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Full-Text Articles in Medical Sciences
Relationship Between C-Reactive Protein/Albumin Ratio And Mucocutaneous Symptom Frequency And Disease Severity In Behçet’S Disease, Erdal Pala, Mustafa Bayraktar
Relationship Between C-Reactive Protein/Albumin Ratio And Mucocutaneous Symptom Frequency And Disease Severity In Behçet’S Disease, Erdal Pala, Mustafa Bayraktar
Turkish Journal of Medical Sciences
Background/aim: There is no specific marker that can be applied to determine the severity of Behçet’s disease. The aim of this study is to investigate the potential of C-reactive protein (CRP)/albumin (CAR) ratio as a tool for assessing the severity of Behçet’s disease.Materials and methods: A retrospective crosssectional study was conducted by examining hospital archives. The CRP and albumin levels of Behçet’s disease patients who presented to our dermatology clinic over a three-year period from February 2020 to February 2022 were included, along with the identical laboratory parameters in the control group. The CAR ratio was calculated and statistically compared …
Serum And Urine Interferon-Inducible Protein 10, Galectin-9, And Siglec-1 As Biomarkers Of Disease Activity In Systemic Lupus Erythematosus, Şafak Mi̇ri̇oğlu, Suzan Çinar, Ömer Uludağ, Erdem Gürel, Sibel Varelci̇, Yasemin Özlük, Işın Kiliçaslan, Yasemin Yalçinkaya, Halil Yazici, Ahmet Gül, Murat İnanç, Bahar Artim Esen
Serum And Urine Interferon-Inducible Protein 10, Galectin-9, And Siglec-1 As Biomarkers Of Disease Activity In Systemic Lupus Erythematosus, Şafak Mi̇ri̇oğlu, Suzan Çinar, Ömer Uludağ, Erdem Gürel, Sibel Varelci̇, Yasemin Özlük, Işın Kiliçaslan, Yasemin Yalçinkaya, Halil Yazici, Ahmet Gül, Murat İnanç, Bahar Artim Esen
Turkish Journal of Medical Sciences
Background/aim: In this prospective study, we aimed to investigate the association of serum (s) and urine (u) IP-10, galectin-9, and SIGLEC-1 with disease activity in patients with systemic lupus erythematosus (SLE).Materials and methods: Sixty-three patients with active SLE (31 renal, 32 extrarenal) were included. Thirty patients with inactive SLE (15 renal, 15 extrarenal), 17 with renal active AAV, and 32 healthy volunteers were selected as control groups. Serum and urine IP-10, galectin-9, and SIGLEC-1 were tested using ELISA.Results: Levels of sIP-10 (p = 0.046), uIP-10 (p < 0.001), sGalectin-9 (p = 0.03), and uSIGLEC-1 (p = 0.006) were significantly higher in active SLE group compared to the inactive SLE; however, no differences were detected in the comparison of uGalectin-9 (p = 0.18) and sSIGLEC-1 (p = 0.69) between two groups. None of the biomarkers discriminated patients with active renal SLE from active extrarenal SLE. ROC analyses revealed an AUC of 0.63 (0.52–0.73) for sIP-10, 0.78 (0.68–0.86) for uIP-10, 0.64 (0.53–0.74) for sGalectin-9, and 0.68 (0.57–0.77) for uSIGLEC-1 in discriminating disease activity in SLE, which did not outperform C3 (0.75, 0.64–0.84) and C4 (0.72, 0.61–0.82). sIP-10 (p = 0.001), uIP-10 (p = 0.042), and uGalectin-9 (p = 0.009) were significantly increased in patients with active renal SLE compared to active renal AAV. sGalectin-9 (p < 0.001) and sIP-10 levels (p = 0.06) were decreased after 8 (5–22.5) months of treatment.Conclusion: sIP-10, uIP-10, sGalectin-9, and uSIGLEC-1 reflect global disease activity in SLE but do not outperform C3 and C4. sIP-10 and uIP-10 may be specific for active SLE compared to active AAV. sIP-10 and sGalectin-9 might be valuable in monitoring response after treatment.
