Diseases Commons^™

Persistent Challenges: Pulmonary Hypertension In Aortic Coarctation Despite Surgical Valve Replacement, Adam Devine, Jacklyn Garcia

East Florida Division GME Research Day 2023

Introduction: Aortic coarctation has an incidence of 0.04% and is typically amendable either through a surgical or interventional approach. Unfortunately, patients that have undergone repair of the coarctation are at risk of systemic hypertension which suggests a more diffuse vasculopathy. The arteriopathy can also affect the pulmonary vasculature leading to pulmonary hypertension (PH). The development of PH is a poor prognostic factor. Patients with a history of coarctation repairs have more significant afterload measurements which stiffen their left ventricle and decrease compliance and diastolic function. Adults with Coarctation of the aorta (CoA) are at increased risk of premature cardiovascular death …

Cannabis Consumption And The Emergence Of Giant Lung Bullae: A Case Report And Clinical Analysis, Rafael Miret, Jose Rodriguez Castro, Armando Cabrera, Mauricio Danckers, Raiko Diaz, Nikhil Bhardwaj

East Florida Division GME Research Day 2023

Please see supplemental content for full abstract with figures and references.

Introduction: Vanishing Lung Syndrome (VLS), also known as idiopathic giant bullous emphysema, is a rare pulmonary condition characterized by the development of large, thin-walled bullae within the lung parenchyma. While the exact etiology of VLS remains unclear, there is growing interest in exploring a potential association between VLS and cannabis use. This case report aims to contribute to the existing body of knowledge by presenting a case of VLS in a patient with a history of chronic cannabis consumption in prior years.

Clinical Presentation: A 44-year-old former smoker male …

A Curious Case Of Biopsy Proven Usual Interstitial Pneumonia, Austin Makadia, Vishesh Persaud, Saiara Choudhury, Asad Chohan, Abhay Vakil

Gulf Coast Division GME Research Day 2023

No abstract provided.

Subacute Combined Degeneration In Atypical Case, Ryan Molina

Gulf Coast Division GME Research Day 2023

No abstract provided.

Crps Successfully Managed With Peripheral Nerve Stimulation: A Case Report, David Gallacher, Christopher Choi, Napatkamon Ayutyanont, Upinder Singh, Sungkook Park

Far West Division GME Research Day 2023

No abstract provided.

Creating Change In Pediatric Health Disparities: Utilizing Systemsbased Thinking To Overcome Disparities Affecting Pediatric Type 1 Diabetes In Kentucky, Sydney Speed

Lewis Honors College Thesis Collection

Healthcare disparities are perpetuated and upheld for patients with type 1 diabetes (T1D) in rural and underserved urban areas of Kentucky. By adopting systems-based thinking, we can identify areas of the healthcare system to change to eliminate these disparities. Namely, key leverage points of this system include distribution and utilization of resources, finances and the movement of money, and communication pathways. To address the disparities surrounding pediatric T1D in Kentucky, a state-wide medical event called Kentucky Diabetes Family Day (KDFD) was hosted. The focus of this event was to lessen the effects of these specific healthcare disparities by altering key …

The Impact Covid-19 On The Healthcare Industry’S Systems And Policies: A Case Study, Jameyshia Franklin

West Chester University Doctoral Projects

People worldwide experienced some impacts from the 2019 Coronavirus at various degree. The healthcare industry worldwide was significantly affected by the high volume of patients being infected with the Coronavirus. The COVID-19 virus brought on several challenges for the healthcare industry and the federal government in the United States. Hospitals operated under severe circumstances to treat sick COVID-19 patients and keep their employees safe from contracting the disease. Government mandated social distancing, mask wearing, and cancelation and closing of services to assist with stopping the spread of the virus. This study aimed to identify how the pandemic affected the healthcare …

Examining A Blood Biomarker Approach To Blood-Brain Barrier Disruption, Samantha Ford

Theses and Dissertations--Medical Sciences

Blood-brain barrier disruption has been identified to associate with the pathogenesis several neurological diseases such as dementia [1, 2], multiple sclerosis[3, 4], acute or chronic cerebral ischemia[5], brain trauma[5], meningitis[5], encephalitis[5], stroke[6], and seizures[7]. Being able to effectively identify blood-brain barrier disruption is limited in methodology. The current standard is using a cerebrospinal fluid (CSF) albumin to serum albumin index, which requires the use of a lumbar puncture. A novel method of identifying blood-brain barrier disruption utilizing blood biomarkers is proposed in this study. Participants in this study had previously collected blood and CSF samples, which were analyzed to compare …

Split Catalytic Probes For The Detection Of Monkeypox Virus, Jaehyun Ahn

Honors Undergraduate Theses

The COVID-19 outbreak highlighted the important role that diagnostic tests play in the healthcare system. To reduce the impact of infectious disease outbreaks, the development of rapid and cost-effective point-of-care-tests (POCTs) is crucial. With the dissemination of the Monkeypox (Mpox) virus, it became a necessity to produce POCTS that are inexpensive and easy to use. This work explored the construction of two colorimetric assays that aim to detect Mpox genetic signatures. One is based on the split-peroxidase-like deoxyribozyme probes (sPDz), while the other utilizes a cascade system of split RNA-cleaving deoxyribozyme (sDz) and peroxidase-like deoxyribozyme (PDz). Both rely on catalytic …

