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Full-Text Articles in Medical Sciences
Transition Of Patients With Systemic Lupus Erythematosus From Pediatric To Adult-Oriented Rheumatology Care, Seher Şener, Gözde Yardimci, Ezgi̇ Batu, Levent Kiliç, Ümmüşen Kaya Akça, Müşerref Kasap Cüceoğlu, Zeynep Balik, Özge Başaran, Yelda Bi̇lgi̇ner, Şule Apraş Bi̇lgen, Seza Özen
Transition Of Patients With Systemic Lupus Erythematosus From Pediatric To Adult-Oriented Rheumatology Care, Seher Şener, Gözde Yardimci, Ezgi̇ Batu, Levent Kiliç, Ümmüşen Kaya Akça, Müşerref Kasap Cüceoğlu, Zeynep Balik, Özge Başaran, Yelda Bi̇lgi̇ner, Şule Apraş Bi̇lgen, Seza Özen
Turkish Journal of Medical Sciences
Background/aim: The transition from pediatric to adult-oriented care for individuals with juvenile-onset systemic lupus erythematosus (SLE) poses significant challenges. This study aims to assess the outcomes of transitioning patients with juvenile-onset SLE from pediatric to adult-oriented care.Materials and Methods: Patients with juvenile-onset SLE were included. They were transferred in face-to-face meetings where at least one pediatric rheumatologist and one adult rheumatologist were present (the transition time: October-December 2020).Results: The median (25th-75th percentiles) age at diagnosis and the time of the first examination at an adult-oriented rheumatology department of 65 SLE patients were 14.3 (10.9-15.1) years and 19.2 (18.5-20.4) years, respectively …
A New Scoring In Differential Diagnosis: Multisystem Inflammatory Syndrome Or Adenovirus Infection?, Mustafa Gençeli̇, Talha Üstüntaş, Özge Akcan, Si̇nan Saylik, Fati̇h Ercan, Sevgi̇ Pekcan, Si̇pi̇l Gençeli̇, Sevgi̇ Durmuş, Mustafa Argun
A New Scoring In Differential Diagnosis: Multisystem Inflammatory Syndrome Or Adenovirus Infection?, Mustafa Gençeli̇, Talha Üstüntaş, Özge Akcan, Si̇nan Saylik, Fati̇h Ercan, Sevgi̇ Pekcan, Si̇pi̇l Gençeli̇, Sevgi̇ Durmuş, Mustafa Argun
Turkish Journal of Medical Sciences
Background/aim: Differentiating multisystem inflammatory syndrome in children (MIS-C) from adenovirus infection (AI) can be challenging due to similar clinical and laboratory findings. This study aimed to identify distinguishing characteristics and develop a scoring system to facilitate accurate diagnosis.Materials and methods: A comprehensive review of medical records was undertaken for 108 MIS-C cases and 259 patients with confirmed AI. A comparison of laboratory data and clinical findings was conducted across patient groups through appropriate statistical tests.Results: MIS-C patients were significantly older than AI patients (p<0.001). Diarrhea, rash, abdominal pain, vomiting, non-exudative conjunctivitis, lymphadenopathy tachycardia, bradycardia, hypotension, hypoxia seizures, agitation, headache, and altered consciousness symptoms were more frequently associated with MIS-C (p<0.001), while cough and runny nose were significantly more common in AI (p<0.001). Lymphopenia and thrombocytopenia were more prevalent in MIS-C patients (p<0.001). AI and MIS-C were scored by giving 1 point each to the parameters that created the difference. For AI, ≤60 months, presence of cough, runny nose and absence of diarrhea, rash, abdominal pain, vomiting, non-exudative conjunctivitis, lymphadenopathy, tachycardia, bradycardia, hypotension, hypoxia seizures, agitation, headache, and altered consciousness, lymphopenia, thrombocytopenia and CRP <124.5 mg/L were determined as each parameter plus one point. A total score above 14 could predict AI with a high degree of accuracy sensitivity values stood at around 97.5% and specificity at 92.6%.Conclusion: The proposed inpatient scoring system, when used in conjunction with polymerase chain reaction testing, may improve the early differentiation of AI and MIS-C. This approach could help reduce unnecessary testing and optimize resource allocation. Further research with larger samples should investigate this novel scoring system to establish its reliability and generalizability.