Antiobesity And Antidyslipidemic Properties Of Clitoria Ternatea Petals Aqueous Extract Against Rats Induced By High-Fat Diet, I Gede Aswin Parisya Sasmana, Desak Made Wihandani, I Gede Krisna Arim Sadeva, Wilson Halim, Putu Putri Agustini, Lalita Samala, I Gusti Ngurah Agung Surya Pratama, Lidiya Nuraliza Rachmawati, Aizar Vesa Prasetyo, Ni Komang Ayu Amanda Setiari Jaya
Antiobesity And Antidyslipidemic Properties Of Clitoria Ternatea Petals Aqueous Extract Against Rats Induced By High-Fat Diet, I Gede Aswin Parisya Sasmana, Desak Made Wihandani, I Gede Krisna Arim Sadeva, Wilson Halim, Putu Putri Agustini, Lalita Samala, I Gusti Ngurah Agung Surya Pratama, Lidiya Nuraliza Rachmawati, Aizar Vesa Prasetyo, Ni Komang Ayu Amanda Setiari Jaya
Turkish Journal of Medical Sciences
Background/aim: Obesity is a chronic metabolic disease involving dysregulation of fat metabolism that affects 13% of the world’s population. Obesity has been linked to dyslipidemia with a lot of complication, including stroke, chronic kidney disease, fatty liver disease, and so on. One of the natural resources that have several potential effects including anticholesterol, antiobesity, and antidyslipidemia is the butterfly pea (Clitoria ternatea/CT). CT’s petal has been found to contain high levels of anthocyanins and tannins that can inhibit the biosynthesis of cholesterol and lipid. This study aims to investigate the antiobesity and antidyslipidemic effects of Clitoria ternatea extract (CTE).Materials and …
The Outcome In Pediatric Acute Myeloblastic Leukemia; Results Of The First-Line Treatment And Contribution Of Hematopoietic Stem Cell Transplantation To Survival Of Relapsed Patients, Nazan Sarper, Intzi Tachzin, Sema Aylan Gelen, Emine Zengi̇n
The Outcome In Pediatric Acute Myeloblastic Leukemia; Results Of The First-Line Treatment And Contribution Of Hematopoietic Stem Cell Transplantation To Survival Of Relapsed Patients, Nazan Sarper, Intzi Tachzin, Sema Aylan Gelen, Emine Zengi̇n
Turkish Journal of Medical Sciences
Background/aim: To analyze the long-term outcome of pediatric patients with acute myeloblastic leukemia.Materials and methods: Data from 69 patients 0–18 years of age diagnosed between December 2001 and October 2019 were analyzed in April 2023. Patients received MRC-AML10 chemotherapy (2ADE+MACE+MidAC). No maintenance chemotherapy or preventive cranial radiotherapy was administered. Twelve patients with Down syndrome and 15 patients with promyelocytic leukemia were in the cohort. Patients with Down syndrome received reduced chemotherapy (cumulative anthracycline 420 mg/m2, cytarabine 3.4 g/m2, etoposide 1400 mg/m2). ATRA was added to chemotherapy in promyelocytic leukemia.Results: Four patients (5.8%) died in the induction (two typhlitis, one intracranial …
Developing Patient Safety Scale For Hospitals, Metin Di̇nçer, Esra Karataş Okyay, Yunus Emre Karataş, Erol Göral
Developing Patient Safety Scale For Hospitals, Metin Di̇nçer, Esra Karataş Okyay, Yunus Emre Karataş, Erol Göral
Turkish Journal of Medical Sciences
Background/aim: The study aimed to contribute to the literature with a reliable and valid scale for hospitals to be used in determining the current patient safety culture and following up on its development.Materials and methods: The study was conducted with the participation of 1137 healthcare professionals selected using the convenience sampling method in 3 secondary-care state hospitals and three research and training hospitals, one of which was affiliated with a medical faculty, and two were affiliated with the Health Sciences University. To begin with, to discover the latent structure of the items on the scale, an Exploratory Factor Analysis (EFA) …
Preoperative Parent Education And Postoperative Nurse-Led Care For Boys Versus Routine Hospital Care For Urethroplasty For Hypospadias In Western China: A Retrospective Study, Lisi Wang, Zhengdong Wang, Xiaohui Mao, Yingjun Fu, Qian Lei, Qin Liao
Preoperative Parent Education And Postoperative Nurse-Led Care For Boys Versus Routine Hospital Care For Urethroplasty For Hypospadias In Western China: A Retrospective Study, Lisi Wang, Zhengdong Wang, Xiaohui Mao, Yingjun Fu, Qian Lei, Qin Liao
Turkish Journal of Medical Sciences