Clonal Diversity, Antibiotic Resistance, And Virulence Factor Prevalence Of Community Associated Staphylococcus Aureus In Southeastern Virginia, Katelyn D. Cranmer, Mohan D. Pant, Suzanne Quesnel, Julia A. Sharp

EVMS School of Health Professions Faculty Publications

Staphylococcus aureus is a significant human pathogen with a formidable propensity for antibiotic resistance. Worldwide, it is the leading cause of skin and soft tissue infections (SSTI), septic arthritis, osteomyelitis, and infective endocarditis originating from both community- and healthcare associated settings. Although often grouped by methicillin resistance, both methicillin-resistant (MRSA) and methicillin-sensitive (MSSA) strains are known to cause significant pathologies and injuries. Virulence factors and growing resistance to antibiotics play major roles in the pathogenicity of community-associated strains. In our study, we examined the genetic variability and acquired antibiograms of 122 S. aureus clinical isolates from SSTI, blood, and urinary …

Evaluation Of Cold Atmospheric Plasma For The Decontamination Of Flexible Endoscopes, R. C. Hervé, Michael G. Kong, Sudhir Bhatt, Hai-Lan Chen, E. E. Comoy, J-P. Deslys, T. J. Secker, C. W. Keevil

Bioelectrics Publications

Background: Despite adherence to standard protocols, residues including live microorganisms may remain on the various surfaces of reprocessed flexible endoscopes. Prions are infectious proteins notoriously difficult to eliminate.

Aim: We tested the potential of cold atmospheric plasma (CAP) for the decontamination of flexible endoscope various surfaces, measuring total proteins and prion-residual infectivity as an indicator of efficacy.

Methods: New PTFE endoscope channels and metal test surfaces spiked with test soil or prion-infected tissues were treated using different CAP-generating prototypes. Surfaces were then examined for the presence of residues using very sensitive fluorescence epi-microscopy. Prion residual infectivity was determined using the …

Covid-19 Vaccination And Alcohol Consumption: Justification Of Risks, Pavel A. Solopov

Bioelectrics Publications

Since the beginning of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, pharmaceutical companies and research institutions have been actively working to develop vaccines, and the mass roll-out of vaccinations against COVID-19 began in January 2021. At the same time, during lockdowns, the consumption of alcoholic beverages increased. During the peak of vaccination, consumption remained at high levels around the world, despite the gradual relaxation of quarantine restrictions. Two of the popular queries on search engines were whether it is safe to drink alcohol after vaccination and whether this will affect the effectiveness of vaccines. Over the past two …

The Impact Of Whole Fruits High In Anthocyanins On Blood Lipids In Middle-Aged Women, Denise N. Leininger

Cal Poly Humboldt theses and projects

Cardiometabolic Diseases (CMDs) are the leading cause of morbidity and mortality among women. During the menopause transition, drops in estrogen play a favorable role in the excess accumulation of Intraabdominal Fat (IAF), altering blood lipid metabolism and inducing inflammatory responses in CMDs attributed to dyslipidemia. This systematic review and meta-analysis examined current research on the effects of whole fruits high in anthocyanins on blood lipid metabolism in women at risk for CMDs. This meta-analysis included 15 studies using the PRISMA 2020 guidelines. Overall, effect sizes were not significant when exploring blood lipid marker outcomes High-Density Lipoprotein (HDL), Low-Density Lipoprotein (LDL), …

Survey Based Investigation On Diet/Bmi In Indian-American Communities, Arjan Deol

Pitzer Senior Theses

Obesity is defined as a disease where abnormal or excessive fat accumulation presents risks to one’s health. It is also associated with a wide variety of metabolic diseases such as diabetes, hypertension, metabolic syndrome, sleep apnea, and cardiovascular health. In recent years, the rates of obesity have continued to grow in the United States, especially amongst the Indian-American community. Asians have a lower BMI cutoff ( ≥27.5 kg/m2) for obesity instead of the standard ≥30.0 kg/m2 recommendations by CDC due to a higher prevalence of weight-related diseases at lower BMI and carrying 3-5% more body fat than an average Western …

Prospective Investigation Of Insomnia Symptoms And Sleep Duration As Risk Factors For Stroke Incidence And All-Cause Mortality In U.S Adult, Wendemi Sawadogo

Theses and Dissertations

Background and Objectives: Stroke is the second leading cause of death in the world. In the United States, on average, someone has a stroke every 40 seconds and someone dies as a result of stroke every 3.5 minutes. Identifying modifiable risk factors of stroke is therefore a public health priority. The purpose of this study was to investigate the extent to which insomnia symptoms and sleep duration contribute to stroke incidence, all-cause mortality, and explore potential causal pathways.