Implementation Of Written Asthma Action Plan Among Asthma Patients In Türkiye: A Multicenter, Cross-Sectional, Descriptive Study, Kurtuluş Aksu, Gürgün Tuğçe Vural Solak, Pinar Mutlu, Levent Cem Mutlu, Görkem Vayişoğlu Şahi̇n, Burcu Yormaz, Ayli̇n Çapraz, Ezgi̇ Erdem Türe, Yavuzalp Solak, Funda Aksu
Implementation Of Written Asthma Action Plan Among Asthma Patients In Türkiye: A Multicenter, Cross-Sectional, Descriptive Study, Kurtuluş Aksu, Gürgün Tuğçe Vural Solak, Pinar Mutlu, Levent Cem Mutlu, Görkem Vayişoğlu Şahi̇n, Burcu Yormaz, Ayli̇n Çapraz, Ezgi̇ Erdem Türe, Yavuzalp Solak, Funda Aksu
Turkish Journal of Medical Sciences
Background/aim: In our country, there is no data on whether the clinicians give an asthma action plan to implement to patients followed up with a diagnosis of asthma, and whether patients can manage their treatment according to this plan. The present study aimed to determine the use of asthma action plans in our country and the awareness levels of patients about the plan.Materials and methods: Multicenter, cross-sectional descriptive study was conducted in outpatient immunology and allergy and pulmonology clinics of secondary and tertiary health-care centers. Adults asthmatics filled out a case registration form regarding age, gender, educational status, duration of …
Evaluation Of The Update On Screening For Retinopathy Of Prematurity In A Tertiary Care Center In Türkiye With Retrospective Cohort, Emi̇ne Kaya Güner, Duygu İnci̇ Bozbiyik
Evaluation Of The Update On Screening For Retinopathy Of Prematurity In A Tertiary Care Center In Türkiye With Retrospective Cohort, Emi̇ne Kaya Güner, Duygu İnci̇ Bozbiyik
Turkish Journal of Medical Sciences
Background/aim: In Turkey, recommendations for screening for retinopathy of prematurity (ROP) have been updated in 2021. Herein, we aimed to present detailed data on the infants included in the screening according to the new criteria and evaluate whether these changes benefit in detecting severe ROP.Materials and Methods: Our hospital's medical records of babies screened for ROP between July 2019 - July 2021 and August 2021 - August 2023 were retrospectively examined. Gestational age (GA), birth weight (BW), gender of the babies, whether there was a multiple pregnancy, ROP examination results, the most advanced ROP level and time, and ROP treatment …
Rare Stat3 Haplotypes Cause A Predisposition To Develop Congenital Anomalies Of The Kidney And Urinary Tract Disorder, Mert Polat, Feri̇de Şahi̇n, Esra Baskin, Uğur Toprak, Kaan Gülleroğlu, Mehmet Haberal, Yunus Terzi̇
Rare Stat3 Haplotypes Cause A Predisposition To Develop Congenital Anomalies Of The Kidney And Urinary Tract Disorder, Mert Polat, Feri̇de Şahi̇n, Esra Baskin, Uğur Toprak, Kaan Gülleroğlu, Mehmet Haberal, Yunus Terzi̇
Turkish Journal of Medical Sciences
Background/aimCongenital anomalies of the kidney and urinary tract (CAKUT) are characterized by renal developmental disorders in the embryonic period. STAT3 is a member of the STAT protein family. The members of this protein family play roles in various cellular mechanisms, such as the early stages of embryonic development, kidney development, and renal diseases. This study aims to determine the frequency of STAT3 rs1053004, rs744166, rs3816769, and rs4796793 polymorphisms in individuals with CAKUT disease.Materials and methodsTwo of the four polymorphisms, rs744166 (c.-1-13666T>C, NM_001369512.1) and rs4796793 ( c.-1915C>G, NM_001369512.1), were analyzed by a polymerase chain reaction and restriction fragment length …
Evaluation Of The Efficacy Of Transfer Energy Capacitive And Resistive Therapy In Patients With Knee Osteoarthritis, Özge Tezen, Emi̇ne Esra Bi̇li̇r, Öznur Uzun, Duygu Yaniktaş, Başak Şentürk, Evren Yaşar
Evaluation Of The Efficacy Of Transfer Energy Capacitive And Resistive Therapy In Patients With Knee Osteoarthritis, Özge Tezen, Emi̇ne Esra Bi̇li̇r, Öznur Uzun, Duygu Yaniktaş, Başak Şentürk, Evren Yaşar
Turkish Journal of Medical Sciences
Background/aim: The aim of present study was to investigate the treatment efficacy of transfer energy capacitive and resistive (TECAR) therapy, a modern application that has been increasingly used in recent years, compared to conventional physical therapy (CPT) applications in the treatment of knee osteoarthritis, according to the evaluation of clinical findings of patients.Materials and methods: A total of 54 patients, aged between 40 and 75 years, were randomly divided into two groups. Both groups received CPT. Group 2 received TECAR therapy in addition to CPT, applied three times a week for two weeks, for a total of 6 sessions. All …
High Sacral Slope, Lumbar Lordosis, And Sacral Slope-To-Pelvic Incidence Ratio Are Associated With New Bone Formation In Ankylosing Spondylitis, Aysun Aksoy, Cemal Gündoğmuş, Mehmet Kesi̇mer, Kemal Nas, İkram Duman, Gazanfer Eki̇nci̇, Murat Bezer, Pami̇r Atagündüz
