Diseases Commons^™

Biochemical Properties Of Cardiac Sarcomeres In Human Heart Failure, Austin Grey Wellette-Hunsucker

Theses and Dissertations--Physiology

Heart failure (HF) exhibits considerable heterogeneity, posing significant challenges for research involving human cohorts. Diastolic dysfunction is a common pathophysiological feature; however, its molecular mechanisms remain incompletely elucidated. Sarcomeric proteins are integral to cardiac contraction and relaxation. Nonetheless, the phosphoproteome and the structural remodeling effects of these proteins on diastolic function within the context of HF have not been comprehensively characterized. This study examined sarcomeric modifications in diastolic dysfunction in human HF, focusing on Dilated and Ischemic HF, with non-failing donor hearts as controls. Analyzing myocardial samples from ~150 patients using electrophoretic and biochemical techniques, it found significant titin remodeling …

The Incidence Of Postmenopausal Breast Cancer In Relation To Occupational Exposure To Textile Fibers And Dusts In Montreal, Canada, 2008-2011, Maymouna Myriam Ka, France Labrèche, Mark S. Goldberg, Vikki Ho

Études primaires

Objective To estimate the associations between occupational exposure to textile fibers/dusts, and incidence of postmenopausal invasive breast cancer.

Methods

A population-based case-control study conducted in Montreal (2008 − 2011) identified hospital cases (N = 695) and population controls (N = 608) from the electoral list. Occupational hygienists examined participants’ occupations and tasks, and attributed exposures to several textile fibers. For all tumors and according to biomolecular subtypes, odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using logistic regression models with different exposure indices, adjusting for potential confounders.

Results

Ever exposure to cotton dust was associated with an increased …

Occupational Exposure To Combustion By-Products And Breast Cancer Risk In Postmenopausal Women, Kahlila Paul-Cole, France Labrèche, Mark S. Goldberg, Sydney Westra, Vikki Ho

Études primaires

Objective

To estimate the association between lifetime occupational exposure to select combustion by-products and postmenopausal breast cancer (BC) risk.

Materials and Methods

Data from a population-based case-control study among postmenopausal women residing in Montréal, Quebec were used. Cases included 661 women aged between 47 and 75 yr, diagnosed with incident malignant BC between 2008 and 2011. Controls comprised 587 women randomly selected from the Quebec Electoral List, frequency-matched to cases by 5-year age groups. Information on risk factors and lifetime occupational histories was collected by interview. Two industrial hygienists used job histories to assign exposure to 293 agents, including 6 …

Fabricating Silver-Ceria Polymer Nanocomposite Scaffolds For Biomedical Therapeutic Applications, Shreya S. Pawar

Honors Undergraduate Theses

Improper healing of bone fractures and limited regeneration of bone following bone tumor resection remain a prevalent complication worldwide. Long-term effects of this include joint instability, limited movement, and arthritis. Bone infections (osteomyelitis), reactive oxygen species (ROS) generation via excessive inflammation, and underlying conditions such as osteoporosis can contribute to suboptimal bone tissue regeneration. ROS accumulation stimulates osteoblast apoptosis, while promoting osteoclast differentiation. These processes inhibit mineralization and osteogenesis. Conventional therapeutics involve the utilization of drugs and bone grafts. However, these approaches pose limitations and can result in subsequent complications. Microbial infections, ROS accumulation, and excessive inflammations are factors that …

Reprogramming Of Immunometabolic Functions In Brain Microvascular Endothelial Cells During Neuroinflammation: Insights From Ischemic Stroke And Sepsis, Shokofeh Rahimpourkaldeh

Graduate Theses, Dissertations, and Problem Reports (ETD)

Ischemic stroke and sepsis-associated encephalopathy (SAE) are two distinct conditions that share common pathophysiological mechanisms affecting brain microvascular endothelial cells (BMECs). Ischemic stroke results from an acute reduction in cerebral blood flow due to thrombosis or embolism, leading to energy failure, oxidative stress, and blood-brain barrier (BBB) dysfunction. SAE, a neurological complication of sepsis, arises from systemic inflammation, endothelial activation, and BBB disruption, leading to cognitive impairment and neuroinflammation. Despite their different etiologies, both conditions involve BMEC dysfunction as a central mediator of neurovascular injury. This dissertation aims to investigate the immunometabolic dysfunction of BMECs in ischemic stroke and sepsis, …

Therapeutic Roles For Alkaline Phosphatases To Target Intestinal Dysfunction In Mouse Models Of Experimental Sepsis And Ischemic Stroke, Rhiannon V. Macom

