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Full-Text Articles in Medical Sciences

Duple-Mondnet: Duple Deep Learning-Based Mobile Net For Motor Neuron Disease Identification, Sony Helen, Joseph Jawhar Feb 2025

Duple-Mondnet: Duple Deep Learning-Based Mobile Net For Motor Neuron Disease Identification, Sony Helen, Joseph Jawhar

Turkish Journal of Medical Sciences

Background/aim: Motor neuron disease (MND) is a devastating neuron ailment that affects the motor neurons that regulate muscular voluntary actions. It is a rare disorder that gradually destroys aspects of neurological function. In general, MND arises as a result of a combination of natural, behavioral, and genetic influences. However, early detection of MND is a challenging task and manual identification is time-consuming. To overcome this, a novel deep learning-based duple feature extraction framework is proposed for the early detection of MND.Materials and methods: Diffusion tensor imaging tractography (DTI) images were initially analyzed for color and textural features using dual feature …


Integrated Convolutional Neural Network For Skin Cancer Classification With Hair And Noise Restoration, Ni̇dhi̇ Bansal, Sri̇dhar Sundaramurthy Feb 2025

Integrated Convolutional Neural Network For Skin Cancer Classification With Hair And Noise Restoration, Ni̇dhi̇ Bansal, Sri̇dhar Sundaramurthy

Turkish Journal of Medical Sciences

Background/aim: Skin lesions are commonly diagnosed and classified using dermoscopic images. There are many artifacts visible in dermoscopic images, including hair strands, noise, bubbles, blood vessels, poor illumination, and moles. These artifacts can obscure crucial information about lesions, which limits the ability to diagnose lesions automatically. This study investigated how hair and noise artifacts in lesion images affect classifier performance and how they can be removed to improve diagnostic accuracy.Materials and methods: A synthetic dataset created using hair simulation and noise simulation was used in conjunction with the HAM10000 benchmark dataset. Moreover, integrated convolutional neural networks (CNNs) were proposed for …


A New Approach In The Treatment Of Ultrasound-Guided Synovial Hypertrophy, Emel Güler, Alper Doğanci Feb 2025

A New Approach In The Treatment Of Ultrasound-Guided Synovial Hypertrophy, Emel Güler, Alper Doğanci

Turkish Journal of Medical Sciences

Background/aimKnee osteoarthritis (OA) causes pain, limited movement, and negatively impacts daily life in older adults. Hypertrophy and changes in the synovial tissue significantly contribute to the pain. While intra-articular injections are common in OA treatment, specific therapies for hypertrophic tissue are rarely mentioned. This study aims to evaluate the long-term outcomes of local anesthetic and steroid injections in the knee's intra-articular space and hypertrophic synovial tissue.Materials and methodsOur retrospective study included patients with grade 3-4 kne OA diagnosed with ultrasound-guided suprapatellar effusion and synovial hypertrophy. Pain was assessed using the Numerical Rating Pain Scale (NRS), and functional capacity was evaluated …


Characteristics Of The Home Environment In Children With Developmental Concerns And Delays: Insights From A Cross-Sectional Study In Türkiye, Emel Ömerci̇oğlu, Ebru Ci̇han Çam, Ömer Nazim Gülçek, Eli̇f N. Özmert Feb 2025

Characteristics Of The Home Environment In Children With Developmental Concerns And Delays: Insights From A Cross-Sectional Study In Türkiye, Emel Ömerci̇oğlu, Ebru Ci̇han Çam, Ömer Nazim Gülçek, Eli̇f N. Özmert

Turkish Journal of Medical Sciences

Background/aim: A stimulating home environment in early childhood plays a crucial role in fostering child development. This study aimed to evaluate the home environment of children who were referred due to developmental delays or concerns and had not received any intervention at the child or family level.Materials and methods: The study comprised of 50 atypically developing preschool children monitored at the Developmental Pediatrics Department of *** and 70 typically developing preschool children from the General Pediatrics Department at ***. Physicians and experienced child development professionals employed the Ages and Stages Questionnaire (ASQ) to perform developmental assessments on each child. The …


Assessing Knowledge Levels Of Intensive Care Unit Nurses And Doctors Regarding Drug Administration Via Enteral Feeding Tubes: A Survey Study, Ayşe Gül Koçoğlu Kinal, Yunus Emre Ayhan, Aslinur Albayrak Feb 2025

