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Articles 1 - 30 of 315
Full-Text Articles in Diseases
Impairment Of The Glial Phagolysosomal System Drives Prion-Like Propagation Of Huntington’S Disease, Graham Davis
Impairment Of The Glial Phagolysosomal System Drives Prion-Like Propagation Of Huntington’S Disease, Graham Davis
Theses and Dissertations
The ability of glia to tightly regulate neuronal health and homeostasis in the CNS is conserved across species. Yet, despite the ability to degrade protein aggregates, glia are vulnerable to the accumulation of neurotoxic amyloid aggregates during neurodegenerative disease progress, and even exacerbate their spread. A developing narrative highlights glia as a double-edged sword in neurodegenerative diseases: initially capable of dynamically responding to amyloid aggregate-ladened dying neurons but also capable of inducing chronic inflammation and creating seeding-competent amyloid oligomers. Thus, uncovering the mechanisms that allow glia to control aggregate deposition while preventing the neurotoxic effects and seed generation is vital …
Huntington’S Disease: A Systematic Review And Overview Of Treatments, Madison Mintz
Huntington’S Disease: A Systematic Review And Overview Of Treatments, Madison Mintz
Undergraduate Honors Theses
Huntington’s Disease (HD) is a genetic neurodegenerative disease that is the result of a mutation of the huntingtin gene. The gene is passed in an autosomal dominant fashion and is the result of multiple Cystine, Adenine, and Guanine base repeats. HD symptoms manifest as motor, cognitive, and psychological symptoms that can range of chorea movements to depression or apathy. The disease progresses through various prodromal and clinical stages as the disease starts to manifest. The current technique to diagnose HD is the use of direct genetic testing, which counts the number of repeats. Due to the nature of HD, both …
A Proud Huntington’S Disease Gene Carrier’S Message To His 'Miracle Baby' Daughter On Her Senior Year In College, Kenneth P. Serbin
A Proud Huntington’S Disease Gene Carrier’S Message To His 'Miracle Baby' Daughter On Her Senior Year In College, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Bidding Farewell To My ‘Mind Coach,’ A Major Ally In My Fight To Avoid Huntington's Disease, Kenneth P. Serbin
Bidding Farewell To My ‘Mind Coach,’ A Major Ally In My Fight To Avoid Huntington's Disease, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Crispr, Curing Huntington’S Disease, And Humanity’S Future In Isaacson's 'Code Breaker', Kenneth P. Serbin
Crispr, Curing Huntington’S Disease, And Humanity’S Future In Isaacson's 'Code Breaker', Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
‘Inequality Is Unsustainable’: A View Of The Quest For Huntington's Disease Treatments From The Global South, Kenneth P. Serbin
‘Inequality Is Unsustainable’: A View Of The Quest For Huntington's Disease Treatments From The Global South, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
‘The First At-Bat Is Never A Grand Slam’: How Huntington's Disease Drug Research Has Matured With The Roche And Wave Setbacks, Kenneth P. Serbin
‘The First At-Bat Is Never A Grand Slam’: How Huntington's Disease Drug Research Has Matured With The Roche And Wave Setbacks, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Roche Confirms Tominersen As Ineffective, While Triplet Provides Key Details For Trial Of Drug To Slow Major Driver Of Huntington's Disease, Kenneth P. Serbin
Roche Confirms Tominersen As Ineffective, While Triplet Provides Key Details For Trial Of Drug To Slow Major Driver Of Huntington's Disease, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
With Proof-Hd In The Lead, The Huntington’S Disease Drug Pipeline Is Still 'Full Of Hope' (Coping With Disappointing Clinical Trial Results – Part Ii), Kenneth P. Serbin
With Proof-Hd In The Lead, The Huntington’S Disease Drug Pipeline Is Still 'Full Of Hope' (Coping With Disappointing Clinical Trial Results – Part Ii), Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Overcoming A ‘Heartbreaking’ Moment For The Huntington's Disease Cause (Coping With Disappointing Clinical Trial Results – Part I), Kenneth P. Serbin
Overcoming A ‘Heartbreaking’ Moment For The Huntington's Disease Cause (Coping With Disappointing Clinical Trial Results – Part I), Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Tough News For Huntington’S, Other Neurological Disease Patients: Roche Halts Dosing In Historic Clinical Trials On Signs Of Inefficacy, Kenneth P. Serbin
Tough News For Huntington’S, Other Neurological Disease Patients: Roche Halts Dosing In Historic Clinical Trials On Signs Of Inefficacy, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Blog Article No. 300: Who Exactly Is Gene Veritas?, Kenneth P. Serbin
Blog Article No. 300: Who Exactly Is Gene Veritas?, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Occupational Therapy’S Role In Addressing Sexuality And Intimacy For Individuals With Progressive Neuromuscular Disorders, Lindsay N. Richards
Occupational Therapy’S Role In Addressing Sexuality And Intimacy For Individuals With Progressive Neuromuscular Disorders, Lindsay N. Richards
Student Capstone Papers
Individuals with progressive neuromuscular disorders (PND); specifically, Parkinson’s disease (PD), Multiple Sclerosis (MS), Huntington’s Disease (HD), and Amyotrophic Lateral Sclerosis (ALS) often face physical, psychological, and social challenges related to sex and intimacy. Occupational therapy (OT) practitioners are experts in activity analysis and are equipped with unique knowledge of performance skills and client factors to address deficits in occupational performance.