Graduate Theses, Dissertations, and Problem Reports (ETD)

Abstract

Therapeutic Roles for Alkaline Phosphatases to Target Intestinal Dysfunction in Mouse Models of Experimental Sepsis and Ischemic Stroke

Rhiannon V. Macom

Stroke is a disease that primarily affects the brain; however, ongoing research continues to show that stroke has far reaching systemic effects that can affect both short- and long-term recovery. The gastrointestinal tract has been shown to be affected post-stroke, and these effects are likely due to the bidirectional communication between the gut and the brain via the gut-brain-axis. Alkaline phosphatases (APs) are common membrane bound enzymes that are known to have a role in mitigating inflammation. The …

Recombinant Factor Viia: New Insights Into The Mechanism Of Action Through Product Innovation, Miguel A Escobar, Maureane Hoffman, Giancarlo Castaman, Cedric Hermans, Johnny Mahlangu, Johannes Oldenburg, Charles L Percy, Mark T Reding, Amy D Shapiro, Steven W Pipe

Faculty, Staff and Student Publications

Management of bleeding in persons with hemophilia and inhibitors involves treatment with bypassing agents, including recombinant activated factor VII (rFVIIa). Two rFVIIa products are commercially approved for use in the United States and the European Union. Eptacog alfa and eptacog beta share the same amino acid sequence but differ in posttranslational modifications. Although rFVIIa has been used to manage bleeding in persons with hemophilia and inhibitors for over 30 years, its mechanisms of action is still being studied. In vitro and in vivo studies have suggested that rFVIIa could promote hemostasis by (1) increasing tissue factor-dependent activation of factor (F)X …

Diabetes Device Knowledge And Confidence Among School Nurses: A Mixed Methods Study, Cassandra F. Moffitt

Nursing Theses and Dissertations

Problem: Type 1 diabetes is one of the most common chronic medical conditions in childhood. While manageable, these children may spend half of their day in the school setting and often need assistance from a school nurse to manage their care.

Theory: Bandura’s Social Cognitive Theory (1977) served as the theoretical framework for this study.

Research Questions: The research questions explored knowledge, confidence, and additional predictors of confidence related to diabetes devices.

Design/Methods: An explanatory sequential mixed methods design was used. The Diabetes Device Confidence Scale (DDCS) was used to measure device confidence, while Subscale 10 of the KAT-1 instrument …

Unintentional Lead Dislodgement In Twiddler’S Syndrome, Howard Tan, Ashok Chaudhary, Nishant Nerella, Suman Pasupuleti

West Florida Division GME Research Day 2025

No abstract provided.

Development Of Intra-Hospital Ceftriaxone Resistance Of Serratia Marcescens Endocarditis, Mahyar Doraji, Michael Denney, Adeel Malik, Praveen Chekka, Nishant K. Nerella

West Florida Division GME Research Day 2025

No abstract provided.

Metastatic Cardiac Tumor: New Onset Cardiac Tamponade And Atrial Fibrillation, Maheen N. Mirza, Aixa M. Rivera Rodriguez, Antonio J. Santiago Rodriguez, Adeel Malik, Matthew Vincent Tavares

West Florida Division GME Research Day 2025

No abstract provided.

Pancytopenia, A Rare Case Associated With Influenza A, Aida Sarita Gonzalez, Ajith Vivek, Gabriela Salazar, Joseph Maslak

West Florida Division GME Research Day 2025

No abstract provided.

A Case Report: Cardiac Tamponade Secondary To Myelofibrosis Induced Extramedullary Hematopoiesis In Pericardium, Jaafar A. Hamdan, Mustafa Tahir, Ahmed Taha, Chrissy Sharma, Amrita Randhawa

West Florida Division GME Research Day 2025

No abstract provided.

Coral Crisis: Palytoxin-Induced Keratoconjunctivitis In Marine Experts, Nikolas Foresteire, Luis Cabrera, Cory Howard, Alexandra Craen, Ori Gat

West Florida Division GME Research Day 2025

No abstract provided.

Hemoptysis In A Previously Healthy Hispanic Male: A Case Of Anca Vasculitis Diagnosis, Muhammad Anzar Ullah, Angel Pacheco-Rueda, Marwa Hegagi

West Florida Division GME Research Day 2025

No abstract provided.

Does Size Matter? Subchorionic Hematomas And Their Pregnancy Outcomes In Ivf Pregnancies, Alexa Wynn, Emily Lluch, Yissa Fonticiella, Mark Sanchez

West Florida Division GME Research Day 2025

No abstract provided.