Background/aim: Urethroplasty is the preferred treatment for hypospadias but is affected by the severity of anomalies, making it a complex procedure with potential postoperative complications. Following surgery, parents receive instructions and recommendations, whether from nurses or physicians, regardless of complication rates. However, nurses play a crucial role in educating caregivers before surgery and providing postoperative care during follow-up. The study aims to assess parents’ knowledge and practices, as well as the frequency of complications in boys who underwent urethroplasty for hypospadias and received postoperative nurse-led care and whose parents received preoperative education against those of boys who underwent urethroplasty under …
The Effect Of Human Recombinant Epidermal Growth Factor On Neovascularization And Pedicle Division Time In A Rat Interpolation Flap Model, Aziz Parspanci, Yavuz Keçeci̇, Peyker Temi̇z
The Effect Of Human Recombinant Epidermal Growth Factor On Neovascularization And Pedicle Division Time In A Rat Interpolation Flap Model, Aziz Parspanci, Yavuz Keçeci̇, Peyker Temi̇z
Turkish Journal of Medical Sciences
Background/aim: In practice, waiting 2–3 weeks for interpolation flaps pedicle division result in certain morbidities and discomfort for patient. The division time of flap pedicle depends on neovascularization from the recipient bed and includes wound healing stages. We aimed to investigate the effect of recombinant human epidermal growth factor (rhEGF) on the flap viability during early pedicle division.Materials and methods: Thirty-six rats were allocated to two main groups as control and study. A cranial based flap measuring 5 × 5 cm was elevated from the back, including all layers of the skin. While the cranial half of the defect was …
Evaluation Of Smoking Cessation Counseling Practices Of Physicians Working In Primary Health Care Institutions, Fatma Nur Karaçorlu, Edibe Pi̇ri̇nçci̇
Evaluation Of Smoking Cessation Counseling Practices Of Physicians Working In Primary Health Care Institutions, Fatma Nur Karaçorlu, Edibe Pi̇ri̇nçci̇
Turkish Journal of Medical Sciences
Background/aim: In this study, we aimed to evaluate the self-reported practice of physicians working in primary health care institutions in Elazığ Province about smoking cessation counseling.Materials and methods: The population of this cross-sectional study consisted of 262 physicians working in primary health care institutions in Elazığ. We aimed to reach the entire population without using the sample selection method and we successfully reached 95.42% (250 people) of the population. A questionnaire form was used for data collection. The data obtained were evaluated by frequency, percentage, mean ± standard deviation, median and minimum–maximum, and binary logistic regression analysis.Results: The mean age …
Internal Mucosal Resection And Llc Suspension: A New Method To Establish A Stable Tip Rotation Angle And Reduce The Nasal Bridge Length, Mehmet Dadaci, Moath Zuhour, Bilsev İnce, Zeynep Altuntaş
Internal Mucosal Resection And Llc Suspension: A New Method To Establish A Stable Tip Rotation Angle And Reduce The Nasal Bridge Length, Mehmet Dadaci, Moath Zuhour, Bilsev İnce, Zeynep Altuntaş
Turkish Journal of Medical Sciences
Background/aim: Herein, we describe a new technique to obtain both the appropriate degree of rotation angle and the ideal nasal bridge length. The aim of this study is to investigate the long-term results of this new technique with regard to these two variables.Materials and methods: A total of 76 (27 males, 49 females) patients were operated in accordance with the presented technique. Internal caudal mucosal excision and lower lateral cartilage (LLC) suspension were applied to all the patients included in this prospective study. Preoperative, immediate postoperative, and postoperative 1st-year photographs were taken. NOSE scores were obtained in the postoperative 1st …
Small Airway Resistance In Obese And Nonobese Patients With Obstructive Sleep Apnea Syndrome Using Impulse Oscillometry, Nejdiye Güngördü, Aytan İsmayi̇lova, Nigar Ali̇yeva, Tamer A M Alhelou, Ayşenur Özdi̇l Eser, Ilgım Vardaloğlu Koyuncu, Nihal Enşen, Ersan Atahan, Şermin Börekçi̇, Bilun Gemi̇ci̇oğlu
Small Airway Resistance In Obese And Nonobese Patients With Obstructive Sleep Apnea Syndrome Using Impulse Oscillometry, Nejdiye Güngördü, Aytan İsmayi̇lova, Nigar Ali̇yeva, Tamer A M Alhelou, Ayşenur Özdi̇l Eser, Ilgım Vardaloğlu Koyuncu, Nihal Enşen, Ersan Atahan, Şermin Börekçi̇, Bilun Gemi̇ci̇oğlu
Turkish Journal of Medical Sciences
