Diseases Commons^™

Best Screening: Introducing The Neonatal Assessment Visual European Grid To Nicus In Tennessee, Gabrielle Sledge

OTD Capstone Projects

Blind Early Services Tennessee (BEST) is an early intervention agency that serves children ages 0-5 with visual impairments across Tennessee. BEST serves over 200 children and families across the state offering early intervention (BEST Start), parent empowerment (BEST Advocate), and family support (BEST Together) programming. The purpose of this project was to assist in the implementation of an early identification initiative (BEST Screening) using the Neonatal Assessment Visual European Grid (NAVEG). The NAVEG is a newborn vision screening shown to identify neurological risk for visual impairments. The long-term goal of this program is to promote the screening and early identification …

Contemporary Approach To Narrow Angles, Wesam Shamseldin Shalaby, Rohit Reddy, Reza Razeghinejad, L. Jay Katz

Wills Eye Hospital Papers

Glaucoma is the leading cause of irreversible blindness worldwide. Among all glaucoma types, primary angle closure glaucoma (PACG) affects approximately 23 million people worldwide, and is responsible for 50% of glaucoma-related blindness, highlighting the devastating consequences of this disease. The main mechanism of PACG is relative pupillary block. High-risk populations are female gender, Asian ethnicity, high hyperopia, short axial length, and a thick/anteriorly positioned lens. This review discusses the clinical diagnosis, classification, and management of patients with a narrow angle with and without intraocular pressure (IOP) elevation and glaucomatous optic nerve damage, including laser peripheral iridotomy (LPI), endocycloplasty (ECPL), lens …

Targeting Cyp51 In The Treatment Of Acanthamoeba Keratitis, Ashkan Hassani, Vineet Sadarangani, Brad Haubrich

Annual Research Symposium

Acanthamoeba castellanii causes a rare but serious ocular infection called Acanthamoeba keratitis. Risk factors for infection include contact with contaminated water and poor hygiene of contact lenses. The first-line treatment is comprised of a months-long schedule of antibiotics. However, in cases where pharmacological interventions fail to address the infection, surgery may be necessary, with the continued risk of potential vision loss. Consequently, new treatments are needed, whether new pharmacological agents or new combination therapies with current agents. As an aerobic parasite, Acanthamoeba synthesizes ergosterol as a cell membrane insert, and ergosterol biosynthesis inhibitors (EBIs), common in antifungal pharmaceuticals, could potentially …

Evaluation Of Novel Therapeutic Agents For The Treatment Of Chronic Dry Eyes, Lilian Huynh, Evonie Villarete, Surajit Dey

Annual Research Symposium

Dry eye disease (DED) is a multifactorial ocular condition, where disrupted tear film stability and ocular surface inflammation affected between 5% to 34% of the worldwide population in 2015 and posed a challenge to conventional ophthalmic treatments. Recent advances have led to potential novel therapeutics aiming to alleviate symptoms and improve patient outcomes.

Dentofacial Effects Of Radiotherapy On Pediatric Population With Retinoblastoma, Kristi Truong

Annual Research Symposium

This literature review investigates the dentofacial consequences of radiotherapy in young patients with retinoblastoma by referencing current research. In addition, the management and rehabilitation of the dentofacial abnormalities, highlighting orthodontic, surgical, and prosthetic approaches, is examined. By understanding the changes of dentofacial development due to retinoblastoma treatment, effective management techniques can be implemented to resolve significant issues, relating to dental and skeletal relationship and facial appearance.