Assessing Knowledge Levels Of Intensive Care Unit Nurses And Doctors Regarding Drug Administration Via Enteral Feeding Tubes: A Survey Study, Ayşe Gül Koçoğlu Kinal, Yunus Emre Ayhan, Aslinur Albayrak

Turkish Journal of Medical Sciences

Background/aimKnowledge deficiency regarding appropriate drug administration through enteral feeding tubes (EFTs). is common in intensive care units (ICUs). The aim of this study is to evaluate the knowledge levels of nurses and doctors in ICUs about drug administration via EFTs.Materials and methodsThis study was conducted as a cross-sectional online survey. Survey questions were created using Google Forms and distributed to nurses and doctors in various ICUs across hospitals in Istanbul, Türkiye. The researchers designed the survey questions based on literature reviews and existing examples. The survey consisted of three sections and a total of 25 questions: the first section included …


Does Cd47 Expression Have Prognostic Significance In Classical Hodgkin Lymphoma?, Aydan Kiliçarslan, Gülnaz Kurt Çevi̇k, Mehmet Doğan, Ayşegül Aksoy Altinboğa, Funda Ceran, Şule Mi̇ne Bakanay Öztürk, Gülşah Efeci̇k Feb 2025

Does Cd47 Expression Have Prognostic Significance In Classical Hodgkin Lymphoma?, Aydan Kiliçarslan, Gülnaz Kurt Çevi̇k, Mehmet Doğan, Ayşegül Aksoy Altinboğa, Funda Ceran, Şule Mi̇ne Bakanay Öztürk, Gülşah Efeci̇k

Turkish Journal of Medical Sciences

Background/aimHodgkin Lymphoma (HL) is highly treatable, but new chemotherapy agents are needed for patients with progression or recurrence. CD47 regulates anti-phagocytic activity by signaling through the SIRPα (signal regulatory protein alpha) pathway on macrophages. This study aims to assess the expression of CD47 in HL cases and explore its relationship with Epstein-Barr Virus (EBV) status and the International Prognostic Index (IPI).Materials and Methods120 patients diagnosed with Classical HL, characterized by the presence of Hodgkin and Reed-Sternberg (HRS) cells, for whom IPI scores were available. Demographic data and EBV status were retrieved from hospital records. CD47 immunohistochemical expression in HRS cells …


Relationship Between Bleeding Risk And Arterial Stiffness In Patients With Cerebral Aneurysms, Mehmet Seli̇m Gel, Hasan Çağri Postuk, İskender Samet Daltaban, Savaş Özer, Ercan Aydin, Emrah Keski̇n Feb 2025

Relationship Between Bleeding Risk And Arterial Stiffness In Patients With Cerebral Aneurysms, Mehmet Seli̇m Gel, Hasan Çağri Postuk, İskender Samet Daltaban, Savaş Özer, Ercan Aydin, Emrah Keski̇n

Turkish Journal of Medical Sciences

Background/aimA risk factor assessment evaluating the susceptibility of cerebral aneurysms (CA) to rupture has not yet been established. Therefore, the clinical management of unruptured CA remains uncertain. Our aim was to assess whether arterial stiffness is associated with the development of rupture in patients with cerebral aneurysms.Materials and methodsAfter magnetic resonance angiography, 49 patients with cerebral aneurysm and subarachnoid haemorrhage and ruptured cerebral aneurysm detected by digital substraction angiography were included in the study. Arterial stiffness was measured using the VaSera VS-1000 vascular scanning system, expressed as cardio-ankle brachial index (CAVI). CAVI values were compared between patient groups.ResultsThe mean age …


Relationship Between Uncoupling Protein 1 (Ucp1) Levels And Psoriasis, Fi̇kret Akyurek, Fatma Tuncez Akyurek, Fatma Sengul Feb 2025

Relationship Between Uncoupling Protein 1 (Ucp1) Levels And Psoriasis, Fi̇kret Akyurek, Fatma Tuncez Akyurek, Fatma Sengul

Turkish Journal of Medical Sciences

Background/aim: Psoriasis is an autoimmune, chronic and common skin disease. Comorbidities also increase the mortality risk of the disease. The aim of this study is to investigate the changes in UCP1 levels in psoriasis patients and to evaluate their possible role in the pathogenesis of the disease, focusing on disease severity (Psoriasis Area and Severity Index), dyslipidemia, inflammation and cardiovascular risk.Materials and methods: This study included 30 psoriasis patients and 30 healthy individuals as a control group. Serum UCP1 was measured using an ELISA test kit. The laboratory results of psoriasis patients and healthy controls were compared.Results: UCP1 level was …