High Sacral Slope, Lumbar Lordosis, And Sacral Slope-To-Pelvic Incidence Ratio Are Associated With New Bone Formation In Ankylosing Spondylitis, Aysun Aksoy, Cemal Gündoğmuş, Mehmet Kesi̇mer, Kemal Nas, İkram Duman, Gazanfer Eki̇nci̇, Murat Bezer, Pami̇r Atagündüz
Turkish Journal of Medical Sciences
Background/aim: Syndesmophyte formation appears to be site specific in Ankylosing spondylitis(AS),and new bone formation seems to occur in regions of micro-trauma that are prone to tensile forces.Pelvic and spinal parameters are unique for individuals. Pelvic tilt and sacral slope are important anatomical features that compensate in harmony in keeping the sagittal balance. After puberty, the sacral slope shapes the lumbar lordosis, whereas the pelvic incidence is set to an individual constant. This study aims to analyze the properties of pelvic parameters in AS patients with and without syndesmophyte formation in the spine after 15years of disease duration.Materials and methods:Whole spine …
Comparison Of Rigid And Elastic Registration Methods In Software-Based Targeted Prostate Biopsy: A Multi-Center Cohort Study, Serhat Çeti̇n, Serdar Çeli̇k, Murat Koparal, Güven Aslan, Sertaç Yazici, Bahadir Şahi̇n, Si̇nan Sözen, Levent Türkeri̇
Comparison Of Rigid And Elastic Registration Methods In Software-Based Targeted Prostate Biopsy: A Multi-Center Cohort Study, Serhat Çeti̇n, Serdar Çeli̇k, Murat Koparal, Güven Aslan, Sertaç Yazici, Bahadir Şahi̇n, Si̇nan Sözen, Levent Türkeri̇
Turkish Journal of Medical Sciences
Background/Aim: This study aims to compare the success rates of rigid registration (RR) and elastic registration (ER)systems in diagnosing all cancers and clinically significant prostate cancer (csPC) in software-based targeted prostate biopsies (TPBs) by performing matching analysis.Materials and Methods: The data of 2,061 patients from six centers where software-based TPB was performed were used. All cancer and csPC detection rates of the RR and ER systems were compared following Mahalanobis distance matching within the propensity score caliper method. Logistic regression analysis was applied to identify factors predicting clinically insignificant prostate cancer (ciPC) and csPC diagnoses. Additionally, the International Society of …
Evaluation Of The Relationship Between Type Of Menopause And Cognitive Functions, Meltem Durakli Ulukök, Ufuk Atlihan, Onur Yavuz
Evaluation Of The Relationship Between Type Of Menopause And Cognitive Functions, Meltem Durakli Ulukök, Ufuk Atlihan, Onur Yavuz
Turkish Journal of Medical Sciences
Background/aim:Menopause is often accompanied by neurological symptoms, including cognitive difficulties, especially with memory and attention. In the present study, the purpose was to examine the relationship between the timing of menopause and the cognitive performance of menopausal patients who applied to our neurology clinic with complaints of forgetfulness.Materials and methods: The data of 538 women who applied to the neurology clinic with complaints of forgetfulness between January 2018 and January 2024and underwent neuropsychological evaluations were scanned retrospectively. A total of 96 patients who applied to neurology and menopause clinics were included in the study.Results: In the present study, attention orientation, …
Achillea Millefolium Ameliorates Doxorubicin-Induced Renal Injury Via Inhibition Of Oxidative Stress And Inflammation In Rats, Mohammed Shaiea, Yi̇mi̇ng Dong, Saleh Alomisy, Hassan Al-Mahbashi, Guozhong Zhang, Chuan Wang
Achillea Millefolium Ameliorates Doxorubicin-Induced Renal Injury Via Inhibition Of Oxidative Stress And Inflammation In Rats, Mohammed Shaiea, Yi̇mi̇ng Dong, Saleh Alomisy, Hassan Al-Mahbashi, Guozhong Zhang, Chuan Wang
Turkish Journal of Medical Sciences
Background/aim: Doxorubicin (Dox) is a potent anticancer medication. Nevertheless, due to nephrotoxicity, its clinical application is restricted. Achillea millefolium (AM) is a traditional medicine used against several disturbances, including kidney disorders. Therefore, this work aims to investigate the preventative properties of AM extract (AME) and their mechanisms against nephrotoxicity caused by Dox in rats. Materials and methods: The rats were assigned randomly to six groups, including a control group, Dox group (5 mg/kg/week via i.p. for 4 weeks), two groups, AME (100 or 200 mg/kg, orally for 28 days), and the last two groups, Dox+ AME (100 or 200 mg/kg, …
The Difference Between Clinical Significance And Statistical Significance: An Important Distinction For Clinical Research, Sadi̇ Elasan
The Difference Between Clinical Significance And Statistical Significance: An Important Distinction For Clinical Research, Sadi̇ Elasan
Turkish Journal of Medical Sciences
No abstract provided.