Methods: The Health and Retirement Study (HRS) and the REasons for Geographic And Racial Differences in Stroke (REGARDS) study were …

Evaluation Of Spliceai For Improved Genetic Variant Classification In Inherited Ophthalmic Disease Genes, Melissa Reeves

Theses and Dissertations

ABSTRACT

EVALUATION OF SPLICEAI FOR IMPROVED GENETIC VARIANT CLASSIFICATION IN INHERITED OPHTHALMIC DISEASE GENES

By Melissa Jean Reeves, Ph.D.

A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University.

Virginia Commonwealth University, 2023

Major Director: Melissa Jamerson, PhD, MLS(ASCP)

Associate Professor, Department of Medical Laboratory Sciences

Inherited ophthalmic diseases impact individuals around the globe. Inherited retinal diseases (IRDs) are the leading cause of blindness in individuals aged 15 to 45. The personal, social, and economic impact of vision loss is profound. Due to individual differences, symptoms can be variable, and …

A Case Of Vibrio Vulnificus In Galveston, Kayla Nguyen, Duyen Quach, Chinasa Anokwuru, Connor Hogan, Mike Liang

Gulf Coast Division GME Research Day 2023

No abstract provided.

An Interesting Case Of Diffuse Alveolar Hemorrhage With An Elusive Etiology, Austin Makadia, Vishesh Persaud, Saiara Choudhury, Asad Chohan, Abhay Vakil

Gulf Coast Division GME Research Day 2023

No abstract provided.

The Re-Emergence Of An Ancient Disease: A Case Presentation Of Spinal Tuberculosis, Danay Herrera, Nargisa Ergasheva, Paola Solari, Daniel Kaswan, Bryan Greendield

East Florida Division GME Research Day 2023

Please see supplemental content for full abstract with references.

Introduction: An ancient disease identified in Egyptian and Peruvian mummies, tuberculous spondylitis caused by Mycobacterium tuberculosis (MTB) is considered the most common form of extrapulmonary tuberculosis (TB) [1,5]. Despite the identification of the causative agent, the improvement in diagnostic tools, the production of the Bacillus Calmette-Guerin (BCG) vaccine, and the development of antimicrobial regimens since the disease was first described, it remains a major health burden today with significant morbidity and mortality among developing countries [5]. Spinal TB can lead to severe deformity and permanent neurological deficits, as such early recognition …

Amiodarone-Induced Thyrotoxicosis Type 2 : Utilization Of Color-Flow Doppler Sonography For Diagnosis, Sam Joseph, Larissa Check, Donald Eagerton

South Atlantic Division GME Research Day 2023

No abstract provided.

Endobronchial Ultrasound Diagnosis Of A Malignant Superior Vena Cava Tumor Thrombus Extending Into The Right Atrium: An Unusual Cause Of Recurrent Syncope., Larissa Check, Ariba Naz, Richard Duff

South Atlantic Division GME Research Day 2023

No abstract provided.

Congenital Mesenteric Defect Results In Internal Hernia In An Adult With Obstructed Small Bowel, Tameem Jamal, Adina Mcnair, Saptarshi Biswas

South Atlantic Division GME Research Day 2023

No abstract provided.

Opioid-Induced Intrathecal Catheter Tip Granuloma Via Pain Pump In A Patient With Chronic Pain Syndrome: A Case Report, Katherine David, R Blake Kline, Jon Halling

South Atlantic Division GME Research Day 2023

No abstract provided.

A Case Report On Cervical Insufficiency And Ehlers Danlos Syndrome, Elizabeth Bogaty, Judy Bowers

South Atlantic Division GME Research Day 2023

No abstract provided.

Maternal Mirror Syndrome As A Consequence Of Fetal Sacrococcygeal Teratoma: A Case Report And Literature Review, Ali Farris, Andrew Royek, Kaitlyn Dorsey

South Atlantic Division GME Research Day 2023

No abstract provided.

Improving Recombinant Zoster Vaccination Rates In Patients Receiving Biologic Therapy, Kathlyn Camargo, Taylor Kann, Marilyn Mosquera, Ravi Shahu, Ariail Schmitz, Kathleen Mccabe, Ashwini Komarla

North Florida Division GME Research Day 2023

No abstract provided.

Efficacy And Safety Of Mavacamten In The Treatment Of Hypertrophic Cardiomyopathy: A Systematic Review, Daniel Bishev, Stephanie Fabara, Isaac Loseke, Akankcha Alok, Hashim Al-Ani, Yvette Bazikian

North Florida Division GME Research Day 2023

No abstract provided.

Case Report On Labetalol Induced Transaminitis, Alexandria Dennison, Minar Rane, Vijaya Samuel

Continental, MidAmerica, & Mountain Divisions GME Research Day 2023

No abstract provided.

Noncompaction Cardiomyopathy: A Catastrophic Cause Of Heart Failure, William Zvagelsky, Ajay Iyer, Rebecca Kurian, Brent Wu, Minar Rane, Rajendran Sabapathy

Continental, MidAmerica, & Mountain Divisions GME Research Day 2023

No abstract provided.

Clinical Presentation Of Immune-Mediated Post Sars-Cov-2 Encephalitis And Vasculitis, Trevi Mancilla, J Lee, W Hills, P Stanford

Continental, MidAmerica, & Mountain Divisions GME Research Day 2023

No abstract provided.