Relationship Between The Density Of Degenerated Neurons In The Carotid Body And Changes In Blood Ph, Hakan Kina, Aydin Si̇nan Apaydin Feb 2025

Relationship Between The Density Of Degenerated Neurons In The Carotid Body And Changes In Blood Ph, Hakan Kina, Aydin Si̇nan Apaydin

Turkish Journal of Medical Sciences

Background/aimCarotid artery is the majority artery for brain feeding. Carotid Bodies (CBs) are located in carotid bifurcation and regulate body fluid pH. We aimed to evaluate the changes in CB-related pH levels as a consequence of degeneration induced by the ligation of both Common Carotid Arteries (BCCAL).Materials and methodsWe included 23 adult male New Zealand rabbits. A control group (n= 5); a sham group (0.5 mL saline injected n=5) and the main study group (subjected to the BCCAL procedure, n = 13). We monitored and recorded pH levels, and cardiac rhythms before, during, and after the experiments at two-day intervals. …


Predictors Of Gleason Score Upgrading In Patients With Biopsy Diagnosis Of Grade Group 1 Prostate Cancer, Bariş Esen, Bengi̇ Gürses, Ari̇f Özkan, Mert Kiliç, Yakup Kordan, Tarik Esen, Di̇lek Ertoy Baydar Feb 2025

Predictors Of Gleason Score Upgrading In Patients With Biopsy Diagnosis Of Grade Group 1 Prostate Cancer, Bariş Esen, Bengi̇ Gürses, Ari̇f Özkan, Mert Kiliç, Yakup Kordan, Tarik Esen, Di̇lek Ertoy Baydar

Turkish Journal of Medical Sciences

Background/aimTransrectal ultrasound-guided biopsy is the most commonly employed method in the diagnostic pathway of prostatic adenocarcinoma. Gleason score of the tumor is the critical tissue-based determinant of patient management after diagnosis, and main approach for low risk patients with grade group (GG) 1 disease is active surveillance rather than definitive interventions. However, a fair proportion of these cases is upgraded following radical prostatectomy (RP) if performed. We aimed to investigate the significance of clinicopathological parameters including PTEN protein in the prediction of higher final grade at radical prostatectomy in patients with biopsy diagnosis of GG1 prostatic carcinoma. Materials and methods33 …


Inflammatory Changes In The Prepuce And Clinical Findings According To The Stages Of Phimosis, Gül Doğan, Di̇lek Yilmaz, Hülya İpek, Mehmet Meti̇n, Hande Afşarlar, Çağatay Evri̇m Afşarlar Feb 2025

Inflammatory Changes In The Prepuce And Clinical Findings According To The Stages Of Phimosis, Gül Doğan, Di̇lek Yilmaz, Hülya İpek, Mehmet Meti̇n, Hande Afşarlar, Çağatay Evri̇m Afşarlar

Turkish Journal of Medical Sciences

Background/aim: Circumcision refers to the surgical removal of all or part of the prepuce. Circumcision is commonly performed on males in childhood to prevent urinary tract infections and for religious reasons. This study was designed to investigate the inflammatory processes in the prepuce according to the degree of phimosis in patients who underwent circumcision.Materials and methods: We conducted a prospective study on 173 male children under the age of 18 who underwent circumcision between June and September 2024. A comprehensive physical examination of the genitourinary system was performed. Foreskin retraction was assessed and recorded using the Kikiros grading score, and …


Relationship Between Hand Osteoarthritis Severity And Serum Resistin Levels In Women With Metabolic Syndrome: A Case-Control Study, Eki̇n Başak Doğanci, Berna İmge Aydoğan, Ni̇lgün Başkal, Safi̇ye Tuncer Feb 2025

Relationship Between Hand Osteoarthritis Severity And Serum Resistin Levels In Women With Metabolic Syndrome: A Case-Control Study, Eki̇n Başak Doğanci, Berna İmge Aydoğan, Ni̇lgün Başkal, Safi̇ye Tuncer