Background/aim: There is limited information on the pathologic changes in the small airways among obese and nonobese patients with obstructive sleep apnea syndrome (OSAS). Impulse oscillometry (IOS) measures airway resistance and reactance independently of patient effort. This study aimed to compare airway resistance in small airways using IOS between obese and nonobese patients with OSAS.Materials and methods: In this real-life cross-sectional study, demographic information was collected from obese and nonobese subjects diagnosed with moderate and severe OSAS without any other underlying diseases. Spirometry and IOS measurements were conducted, and the values of both groups were statistically analyzed.Results: The nonobese group …
Minimally Invasive Sacroiliac Fusion; Current Insights And A Comprehensive Literature Review, Aydin Apaydin, Mehmet Yurtluk, Khoi̇ Than
Minimally Invasive Sacroiliac Fusion; Current Insights And A Comprehensive Literature Review, Aydin Apaydin, Mehmet Yurtluk, Khoi̇ Than
Turkish Journal of Medical Sciences
The sacroiliac joint (SIJ) is an easily dismissable cause of lower back pain (LBP). Recently has gained attention as the source of pain and surgeries addressing this issue have gained attention among surgeons. Classically open fusion surgery was used for the pelvic and sacral fractures to stabilize the structure and then open SIJ fusion surgery started to be used for pain management until the discovery of minimally invasive surgery (MIS). MIS offered fast and effective pain relief with significantly less risk of adverse events following the surgery. Therefore gaining more and more attention each day among surgeons. Our literature review …
Evaluating The Performance Of The Mskcc Gastric Cancer Survıval Calculator In The Turkısh Population, İlknur Deli̇ktaş Onur, Tuğba Başoğlu Tüylü, Nazim Demi̇rcan, Tuğba Akin Telli̇, Ruki̇ye Arikan, Özlem Ercelep, Serdar Turhal, Mehmet Öztürk, Perran Yumuk, Faysal Dane
Evaluating The Performance Of The Mskcc Gastric Cancer Survıval Calculator In The Turkısh Population, İlknur Deli̇ktaş Onur, Tuğba Başoğlu Tüylü, Nazim Demi̇rcan, Tuğba Akin Telli̇, Ruki̇ye Arikan, Özlem Ercelep, Serdar Turhal, Mehmet Öztürk, Perran Yumuk, Faysal Dane
Turkish Journal of Medical Sciences
Bacground/Aim: The MSKCC(Memorial Sloan Kettering Cancer Center) nomogram was developed to predict survivorship in gastric cancer patients undergoing R0 resection. This study aimed to evaluate the predictive power of this nomogram in the Turkish patient population. Materials and Methods: Gastric cancer patients over 18 years of age who were admitted to our clinic between 2000 and 2019 and underwent primary curative surgery and R0 resection were included in the study. The 5-year and 9-year overall survival rates of 489 patients were analyzed. Real-life survival rates and those calculated with the MSKCC tool were compared in all patients and subgroups. The …
Association Between Papillary Thyroid Cancer And Xrcc6 Gene Polymorphisms In The Turkish Population, Egemen Akgün, Fadi̇me Mutlu İçduygu, Demet Şengül, Ebru Alp, Mehmet Alkanat, Aysegül Cebi̇, Tuncer Ozturk
Association Between Papillary Thyroid Cancer And Xrcc6 Gene Polymorphisms In The Turkish Population, Egemen Akgün, Fadi̇me Mutlu İçduygu, Demet Şengül, Ebru Alp, Mehmet Alkanat, Aysegül Cebi̇, Tuncer Ozturk
Turkish Journal of Medical Sciences
Background/aim: This study aims to investigate the association between rs2267437, rs5751129 and rs132770 polymorphisms of the XRCC6 gene, which plays a role in repairing DNA double strand breaks, and the risk of Papillary Thyroid Cancer (PTC).Methods: The study included 150 patients who had been diagnosed with PTC and 204 healthy control subjects. Genotyping of SNPs was performed by Polymerase Chain Reaction - Restriction Fragment Length Polymorphism method (PCR - RFLP).Results: In rs2267437 polymorphism, individuals with GG genotype had lower risk of PTC than wild-type CC genotype (p=0.037, 95% CI=0.19-0.96, OR=0.67). The combined genotypes CG+GG were found to be related to …
Reliability And Validity Of The Turkish Version Of The Infant Motor Activity Log In Infants With Upper Extremity Functional Asymmetry: How Often And How Well?, Kübra Seyhan Biyik, Cemi̇l Özal, Kivanç Deli̇oğlu, Mi̇ntaza Kerem Günel
Reliability And Validity Of The Turkish Version Of The Infant Motor Activity Log In Infants With Upper Extremity Functional Asymmetry: How Often And How Well?, Kübra Seyhan Biyik, Cemi̇l Özal, Kivanç Deli̇oğlu, Mi̇ntaza Kerem Günel
Turkish Journal of Medical Sciences