Response Of Mucinous Breast Carcinoma To Neoadjuvant Chemotherapy, Berkay Kiliç, Burak İlhan
Response Of Mucinous Breast Carcinoma To Neoadjuvant Chemotherapy, Berkay Kiliç, Burak İlhan
Turkish Journal of Medical Sciences
Background/aim: Mucinous breast carcinoma (MC) is thought to be a favorable-differentiated form of invasive breast cancer and is rarely preferred for neoadjuvant chemotherapy (NAC). The study aimed to define the response of MCs to NAC.Materials and methods: The study reviewed the demographic, clinicopathologic characteristics, management, and follow-up data of 70 patients diagnosed with MC between May 2010 to December 2020 by examining patients’ historical files and oncology records.Results: The median age, tumor size, and follow-up period of patients were respectively 52.9 (range 32 to 87) years, 25.8 (range 8 to 88) mm, and 61.5 (range 18 to 143) months. Out …
The Relationship Between Drug Induced Immunogenicity And Hypersensitivity Reactions And Skin Tests Related To Infliximab, Etanercept And Adalimumab In Patients With Rheumatoid Arthritis And Ankylosing Spondylitis, Alper Doğanci, Şebnem Ataman, Ali̇ Özdemi̇rel, Recep Seçki̇n, Ayşe Yalçin, Sevi̇m Bavbek
The Relationship Between Drug Induced Immunogenicity And Hypersensitivity Reactions And Skin Tests Related To Infliximab, Etanercept And Adalimumab In Patients With Rheumatoid Arthritis And Ankylosing Spondylitis, Alper Doğanci, Şebnem Ataman, Ali̇ Özdemi̇rel, Recep Seçki̇n, Ayşe Yalçin, Sevi̇m Bavbek
Turkish Journal of Medical Sciences
Background and aim: We aimed to investigate the relationship between serum anti-drug antibody (ADAb), hypersensitivity reactions (HSRs) to anti-tumor necrosis factors (anti-TNFs) drugs and to detect the role of skin tests in the diagnosis of HSRs against anti-TNFs.Material and methods: 69 ankylosing spondilitis (AS) and 46 rheumatoid artritis (RA) patients using infliximab, adalimumab, and etanercept were enrolled. Disease activity scores for AS and RA patients were assessed. Serum levels of anti-TNFs and ADAb to these agents were measured with the ELISA.These blood samples were taken 24 hours before the next drug dose.The patients with anti-TNF-associated HSRs were evaluated with a …
Telemedicine In Pediatric Rheumatology: The Video Pediatric Gait, Arms, Legs, And Spine (V-Pgals), Zeynep Balik, Seher Şener, Yağmur Bayindir, Müşerref Kasap Cüceoğlu, Emi̇l Ali̇yev, Özge Başaran, Yelda Bi̇lgi̇ner, Seza Özen, Ezgi̇ Deni̇z Batu
Telemedicine In Pediatric Rheumatology: The Video Pediatric Gait, Arms, Legs, And Spine (V-Pgals), Zeynep Balik, Seher Şener, Yağmur Bayindir, Müşerref Kasap Cüceoğlu, Emi̇l Ali̇yev, Özge Başaran, Yelda Bi̇lgi̇ner, Seza Özen, Ezgi̇ Deni̇z Batu
Turkish Journal of Medical Sciences
Background/aim: Video pediatric gait, arms, leg, and spine (v-pGALS) is a virtual application of pediatric gait, arms, leg, and spine (pGALS) examination performed by video. We aimed to verify the applicability, validity, and accuracy of the Turkish translation of the v-pGALS in a large pediatric patient cohort.Materials and methods: Children aged 4-18 years were included between May and June 2022. A hands-on physical examination and v-pGALS were performed. Demographics, active symptoms, physical examination findings, diagnosis, and v-pGALS findings were recorded. The acceptability of v-pGALS by the parent/patient was measured using a visual analog scale (VAS), in terms of additional distress …
How To Mitigate The Risks Of Deployment Of Artificial Intelligence In Medicine?, Sevi̇l Uygun İli̇khan, Mahmut Özer, Hande Tanberkan, Veysel Bozkurt
How To Mitigate The Risks Of Deployment Of Artificial Intelligence In Medicine?, Sevi̇l Uygun İli̇khan, Mahmut Özer, Hande Tanberkan, Veysel Bozkurt
Turkish Journal of Medical Sciences
The aim of this study is to examine the risks associated with the use of artificial intelligence (AI) in medicine and to offer policy suggestions to reduce these risks and optimize the benefits of AI technology. Artificial intelligence is a multifaceted technology. If harnessed effectively, it has the capacity to significantly impact the future of humanity in the field of health, as well as in several other areas. However, the rapid spread of this technology also raises significant ethical, legal, and social issues. This study examines the potential dangers of AI integration in medicine by reviewing current scientific work and …