Turkish Journal of Medical Sciences

Background/aimWe aimed to determine the relationship between clinical and radiological severity of hand osteoarthritis and serum resistin levels in women diagnosed with metabolic syndrome.Materials and methodsThe study was designed as a case-control study. A total of 87 women aged 50-65 years were evaluated; 29 patients diagnosed with metabolic syndrome and hand osteoarthritis (MetS (+), hand OA (+); Group 1), 29 patients without metabolic syndrome but with hand osteoarthritis (MetS (-), hand OA (+); Group 2) and 29 healthy controls (MetS (-), hand OA (-); Group 3). The diagnostic criteria of American College of Rheumatology (ACR) for hand osteoarthritis and National …


Does Femoral Tunnel Location Have An Effect On Functional And Clinical Results In Medial Patellofemoral Ligament Reconstruction?, İbrahi̇m Kaya, Murat Çi̇çekli̇dağ, Resul Bi̇rcan, Mustafa Odluyurt, Abdurrahman Vural, İnci̇ Hazal Ayas, Muhammet Baybars Ataoğlu, Ulunay Kanatli Feb 2025

Does Femoral Tunnel Location Have An Effect On Functional And Clinical Results In Medial Patellofemoral Ligament Reconstruction?, İbrahi̇m Kaya, Murat Çi̇çekli̇dağ, Resul Bi̇rcan, Mustafa Odluyurt, Abdurrahman Vural, İnci̇ Hazal Ayas, Muhammet Baybars Ataoğlu, Ulunay Kanatli

Turkish Journal of Medical Sciences

Background/aimMultiple reconstruction techniques have been described to mimic the normal anatomy and physiology of medial patellofemoral ligament reconstruction (MPFL). The success of the MPFL depends on various factors such as graft selection, the location of the patellar tunnel and femoral tunnel (FT), and graft fixation methods. The aim of this study is to analyze the relationship of femoral tunnel location with functional and clinical outcomes after MPFL reconstruction.Materials and methodsIn this study, the mid-term clinical results of patients who underwent MPFL reconstruction for patellofemoral instability in a single institution between 2013 and 2019 were evaluated retrospectively. If the FT was …


Relationship Between Menstrual Cycle And Cognitive Functions In Women With Primary Dysmenorrhea, Ufuk Atlihan, Meltem Durakli Ulukök, Onur Yavuz Feb 2025

Relationship Between Menstrual Cycle And Cognitive Functions In Women With Primary Dysmenorrhea, Ufuk Atlihan, Meltem Durakli Ulukök, Onur Yavuz

Turkish Journal of Medical Sciences

Background/aim: To evaluate the relationship between the change in pain intensity over days in the menstrual-cycle and cognitive functions in females having primary dysmenorrhea.Materials and Methods: One hundred thirty-four females with primary dysmenorrhea who were admitted to our hospital from January 2021 to November 2023 were assessed. Of these participants, 46 individuals who subjectively stated that their cognitive functions were affected, for whom neurology consultation was requested, and for whom patient data were available, were included in the study.Results: Significant decrease was seen in phonemic fluency and semantic fluency in patients who were evaluated on the 3rd day of menstrual …


Outbreak Of Bacteremia Caused By Ralstonia Insidiosa Isolated From Contaminated Blood Gas Syringe, Eli̇f Ayça Şahi̇n, Özge Özgen Top, Pınar Aysert Yildiz, Eli̇f Seren Tanriverdi̇, Hasan Selçuk Özger, Bariş Otlu, Özlem Güzel Tunçcan, Murat Di̇zbay, Ayşe Kalkanci, Kayhan Çağlar Feb 2025

Outbreak Of Bacteremia Caused By Ralstonia Insidiosa Isolated From Contaminated Blood Gas Syringe, Eli̇f Ayça Şahi̇n, Özge Özgen Top, Pınar Aysert Yildiz, Eli̇f Seren Tanriverdi̇, Hasan Selçuk Özger, Bariş Otlu, Özlem Güzel Tunçcan, Murat Di̇zbay, Ayşe Kalkanci, Kayhan Çağlar

Turkish Journal of Medical Sciences

Background/aim: Ralstonia species are opportunistic, waterborne microorganisms known for their ability to survive and proliferate in a wide range of water-based environments. They can contaminate solutions used for patient care and cause hospital outbreaks due to contaminated solutions. The aim of this study was to investigate the source and clonal relationship of Ralstonia insidiosa bacteremia detected in 28 patients between August and December 2021, as part of an unusual outbreak.Materials and methods: Active prospective surveillance studies were conducted, and environmental samples, including saline, antiseptic, and antibiotic solutions, injectors, arterial blood gas syringes, tap water, and hand soap, were collected from …