Background/aim: Functional asymmetry in the upper extremities may occur in infants with neuromotor problems due to neurodevelopmental or musculoskeletal disorders. The aim of this study was to investigate the validity and reliability of the Turkish version of the Infant Motor Activity Log Scale (IMAL-T), which asks about the frequency (how often) and quality (how well) of the affected arm usage during activities in infants with functional asymmetry in the upper extremities.Materials and methods: The IMAL-T was administered face-to-face to parents of 102 infants (60 infants at high risk of cerebral palsy (CP) and 42 infants with brachial plexus birth injury …
Evaluation Of The Association Of Mucosa-Associated Invariant T (Mait) Cells With Childhood Asthma, Meral Ekşi̇, Huri̇ Bulut, Erdem Akalin, Feyza Ustabaş Kahraman, Hakan Yazan, Mebrure Yazici, Mustafa Nursoy, Emi̇n Özkaya, Abdürrahi̇m Koçyi̇ği̇t, Erkan Çakir
Evaluation Of The Association Of Mucosa-Associated Invariant T (Mait) Cells With Childhood Asthma, Meral Ekşi̇, Huri̇ Bulut, Erdem Akalin, Feyza Ustabaş Kahraman, Hakan Yazan, Mebrure Yazici, Mustafa Nursoy, Emi̇n Özkaya, Abdürrahi̇m Koçyi̇ği̇t, Erkan Çakir
Turkish Journal of Medical Sciences
Background/aim: Innate-like T lymphocytes are a recently defined group of T cells comprising mainly mucosa-associated invariant T (MAIT) cells. The relationship between MAIT cells and childhood asthma is controversial. In this study, we aimed to determine the role of MAIT cells in patients with allergic asthma (AA) and nonallergic asthma (NAA). This is the first study to compare the ratios of these cells in patients with AA and NAA.Materials and methods: The study included children aged 6–18 years with AA (n = 41) or NAA (n = 30) and healthy control subjects (n = 36). The control group consisted of …
Clinicopathological Features For The Prediction Of Immunosuppressive Treatment Responses In Sarcoidosis-Related Kidney Involvement: A Single-Center Retrospective Study, Ahmet Burak Di̇ri̇m, Vafa Suleymanova, Ozge Hurdogan, Özgür Oto, Ayşe Artan, Savas Ozturk, Yasemi̇n Ozluk, Isi̇n Ki̇li̇caslan, Hali̇l Yazi̇ci̇
Clinicopathological Features For The Prediction Of Immunosuppressive Treatment Responses In Sarcoidosis-Related Kidney Involvement: A Single-Center Retrospective Study, Ahmet Burak Di̇ri̇m, Vafa Suleymanova, Ozge Hurdogan, Özgür Oto, Ayşe Artan, Savas Ozturk, Yasemi̇n Ozluk, Isi̇n Ki̇li̇caslan, Hali̇l Yazi̇ci̇
Turkish Journal of Medical Sciences
Background/aim: Sarcoidosis is a multisystem disorder that affects many organs, including the kidneys. This single-center retrospective study investigated the clinical, pathological, and laboratory findings of patients with kidney sarcoidosis who were treated with immunosuppressives.Materials and Methods: Twenty-three patients with biopsy-confirmed kidney sarcoidosis were included. Demographics, clinical, pathological, and laboratory findings, in addition to treatments, and outcomes of twenty patients with at least one month of follow-up were evaluated.Results: Median age at the time of biopsy was 47 years(60.9 % female). Median baseline eGFR and proteinuria were 21.5 ml/min and 1 g/g or g/day, respectively. Nineteen of the 23 patients were …
Comparison Of Classical Methods For Bone Age Determination With Capitohamate Planimetry On Wrist X-Rays, Hasan Yildiz, Nadi̇re Ünver Doğan, Mehmet Öztürk, Zeli̇ha Fazlioğullari, Muslu Körez, Ahmet Karabulut
Comparison Of Classical Methods For Bone Age Determination With Capitohamate Planimetry On Wrist X-Rays, Hasan Yildiz, Nadi̇re Ünver Doğan, Mehmet Öztürk, Zeli̇ha Fazlioğullari, Muslu Körez, Ahmet Karabulut
Turkish Journal of Medical Sciences
Background/aim: This study aims to compare the Greulich–Pyle (GP) and Tanner–Whitehouse 2 (TW2) methods, both used in left wrist radiography for bone age determination in the pediatric age group, with the Capitohamatum method (CH) due to the importance of determining bone age in the pediatric period.Materials and methods: Direct radiographs of 210 female and 291 male individuals between the ages of 0–15 without any pathology in the left wrist bones were obtained; 501 os capitatum and os hamatum on anterior-to-posterior direct graphic images were measured using the GP, TW2, and CH planimetry methods. The estimated age of each measurement was …
Effect Of Δnp63Β On Cell Cycle And Apoptosis In T98g Cells, Buse Turegun Atasoy, Fi̇kret Sahin
Effect Of Δnp63Β On Cell Cycle And Apoptosis In T98g Cells, Buse Turegun Atasoy, Fi̇kret Sahin
Turkish Journal of Medical Sciences