Efficacy And Safety Of Artificial Tears Containing Lipidure And Hypromellose For The Treatment Of Moderate Dry Eye Disease In Contact Lens Wearers, Caterina Gagliano, Marco Zeppieri, Antonio Longo, Giovanni Rubegni, Roberta Amato, Roberta Foti, Francesco Cappellani, Massimiliano Cocuzza, Federico Visalli, Ludovica Cannizzaro, Alessandro Avitabile, Giuseppe Gagliano, Lucia Lapenna, Fabiana D'Esposito

Wills Eye Hospital Papers

Background and Objectives: Dry eye disease (DED) affects 5–50% of the global population and deeply influences everyday life activities. This study compared the efficacy, tolerability, and safety of novel Respilac artificial tears containing lipidure and hypromellose (HPMC) with the widely used Nextal artificial tears, which are also HPMC-based, for the treatment of moderate DED in contact lenses (CL) wearers.

Materials and Methods: In a prospective, single-center, randomized investigation, 30 patients aged ≥18 years, diagnosed with moderate DED, and wearing CL were randomly assigned to the Respilac (n = 15) or Nextal group (n = 15). Patients self-administrated one drop of …

A Reliable Diabetic Retinopathy Grading Via Transfer Learning And Ensemble Learning With Quadratic Weighted Kappa Metric, Sai Venkatesh Chilukoti, Liqun Shan, Vijay Srinivas Tida, Anthony S. Maida, Xiali Hei

Computer Science Faculty Publications

The most common eye infection in people with diabetes is diabetic retinopathy (DR). It might cause blurred vision or even total blindness. Therefore, it is essential to promote early detection to prevent or alleviate the impact of DR. However, due to the possibility that symptoms may not be noticeable in the early stages of DR, it is difficult for doctors to identify them. Therefore, numerous predictive models based on machine learning (ML) and deep learning (DL) have been developed to determine all stages of DR. However, existing DR classification models cannot classify every DR stage or use a computationally heavy …

Long-Term Surgical Outcomes Of Glaucoma Drainage Implants In Eyes With Preoperative Intraocular Pressure Less Than 19 Mmhg, Shahin Hallaj, Jae-Chiang Wong, Lauren E. Hock, Natasha Nayak Kolomeyer, Aakriti G. Shukla, Michael J. Pro, Marlene R. Moster, Jonathan S. Myers, Reza Razeghinejad, Daniel Lee

Wills Eye Hospital Papers

BACKGROUND: This retrospective review reports on patients who underwent glaucoma drainage implant (GDI) surgery and had baseline intraocular pressure (IOP) of ≤18 mmHg with at least one year of follow-up.

METHODS: Clinical data of 67 eyes of 67 patients were collected from patients' charts, and the outcomes of GDI were evaluated until 7 years. GDI failure was defined as IOP reduction of less than 20% from the baseline at two consecutive visits three months after surgery, decline to no light perception, or if additional glaucoma surgery was performed.

RESULTS: The average age was 65.9 ± 13.2 years. Most cases were …

“Everything Seems To Be The Right Eye In Our Family”: Intergenerational Family Living With Facial Eye Disfigurement: An Interpretative Phenomenological Analysis, Zali M. O'Dea Ms, Jane Southcott

The Qualitative Report

This paper presents the lived experience of an intergenerational family, spanning three generations living with Facial Eye Disfigurement (FED). Living with vision loss and FED is estimated to affect nearly 8 billion people worldwide. Inadequate attention is paid to the impact of Living with FED (LwFED) on the lives of individuals. This research offers a deep dive into the lived experiences of one family LwFED. This family comprises a grandfather (deceased), son, wife, and child, all of whom have lived or live with FED. In this Interpretive Phenomenological Analysis (IPA) study three interviewees are deemed the experts. Data were collected …

Horner’S Syndrome, A Rare Complication Of Transcarotid Artery Revascularization, Mollie Ahn, April Miller, Shonda Banegas, Edic Stephanian

