Of Postoperative Intraabdominal Adhesion, Ahmet Gökhan Güler, Ali̇ Erdal Karakaya, Ahmet Burak Doğan, Abdulkadi̇r Yasi̇r Bahar, Sadik Yurttutan
The Effect Of Natural Surfactants On The Development Of Postoperative Intraabdominal Adhesion, Ahmet Gökhan Güler, Ali̇ Erdal Karakaya, Ahmet Burak Doğan, Abdulkadi̇r Yasi̇r Bahar, Sadik Yurttutan
Turkish Journal of Medical Sciences
Background/aim: The development of postoperative adhesion after abdominal surgery is sometimes a severe problem. Our study investigates the effectiveness of exogenous surfactant application in preventing adhesion development in the experimental adhesion model. Materials and methods: This randomized-controlled interventional study was carried out in the animal laboratory of Kahramanmaraş Sütçü İmam University between March 1 and March 31, 2020. An experimental intra-abdominal adhesion model was established in 24 adult female rats by cecal abrasion. Rats were randomly divided into four groups. Groups I, II, and III were taken intraperitoneally as beractant, poractant, and calfactant applied groups, respectively. Group IV was the …
Rasch Analysis, Reliability, And Validity Of The Turkish Version Of The Lumbar Spine Instability Questionnaire, Erkan Erol, Umut Apaydin, Ramazan Yildiz, Ayşe Yildiz, Si̇nem Erturan, Derya Gökmen, Özlem Akkoyun Sert, Bayram Sönmez Ünüvar, Hasan Gerçek, Bülent Elbasan
Rasch Analysis, Reliability, And Validity Of The Turkish Version Of The Lumbar Spine Instability Questionnaire, Erkan Erol, Umut Apaydin, Ramazan Yildiz, Ayşe Yildiz, Si̇nem Erturan, Derya Gökmen, Özlem Akkoyun Sert, Bayram Sönmez Ünüvar, Hasan Gerçek, Bülent Elbasan
Turkish Journal of Medical Sciences
Background/aim: Lumbar instability is an important condition that can be seen frequently in people with low back pain, affecting both the progression and the choice of appropriate exercise. The Lumbar Spine Instability Questionnaire (LSIQ) is a simple and low-cost tool for evaluating disturbed back stability in people with low back pain. The aim of this study is to develop the Turkish version of the LSIQ (LSIQ-T) and to evaluate its psychometric properties using the Rasch model. Materials and methods: One hundred participants with chronic low back pain completed the LSIQ-T. The LSIQ-T was repeated for 30 participants after 1 week …