Efficiency Of Cervical Cerclage And Pessary In Addition To Vaginal Progesterone To Prevent Preterm Birth In Twin Pregnancies: A Case-Control Study From A Tertiary Center, Göksun İpek, Atakan Tanaçan, Ilim Demet, Zahi̇d Ağaoğlu, Ezgi̇ Başaran, Özgür Kara, Di̇lek Şahi̇n Feb 2025

Efficiency Of Cervical Cerclage And Pessary In Addition To Vaginal Progesterone To Prevent Preterm Birth In Twin Pregnancies: A Case-Control Study From A Tertiary Center, Göksun İpek, Atakan Tanaçan, Ilim Demet, Zahi̇d Ağaoğlu, Ezgi̇ Başaran, Özgür Kara, Di̇lek Şahi̇n

Turkish Journal of Medical Sciences

Background/aim: To evaluate the efficiency of cervical cerclage and pessary in addition to vaginal progesterone to prevent preterm birth in twin pregnanciesMaterials and methods: The presented retrospective case-control study was conducted on 46 twin pregnancies with cervical insufficiency and delivered at the xxx Hospital, January 2022-2024. Patients were grouped as the cervical cerclage in addition to vaginal progesterone (n=10), cervical pessary in addition to vaginal progesterone (n=11), and only vaginal progesterone (n=25). Patients’ data were obtained from the hospital database. Obstetrical parameters (gravidity, parity, abortion, artificial reproductive technologies, second-trimester abortion) and ultrasound parameters (cervical length, intra-amniotic sludge) were recorded. Gestational …


The Abdominal Compliance Index And Postoperative Pain After Laparoscopic Gynecologic Surgery: A Preliminary Observational Cohort Study, Ebru Akgün Şarer, Mustafa Tahtaci, Umut Cahi̇t Ersoy, Mehtap Honca Feb 2025

The Abdominal Compliance Index And Postoperative Pain After Laparoscopic Gynecologic Surgery: A Preliminary Observational Cohort Study, Ebru Akgün Şarer, Mustafa Tahtaci, Umut Cahi̇t Ersoy, Mehtap Honca

Turkish Journal of Medical Sciences

Background/aimLaparoscopic surgery in gynecology has advantages of reduced scarring, less postoperative pain, faster recovery and lower risk of complications. Despite these adavantages, shoulder pain still remains a major concern affecting upto 90% of patients undergoing gynecologic laparoscopic surgery. The use of Abdominal compliance index (ACI) may offer the benefits of gaining work space for safer surgery and may prevent the drawbacks of applying higher insuflation pressures.We investigated the relation of shoulder pain and abdominal pain and analgesic use with the recently advised ACI which is a surrogate index of abdominal expansion in patients undergoing gynecologic laparoscopic surgery.Materials and methodsThirty one …


In Vitro Anticancer, Antioxidant And Chelating Activities Of Natural Organosulfur Compounds Originated From Türkiye: An Investigation On Breast And Colorectal Cancer Cells, Ümmügülsüm Polat Korkunç, Hi̇lal Çalik, Leyla Polat Köse, Rabi̇a Çakir Koç, Emi̇ne Karakuş Feb 2025

In Vitro Anticancer, Antioxidant And Chelating Activities Of Natural Organosulfur Compounds Originated From Türkiye: An Investigation On Breast And Colorectal Cancer Cells, Ümmügülsüm Polat Korkunç, Hi̇lal Çalik, Leyla Polat Köse, Rabi̇a Çakir Koç, Emi̇ne Karakuş

Turkish Journal of Medical Sciences

Background/aim:Taşköprü garlic, cultivated in the Taşköprü region of Kastamonu province, is a very famous in Türkiye.This study aimed to determine the anticancer and antioxidant effects of extracts from Kastamonu Taşköprü garlic on human breast cancer and colorectal cancer cells.Materials and methods:Taşköprü garlic, which contains natural organosulfur compounds, has a geographical registration. Taşköprü garlic, which contains natural organosulfur compounds (OSCs), has a geographical registration.Garlic contains oil- and water-soluble OSCs known to exhibit anticancer activity by interfering with MCF-7 and Caco-2 proliferation and tumor metastasis. In this study, the antiproliferative activity of oil- and water-soluble garlic extracts with and without glutathione at …