North Texas Research Forum 2024

Extracranial carotid artery aneurysm is a rare sequela of atherosclerosis, trauma, and conditions of chronic inflammation. Standard treatments include antiplatelet medications, open resection, or endovascular stenting. Transcarotid artery revascularization (TCAR) has become a well-recognized alternative treatment in the past few decades. This case study documents the first reported case of Horner’s syndrome post-TCAR for an internal carotid artery (ICA) aneurysm. A 68 year-old male with intermittent double vision was referred to vascular surgery clinic with brain CT angiography showing a 9mm saccular aneurysm with dissection flap of the right cervical ICA. Prior attempts by neuro-interventional radiology were unsuccessful due to …

Glaucoma Neovascular, Una De Las Consecuencias De La Oclusión De La Vena Central De La Retina, Nicol Daniela Jiménez Rojas

Ciencia y Tecnología para la Salud Visual y Ocular

Objetivo. Estudiar y describir la relación entre la oclusión de la vena central de la retina y el glaucoma neovascular, su etiología, epidemiología, fisiopatología, factores de riesgo, presentación clínica y tratamientos. Metodología. Revisión de la literatura acerca del glaucoma neovascular secundario a oclusión de la vena central de la retina, tomando artículos comprendidos entre 2014 y 2022, con criterios de exclusión artículos de series de casos. Resultados. El glaucoma neovascular (GNV) es una afectación patológica ocular, secundaria a una afección ocular y/o sistémica hipóxica que conduce a isquemia retiniana, dentro de las etiologías más comunes (33 %) se encuentra la …

Impacto De La Pandemia Por Covid-19 En La Decisión De Los Pacientes Sometidos A Cirugía Refractiva En Una Institución Privada En Bogotá, Colombia, Juliana Palacio Varona, Brian Pérez Riaño, María Paula Castro Mora, María Andrea Estevez Florez, Luis Guillermo Isaza Gómez, Diana V. Rey-Rodríguez

Ciencia y Tecnología para la Salud Visual y Ocular

En el 2020, durante la pandemia por covid-19, disminuyeron los procedimientos en los centros de cirugía refractiva, pero resurgieron para octubre de ese mismo año, ya que aumentaron un 4 % en comparación con el 2019. Existe una información limitada sobre el impacto de la pandemia en la realización de cirugías y la razón que obedece a dicho aumento. Objetivo: identificar el efecto de la pandemia por covid-19 en la cirugía refractiva mediante la delimitación de las principales motivaciones para la realización del procedimiento. Métodos: estudio descriptivo observacional de corte transversal, por medio de la respuesta de un cuestionario sobre …

Prevalencia De Astenopia En Niños Escolares De 6 A 17 Años, Por El Uso De Pantallas Digitales Durante La Pandemia Por Covid-19 (2020-2022): Revisión Sistemática, Jenny Paola Acosta Castellanos, Nancy Piedad Molina-Montoya

Ciencia y Tecnología para la Salud Visual y Ocular

Introducción: El uso de dispositivos electrónicos es primordial en la vida cotidiana a nivel mundial y gracias a la emergencia sanitaria por COVID-19 se incrementó, obligando a los estudiantes a tomar clases virtuales, y esto aumento la prevalencia de astenopia. Objetivo General: Determinar la prevalencia de astenopia reportada por la literatura en niños escolares de 6 a 17 años, por el uso de pantallas digitales durante la pandemia por COVID-19. Método de Investigación: Se realizo una revisión sistemática cualitativa mediante la pregunta PECO; la búsqueda bibliográfica de realizo en bases las bases de datos, con ecuaciones construidas con palabras clave …

Diabetes-Associated Hyperglycemia Causes Rapid-Onset Ocular Surface Damage, Judy Weng, Christopher Ross, Jacob Baker, Saleh Alfuraih, Kiumars Shamloo, Ajay Sharma

Pharmacy Faculty Articles and Research

Purpose: The metabolic alterations due to chronic hyperglycemia are well-known to cause diabetes-associated complications. Short-term hyperglycemia has also been shown to cause many acute changes, including hemodynamic alterations and osmotic, oxidative, and inflammatory stress. The present study was designed to investigate whether diabetes-associated hyperglycemia can cause rapid-onset detrimental effects on the tear film, goblet cells, and glycocalyx and can lead to activation of an inflammatory cascade or cellular stress response in the cornea.