Background/aim: The p53 protein, a crucial tumor suppressor, governs cell cycle regulation and apoptosis. Similarly, p63, a member of the p53 family, exhibits traits of both tumor suppression and oncogenic behavior through its isoforms. However, the functional impact of ΔNp63β, an isoform of the p63 protein, on human glioma cancer cells like T98G cells remains poorly understood, representing the novelty of this study in the current literature.Materials, methods: Employing the pRetroX-Tet-On vector system, we investigated ΔNp63β's apoptotic effects on T98G cell lines and assessed its influence on the cell cycle. Initially, we established a rtTA-expressing vector, a component of the …
Investigating The Biomarker Potential And Molecular Targets Of Tigd1 In Lung Cancer Using Bioinformatics, Merve Gulsen Bal Albayrak, Tuğcan Korak, Murat Kasap, Gurler Akpinar
Investigating The Biomarker Potential And Molecular Targets Of Tigd1 In Lung Cancer Using Bioinformatics, Merve Gulsen Bal Albayrak, Tuğcan Korak, Murat Kasap, Gurler Akpinar
Turkish Journal of Medical Sciences
Background/aimLung cancer, a predominant contributor to cancer mortality, is characterized by diverse etiological factors, including tobacco smoking and genetic susceptibilities. Despite advancements, particularly in non-small cell carcinoma (NSCC), therapeutic options for squamous cell carcinoma (LUSC) are limited. Transposable elements (TE) and their regulatory proteins, such as Transposable element derived (TIGD) family proteins, have been implicated in cancer development. TIGD1, upregulated in various cancers, including LUSC, lacks a defined function. This study aimed to elucidate the biological functions, associated pathways, and interacting proteins of TIGD1.Materials and methodsThe GSE229260 microarray dataset were investigated using GEO2R tool to identify the differentially expressed genes …
Severe Degranulation Of Mesenteric Mast Cells In An Experimental Rat Mammary Tumor Model, Senem Yavaş, Özkan Yavaş, Semi̇ha Ersoy, Gürsel Sönmez
Severe Degranulation Of Mesenteric Mast Cells In An Experimental Rat Mammary Tumor Model, Senem Yavaş, Özkan Yavaş, Semi̇ha Ersoy, Gürsel Sönmez
Turkish Journal of Medical Sciences
Background/aim: Breast cancers are one of the most common cancers in women and are responsible for many deaths worldwide. Mast cells are inflammatory cells. Their role in cancers is controversial, and there is limited data on systemic mast cell activation in cancer cases. This study aimed to evaluate systemic mast cell activation in an experimentally induced rat model of breast cancer. Materials and methods: Sprague Dawley female rats were divided into control (n=6) and mammary tumor (n=12) groups. In the tumor group, 20 mg 12-dimethylbenz[a]anthracene (DMBA) dissolved in 1 ml cottonseed oil was administered intragastrically by gavage, and the rats …
In Silico Study Of Bioactive Compounds Derived From Indonesian Marine Invertebrates As Novel Antituberculosis Agent, Ayu Masyita, Eri̇s Septiana, Asep Bayu, Bustanussalam Bustanussalam, Jonathan A. Panggabean, Fi̇rdayani̇ Firdayani, Tuti̇k Murniasih
In Silico Study Of Bioactive Compounds Derived From Indonesian Marine Invertebrates As Novel Antituberculosis Agent, Ayu Masyita, Eri̇s Septiana, Asep Bayu, Bustanussalam Bustanussalam, Jonathan A. Panggabean, Fi̇rdayani̇ Firdayani, Tuti̇k Murniasih
Turkish Journal of Medical Sciences
Background/aim: Tuberculosis has still become the most deadly disease globally. The problem of finding an effective therapeutic is one of the obstacles in the treatment of patients. Marine invertebrates were a treasure since they produced many active compounds. Following up on this issue, screening active compounds is very important. This study will explain the result of anti-tuberculosis screening of compounds derived from marine invertebrates using in silico and confirmed to the in vitro-data.Materials and methods: Three-dimensional (3D) structures of pantothenate kinase (MtPanK type 1, PDB ID: 4BFT), Mycobacterium tuberculosis InhA (MtInhA, PDB ID: 2X23), protein kinase B (PDB ID: 5U94), …
The Role Of Circadian Rhythm Proteins Rev-Erb Α/ And Β In The Development Of Neuronal Injury After Taumatic Brain Injury, Mahmud Pençe, Enes Dogan, Hali̇l Koç, Ci̇gdem Bayraktaroglu, Serdar Altunay, Zeynep Balçikanli, Ertugrul Kiliç, Mustafa Beker
The Role Of Circadian Rhythm Proteins Rev-Erb Α/ And Β In The Development Of Neuronal Injury After Taumatic Brain Injury, Mahmud Pençe, Enes Dogan, Hali̇l Koç, Ci̇gdem Bayraktaroglu, Serdar Altunay, Zeynep Balçikanli, Ertugrul Kiliç, Mustafa Beker
Turkish Journal of Medical Sciences