Impact Of Ivermectin On Nerve Regeneration Following Sciatic Injury In Mice: The Consequences Of Dietary High Fructose, Ezgi̇ Deni̇z Arikan, Barişcan Çi̇men, Ayşe Ece Gezen Yilmaz, Eli̇f Akaydin, Berkay Alpay, Deni̇z Eki̇n Erbaş, Erblina Nikshiqi, Sevda Müftüoğlu, Yildirim Sara Feb 2025

Impact Of Ivermectin On Nerve Regeneration Following Sciatic Injury In Mice: The Consequences Of Dietary High Fructose, Ezgi̇ Deni̇z Arikan, Barişcan Çi̇men, Ayşe Ece Gezen Yilmaz, Eli̇f Akaydin, Berkay Alpay, Deni̇z Eki̇n Erbaş, Erblina Nikshiqi, Sevda Müftüoğlu, Yildirim Sara

Turkish Journal of Medical Sciences

Background/aimPeripheral nerve injuries (PNI) are debilitating disorders affecting predominantly the younger generation, often leading to significant disabilities. Current treatment strategies are inadequate in addressing the complex nature of these injuries. Peripheral nerve healing and functional recovery are crucial components of both pathophysiology and therapeutic approach. High fructose corn syrup (HFCS) is a frequently used sweetener in several beverages and foods. And it is associated with several metabolic disturbances including insulin resistance and may impair nerve healing. This study investigates the therapeutic role of ivermectin on nerve regeneration following sciatic nerve injury and evaluates motor and sensorial functions together with histopathological …


Are Cinnamon Derivatives Effective And Safe For Diabetes?, Methi̇ye Mancak, Ufuk Koca Çalişkan Feb 2025

Are Cinnamon Derivatives Effective And Safe For Diabetes?, Methi̇ye Mancak, Ufuk Koca Çalişkan

Turkish Journal of Medical Sciences

Background/aimCinnamon spice is obtained by drying the tree bark of the Cinnamomum Schaeff genus. Cinnamomum genus belongs to the Lauraceae family and there are approximately 250 different species around the world. The most common species in the market are Cinnamomum verum J. S. Presl, C. cassia (L.) J. Presl, C. burmannii (Nees & T. Nees) Blume and C. loureiroi Nees. Cinnamon and its by-products are used for many years for their antidiabetic effect. In this research, the major chemical content and in vitro antidiabetic activities of different commercially available cinnamon samples were evaluated to conclude whether they are safe to …


Association Of Certain Biochemical Parameters Related To Bone Cycle With Genotype In Mps Iii-B Patients, Seda Gökkurt, İrem Peker Eyüboğlu, Banu Nur Güzel, Ercan Mihçi, Ayşe Özer, Mustafa Akki̇pri̇k Feb 2025

Association Of Certain Biochemical Parameters Related To Bone Cycle With Genotype In Mps Iii-B Patients, Seda Gökkurt, İrem Peker Eyüboğlu, Banu Nur Güzel, Ercan Mihçi, Ayşe Özer, Mustafa Akki̇pri̇k

Turkish Journal of Medical Sciences

Background/aim: The aim of this study is to investigate the genotype-phenotype correlation in Sanfilippo type B patients in terms of bone formation/resorption parameters, and to determine the release/inhibition of biomarkers accompanying osteoporosis.Materials and Methods: Plasma levels of Osteoprotegerin, Matrix metalloproteinases (MMP2, MMP9), TIMP-1, TIMP-2, BALP, Cathepsin K, and TRACP-5b were examined by ELISA method in MPS IIIB patients. At the same time, mutations in the NAGLU gene causing this disease were detected by whole exome sequencing, and their correlation with biochemical parameters was investigated.Results: Based on the enzyme analysis results, MMP-9, TIMP1, TIMP-2, and MMP-2 were significantly high, while Cathepsin-K …


Ascorbic Acid Exhibits More Of A Protective Effect Than Estradiol Against Nephrotoxicity Induced By Malathion In Rats: A Histopathological And Molecular Docking Study, Mohammad Alhilal, Mahmoud Salem, Ahmed Albakoush, Suzan Alhilal, Basant Farag, Sobhi M. Gomha Feb 2025

