Dentistry Commons^™

Il-34 Exacerbates Pathogenic Features Of Alzheimer's Disease And Calvaria Osteolysis In Triple Transgenic (3x-Tg) Female Mice., Anny Ho, Bidii Ngala, Chiaki Yamada, Christopher Garcia, Carolina Duarte, Juliet Akkaoui, Dumitru Ciolac, Amilia Nusbaum, William Kochen, Daniela Efremova, Stanislav Groppa, Lubov Nathanson, Stephanie Bissel, Adrian Oblak, Melissa A. Kacena, Alexandru Movila

HPD Articles

Hallmark features of Alzheimer's disease (AD) include elevated accumulation of aggregated Aβ40 and Aβ42 peptides, hyperphosphorylated Tau (p-Tau), and neuroinflammation. Emerging evidence indicated that interleukin-34 (IL-34) contributes to AD and inflammatory osteolysis via the colony-stimulating factor-1 receptor (CSF-1r). In addition, CSF-1r is also activated by macrophage colony-stimulating factor-1 (M-CSF). While the role of M-CSF in bone physiology and pathology is well addressed, it remains controversial whether IL-34-mediated signaling promotes osteolysis, neurodegeneration, and neuroinflammation in relation to AD. In this study, we injected 3x-Tg mice with mouse recombinant IL-34 protein over the calvaria bone every other day for 42 days. Then, …

Group 4 Iti Consensus Report: Patient Benefits Following Implant Treatment In Partially And Fully Edentulous Patients., Martin Schimmel, Mauricio Araujo, Samir Abou-Ayash, Ramona Buser, Supriya Ebenezer, Manrique Fonseca, Lisa J. Heitz-Mayfield, Lucrezia Paterno Holtzman, Porawit Kamnoedboon, Robert Levine, Gerry Mckenna, Sabrina Maniewicz, Flavia Matarazzo, Nikos Mattheos, Panos Papaspyridakos, André Barbisan De Souza, Murali Srinivasan, Charlotte Stilwell, Hans Peter Weber

HPD Articles

OBJECTIVES: The aim of Working Group 4 was to address patient benefits associated with implant dentistry. Focused questions on (a) dental patient-reported outcomes (dPROs), (b) improvement in orofacial function, and (c) preservation of orofacial tissues in partially and fully edentulous patients following provision of implant-retained/supported dental prostheses were addressed.

MATERIALS AND METHODS: Three systematic reviews formed the basis for discussion. Participants developed statements and recommendations determined by group consensus based on the findings of the systematic reviews. These were then presented and accepted following further discussion and modifications as required by the plenary of the 7th ITI Consensus Conference, taking …

Covid-19: Variants, Immunity, And Therapeutics For Non-Hospitalized Patients., Cameron Y.S. Lee, Jon B. Suzuki

HPD Articles

The continuing transmission of coronavirus disease 2019 (COVID-19) remains a world-wide 21st-century public health emergency of concern. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused greater than 600 million cases of COVID-19 and over 6 million deaths globally. COVID-19 continues to be a highly transmissible disease despite efforts by public health officials and healthcare providers to manage and control the disease. Variants identified in selected worldwide epicenters add to the complexity of vaccine efficacy, overage, and antibody titer maintenance and bioactivity. The identification of the SARS-CoV-2 variants is described with respect to evading protective efficacy of COVID-19 vaccines and …

Cpg Odn/Mangiferin Dual Delivery Through Calcium Alginate Hydrogels Inhibits Immune-Mediated Osteoclastogenesis And Promotes Alveolar Bone Regeneration In Mice., Yingzhi Gu, Yang Hu, Shengyuan Huang, Sunniva Ruiz, Toshihisa Kawai, Yuxing Bai, Xiaozhe Han

HPD Articles

The immune system plays an important role in the skeletal system during bone repair and regeneration. The controlled release of biological factors from the immune system could facilitate and optimize the bone remodeling process through the regulation of the activities of bone cells. This study aimed to determine the effect of the controlled delivery of immunomodulatory biologicals on bone regeneration. Immunostimulatory cytosine-phosphate-guanosine oligodeoxynucleotides (CpG ODN) and glucosylxanthone Mangiferin (MAG)-embedded microbeads were incubated with P. gingivalis-challenged splenocytes, or co-cultured with RAW264.7 cells. The effect of CpG ODN/MAG-containing microbeads on bone regeneration was then tested in vivo in a mouse alveolar bone …

Repair Of An Extensive External Cervical Resorption Lesion Using Intentional Replantation With Crown Rotation., Motoki Okamoto, Yoko Asahi, Henry Fergus Duncan, Nanako Kuriki, Yusuke Takahashi, Mikako Hayashi

HPD Articles

Treatment of large external cervical resorption (ECR) lesions may be compromised, rendering the tooth unrestorable. Intentional replantation is a potential treatment option depending on the site and extent of ECR. We present a case of a large ECR successfully managed with intentional replantation with rotation of the tooth. The female patient consulted the hospital clinic, with an extensive palatal ECR on the maxillary lateral incisor. Routine planar radiographs and cone-beam computed tomography demonstrated a larger palatal than the ECR lesion (Heithersay Class III and Patel's Class 2Bp) not amenable to nonsurgical treatment. Intentional replantation after short-term extrusion was planned. The …

Association Between Symptoms Of Severe Periodontitis And Post-Bronchodilator Lung Function: Results From The China Pulmonary Health Study., Zhiqiang Liu, Xuan Zhou, Lirong Liang, Xiaozhe Han, Ting Yang, Kewu Huang, Yingxiang Lin, Zuomin Wang, Chen Wang

HPD Articles

BACKGROUND: The association between periodontitis and post-bronchodilator lung function is unclear. We aimed to determine the associations between symptoms of severe periodontitis (SSP) and post-bronchodilator lung function in the Chinese population.