Impact Of Celiac Disease In Behçet’S Syndrome Patients: A Study Based On The Database Of Türkiye, Nuray Yilmaz Çakmak, Nai̇m Ata, Serdar Can Güven, Emi̇n Gemci̇oğlu, Mustafa Mahi̇r Ülgü, Şuayi̇p Bi̇ri̇nci̇
Impact Of Celiac Disease In Behçet’S Syndrome Patients: A Study Based On The Database Of Türkiye, Nuray Yilmaz Çakmak, Nai̇m Ata, Serdar Can Güven, Emi̇n Gemci̇oğlu, Mustafa Mahi̇r Ülgü, Şuayi̇p Bi̇ri̇nci̇
Turkish Journal of Medical Sciences
Background/Aim Our primary aim was to investigate the effects of concomitant celiac disease (CD) on the clinical characteristics of Behçet’s syndrome (BS) patients. Materials and method The study was a retrospective, nationwide, multi-center study. Turkish Ministry of Health National Electronic Database (e-Nabız) is used under Health Ministry's supervision to extract the subject's data. Statistical Analysis Statistical analyses were made by the Statistical Package for Social Sciences (SPSS) software version 20 (IBM Corp., Armonk, New York). Continuous variables were presented by mean ± standard derivation (SD) or median (min–max) according to normality and compared by student-T test. Results A total of …
The Effect Of Phototherapy Treatment On Serum Melatonin Levels In Term Newborns, Ali̇ Bülbül, İlkay Özmeral Odabaşi, Duygu Besni̇li̇ Açar, Semra Ti̇ryaki̇ Demi̇r
The Effect Of Phototherapy Treatment On Serum Melatonin Levels In Term Newborns, Ali̇ Bülbül, İlkay Özmeral Odabaşi, Duygu Besni̇li̇ Açar, Semra Ti̇ryaki̇ Demi̇r
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the effect of phototherapy treatment on serum melatonin levels in term newborn infants. Material and methods: This study was planned as a single-center, prospective, observational, case-control study. Term infants (gestation week ≥37 weeks) who received at least 6 h of phototherapy due to jaundice constitute the phototherapy group, while the term infants without jaundice and who were exclusively breastfed constitute the control group. Melatonin levels were examined by taking blood samples from babies in both groups at 02:00 at night. Melatonin values were compared between groups. The effect of phototherapy on …
Patterns Of Longitudinal Subcortical Atrophy Over One Year In Amnestic Mild Cognitive Impairment And Its Impact On Cognitive Performance: A Preliminary Study, Berri̇n Çavuşoğlu, Duygu Hünerli̇, Derya Durusu Emek Savaş, Görsev Yener, Emel Ada
Patterns Of Longitudinal Subcortical Atrophy Over One Year In Amnestic Mild Cognitive Impairment And Its Impact On Cognitive Performance: A Preliminary Study, Berri̇n Çavuşoğlu, Duygu Hünerli̇, Derya Durusu Emek Savaş, Görsev Yener, Emel Ada
Turkish Journal of Medical Sciences
Background/aim: Amnestic mild cognitive impairment (aMCI) is a risk factor for dementia, and thus, it is of interest to enlighten specific brain atrophy patterns in aMCI patients. We aim to define the longitudinal atrophy pattern in subcortical structures and its effect on cognition in patients with aMCI.Materials and methods: Twenty patients with aMCI and 20 demographically matched healthy controls with baseline and longitudinal structural magnetic resonance imaging scans and neuropsychological assessments were studied. The algorithm FIRST (FMRIB’s integrated registration and segmentation tool) was used to obtain volumes of subcortical structures (thalamus, putamen, caudate nucleus, nucleus accumbens, globus pallidus, hippocampus, and …
Sting Activation Increases The Efficiency Of Temozolomide In Pten Harbouring Glioblastoma Cells, Zafer Yildirim, Eda Doğan, Hale Güler Kara, Buket Kosova, Vi̇ldan Bozok
Sting Activation Increases The Efficiency Of Temozolomide In Pten Harbouring Glioblastoma Cells, Zafer Yildirim, Eda Doğan, Hale Güler Kara, Buket Kosova, Vi̇ldan Bozok
Turkish Journal of Medical Sciences
Background/aim: Glioblastoma is one of the most aggressive tumours, resistant to all applied therapy regiments and prone to relapse. Median survival rates are therefore only expressed as months. STING agonists are immunomodulatory molecules that activate type I interferon expression, making them potentially useful in regulating the tumour microenvironment. Since PTEN serves as a critical phosphatase in activating interferon-regulating transcription factors and is frequently mutated in glioblastoma cells, this study aimed to investigate STING activation in glioblastoma cell lines, examining whether they harbour the PTEN protein or not.°Materials and methods: T98G and U118MG glioblastoma cell lines were treated with the 2ʹ3ʹ-c-di-AM(PS)2(Rp,Rp) …