Methods: Mouse models of type 1 and type 2 diabetes were used. Tear film volume, goblet cell number, and corneal glycocalyx area were measured on …

Dha Shortage Causes The Early Degeneration Of Photoreceptors And Rpe In Mice With Peroxisomal Β-Oxidation Deficiency, Daniëlle Swinkels, Sai Kocherlakota, Yannick Das, Adriaan D. Dane, Eric J.M. Wever, Frédéric M. Vaz, Nicolas G. Bazan, Paul P. Van Veldhoven, Myriam Baes

School of Medicine Faculty Publications

PURPOSE. Patients deficient in peroxisomal β-oxidation, which is essential for the synthesis of docosahexaenoic acid (DHA, C22:6n-3) and breakdown of very-long-chain polyunsaturated fatty acids (VLC-PUFAs), both important components of photoreceptor outer segments, develop retinopathy present with retinopathy. The representative mouse model lacking the central enzyme of this pathway, multifunctional protein 2 (Mfp2−/−), also show early-onset retinal decay and cell-autonomous retinal pigment epithelium (RPE) degeneration, accompanied by reduced plasma and retinal DHA levels. In this study, we investigated whether DHA supplementation can rescue the retinal degeneration of Mfp2−/− mice. METHODS. Mfp2+/− breeding pairs and their offspring were fed a 0.12% DHA …

Sagging Eye Syndrome--An Overlooked Diagnosis, Zachary Tlumak Od, Theresa Zerilli-Zavgorodni Od, Nancy Shenouda-Awad Od

Optometric Clinical Practice

Abstract

Background: Sagging Eye Syndrome (SES) is a relatively unknown cause for binocular distance diplopia. SES presents with an acquired comitant or non-comitant small angle esotropia and/or hypotropia commonly occurring in the elderly population. Inferior displacement of the lateral rectus secondary to age-related degeneration of orbital connective tissue and extraocular muscles appears to be responsible for the ocular misalignment. SES patients often present with new onset or progressively worsening distance diplopia, typically warranting neuroimaging. However, through understanding SES, eye care practitioners may identify these cases, avoiding unnecessary imaging studies. Case Report: A 90-year-old male presented with complaints of intermittent horizontal …

Autosomal Dominant Optic Atrophy Plus Syndrome, Aaron W. Case Od, Lovelee E. Sayomac Od, Matthew J. Anderson Od

Optometric Clinical Practice

Background: Dominant optic atrophy (DOA) is the most commonly encountered hereditary optic neuropathy in clinical practice and is the result of a mutation in the OPA1 or OPA3 genes encoding mitochondrial membrane proteins. The resultant mitochondrial dysfunction causes a distinct set of ophthalmic findings and may progress to extra-ocular systems known as OPA plus syndrome. We present a case of late-onset OPA plus syndrome encompassing both typical ophthalmic findings and the rarer extra-ocular findings. Case Report: A 41 year-old Caucasian male presents for a second opinion regarding a previously diagnosed traumatic optic neuropathy. Examination revealed decreased best-corrected acuities, …

Diagnosis And Management Of A Patient With Methicillin-Resistant Staphylococcus Aureus Conjunctivitis, Michael Chocky Od

Optometric Clinical Practice

Background : Methicillin-resistant Staphylococcus aureus (MRSA) infections are becoming more common. These infections can cause various ocular conditions including conjunctivitis. Conjunctival cultures are an important tool to assist with proper diagnosis and treatment of these infections. Case Report : A 61-year-old African American male presented with the complaint of redness and drainage from his eyes. With the assistance of conjunctival cultures, he was diagnosed with MRSA conjunctivitis. Treatment with vancomycin ultimately led to resolution of the condition. Conclusion : MRSA conjunctivitis should always be considered when a conjunctivitis is not responding to empirical therapy. Eye care professionals should be aware …