Ascorbic Acid Exhibits More Of A Protective Effect Than Estradiol Against Nephrotoxicity Induced By Malathion In Rats: A Histopathological And Molecular Docking Study, Mohammad Alhilal, Mahmoud Salem, Ahmed Albakoush, Suzan Alhilal, Basant Farag, Sobhi M. Gomha

Turkish Journal of Medical Sciences

Background/Aim: Despite the known harmful effects associated with malathion toxicity in various organs, it continues to be widely used for plant protection and insect control. This study is the first to compare the protective effects of estradiol and ascorbic acid against malathion-induced nephrotoxicity through histopathological assessment and molecular docking analyses.

Materials and Methods: This study was conducted using 20 female albino rats that were distributed into sham, malathion, malathion + estradiol, and malathion + ascorbic acid groups. Nephrotoxicity was induced by daily treatment with malathion, and the effects of estradiol and ascorbic acid on nephrotoxicity were evaluated. After 4 weeks …


Could Eras Protocols Be Integrated Into The National Standards For Quality In Healthcare In Türkiye?, Mi̇ne Gürsaç Çeli̇k, Adem Az, Mehmet Çeti̇n, Nesli̇han Alkiş Feb 2025

Could Eras Protocols Be Integrated Into The National Standards For Quality In Healthcare In Türkiye?, Mi̇ne Gürsaç Çeli̇k, Adem Az, Mehmet Çeti̇n, Nesli̇han Alkiş

Turkish Journal of Medical Sciences

No abstract provided.


Erratum To “ Telemedicine In Pediatric Rheumatology: The Video Pediatric Gait, Arms, Legs, And Spine (V-Pgals) Examination” [Turkish Journal Of Medical Sciences 54 (5) 2024 963-969 ], Zeynep Balik, Seher Şener, Yağmur Bayindir, Müşerref Kasap Cüceoğlu, Emi̇l Ali̇yev, Özge Başaran, Yelda Bi̇lgi̇ner, Seza Özen, Ezgi̇ Deni̇z Batu Feb 2025

Erratum To “ Telemedicine In Pediatric Rheumatology: The Video Pediatric Gait, Arms, Legs, And Spine (V-Pgals) Examination” [Turkish Journal Of Medical Sciences 54 (5) 2024 963-969 ], Zeynep Balik, Seher Şener, Yağmur Bayindir, Müşerref Kasap Cüceoğlu, Emi̇l Ali̇yev, Özge Başaran, Yelda Bi̇lgi̇ner, Seza Özen, Ezgi̇ Deni̇z Batu

Turkish Journal of Medical Sciences

This erratum is written to correct an error in our previous publication. Supplement Figure 2 was published incorrectly as one page instead of six.
DOI of original article: https://doi.org/10.55730/1300-0144.5874


A Comparison Study Of Sensory Processing In Older Adults With And Without Dementia, Medi̇ne Nur Özata Değerli̇, Di̇dem Karaduman, Burcu Balam Doğu, Onur Altuntaş Feb 2025

A Comparison Study Of Sensory Processing In Older Adults With And Without Dementia, Medi̇ne Nur Özata Değerli̇, Di̇dem Karaduman, Burcu Balam Doğu, Onur Altuntaş

Turkish Journal of Medical Sciences

Background/aim: Sensory processing is affected by aging, and dementia may lead to changes in sensory processing. This study aimed to examine the differences in sensory processing and sensory modulation between older adults with and without dementia.Materials and methods: This study was designed as a comparative study of community-dwelling older adults aged 65 years and older with and without dementia. Participants and their caregivers were recruited at the occupational therapy clinic of a public hospital. They completed a sociodemographic information form and the Adolescent/Adult Sensory Profile to assess sensory processing and sensory modulation.Results: The study included 120 older adults (60 with …


Cardiac Effects And Comorbidities Of Neurological Diseases, Bi̇lgi̇n Öztürk Dec 2024