METHODS: A cross-sectional study (China Pulmonary Health study) was conducted from 2012 to 2015 in a large Chinese nationally representative sample of 49,202 participants aged 20-89 years. Data on demographic characteristics and periodontal symptoms of participants were collected by questionnaire. Participants who had at least one of the two severe symptoms (tooth mobility and natural tooth loss) in the past year were defined to have SSP, which was set …

Periodontal Regeneration Risk Assessment In The Treatment Of Intrabony Defects., Robert A. Levine, Muhammad H A Saleh, Debora R. Dias, Jeffrey Ganeles, Maurício G. Araújo, Franck Renouard, Harold M. Pinsky, Preston D. Miller, Hom-Lay Wang

HPD Articles

BACKGROUND: Regenerative approaches performed in periodontics seems to be efficient in treating intrabony defects. There are, however, many factors that may affect the predictability of the regenerative procedures. The present article aimed to propose a new risk assessment tool for treating periodontal intrabony defects by regenerative therapy.

METHODS: Different variables that could affect the success of a regenerative procedure were considered based on their impact on (i) the wound healing potential, promoting wound stability, cells, and angiogenesis, or (ii) the ability to clean the root surface and maintain an optimal plaque control or (iii) aesthetics (risk for gingival recession).

RESULTS: …

Preprocedural Viral Load Effects Of Oral Antiseptics On Sars-Cov-2 In Patients With Covid-19: A Systematic Review., Miriam Ting, Alex Dahlkemper, Jeremy J. Schwartz, Manzel Woodfork, Jon B. Suzuki

HPD Articles

(1) There are limited clinical trials to support the effectiveness of mouth rinses when used as a preprocedural rinse against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This systematic review aims to evaluate the efficacy of antiseptic mouth rinses as a preprocedural rinse in reducing SARS-CoV-2 oral viral load in-vivo. (2) Methods: A literature search was conducted through November 2022 for the following databases: PubMed, Web of Science, Cochrane Library, and Google Scholar. The evaluated outcomes were quantitative changes in viral load and the statistical significance of that change after using antiseptic mouth rinses. (3) Results: 14 randomized controlled trials …

Parental Acceptance Of Silver Diamine Fluoride Treatment For Carious Lesions, Mitchell Miller, Kelly Hart, Maria A. Levi-Minzi, Jennifer Chung, Judith Chin, Oscar Padilla, Romer Ocanto

HPD Articles

Objectives The purpose of this study was to determine parental acceptability of the use of Silver Diamine Fluoride (SDF) as an alternative treatment for carious legions. In addition, we examined potential factors influencing higher levels of SDF acceptance. Methods Project was approved by the institutional review board. Parents of patients receiving care at Nova Southeastern University’s dental clinics were asked to review an educational document related to the use and side effects of SDF; surveys were then distributed to assess willingness to use this treatment for their child. SDF acceptance was measured by mean scores on the SDF Feasibility Questionnaire; …

Using Motivational Interviewing To Increase Confidence In Nutritional Counseling Among Dental Hygienists: A Pilot Study, Heather M. Anderson, Sarah Jackson, Lisa Bilich, Craig Hunt, Elizabeth Tipton

Internet Journal of Allied Health Sciences and Practice

Purpose: Dental hygienists have the unique opportunity to educate patients on connections between nutrition and oral health. Dental hygiene students are introduced to these concepts but struggle to gain confidence to share this knowledge with patients. This pilot study looked at an educational module on motivational interviewing (MI) and an assessment and counseling tool to build student confidence with nutritional counseling. Methods: Dental hygiene students participated in an educational module to review MI and introduce a nutritional risk assessment and counseling tool. Prior to the module, participants completed a pretest about confidence levels regarding MI and nutritional counseling. After three …

Assessing Faculty Preference Regarding Online Tools For Assessment In Medical Education: A Cross-Sectional Multi-Center Study, Zarreen Raza, Samira Adnan, Sanaa Ahmed, Zahid Memon, Saad Saleem, Ziyad Sanaullah

Internet Journal of Allied Health Sciences and Practice

Purpose: E-assessment is a novel practice in developing countries; hence it is essential to determine the online platforms and tools preferred by health sciences education faculty for online assessment. The purpose of this study was to assess the preference of faculty in medical and dental education regarding the online tools for e-assessment of undergraduate students. Methods: This cross-sectional, descriptive study was conducted from June until August 2020 on the faculty of medical and dental undergraduate programs of private and public sector institutes across Karachi, with a sample size of 152. Data was collected through convenience sampling using a validated questionnaire …