Insulin In Combination With N-Acetylcysteine Protects Hypoxia-Induced Toxicity In 661w Cells, Lili M. Guerra, Laura Valdez, Benxu Cheng, Andrew Tsin

Research Colloquium

Background: Proliferative diabetic retinopathy (PDR) is the leading cause of blindness among working-age adults. Photoreceptors are the most numerous and metabolically demanding cells in the retina thus oxygen is essential for retinal function. It has been reported that photoreceptors found in rat retina are specifically vulnerable to hypoxia. Hypoxia-induced metabolic stress leads to photoreceptor atrophy and retinopathy. Furthermore, photoreceptor cell death is known to occur mainly through apoptosis. However, the protection of hypoxia-induced-cytotoxicity in cone photoreceptor cells has not been investigated extensively. The aim of this study was to determine whether co-treatment of insulin and the N-Acetyl-L-Cysteine (NAC) (a free …

Bilateral Severe Iatrogenic Pigmentary Glaucoma Following Laser Treatment For Cosmetic Iris Color Change, Jiaru Liu, Salim Korban, Marlene R. Moster, Marc-André Rhéaume, Qianqian Wang

Wills Eye Hospital Papers

PURPOSE: We report a case of bilateral severe pigmentary glaucoma and paracentral acute middle maculopathy (PAMM) following laser treatment for iris color change.

OBSERVATIONS: A 32-year-old female presented to our emergency clinic after having undergone 4 sessions of bilateral cosmetic iris laser treatment in Turkey to lighten the color of her dark brown irides. Visual acuity was 20/150 in the right eye (OD) and counting fingers in the left eye (OS) at presentation. Intraocular pressures (IOP) were 50 mmHg in the right eye and 42 mmHg in the left eye, with 4+ free-floating pigmented cells in the anterior chamber. The …

Correlación Entre La Sintomatología Ocular Asociada Al Síndrome Visual Informático E Insuficiencia De Convergencia, César Luis Ruiz Sanabria, Erika Yuliana Niño Vega, Sandra Patricia Jurado

Ciencia y Tecnología para la Salud Visual y Ocular

El incremento en la demanda de uso de dispositivos electrónicos y pantallas digitales ha provocado la aparición de trastornos músculo esqueléticos, psicosociales y visuales; dentro de estos últimos se encuentra el trastorno denominado síndrome visual informático (svi), que se ha reportado desde hace más de veinte años; su tasa en la población oscila entre el 37 % y el 70 % (1). La alta recurrencia de alteraciones visuales dentro del svi permite relacionarlo con disfunciones de la visión binocular como la insuficiencia de convergencia (ic). Objetivo general: identificar la correlación existente entre la sintomatología ocular asociada al síndrome visual informático …

Rod-Specific Downregulation Of Omega-3 Very-Long-Chain Polyunsaturated Fatty Acid Pathway In Age-Related Macular Degeneration, William C. Gordon, Marie Audrey I. Kautzmann, Bokkyoo Jun, Megan L. Cothern, Zhide Fang, Nicolas G. Bazan

School of Medicine Faculty Publications

Docosahexaenoic acid (DHA; 22:6) plays a key role in vision and is the precursor for very-long-chain polyunsaturated fatty acids (VLC-PUFAs). The release of 32- and 34-carbon VLC-PUFAs and DHA from sn-1 and sn-2 of phosphatidylcholine (PC) leads to the synthesis of cell-survival mediators, the elovanoids (ELVs) and neuroprotectin D1 (NPD1), respectively. Macula and periphery from age-related macular degeneration (AMD) donor retinas were assessed for the availability of DHA-related lipids by LC-MS/MS-based lipidomic analysis and MALDI-molecular imaging. We found reduced retina DHA and VLC-PUFA pathways to synthesize omega-3 ELVs from precursors that likely resulted in altered disks and photoreceptor loss. Additionally, …