Cardiac Effects And Comorbidities Of Neurological Diseases, Bi̇lgi̇n Öztürk

Turkish Journal of Medical Sciences

Neurological disorders encompass a complex and heterogeneous spectrum of diseases affecting the brain, spinal cord, and peripheral nervous system, each presenting unique challenges that extend well beyond primary neurological symptoms. These disorders profoundly impact cardiovascular health, prompting an intensified exploration into the intricate interconnections between the neurological and cardiovascular systems. This review synthesizes current insights and research on cardiovascular comorbidities associated with major neurological conditions, including stroke, epilepsy, Parkinson’s disease, multiple sclerosis (MS), and Alzheimer’s disease.The cardiovascular sequelae of these neurological disorders are multifactorial. For instance, strokes not only predispose individuals to arrhythmia and heart failure but also exacerbate pre-existing …


Hematological Diseases And Heart, Ferda Can Dec 2024

Hematological Diseases And Heart, Ferda Can

Turkish Journal of Medical Sciences

The heart, main part of the circulatory system, is one of the organs that frequently affected in hematological diseases. Cardiac problems may develop during the course and treatment of benign and malign hematological diseases. Determining cardiac approaches in hematological diseases with knowledge and experience about the development of cardiac involvements with pathophysiological conditions has an important role in the diagnosis and treatment process of patients. In this section, information about hematological diseases and the heart is included, and key points that will help in the diagnosis and treatment process are mentioned.


Thyroid And Cardiovascular Diseases, Si̇nem Başak Tan Öksüz, Mustafa Şahi̇n Dec 2024

Thyroid And Cardiovascular Diseases, Si̇nem Başak Tan Öksüz, Mustafa Şahi̇n

Turkish Journal of Medical Sciences

The thyroid gland is one of the major regulator organs of hemostasis in the human body, controlling the function of numerous systems. Thyroid hormones exert a modulating effect on particularly cardiovascular system, ensuring optimal functioning within the normal range. Triiodothyronine (T3), as an active form of thyroid hormones, is mainly responsible for this effect via both genomic and non-genomic mechanisms. It has been reported that overt thyroid disorders are associated with a number of cardiovascular diseases and cardiac mortality. While hyperthyroidism appears to be related to atrial fibrillation and heart failure, the most pronounced cardiovascular complication of hypothyroidism seems to …


Coexisting Growing Teratoma Syndrome And Gliomatosis Peritonei Following Ovarian Immature Teratoma: A Case Report And Literature Review, Osman Türkmen, Serra Akar İnan, Serap Akbay, Mohammad İbrahi̇m Hali̇lzade, İnci̇ Hali̇lzade, Özlem Moraloğlu Teki̇n Dec 2024

Coexisting Growing Teratoma Syndrome And Gliomatosis Peritonei Following Ovarian Immature Teratoma: A Case Report And Literature Review, Osman Türkmen, Serra Akar İnan, Serap Akbay, Mohammad İbrahi̇m Hali̇lzade, İnci̇ Hali̇lzade, Özlem Moraloğlu Teki̇n

Turkish Journal of Medical Sciences

Background/aim: Growing teratoma syndrome (GTS) is marked by the reduction in serum tumor markers, despite the growth of a benign mature teratomatous mass after chemotherapy treatment for germ cell tumors. Gliomatosis Peritonei (GP) is often seen with ovarian teratomas, involving the spread of mature glial tissue on the peritoneum. The coexistence of GP with GTS following treatment for ovarian immature teratoma (IMT) is particularly rare with about 20 cases reported thus far.Case: A 25-year-old patient underwent surgical removal of an adnexal mass. On paraffin pathology, she was deemed to have stage III A grade 3 ovarian IMT with parametrial involvement. …


Factors Associated With Morbidity Of Totally Implantable Venous Access Device In Patients With Breast Cancer, Burak İlhan, Berkay Kiliç Dec 2024

Factors Associated With Morbidity Of Totally Implantable Venous Access Device In Patients With Breast Cancer, Burak İlhan, Berkay Kiliç

Turkish Journal of Medical Sciences

Background/aim: To investigate the possible morbidities associated with the implantation of a totally implantable venous access device (TIVAD) in breast cancer (BC) patients.Materials and methods: Clinical data and developed complications in 546 BC patients with TIVAD between 2017 and 2021 were analyzed retrospectively. Among these patients, 524 (96.0%) patients who underwent TIVAD implantation via the right subclavian vein (SCV) route were examined separately.Results: The mean patient age was 56.1±11.4 years, and the mean patient body mass index was 25.3±6.5. The incidence of early complications was 2.3% (12 cases), and late complications were 2.6% (14 cases). Among these complications, 10 (1.9%) …