Background/Aim:Circadian rhythm proteins (CRP) play critical roles in both physiological and pathophysiological conditions, including neurodegenerative disorders. As member of CRP, the nuclear receptors REV-ERBα/β regulates circadian rhythm particularly by inhibiting Bmal1 protein and involved in the neuroinflammation- and cell death processes. However, their roles in the development of neuronal injury after traumatic brain injury (TBI) were largely unexplored, which were investigated in the present study.Materials and Methods: For the induction of TBI, animals were submitted to the cryogenic model of TBI, which is a commonly used animal model and shares essential similarities with cerebral ischemia in terms of pathophysiological cascades. …
Epidemiology Of Heart Failure In Türkiye, Nai̇m Ata, İnci̇ Tuğçe Çöllüoğlu, Anil Şahi̇n, Mehmet Bi̇rhan Yilmaz, Sanem Nalbantgi̇l, Şuayi̇p Bi̇ri̇nci̇, Mustafa Mahi̇r Ülgü, Emi̇ne Arzu Kanik, Di̇lek Ural, Lale Di̇nç Asarcikli, Emre Demi̇r, Yüksel Çavuşoğlu, Selda Murat, Ahmet Çeli̇k
Epidemiology Of Heart Failure In Türkiye, Nai̇m Ata, İnci̇ Tuğçe Çöllüoğlu, Anil Şahi̇n, Mehmet Bi̇rhan Yilmaz, Sanem Nalbantgi̇l, Şuayi̇p Bi̇ri̇nci̇, Mustafa Mahi̇r Ülgü, Emi̇ne Arzu Kanik, Di̇lek Ural, Lale Di̇nç Asarcikli, Emre Demi̇r, Yüksel Çavuşoğlu, Selda Murat, Ahmet Çeli̇k
Turkish Journal of Medical Sciences
Background/aim:The epidemiological data on heart failure (HF) vary between regions within the same country.We aimed to investigate the epidemiological data on HF in Turkiye across all age groups regarding seven geographical regions.Materials and methods:We included all patients in the Turkish population with a first diagnosis of HF between January 1, 2016 and December, 31 2022, with the use of ICD-10 codes from the National Electronic Healthcare Database.The data were categorized by seven geographical regions of Turkiye.Results:The median age of index diagnosis of HF was 70(60-78) years in all age groups and 4(1-12) years in pediatric population.Prevalence rate of HF was …
Approaching A Nationwide Registry: Analyzing Big Data In Patients With Heart Failure, Tuğçe Çöllüoğlu, Anil Şahi̇n, Ahmet Çeli̇k, Emi̇ne Arzu Kanik
Approaching A Nationwide Registry: Analyzing Big Data In Patients With Heart Failure, Tuğçe Çöllüoğlu, Anil Şahi̇n, Ahmet Çeli̇k, Emi̇ne Arzu Kanik
Turkish Journal of Medical Sciences
Background/aim:Randomized controlled trials usually lack generabilizity to real-world context.Real-world data, enabled by the use of big data analysis, serve as a connection between the results of trials and the implementation of findings in clinical practice.Nevertheless, using big data in the healthcare has difficulties such as ensuring data quality and consistency.This article aimed to examine the challenges in accessing and utilizing healthcare big data for heart failure (HF) research, drawing from experiences in creating a nationwide HF registry in Turkiye.Materials and methods:We established a team including cardiologists, HF specialists, biostatistics experts, and data analysts. We searched certain key words related to …
Diagnostic Approach To Heart Failure In Türkiye, Di̇lek Ural, Lale Di̇nç Asarcikli, İnci̇ Tuğçe Çöllüoğlu, Anil Şahi̇n, Yüksel Çavuşoğlu, Mehmet Bi̇rhan Yilmaz, Sanem Nalbantgi̇l, Nai̇m Ata, Mustafa Mahi̇r Ülgü, Şuayi̇p Bi̇ri̇nci̇, Selda Murat, Emre Demi̇r, Emi̇ne Arzu Kanik, Ahmet Çeli̇k
Diagnostic Approach To Heart Failure In Türkiye, Di̇lek Ural, Lale Di̇nç Asarcikli, İnci̇ Tuğçe Çöllüoğlu, Anil Şahi̇n, Yüksel Çavuşoğlu, Mehmet Bi̇rhan Yilmaz, Sanem Nalbantgi̇l, Nai̇m Ata, Mustafa Mahi̇r Ülgü, Şuayi̇p Bi̇ri̇nci̇, Selda Murat, Emre Demi̇r, Emi̇ne Arzu Kanik, Ahmet Çeli̇k
Turkish Journal of Medical Sciences
Background/aim:Final diagnosis of heart failure (HF) relies on a combination clinical findings, laboratory and imaging tests.The aim of this study was to review the diagnostic approach to HF in Turkiye.Materials and methods:This study is a subanalysis of the nationwide TRends-HF study based on anonymized data of National Electronic Database between January 1, 2016, and December 31, 2022.Variables including date of birth, sex, socioeconomic development index, place of initial HF diagnosis, comorbidities, investigations, and diagnostic procedures were reported.Laboratory variables, including complete blood count, natriuretic peptides (NP), estimated glomerular filtration rate, uric acid, electrolytes, albumin, lipid profile, ferritin and hemoglobin A1c levels …
Burden Of Comorbidities In Heart Failure Patients In Türkiye, Yüksel Çavuşoğlu, Selda Murat, Anil Şahi̇n, İnci̇ Tuğçe Çöllüoğlu, Di̇lek Ural, Mehmet Bi̇rhan Yilmaz, Sanem Nalbantgi̇l, Nai̇m Ata, Mustafa Mahi̇r Ülgü, Şuayi̇p Bi̇ri̇nci̇, Emre Demi̇r, Emi̇ne Arzu Kanik, Lale Di̇nç Asarcikli, Ahmet Çeli̇k