Calidad De Vida Y Productividad En Trabajadores Présbitas No Corregidos: Revisión Sistemática, Laura Natalia León Maldonado, Natalia Andrea Carrasco Romero, Karoll Lindhey Núñez Carranza, Nancy Piedad Molina-Montoya

Ciencia y Tecnología para la Salud Visual y Ocular

La presbicia es un proceso degenerativo normal asociado a la edad, que afecta al sistema visual dificultando enfocar con nitidez las imágenes en visión próxima, aspecto que puede generar la disminución de la productividad de los trabajadores que precisan realizar tareas de cerca y consecuentemente afectar su calidad de vida. La presente investigación tiene por objetivo sintetizar la evidencia científica sobre cómo la presbicia no corregida disminuye la productividad y la calidad de vida del trabajador mayor de 40 años. La metodología utilizada se basó en una búsqueda bibliográfica y el reporte se realizó cumpliendo los criterios de la declaración …

Caracterización Socioeconómica, Demográfica, Laboral Y Académica De Los Graduados De Optometría De La Universidad El Bosque En Bogotá, Colombia, Diana García-Lozada, José Rudas-Valero, Reinaldo Acosta-Martínez, Jenny Maritza Sánchez-Espinosa, Alejandra Mendivelso-Suárez, Lady Johana Morales-Solano

Ciencia y Tecnología para la Salud Visual y Ocular

Objetivo: conocer las características socioeconómicas, demográficas, laborales y académicas de los graduados del Programa de Optometría de la Universidad El Bosque, entre el 2013 y el 2022. Métodos: estudio observacional de corte transversal analítico, en el que se envió una encuesta electrónica a 365 graduados del Programa de Optometría. El instrumento incluyó 54 preguntas sobre variables demográficas, socioeconómicas, laborales y de formación académica posgradual. Resultados: de 190 graduados que respondieron la encuesta el 79,7 % eran de sexo femenino y el 90,6 % tenían entre 21 y 30 años. El 76,3 % permanecían solteros, el 76,8 % no tenían personas …

Unilateral Acute Iris Transillumination Syndrome With Glaucoma And Iris Pigment Epithelium Dispersion Simulating Iris Melanoma, Orlando Gonzalez Martinez, Carol L. Shields, Jerry Shields, Patricia Chévez-Barrios, Debbie Rigney Walley, Ralph C. Eagle Jr., Tatyana Milman

Wills Eye Hospital Papers

Purpose

To report a patient with a unilateral presentation of glaucoma, pain, and acute iris transillumination syndrome simulating iris melanoma.

Observations

A 53-year-old male presented with blurred vision and pain in his right eye several weeks following a respiratory sinus infection managed by oral azithromycin. Examination of the right eye was notable for elevated intraocular pressure of 46 mm Hg, an irregular mid-dilated pupil, and diffuse iris transillumination with pigmentary seeding on the iris surface, in the anterior chamber angle, and on the sclera, suspicious for diffuse iris melanoma with glaucoma and extrascleral extension. Ultrasound biomicroscopy (UBM) of the right …

Yoga Ocular, Una Práctica Que Podría Reducir La Sintomatología Y Mejorar Algunos Aspectos De La Función Binocular En Pacientes Jóvenes, Nancy Piedad Molina-Montoya

Ciencia y Tecnología para la Salud Visual y Ocular

No abstract provided.