Early Management Of Kodamaea Ohmeri Infection In A Diabetic Patient With Recurrent Otitis Externa: A Case Report, Madison Groom, Linette Diaz, Ryan Fernandez, Jose Vasquez

West Florida Division GME Research Day 2025

No abstract provided.

Interaction Between Dapsone And Warfarin Causes Supratherapeutic Inr, Farhan Hiya, Omar Jureyda, Zachary Harwood, Fernando Lugo, Andrew Niclosi

West Florida Division GME Research Day 2025

No abstract provided.

When Autoimmunity Meets Pregnancy: Investigating Antiphospholipid Syndrome & Preeclampsia, Brianna Mcdonald, Madison Pearson, U Perni, Shiloh Smajstrla, Stephen Zweibach, James Baron

West Florida Division GME Research Day 2025

No abstract provided.

Massive Fibroid Uterus Leading To Multiple Sequalae: A Case Report Of Fumarate Hydratase Deficiency, Benjamin Duplaga, Tara Feehan, Heather Miller

West Florida Division GME Research Day 2025

No abstract provided.

Bilateral Spontaneous Pneumothorax In Suspected Pulmonary Lymphangioleiomyomatosis (Lam), Fernando Lugo-Hernandez, Madison Groom, Muhammad Anzar Ullah, Muhammad Zain Abideen, Ahmad Hayat, Nadia Eid

West Florida Division GME Research Day 2025

No abstract provided.

Pill Impaction Unmasking Eosinophilic Esophagitis And Acute Ulcerative Herpes Simplex Esophagitis In An Immunocompetent Patient, Fernando Lugo-Hernandez, Omar Jureyda, Bhavtosh Dedania

West Florida Division GME Research Day 2025

No abstract provided.

A Rare Case Of Maffucci Syndrome Presenting With Cord Compression And Paradoxical Stroke, Fernando Lugo-Hernandez, Nicholas Farelo-Camargo, Adriana Rivera-Diaz, Mariana Villamizar-Suarez, Marwa Hegagi

West Florida Division GME Research Day 2025

No abstract provided.

A Case Study Of Necrobiosis Lipoidica And Literature Review, Kylee Arthurs, Brianna Tischner, Michael Higginbotham, Nathalie Ruiz, Juan Socas

West Florida Division GME Research Day 2025

No abstract provided.

Inflammation Without Borders: A Rare Case Of Takayasu Arteritis In A Young Adult, Alexander Yaylayan, Walaa Abualhuda, Yash Dara, Joshini Simon, Jeffrey Steinhoff, Mark Starnes, Robert Digiovanni

West Florida Division GME Research Day 2025

No abstract provided.

Breaking The Iv Habit: Oral Antibiotics For Gram-Negative Bacteremia In The Modern Era, Adam Albadawi, Maria Milko

West Florida Division GME Research Day 2025

No abstract provided.

A Rare Case Of Right Sided Aortic Arch And Type B Dissection, Armaan Handa, Nayeem Chowdhury, Joshni Simon, Mohamed Tashani, Jeffrey Steinhoff, Jesse Klein, Christiano Caldeira

West Florida Division GME Research Day 2025

No abstract provided.

First Reported Case Of Upadacitinib-Induced Cmv Viremia And Pneumonitis In Ulcerative Colitis, Wilfredo Jhoel Javier-Rojas, Alvin Boyd Newman-Caro, Mamoon Guellai, Vamsee Mupparaju, Sreekanth Chandrupatla, Yizhi Lin, Ivan Rascon-Aguilar

West Florida Division GME Research Day 2025

No abstract provided.

Comparison Of Fasting And Non-Fasting Regimens Outcomes Before Catheterization Laboratory Procedures: A Systematic Review And Meta-Analysis, Ali Moradi, Shayan Shojaei, Asma Mousavi, Mehrdad Mahalleh, Soheil Rahmati, Parnian Soltani, Mashood Farooqi

West Florida Division GME Research Day 2025

No abstract provided.

Redo Surgical Aortic Valve Replacement (Savr) Vs. Valve-In-Valve Transcatheter Aortic Valve Implantation (Viv-Tavi) For Patients As A Treatment For Degenerative Valves: A Systematic Review And Meta-Analysis, Ali Moradi, Pouya Ebrahimi, Maryam Taheri, Hamidreza Soleimani, Homa Taheri, Babak Sattartabar, Morvarid Taebi

West Florida Division GME Research Day 2025

No abstract provided.