Changes In Blink Reflex After Simultaneous Supraorbital And Mental Nerve Stimulations In Healthy Subjects, Ayşegül Gündüz, Tuba Cerrahoğlu Şi̇ri̇n, Pinar Bekdi̇k Şi̇ri̇nocak, Tuba Akinci, Burcu Nuran Arkali, Fatma Candan, Meral E. Kiziltan
Changes In Blink Reflex After Simultaneous Supraorbital And Mental Nerve Stimulations In Healthy Subjects, Ayşegül Gündüz, Tuba Cerrahoğlu Şi̇ri̇n, Pinar Bekdi̇k Şi̇ri̇nocak, Tuba Akinci, Burcu Nuran Arkali, Fatma Candan, Meral E. Kiziltan
Turkish Journal of Medical Sciences
Background/aim: In this study, we investigated the blink reflex (BR) after simultaneous and asynchronous stimulation of two trigeminal nerve branches. The objective was to characterize the physiology of trigeminal and facial circuits.Materials and methods: We performed three sets of experiments: recording BR response i. after supraorbital nerve stimulation (SON), after mental nerve stimulation (MN), and after simultaneous SON and MN stimulation (SON+MN) in 18 healthy individuals; ii. after MN (at an intensity eliciting BR response) preceding SON at various interstimulus intervals (ISIs) in seven healthy subjects; iii after MN (at sensory threshold) preceding SON at various ISIs. We compared the …
Cross-Cultural Adaptation Of The Thoracic Outlet Syndrome Index For Turkish-Speaking Patients With Thoracic Outlet Syndrome, Hakki Çağdaş Basat, Fati̇h Özyurt, Muhammed İhsan Kodak, Gülşah Özsoy, Caner Kararti
Cross-Cultural Adaptation Of The Thoracic Outlet Syndrome Index For Turkish-Speaking Patients With Thoracic Outlet Syndrome, Hakki Çağdaş Basat, Fati̇h Özyurt, Muhammed İhsan Kodak, Gülşah Özsoy, Caner Kararti
Turkish Journal of Medical Sciences
Background/aim: Considering that there is no specifically designed scale to measure quality of life (QoL) and level of functioning among Turkish-speaking patients with thoracic outlet syndrome (TOS), the aim of this study was to adapt the Thoracic Outlet Syndrome Index (TOSI) to the Turkish language (TOSI-TR) and analyze its psychometric properties in patients with TOS. Materials and methods: Thirty-nine patients with symptomatic TOS were included in the study. The participants were assessed using the following measures: the QuickDASH, the Western Ontario Rotator Cuff Index (WORC), and a visual analog scale (VAS). The psychometric properties of the TOSI-TR were examined in …
Central Thromboxane A2, Prostaglandin F2Α, Prostaglandin E, And Prostaglandin D Contribute To The Cardiovascular Effects Elicited By Nesfatin-1, Gökçen Güvenç Bayram, Murat Yalçin
Central Thromboxane A2, Prostaglandin F2Α, Prostaglandin E, And Prostaglandin D Contribute To The Cardiovascular Effects Elicited By Nesfatin-1, Gökçen Güvenç Bayram, Murat Yalçin
Turkish Journal of Medical Sciences
Background/aim: Our recent study revealed that the expression of lipoxygenase (LOX) and cyclooxygenase (COX) enzymes in the hypothalamus is activated by nesfatin-1, leading to the liberation of leukotrienes and prostaglandins (PG), respectively. Moreover, our prior report explained that intracerebroventricular (ICV) nesfatin-1 treatment triggers cardiovascular responses mediated by central LOX and COX enzymes. Building upon our prior reports, the present investigation sought to clarify the role of cardiovascularly active central COX products, such as thromboxane (TX) A2, PGF2α, PGE, and PGD, in orchestrating nesfatin-1-evoked reactions in mean arterial pressure (MAP) and heart rate (HR).Materials and methods: The Sprague Dawley rats, which …
Evaluation Of The Results Of The Patients Who Underwent Plasmapheresis In The Pediatric Intensive Care Unit, Mehmet Nur Talay, Özhan Orhan, Murat Kanğin, Eşe Eda Turanli, Mehmet Nuri̇ Özbek
Evaluation Of The Results Of The Patients Who Underwent Plasmapheresis In The Pediatric Intensive Care Unit, Mehmet Nur Talay, Özhan Orhan, Murat Kanğin, Eşe Eda Turanli, Mehmet Nuri̇ Özbek
Turkish Journal of Medical Sciences
Background/aim: Therapeutic plasma exchange (TPE) is an extracorporeal treatment method that removes large molecular weight substances from plasma. In our study, we aimed to retrospectively examine the indications and procedural methods of the patients who had undergone TPE, and the complications that occurred during the procedure. Materials and methods: Forty-one patients who were monitored in thePICU of Gazi Yaşargil Training and Research Hospital and had indications for TPE between 2017 and 2021 were included in the study. Laboratory parameters were checked before and after the TPE procedure. In addition to these, patients’ diagnosis, weight, type of procedure and type of …