Discromatopsias Y Su Relación Con El Desempeño Biopsicosocial Cotidiano, Myrna Miriam Valera-Mota, Mitzi Rubi Valencia-Estrada, Javier Alonso-Trujillo, Abraham Alonso-Ricardez, Luz Elena Maya-López, Ma. Consepcion Rodríguez-Salgado, Paola Guadalupe García-Guízar, Marco Antonio Reynoso-Castro

Ciencia y Tecnología para la Salud Visual y Ocular

Objetivo. Conocer cómo influye la visión de los pacientes discrómatas, particularmente de tipo congénito (deuteranómalos, protanómalos, deuteranopes y protanopes), en su vida cotidiana escolar, laboral o profesional y las principales dificultades enfrentadas, de acuerdo con el modelo biopsicosocial. Método. Se diseñó un instrumento de calidad de vida del paciente discrómata en el que se incluyeron diferentes categorías de la vida cotidiana, con un total de veintitrés reactivos que fueron aplicados a todos los pacientes diagnosticados con alguna discromatopsia en el gabinete de color de la Clínica de Optometría de la Facultad de Estudios Superiores Iztacala, de la Universidad Nacional Autónoma …

Percepción De Los Deportistas Sobre La Importancia Del Sistema Visual En El Rugby Paralímpico, Ana María Parra Arroyo, Sandra Patricia Jurado Medina, Sandra Milena Medrano, Nancy Piedad Molina-Montoya

Ciencia y Tecnología para la Salud Visual y Ocular

En las últimas décadas, se ha incrementado la atención sobre la relación de las habilidades visuales y el deporte. No obstante, son pocas las investigaciones realizadas sobre este tema en deportes paralímpicos y, en particular, aquellas que indaguen sobre la percepción de la influencia del sistema visual en el desempeño deportivo de los atletas. El objetivo de este estudio fue determinar la percepción de los jugadores de rugby en silla de ruedas sobre la influencia del sistema visual en el deporte. Se incluyeron quince deportistas pertenecientes a la selección paralímpica de rugby de Bogotá y Cundinamarca, a quienes se les …

Yes-Associated Protein-1 Overexpression In Ocular Surface Squamous Neoplasia; A Potential Diagnostic Marker And Therapeutic Target, Peter Julius, Stepfanie N. Siyumbwa, Fred Maate, Phyllis Moonga, Guobin Kang, Trevor Kaile, John T. West, Charles Wood, Peter C. Angeletti

School of Graduate Studies Faculty Publications

Yes-associated protein-1 (YAP-1) is a Hippo system transcription factor, which serves as an oncogene in squamous cell carcinoma, and several solid tumors when the Hippo pathway is dysregulated. Yet, the activity of YAP-1 in ocular surface squamous neoplasia (OSSN) has not been determined. Here, we investigate the relationship between YAP-1 overexpression and OSSN. Using a cross-sectional study design, we recruited 227 OSSN patients from the University Teaching Hospitals in Lusaka, Zambia. Immunohistochemistry was used to assess YAP-1 protein overexpression in tumor tissue relative to surrounding benign squamous epithelium. OSSN patient samples (preinvasive, n = 62, 27% and invasive, n = …

Abcb5+ Limbal Epithelial Stem Cells Inhibit Developmental But Promote Inflammatory (Lymph) Angiogenesis While Preventing Corneal Inflammation, Berbang Meshko, Thomas L. A. Volatier, Karina Hadrian, Shuya Deng, Yanhong Hou, Mark A. Kluth, Christoph Ganss, Markus H. Frank, Natasha Y. Frank, Bruce Ksander, Claus Cursiefen, Maria Notara

Research outputs 2022 to 2026

The limbus, the vascularized junction between the cornea and conjunctiva, is thought to function as a barrier against corneal neovascularization. However, the exact mechanisms regulating this remain unknown. In this study, the limbal epithelial stem cell (LESC) marker ABCB5 was used to investigate the role of LESCs in corneal neovascularization. In an ABCB5KO model, a mild but significant increase of limbal lymphatic and blood vascular network complexity was observed in developing mice (4 weeks) but not in adult mice. Conversely, when using a cornea suture model, the WT animals exhibited a mild but significant increase in the number of lymphatic …