Burden Of Comorbidities In Heart Failure Patients In Türkiye, Yüksel Çavuşoğlu, Selda Murat, Anil Şahi̇n, İnci̇ Tuğçe Çöllüoğlu, Di̇lek Ural, Mehmet Bi̇rhan Yilmaz, Sanem Nalbantgi̇l, Nai̇m Ata, Mustafa Mahi̇r Ülgü, Şuayi̇p Bi̇ri̇nci̇, Emre Demi̇r, Emi̇ne Arzu Kanik, Lale Di̇nç Asarcikli, Ahmet Çeli̇k
Turkish Journal of Medical Sciences
Background/aim: Heart Failure (HF) is associated with a wide range of comorbidities that negatively impact on clinical outcomes and cause to high economic burden. We aimed to evaluate frequency and burden of comorbidities in HF patients in Türkiye and their relationship with the patient's demographic characteristics.Materials and methods: Based on ICD-10 codes in National Electronic Database of the Turkish Ministry of Health, covering the entire population of Türkiye (n=85,279,553), from January 1, 2016, to December 31, 2022, prevalence of comorbidities in HF patients were obtained. Frequency and burden of comorbidities were analyzed separately by age groups, gender and socioeconomic status …
Outcomes Of Patients With Heart Failure In Türkiye, Anil Şahi̇n, Mehmet Bi̇rhan Yilmaz, Ahmet Çeli̇k, Tuğçe Çöllüoğlu, Di̇lek Ural, Lale Di̇nç Asarcikli, Sanem Nalbantgi̇l, Emre Demi̇r, Yüksel Çavuşoğlu, Selda Murat, Emi̇ne Arzu Kanik, Nai̇m Ata, Mustafa Mahi̇r Ülgü, Şuayi̇p Bi̇ri̇nci̇
Outcomes Of Patients With Heart Failure In Türkiye, Anil Şahi̇n, Mehmet Bi̇rhan Yilmaz, Ahmet Çeli̇k, Tuğçe Çöllüoğlu, Di̇lek Ural, Lale Di̇nç Asarcikli, Sanem Nalbantgi̇l, Emre Demi̇r, Yüksel Çavuşoğlu, Selda Murat, Emi̇ne Arzu Kanik, Nai̇m Ata, Mustafa Mahi̇r Ülgü, Şuayi̇p Bi̇ri̇nci̇
Turkish Journal of Medical Sciences
Background/Aim: Despite Türkiye's younger population, there is an emerging trend of earlier diagnoses of chronic diseases, including heart failure (HF). This study aims to shed light on survival rates, potential influences of guideline-directed therapies, and gender-based differences necessitating personalized management in HF.Materials and Methods: We conducted a nationwide retrospective cohort analysis on 2,722,151 patients with HF using de-identified data from the Turkish Ministry of Health’s National Electronic Database. Out of the total, there were 2,701,099 adult patients with HF. Adult patients were divided into two groups based on their outcome: those who were deceased and those who survived, and then …
Determination Of The Embryotoxic Effects Of Propofol Injected Into Eggs On The Cerebellum And Spinal Cord Using Histologic Methods: An Animal Study, Murat İzgi̇, Emrah Sur
Determination Of The Embryotoxic Effects Of Propofol Injected Into Eggs On The Cerebellum And Spinal Cord Using Histologic Methods: An Animal Study, Murat İzgi̇, Emrah Sur
Turkish Journal of Medical Sciences
This study aims to determine the possible embryotoxic effects of propofol on the cerebellum and spinal cord using fertile chicken eggs. Materials and methods: A total of 430 fertile eggs were divided into 5 groups: control, saline, 2.5 mg.kg–1, 12.5 mg.kg–1, and 37.5 mg.kg–1 propofol. Injections were made immediately before incubation via the air chamber. On the 15th, 18th, and 21st day of incubation, 6 embryos from each group were evaluated. Serial paraffin sections taken from the cerebellum and spinal cord were stained with hematoxylin–eosin, Kluver–Barrera, toluidine blue, and periodic acid-Schiff ’s reaction. The outer granular layer and total cortex …
Tracking The Footsteps Of Burkholderia Mallei: Determination Of The Molecular Differences And Potential Resistance Genes, Dilek Dülger, Seda Eki̇ci̇, Mehmet Demi̇rci̇, Akın Yi̇ği̇n, Orkun Babacan
Tracking The Footsteps Of Burkholderia Mallei: Determination Of The Molecular Differences And Potential Resistance Genes, Dilek Dülger, Seda Eki̇ci̇, Mehmet Demi̇rci̇, Akın Yi̇ği̇n, Orkun Babacan
Turkish Journal of Medical Sciences
Chemical biological radiological nuclear threats are at an important point in the agenda of world health today, as theycan cause mass deaths. B. mallei attracts attention as a potential biological warfare agent due to its features such as multidrug resistance,a rapid transmission mechanism via aerosol, the absence of a complete treatment protocol for the infection it causes, and the absence ofan approved vaccine for protection against the bacteria. B. mallei suspect samples must be studied by experienced personnel in biosafetylevel III laboratories. B mallei is a difficult and troublesome pathogen to diagnose and many unknowns about B. mallei today. Therefore,the …