Comparison Of Radiologic Findings Between Sars-Cov-2 And Other Respiratory Tract Viruses In Critically Ill Children During The Covid-19 Pandemic, Oktay Perk, Tanil Kendi̇rli̇, Emel Uyar, Bi̇rsel Şen Akova, Hati̇ce Albayrak, Hasan Ağin, Ebru Ati̇ke Ongun, Eşe Eda Turanli, Sare Güntülü Şik, Şahi̇n Si̇ncar, Gürkan Bozan, Demet Demi̇rkol, Nazan Ülgen Tekerek, Mey Tali̇p, Arzu Oto, Feyza İnceköy Gi̇rgi̇n, Ferhat Sari, Nuretti̇n Onur Kutlu, Altan Güneş, Ömer Suat Fi̇töz
Comparison Of Radiologic Findings Between Sars-Cov-2 And Other Respiratory Tract Viruses In Critically Ill Children During The Covid-19 Pandemic, Oktay Perk, Tanil Kendi̇rli̇, Emel Uyar, Bi̇rsel Şen Akova, Hati̇ce Albayrak, Hasan Ağin, Ebru Ati̇ke Ongun, Eşe Eda Turanli, Sare Güntülü Şik, Şahi̇n Si̇ncar, Gürkan Bozan, Demet Demi̇rkol, Nazan Ülgen Tekerek, Mey Tali̇p, Arzu Oto, Feyza İnceköy Gi̇rgi̇n, Ferhat Sari, Nuretti̇n Onur Kutlu, Altan Güneş, Ömer Suat Fi̇töz
Turkish Journal of Medical Sciences
Background/aim: This study was planned because the radiological distinction of COVID-19 and respiratory viral panel (RVP)-positive cases is necessary to prioritize intensive care needs and ensure non-COVID-19 cases are not overlooked. With that purpose, the objective of this study was to compare radiologic findings between SARS-CoV-2 and other respiratory airway viruses in critically ill children with suspected COVID-19 disease.Materials and methods: This study was conducted as a multicenter, retrospective, observational, and cohort study in 24 pediatric intensive care units between March 1 and May 31, 2020. SARS-CoV-2- or RVP polymerase chain reaction (PCR)-positive patients’ chest X-ray and thoracic computed tomography …
Short- And Long-Term Neurological Outcomes Of Congenital Cytomegalovirus Infection, Fati̇h Mehmet Aki̇f Özdemi̇r, Yasemi̇n Taşci Yildiz, Rüveyda Gümüşer Ci̇nni̇, Ayşegül Zenci̇roğlu, Deni̇z Yüksel
Short- And Long-Term Neurological Outcomes Of Congenital Cytomegalovirus Infection, Fati̇h Mehmet Aki̇f Özdemi̇r, Yasemi̇n Taşci Yildiz, Rüveyda Gümüşer Ci̇nni̇, Ayşegül Zenci̇roğlu, Deni̇z Yüksel
Turkish Journal of Medical Sciences
Background/aim: Cytomegalovirus (CMV) is the most common congenital viral infection. Although most children with congenital CMV (approximately 85%–90%) are asymptomatic at birth, findings such as sensorineural hearing loss, microcephaly, and neurodevelopmental retardation can be observed during the follow-up. Among the brain magnetic resonance imaging (MRI) findings of CMV are white matter abnormalities, polymicrogyria, and periventricular calcification. Since a definitive diagnosis of congenital CMV cannot be made after the neonatal period, the identification of the associated phenotype is diagnostically important, but data are limited in patients who have been retrospectively diagnosed with congenital CMV infection. The aim of this study was …
Total Kidney Volume In Autosomal Dominant Polycystic Kidney Disease: Intraobserver And Interobserver Agreement Of Two Methods With Mri, Eli̇f Gündoğdu, Çağatay Ci̇han, Celal Yazici
Total Kidney Volume In Autosomal Dominant Polycystic Kidney Disease: Intraobserver And Interobserver Agreement Of Two Methods With Mri, Eli̇f Gündoğdu, Çağatay Ci̇han, Celal Yazici
Turkish Journal of Medical Sciences
Background/aim: Total kidney volume (TKV) is a parameter used in both treatment decision and follow-up in autosomal dominant polycystic kidney disease (ADPKD) patients. The objective of this study was to evaluate intra- and interobserver agreement of the ellipsoid formula (EF) and manual boundary tracing method (MBTM) used in TKV measurement of ADPKD patients across different levels of experience radiologists. Additionally, the study aimed to evaluate the correlation between the EF and MBTM, which is considered the gold standard for TKV. Materials and methods: A retrospective evaluation was conducted on magnetic resonance imaging (MRI) data from 55 ADPKD patients who underwent …
Control Of Cardiometabolic Risk Factors And Their Association With Carotid Intima Media Thickness Among Patients With Type 2 Diabetes Mellitus-Single Center Experience In A Developing Country, Thilak Priyantha Weerarathna, Sarath Lekkamwasam, Iroshani Kodikara, Keddegoda Gamage Piyumi Wasana, Lakmal Fonseka