Though there is literature presenting the effects of PND on sexual occupations, a gap exists as it relates to qualitative data from the perspective of the individual and their partners. A mixed-methods survey was conducted examining the lived experience of …
Getting The Covid-19 Vaccine And A New Exercise Bike To Keep Stable In The Fight Against Huntington's Disease, Kenneth P. Serbin
Getting The Covid-19 Vaccine And A New Exercise Bike To Keep Stable In The Fight Against Huntington's Disease, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
My Arduous, Lucky, And Enlightening Journey Since My Mother's Death From Huntington's Disease 15 Years Ago, Kenneth P. Serbin
My Arduous, Lucky, And Enlightening Journey Since My Mother's Death From Huntington's Disease 15 Years Ago, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
A Veteran Neurologist’S Book Offers Tools For Navigating The 'Turbulent World' Of Huntington's Disease, Kenneth P. Serbin
A Veteran Neurologist’S Book Offers Tools For Navigating The 'Turbulent World' Of Huntington's Disease, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
After A Horrid Year, Free Streaming Of ‘Dancing At The Vatican' Is An Inspirational Gift And A Call To Aid Huntington's Disease Families, Kenneth P. Serbin
After A Horrid Year, Free Streaming Of ‘Dancing At The Vatican' Is An Inspirational Gift And A Call To Aid Huntington's Disease Families, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Happy Thanksgiving! And Hail To The Pharmaceutical And Biotech Industries – And The Scientists!, Kenneth P. Serbin
Happy Thanksgiving! And Hail To The Pharmaceutical And Biotech Industries – And The Scientists!, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Annual Huntington Study Group Meeting Reveals An Hd Community Energized To Aid Families, Develop Treatments, Kenneth P. Serbin
Annual Huntington Study Group Meeting Reveals An Hd Community Energized To Aid Families, Develop Treatments, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Triplet Therapeutics Aims To Transform The Approach To Treating Huntington's Disease, Similar Disorders, Kenneth P. Serbin
Triplet Therapeutics Aims To Transform The Approach To Treating Huntington's Disease, Similar Disorders, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
In This Electoral Season, Let’S Highlight Our Natural Role As Caregivers And Support Care Professionals, Kenneth P. Serbin
In This Electoral Season, Let’S Highlight Our Natural Role As Caregivers And Support Care Professionals, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Wonder If You’Ll Get Huntington’S Disease? Preparing For The Big, 'Intensely Personal' Decision To Undergo Predictive Testing, Kenneth P. Serbin
Wonder If You’Ll Get Huntington’S Disease? Preparing For The Big, 'Intensely Personal' Decision To Undergo Predictive Testing, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
In The Pandemic, We Need To Rediscover Patience And Grasp Our Responsibility, Kenneth P. Serbin
In The Pandemic, We Need To Rediscover Patience And Grasp Our Responsibility, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Combatting The Pandemic, Roche Also Forges Ahead With Critical Phase 3 Huntington's Disease Clinical Trial, Kenneth P. Serbin
Combatting The Pandemic, Roche Also Forges Ahead With Critical Phase 3 Huntington's Disease Clinical Trial, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Giving Back During The Covid-19 Pandemic, Kenneth P. Serbin
Giving Back During The Covid-19 Pandemic, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
In Times Of Crisis, Huntington’S And Other Chronic Disease Communities Provide Examples Of Fortitude, Kenneth P. Serbin
In Times Of Crisis, Huntington’S And Other Chronic Disease Communities Provide Examples Of Fortitude, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Chdi Head Scientist Pacifici: ‘Hang On In The Learning Roller Coaster Ride Of Huntington's Disease Clinical Trials', Kenneth P. Serbin
Chdi Head Scientist Pacifici: ‘Hang On In The Learning Roller Coaster Ride Of Huntington's Disease Clinical Trials', Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
At Therapeutics Conference, Landmark Study Of Young Gene Carriers Highlights How Huntington's Disease Researchers Seek To Solve Critical Puzzles, Kenneth P. Serbin
At Therapeutics Conference, Landmark Study Of Young Gene Carriers Highlights How Huntington's Disease Researchers Seek To Solve Critical Puzzles, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
Striving To Overcome The Doom Of Huntington’S Disease, Kenneth P. Serbin
Striving To Overcome The Doom Of Huntington’S Disease, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.
I’M A Huntington’S Disease Gene Carrier At Age 60, So Why Haven't I Developed Symptoms Yet?, Kenneth P. Serbin
I’M A Huntington’S Disease Gene Carrier At Age 60, So Why Haven't I Developed Symptoms Yet?, Kenneth P. Serbin
At Risk for Huntington's Disease
No abstract provided.