Control Of Cardiometabolic Risk Factors And Their Association With Carotid Intima Media Thickness Among Patients With Type 2 Diabetes Mellitus-Single Center Experience In A Developing Country, Thilak Priyantha Weerarathna, Sarath Lekkamwasam, Iroshani Kodikara, Keddegoda Gamage Piyumi Wasana, Lakmal Fonseka
Turkish Journal of Medical Sciences
Background/aim: Type 2 diabetes mellitus (T2DM) is closely associated with atherosclerotic cardiovascular diseases (ASCVD). The objective of this study was to describe the degree of ASCVD risk factor control and their association with carotid intima-media thickness (CIMT) in T2DM patients followed up at a diabetes clinic in Southern, Sri Lanka. Materials and methods: A crosssectional study was conducted to examine the association between CIMT and nonalcoholic fatty liver disease (NAFLD)in 300 T2DM patients. Both CIMT and its associations with modifiable cardiometabolic risk factors were examined using ultrasonography. The recommended optimal targets for risk factors were defined as glycated hemoglobin (HbA1C) …
Autism Spectrum Disorder: Evaluation Of Community-Based Screening Program, Mehmet Aki̇f Sezerol, Seli̇n Davun
Autism Spectrum Disorder: Evaluation Of Community-Based Screening Program, Mehmet Aki̇f Sezerol, Seli̇n Davun
Turkish Journal of Medical Sciences
Background/aim: This study was conducted to evaluate the results of autism spectrum disorder (ASD) screenings conducted in a region of İstanbul between 2018 and 2023.Materials and methods: This descriptive study was conducted between April 2018 and February 2023 among 25,839 children aged between 18–36 months who had been screened for autism spectrum disorder in Sultanbeyli, İstanbul. Children between 18–36 months are examined and a form consisting of 5 questions and typical symptoms of ASD is filled. Each question is answered as yes or no. Answering yes to at least one of the questions is sufficient to direct them to child …
Displaced Sigmoid Notch Fracture And Higher Patient Age Are Associated With Distal Radioulnar Joint Subluxation, Saygın Kamaci, Melih Oral, Engin Türkay Yilmaz, Taha Aksoy, Barış Kafa, Mazhar Tokgözoğlu
Displaced Sigmoid Notch Fracture And Higher Patient Age Are Associated With Distal Radioulnar Joint Subluxation, Saygın Kamaci, Melih Oral, Engin Türkay Yilmaz, Taha Aksoy, Barış Kafa, Mazhar Tokgözoğlu
Turkish Journal of Medical Sciences
Background/aim : Distal radius fractures (DRFs) are frequently associated with distal radioulnar joint (DRUJ) instability. The purpose of this study is to evaluate the effect of the sigmoid notch and ulna styloid fracture types on DRUJ subluxation following closed reduction and casting of DRFs via calculating radioulnar ratio (RUR) on post-reduction computed tomography (CT) images. Materials and methods: In our study, post-reduction CT images of 202 patients with distal radius fractures was evaluated retrospectively. CT images were evaluated for RUR, sigmoid notch fracture, and ulna styloid types. Sigmoid notch fractures were classified as non-displaced in the sigmoid notch fractures (NDS) …
Clinical, Radiological, And Surgical Outcomes Of 431 Patients With Adrenal Incidentalomas: Retrospective Study Of A 10-Year Single-Center Experience, Nari̇n Nasiroğlu İmga, Yılmaz Aslan, Merve Çatak, İbrahim Can Aykanat, Altuğ Tuncel, Dilek Berker
Clinical, Radiological, And Surgical Outcomes Of 431 Patients With Adrenal Incidentalomas: Retrospective Study Of A 10-Year Single-Center Experience, Nari̇n Nasiroğlu İmga, Yılmaz Aslan, Merve Çatak, İbrahim Can Aykanat, Altuğ Tuncel, Dilek Berker
Turkish Journal of Medical Sciences
Background/aim: The incidence of adrenal tumors is increasing due to the widespread utilization of radiographic imaging techniques. Factors such as tumor size, radiological characteristics, and functionality of adrenal adenomas play crucial roles in diagnosis and subsequent management. In this retrospective study, we investigated the clinical, radiological, and surgical features of patients with adrenal incidentalomas (AIs) and evaluated their follow-up results.Materials and methods: We analyzed data from 431 patients diagnosed with AIs (130 males, 301 females) who underwent adrenal hormone evaluation at our center. We compared nonfunctioning and functioning AIs in terms of radiological features. We also compared baseline and follow-up …